... 5-HT2A receptors mediate the inflammatory response to serotonin Recent animal and human data suggest that certain subtypes of serotonin receptors may play a role in mediating inflammatory processes ... antiinflammatory drug; QUIN: quinolinic acid; RA: rheumatoid arthritis; SERT: serotonin transporter; SPECT: single-photon emission computed tomography; SSRI: specific serotonin-reuptake inhibitor; TCA: ... bi-directional relation seems to exist between biologic substrates of mood disorders and inflammation For example, inflammatory mediators like proinflammatory cytokines are thought to have a direct impact...
Ngày tải lên: 11/08/2014, 00:23
... USA), which was placed into an oven at 60 C for h The lid to the vessel was sealed to prevent evaporation At the end of the period, the vessel was cooled to room temperature to remove the specimens ... hexahydrate (Zn(NO3)$6H2O) was used to grow ZnO crystals, and aluminum nitrate hexahydrate (Al(NO3)$6H2O) and tri-sodium citrate (Na3C6H5O7) were used as surfactant chemicals to control the shape of the ... magnetron sputtering at room temperature, were cleaned sequentially in acetone and isopropyl alcohol The substrates were then fixed to a Teflon insert with the ZnO seed layer side facing down within a...
Ngày tải lên: 06/05/2014, 13:23
Báo cáo hóa học: "Reference values and physiological characterization of a specific isolated pig kidney perfusion model" doc
... B2-solution pursuant to von Baeyer [8]) was then applicated into the artery and the kidneys were transferred under sterile, hypothermic (4°C) conditions from the abattoir to the laboratory Perfusion ... analysis using an automated blood gas analysator (Radiometer Copenhagen, ABL) to assess pH- and electrolyte status Further sample fractions were stored for a later Kidneys from laboratory animals were ... autologously perfused porcine livers Arch Toxicol 2004, 78:697-705 Groneberg DA, Grosse-Siestrup C, Fischer A: In vitro models to study hepatotoxicity Toxicol Pathol 2002, 30:394-399 Modersohn...
Ngày tải lên: 20/06/2014, 00:20
Báo cáo khoa học: "Commissioning and early experience with a new-generation low-energy linear accelerator with advanced delivery and imaging functionalities" doc
... 10x10cm2, dmax Tolerance:
Ngày tải lên: 09/08/2014, 09:21
Báo cáo y học: "gA retroperitoneal abscess caused by Haemophilus parainfluenza after endoscopic retrograde cholangiopancreatography and open cholecystectomy with a common bile duct exploration: a case report" ppt
... involved ERCP with papillotomy, a possible port of entry for the bacterium The common duct stone was too large (3 to cm) to remove via ERCP; therefore an open cholecystectomy and CBD exploration ... cholangiogram The stone was assumed to have been present in the CBD for many years since it was significantly large The possibility of it being a primary CBD stone or a stone that was passed into the CBD ... flank (figure 1) Our patient was taken to the operating room where a retroperitoneal abscess was found that tracked into the right paracolic gutter and into the right flank There was no subhepatic...
Ngày tải lên: 11/08/2014, 12:20
Báo cáo y học: " A gastrointestinal stromal tumour presenting incidentally with haemorrhage and perforation associated with a Meckel’s diverticulum: a case report" pps
... prognostic indicators are based on consensus guidelines The most important adverse factors are thought to be a tumour diameter of greater than cm and a high mitotic count exceeding five mitotic figures ... symptomatic Meckel’s diverticula in adults to be bleeding (38%), obstruction (34%), diverticulitis (28%) and perforation (10%) [6] Perforation is most common secondary to ulceration of ectopic ... histological specimens and provided the histological diagnosis All authors read and approved the final manuscript Acknowledgements The authors would like to thank the patient for allowing us to...
