rab5 glutathione s transferase gst and p85 proteins
Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
Ngày tải lên :
10/08/2014, 05:21
... polymorphisms (SNPs) genotyping was performed The association of GSTM1, GSTT1, GSTP1, GSTO1 and GSTO2 with UC risk was examined In addition, the joint effect of such genes with levels of arsenic exposure ... 1.19); Although these studies show inconsistent results for the association between GSTs and urinary arsenic metabolite pattern, the findings indicate that the GSTT1is possibly responsible for a part ... of GSTs with the risk of urothelial carcinoma according to various cutoff points of arsenic exposure level List of abbreviations As: arsenic; GST: glutathione S- transferase; GSTO: Glutathione S- transferase...
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Tài liệu Báo cáo Y học: Characterization of an omega-class glutathione S-transferase from Schistosoma mansoni with glutaredoxin-like dehydroascorbate reductase and thiol transferase activities pptx
Ngày tải lên :
21/02/2014, 01:21
... blot analysis was performed using S mansoni cercariae purified DNA as described [26] Alignments and phylogenetic analysis of S mansoni GSTs Sm2 6GST, Sm2 8GST and SmGSTO amino acid sequences were aligned ... FEBS 2002 Omega-class GST from Schistosoma mansoni (Eur J Biochem 269) 5513 At least five GST activities have been described in the human parasite Schistosoma mansoni (SmGST-1 to SmGST-5) SmGST-5 ... SmGSTO Concerning the two other S mansoni GSTs, Sm2 6GST grouped within mu-class GSTs with a high local bootstrap value and Sm2 8GST remains in a nondefined position between sigma and pi classes...
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Báo cáo khoa học: Purification and cloning of a Delta class glutathione S-transferase displaying high peroxidase activity isolated from the German cockroach Blattella germanica pptx
Ngày tải lên :
23/03/2014, 09:21
... at least six classes of cytosolic GSTs in insects [2] The majority of GSTs are in the Delta and Epsilon classes, and the remaining enzymes are in the Omega, Sigma, Theta and Zeta classes The ... sexta Anopheles gambiae Anopheles gambiae Anopheles gambiae Anopheles gambiae Anopheles gambiae DmGSTD1 NM_079602 NlGST1-1 LcGST1 AgGSTD3 BmGST1 MsGSTolf1 AgGSTD7 AgGSTS1 Bla g DmGSTS1 AF448500 ... cockroach GST compared with those of other insect GSTs Values are the means ± SE from three separate experiments Substrate specificities of Delta class GSTs from D melanogaster D1 [22], N lugens 1–1...
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Báo cáo khoa học: Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells pdf
Ngày tải lên :
30/03/2014, 13:20
... proteins [hGSTA4-4, hGSTA44(Y212F), mGSTA4-4, DmGSTD1-1, hGSTA1-1, and hGSTP1-1] indicates that a causal involvement of 4-HNE in the mechanism of hGSTA4-4-mediated transformation of HLE B-3 and ... changes in the homeostasis of 4-HNE and its metabolites that provides the mechanistic basis for the transformation This possibility needs to be explored in future studies Our results show that some ... (2003) Cloning, expression and biochemical characterization of one Epsilon-class (GST- 3) and ten Delta-class (GST- 1) glutathione S- transferases from Drosophila melanogaster, and identification of...
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Báo cáo khoa học: Purification and partial characterization of seven glutathione S -transferase isoforms from the clam Ruditapes decussatus pptx
Ngày tải lên :
31/03/2014, 09:20
... alpha, pi GST classes consensus sequences of mammals are from Fitzpatrick et al [28] Species GST 44 GSH binding protein GST GST Consensus mu Consensus alpha Consensus pi N-terminal sequence Identity ... acid sequence of R decussatus GST 4-4 isoform with other known GST sequences Clonorchis sinensis and F hepatica GST sequences are from the SWISS-PROT database; M edulis binding protein and mu, ... kcat, and the catalytic efficiency, kcat/Km(substrate), allowed us to distinguish the four GSTs tested As few studies gave such kinetics constants for GST and none for GSTs from mollusc organisms,...
