quality bias and limitations of patient registry data

... most of us would tend to keep a patient on a given therapy if that patient has already improved to some extent since the initiation of the respective treatment Showing such large amounts of improvement ... all treatment terminations and then at only those terminations for the reason of ineffectiveness and terminated for the reason of toxicity This was done by censoring patients with treatment terminations ... unacceptable flares, and others clearly will have unacceptable toxicity; however, the vast majority of patients will have some combination of the two, which will hamper a clear adjudication of the reason...

Ngày tải lên: 09/08/2014, 14:20

... the quality of training, and curriculum of training With the companies: - The requirement of labor (type, skills, etc ) - Number of labor required from now to 2000 - Evaluation the quality of ... learning and skills building through observation and of specific techniques and practices Seminar and workshop - These could be in-plant or public offerings Both cost and overall effectiveness of these ... culture and education, as well as general social progress and equality By focusing on the improvement of the populace and the quality of human resources, Vietnam hopes to enable all of its people...

Ngày tải lên: 13/04/2013, 10:31

... determination of the basic long-term goals and objectives of an enterprises, and the adoption of courses of action and the allocation of resources necessary for carrying out these goals” (Chandler,1989) ... number of buyers and their relative sizes • The prevalence of backward and forward integration • Ease of entry and exit • The pace of technological change in both production processes and new ... Organisation structure and relationships Division of labor Coordination of divided responsibility Information systems Organisational process and behavior Standards and measurement Motivation and incentive...

Ngày tải lên: 13/04/2013, 10:32

... processing program that must be able to handle very large amounts of text necessitates dictionaries of substantial size, of the order of at least tens of thousands of entries, perhaps even more than ... This rapid and necessarily incomplete overview of the organization of the lexicon and the role of morphology in theoretical and computational linguistics has emphasized two basic types of requirements: ... measure of the length of the lexicon, i.e the sum of the symbols contained in the lexicon A third type of considerations which are often overlooked in academical discussions, but turns out to be of...

Ngày tải lên: 22/02/2014, 09:20

... version of their databaseand time-seriesdatablade ,and free accessto their user-supportpersonnel David Dewitt and Mike Carey gave helpful advice and support during the performanceevaluation of SEQ.Kurt ... In PIVceeding of the ACM SIGMOD Conference on Management of Data, May 1994 [CS92] RakeshChandmand Arie Segev.ManagingTemporalFinancial Data in anExtensible Database.In Proceedings of the International ... stocks S; a sequence hourly information on the high and low prices ,and the of As part of the type-check of the SQL query, the type of the volume of the stock tradedin eachhour SEQUN function is...

Ngày tải lên: 16/03/2014, 16:20

... Bank of England (Butler) outstanding government debt In terms of market value, the indexed bonds account for about 15 percent of the UK’s outstanding government debt POTENTIAL BENEFITS OF INFLATION ... to process and are only available for a limited number of time horizons In addition, surveys can cover only a small group of people and often reflect off-the-cuff answers In contrast, data on Treasury ... benefits, these benefits could be partially offset by some limitations arising from the design and issuance of the bonds Some of the limitations are small and would not have much effect on the benefits...

Ngày tải lên: 22/03/2014, 18:20

... coordinate and rationalize their collection of data on water quantity and quality, water use and reuse, and related issues in the Region and globally, and to ensure accessibility to these data sets ... water quality management Usually the selection of water quality parameters is out -of- date, methodologies are often very old, the data are often not quality controlled or quality assured and may ... comparison, and evaluation of pollution sources, water quality and pollution loads throughout the basin, including evaluation of data quality; • identification and characterization of areas and issues...

Ngày tải lên: 23/03/2014, 00:20

... amidst competing demands: effects of patient health habits and visit characteristics Med Care 1999, 37:738-747 Assessing health status and quality- of- life instruments: attributes and review criteria ... Department of Health and Human Services, Food and Drug Administration; 2006 Skevington SM, O'Connell KA: Can we identify the poorest quality of life? Assessing the importance of quality of life ... in other fields of clinical and epidemiological research Figure An example of a MMI model of Treatment Satisfaction An example of a MMI model of Treatment Satisfaction Page 10 of 12 (page number...

Ngày tải lên: 20/06/2014, 16:20

... personal data • Common metadata to manage heterogeneous data from a variety of data sources • Management of data permission and user authorization • Unified user interfaces to explore data • User ... labels and charts Landmarks contain representative data within a period of time When users click on landmarks, related personal data appear In Figure 4, since landmark ‘M2’ is representative of data ... feasibility of visualization and interaction with heterogeneous personal data It basically used over 15,000 pieces of personal data from a test user and a lot of data from public including Flickr and...