Ngày tải lên: 11/08/2014, 17:21
Báo cáo y học: "Dialectical Behavioral Therapy for Adolescents (DBT-A): a clinical Trial for Patients with suicidal and self-injurious Behavior and Borderline Symptoms with a one-year Follow-up" pot
... of these, up to 11% eventually die by suicide [4] Unfortunately, up to 77% of adolescent suicide attempters either not attend outpatient treatment or drop out before learning how to tolerate distress ... Skills, Distress Tolerance Skills, Emotion Regulation Skills, Family Skills and “Walking the Middle Path” In the multi family skills training groups, we included up to 12 persons (up to five adolescents ... appropriate for him, owing to severe bulimic symptoms that required specific treatment A third patient was not able to keep the appointments regularly due to extensive social phobic pathology These...
Ngày tải lên: 13/08/2014, 18:21
Báo cáo y học: "Blunt traumatic pericardial rupture and cardiac herniation with a penetrating twist: two case reports" ppt
... and was intubated prior to transfer for computed tomography (CT) scan to be on a FiO2 of 1.0 with PaO2 around 10 kPa and requiring high dose norepinephrine and epinephrine to sustain his mean arterial ... the heart into the right hemithorax was also causing concern At this stage the patient's condition had not improved and, on balance, it was agreed to take the patient to theatre to investigate ... sac; prominent pulmonary artery contour; herniation and rotation of the heart into either hemithorax with a possible pericardial sac contour visible distinct to the cardiac silhouette [2,8,10,13]...
Ngày tải lên: 13/08/2014, 23:21
money and trade considered, with a proposal for supplying the nation with money
... yearly 500 lib to his Stock Wheras a Scots Merchant, whose Stock is 500 lib and his yearly Expense 50; cannot trade so cheap If 'tis ask't how a Dutch Merchant trades wo has only 500 lib Stock? He ... cent Profit, and to Holland 15; The English Merchant will choose to send such Goods to Holland for 15 per cent, rather than to Portugal for 25: And the Dutch Merchant who is able to Trade cheaper, ... continued at in Scotland; if Money were to be had equal to the Demands at 6, the Advantages we have for Trade, which the Dutch have not, would enable us to extend Trade to its other Branches, notwithstanding...
Ngày tải lên: 05/11/2014, 09:13
The herpetofauna of the peruvian dry forest along the andean valley of the marañón river and its tributaries, with a focus on endemic iguanians, geckos and tegus
... been surveyed in herpetological terms The present study was organized to contribute to the knowledge of the herpetofauna of this peculiar dry forest habitat Field surveys to Peru were conducted ... surveyed in herpetological terms To contribute to the knowledge of the herpetofauna of this peculiar dry forest habitat we conducted several field trips between July 2005 and November 2010 to 22 different ... DRY FOREST HERPETOFAUNA Peru), resulting in a splitting of some villages, with one part belonging to the Region sinistral to the river and another part belonging to the Region to the right side...
Ngày tải lên: 19/11/2015, 15:51
Báo cáo khoa học: Structural and biological effects of a b2- or b3-amino acid insertion in a peptide Application to molecular recognition of substance P by the neurokinin-1 receptor ppt
... remains close to Hz, indicating that Gln5 always adopts a helical conformation This invariable folding of Gln5 is related to the helix initiator propensity of Pro4 and decreases from Gln5 to Gly9 In ... potency to stimulate PLC (Fig 4B) Whatever the affinity measured for the NK-1m binding site for these agonists (from pM to 0.54 nM), the corresponding potency to stimulate PLC is always close to nM ... receptors to be occupied by these agonists to get activation of the second messenger cascade as reported [40] Enzymatic degradation of SP analogues ACE is a dipeptidyl carboxypeptidase known to...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo Y học: Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression doc
... cell cultures that were transfected with plasmid only, to 9% in cell cultures cotransfected with ODN and plasmid This is probably due to cytotoxicity of DOTAP, as a larger amount of DOTAP was used ... mixture to a solution of DOTAP in HBS (1 lgÆlL)1; charge ratio DNA : DOTAP ¼ : 5) The DNA and DOTAP solutions were mixed by repeated pipetting The transfection mixture was diluted with HBS to a total ... buffer) EGFP was detected by an enhanced chemiluminescence assay, according to the manufacturer’s protocol Flow cytometry Cells were detached from the culture plates with trypsin, centrifuged...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo hóa học: " Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors" docx
... in a C57BL/6 mixed strain to show that mTOR inhibitor treatment reduces kidney tumor severity, to investigate the timing of mTOR inhibitor Page 13 of 18 treatment, and to show that addition of ... MEK1/2 inhibitor (CI-1040) [70] and a dual PI3K/mTOR inhibitor (NVP-BEZ-235) [71] Drugs for which combination with mTOR inhibitor treatment is more effective than single agent mTOR inhibitor include ... was obtained from LC Laboratories (Woburn, MA) and a 20 mg/ml stock of rapamycin was made in ethanol (stored at -20°C for up to one week) The stock solution was diluted to 1.2 mg/ml in vehicle (0.25%...