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Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression doc
Ngày tải lên :
31/03/2014, 15:20
... concentrations of AS-1 (A), AS-2 (B), AS-5 (C), AS-6 (D) or AS-9 (E) AS1 and AS-6 are directed against GSTM1, AS-5 is directed against GSTM2, whereas AS-2 and AS-9 are complementary to both GSTM1 and GSTM2 ... isoform specificity of AS-5 and AS-10 in the EGFP assay, compared to the GST assay In summary, we selected several effective antisense ODNs against rat GSTM1 and GSTM2 from a set of 15 PS-ODNs ... cells With this assay, we determined the effectiveness of a set of antisense PS-ODNs directed against the glutathione S- transferase Mu1 (GSTM1) and Mu2 (GSTM2) isoforms of the rat GSTs play an important...
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Báo cáo y học: " Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients" potx
Ngày tải lên :
12/08/2014, 15:20
... against cigarette smoke induced oxidative stress GSTO belongs to the glutathione- S- transferase family (GST) that detoxifies toxic substrates present in tobacco smoke by a GSHdependent mechanism GSTO ... (not shown) Western blot analysis for GSTO1-1 showed decreased levels of GSTO11 in the supernatants of COPD patients compared to nonsmokers (p = 0.023) (Figure 5A) These results suggest that GSTO1-1 ... cigarette role of GSTO oxidative stress Suggested role of GSTO (glutathione transferase omega) in cigarette smoke induced oxidative stress Enzymes maintaining GSH homeostasis are important in...
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Báo cáo y học: "Anticitrullinated protein antibody (ACPA) in rheumatoid arthritis: influence of an interaction between HLA-DRB1 shared epitope and a deletion polymorphism in glutathione s-transferase in a cross-sectional study" ppt
Ngày tải lên :
12/08/2014, 15:22
... GSTM1smoking and smoking-SE), and associations of these risk factor assignments with outcomes were examined using similar regression techniques Gene-gene (GSTM1-SE) and gene-environment (GSTM1-smoking and ... immunosorbent assays (ELISAs) in VARA (Diastat, Axis-Shield Diagnostics Ltd., Dundee, Scotland, UK; positive ≥5 U/ml) and SONORA (Inova Diagnostics, San Diego, CA, USA; positive ≥20 U/ml) using serum ... VARA Registry and 65% in SONORA; P < 0.05) Age- and gender-adjusted associations Associations of GSTM1, smoking, and HLA-DRB1 status with ACPA positivity in the VARA registry and SONORA are summarized...
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ẢNH HƯỞNG CỦA THUỐC TRỪ SÂU HOẠT CHẤT QUINALPHOS ĐẾN HOẠT TÍNH MEN CHOLINESTERASE VÀ GLUTATHIONE-S-TRANSFERASE CỦA CÁ CHÉP (CYPRINUS CARPIO) ppt
Ngày tải lên :
11/03/2014, 05:21
... cholinesterase measurement in assessing the impact of pesticides on terrestial and aquatic invertebrates In: Mineau, P (Ed.), Cholinesterase Inhibiting Insecticides Their Impact on Wildlife and ... Effects of subchronic exposure to Successor® 600 on common carp Cyprinus carpio Neuroendocrinology Letters Volume 30 Suppl 2009, p 230-235 Koesomadinata, S and R Djajadiredja., 1976 Some Aspects ... azinphosmethyl, parathion and carbaryl exposure in the goldfish (Carassius auratus) Ecotoxicology and Environmental Safety, 57, pp: 420– 425 Guimaraes, A.T.B., H.C .S Assis., W Boeger., 2007 The...
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Báo cáo y học: "4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase" doc
Ngày tải lên :
09/08/2014, 13:21
... proteins Statistical analysis Results were expressed as the mean ± standard error of the mean of eight specimens, and assays were performed in three independent experiments Statistical analysis ... apoptotic response of chondrocytes to HNE is associated with decreased Bcl-2 expression and increased Bax expression This suggests that chondrocytes need to modulate the synthesis of at least several ... transfection GSTA4-4 small interfering RNA (siRNA) and randomly sequenced siRNA as negative controls were purchased from Ambion (Austin, TX, USA) Wild-type and mutant GSTA4-4 expression plasmids...
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Báo cáo y học: " Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study" pps
Ngày tải lên :
12/08/2014, 16:20
... 1.1 -6.5, 7.5 0.15 0.88 GSTM1T1 both non-null GSTM1T1 either null GSTM1T1 both null GSTT1*GSTM1Interaction Sex* Genotype Interaction†† sex*GSTT1 sex*GSTM1 sex*GSTP1 sex*GSTT1M1 931 1276 248 -0.9 ... We assessed the impact of genetic GST deficiency on lung function decline sepa- rately for never smokers and persistent smokers; associations observed in ever-smokers were similar to those reported ... ever smokers), as well as BHR and age, was assessed by including according multiplicative interaction terms in the regression models Trend tests for the combination of GSTT1 and GSTM1 genotypes...
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Glutathione s transferase pi expression in invasive ductal breast carcinoma
Ngày tải lên :
16/09/2015, 17:14
... analysis 49 2.10 Statistical analysis 50 RESULTS 51 3.1 Glutathione S- transferase pi (GST- pi) expression 52 3.2 Total glutathione S- transferase (GST) activity 55 v 3.3 Bcl-2 expression 59 3.4 Association ... Resisting intrinsic pressures for apoptosis 23 1.6.2 Resisting extrinsic pressures for apoptosis 25 1.6.3 Chemotherapy resistance 27 1.7 Glutathione S- transferase pi (GST- pi) 30 1.8 Scope of study ... adaptations allows it to modulate the severity of the onslaught and survive Introduction 30 Figure Defence against apoptosis 1.7 Glutathione S- transferase pi (GST- pi) Glutathione S- transferases (GSTs)...
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Báo cáo khoa học: Purification and properties of the glutathione S-transferases from the anoxia-tolerant turtle, Trachemys scripta elegans pdf
Ngày tải lên :
23/03/2014, 15:20
... typically shows only minor activity towards cumene hydroperoxide The classification of GSTs also depends on their responses to substrates and inhibitors Like all GSTs, turtle liver GSTs showed activity ... mass of some yeast (Y lipolytica) GSTs, however, is 110 kDa [32] Thus GSTs can vary widely in their subunit size The larger molecular mass of turtle GSTs may arise as a result of post-translational ... turtles the turtle liver GSTs are consistent with their classification as a class enzymes Responses to inhibitors also generally supported this conclusion Cibacron Blue causes greatest to least inhibition...
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báo cáo hóa học: " Leader (L) and L* proteins of Theiler''''s murine encephalomyelitis virus (TMEV) and their regulation of the virus'''' biological activities" docx
Ngày tải lên :
19/06/2014, 22:20
... express class I MHC molecules and therefore lack CD8+ T lymphocytes, abrogates resistance to the DA strain, allowing the virus to persist [43] This report suggests that class I-restricted CD8+ ... contains a zinc-binding motif Cys-His-Cys-Cys that, interestingly, is present in L from all the cardioviruses [6,36] Our unpublished data demonstrate that L is synthesized with the same kinetics as ... translate the 17–18 kDa protein, designated L* The synthesis of L* is TO subgroup-specific because this alternative initiation site is not present in GDVII subgroup strains (where the L* AUG is substituted...
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Báo cáo y học: "Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity" ppsx
Ngày tải lên :
12/08/2014, 14:20
... reason is the presence of various alphaclass GSTs in human lung tissues but not in sputum supernatants Two GST alpha subtypes have been earlier documented in rat tissue homogenates and porcine Sertoli ... increase followed by the subsequent decline of several enzymes related to GSH synthesis/homeostasis including GST in COPD as shown in this study and in the previous investigations parallels with ... bands from the tissues but not from sputum supernatants These results can be related to many reasons one of those being proteolysis of GST alpha in the tissues Another, even more likely reason...
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FAILURES IN LOGISTICS MANAGEMENT OF VINALINK’S LOGISTICS DEPARTMENT AND RECOMMENDATIONS
Ngày tải lên :
20/04/2013, 11:13
... organization s business strategies Because market demand is changing, business strategies should be ready to change to satisfy customers’ needs and wants However, any changes of strategies should be ... solutions for their businesses Moreover, these lessons will lower risks when implementing business strategies and losses resulting from bad decisions Finally, manager should be alerted and ready ... reserve stock As a result, it is more necessary for Vinalink s warehouses to make good use of space to stock as much goods as possible Having many wide aisles becomes a disadvantage in this case because...
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