Ngày tải lên: 18/06/2014, 16:20
Báo cáo sinh học: "Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" pptx
... intratumoral injection to maximize its concentration within the tumor, and converted into cytotoxic metabolites by HRP It was demonstrated that HRP/IAA system was more cytotoxic to tumors than the ... by adenovirus vectors and the tumor specific promoter (hTERT) was efficient to drive target gene expression In addition, the HRP/IAA system was reported to be more cytotoxic to tumor cells than ... according to the manufacturer’s instructions Immunohistochemical analysis and apoptosis assay Tumor tissues were formalin fixed and μm sections were stained with hematoxylin and eosin for routine histological...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học: " The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism" pot
... pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases Autoimmunity may have a role in the pathogenesis of autism in some patients We are the first to ... production of pro-inflammatory cytokines and cell apoptosis [27] Evidence for an interaction between chronic inflammation in autoimmune diseases and neural dysfunction points to an involvement linking ... lead to immune dysregulation resulting from altered cytokine production, resulting in autoimmune or atopic diseases Thus, the stress response with subsequent induction of a dysregulation of cytokine...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo hóa học: " Nucleotide mismatches between the VP7 gene and the primer are associated with genotyping failure of a specific lineage from G1 rotavirus strains" potx
... primers to avoid the mismatches between the primer and the VP7 gene [17,20] Lineage I In a recent paper published by Rahman et al [19], it was reported the failure of the Das's RT-PCR strategy to ... lineage I were the most reported worldwide It was suggested to use modified or degenerated primers, or change the priming binding site, in order to avoid the mismatches between the primer and the VP7 ... failure on the detection of the G1 strains could be due to the diversification of rotavirus strains in phylogenetic lineages, as it was showed by Santos et al [7] in G9 strains when they used the Gouvea's...
Ngày tải lên: 20/06/2014, 01:20
báo cáo hóa học:" Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma" doc
... intratumoral injection to maximize its concentration within the tumor, and converted into cytotoxic metabolites by HRP It was demonstrated that HRP/IAA system was more cytotoxic to tumors than the ... by adenovirus vectors and the tumor specific promoter (hTERT) was efficient to drive target gene expression In addition, the HRP/IAA system was reported to be more cytotoxic to tumor cells than ... according to the manufacturer’s instructions Immunohistochemical analysis and apoptosis assay Tumor tissues were formalin fixed and μm sections were stained with hematoxylin and eosin for routine histological...
Ngày tải lên: 20/06/2014, 03:20
Báo cáo toán học: "Positive cones and $L^p$-spaces associated with a von Neumann algebra " pptx
Ngày tải lên: 05/08/2014, 10:20
Báo cáo y học: "Validation of a specific measure to assess healthrelated quality of life in patients with schizophrenia and bipolar disorder: the ‘Tolerability and quality of life’ (TOOL) questionnaire" doc
... Figure The ‘TOlerability and quality Of Life’ (TOOL) questionnaire Retesting was carried out to weeks after the first visit In order to analyse the psychometric properties of the TOOL questionnaire, ... used to study the association between each of the TOOL items and SF-6 D and EQ-5 D measurements In order to evaluate criterion validity, patients were categorised taking into account the CGI-S to ... 6Dimensions; TOOL = ‘TOlerability and quality Of Life’; UKU = Udvalg for Kliniske Undersøgelser; YMRS = Young Mania Rating Scale significant and mild to high With respect to specific measures, the TOOL...
Ngày tải lên: 09/08/2014, 01:21