Ngày tải lên: 21/06/2014, 17:20

... personal data • Common metadata to manage heterogeneous data from a variety of data sources • Management of data permission and user authorization • Unified user interfaces to explore data • User ... labels and charts Landmarks contain representative data within a period of time When users click on landmarks, related personal data appear In Figure 4, since landmark ‘M2’ is representative of data ... feasibility of visualization and interaction with heterogeneous personal data It basically used over 15,000 pieces of personal data from a test user and a lot of data from public including Flickr and...

Ngày tải lên: 21/06/2014, 19:20

... Edition of MINITAB® (CD Only) The Student Edition of MINITAB is a condensed version of the Professional Release of MINITAB statistical software It offers the full range of statistical methods and ... as a way of thinking about data and quantifying uncertainty, not a maze of numbers and messy formulas Statistics Statistics is the art and science of designing studies and analyzing the data that ... in the data Files of raw data are often huge For example, over time the General Social Survey has collected data about hundreds of characteristics on many thousands of people Such raw data are...

Ngày tải lên: 28/06/2014, 20:20

... is Professor of Bioethics and Philosophy of Law, University of Manchester MATTI ¨ HAYRY is Lecturer, University of Iceland, in Privacy Law at the Faculty of Law, and in Computer Security and Cryptography ... Iceland.3 The database is to include data from medical records from the Icelandic population, and the data can be temporarily cross-referenced with genetic data and genealogical data The database ... the construction of these databases but also provided us with new and effective means of keeping participants informed This offers participants ways of checking the use of data and facilitates...

Ngày tải lên: 05/08/2014, 13:20

... purposes of data collection and use, * confidentiality can be trumped by social and communal considerations, * security is important to check eugenic uses of the data, and The mezzanine rules of ethical ... Obligations and Social Duties’, Journal of Medicine and Philosophy 25 (2000), pp 107–113 20 Matti Hayry and Tuija Takala ¨ Security Genetic databanks need systems and procedures to secure the privacy and ... complementary The promotion of objective security is a matter of safety mechanisms, data protection, scientific risk assessment and good professional practice in handling sensitive information...

Ngày tải lên: 05/08/2014, 13:20

... in Iceland that aims at discovering more about Icelanders’ perceptions of privacy of personal information in general and privacy of medical and genetic data in particular, and their trust of private ... creation and operation of a centralised database of non-personally identifiable health data with the aim of increasing knowledge in order to improve health and health services’.1 The passing of the ... a random sample of 1,000 Swedes between eighteen and seventy-five years of age The questions were aimed at mapping attitudes and opinions and did not measure actual knowledge of the field of...

Ngày tải lên: 05/08/2014, 13:20

... establishment of the Icelandic database.14 Symbolic power of metaphors Even before the detailed plans of the EGP were introduced in public, one of the main initiators and public proponents of the project, ... Palsson and Hardardottir argue, both ´ ´ supporters and opponents of the Icelandic database have appeared to be informed by ‘deeper’ cultural and political considerations; and public support of the ... local history and the nationalistic discourse of Icelanders, emphasizing the uniqueness of the Icelandic biological and cultural heritage.17 Weighing risks and benefits In the context of public acceptance...

Ngày tải lên: 05/08/2014, 13:20

... ascendants and descendants of a gene donor These genealogies may only be used within the genetic database for organizing biological samples, and creating descriptions of DNA and descriptions of state of ... Use of Personal Genetic Data (May 2002), paras 9.53 and 9.54 Ibid., paras 5.50 and 9.55 Third parties’ interests in population genetic databases 115 and requests are expected to be made and ... (Strasbourg: Council of Europe, Committee of Ministers, 1997) Convention on the Protection of Human Rights and Dignity of the Human Being with Regard to the Application of Biology and Medicine: Convention...

Ngày tải lên: 05/08/2014, 13:20

... Finally, at a deeper level there are different understandings of ethics and the appropriate role and resourcing of research, and indeed of the concept of global public goods itself Our argument proceeds ... reconsideration of the definition of an orphan medicine, with particular reference to the implications of genetic stratification of both patients and diseases’.21 Here the relevance of the normative and ... reasons, such as different cultural understandings of disease and genetics, of identity, and different perceptions of the benefits of genetic technologies Benefits and costs: alternative interpretations...

Ngày tải lên: 05/08/2014, 13:20

... because of the nature of personal information, because of difficulties with distinguishing adequately between sensitive and nonsensitive information, and because of the nature of computerized databases ... instance listed in the Book of Icelanders, which is a database containing the genealogical information of 95% of the Icelandic population since the settlement of Iceland over 1,000 years ago, simply ... security standards and protection of personal information that refers to the usage of information in databases and who has access to it, and regulations on how different personal data are linked...

Ngày tải lên: 05/08/2014, 13:20

... Blood and Data: Ethical, Legal and Social Aspects of Human Genetic Databases (Reykjavık: University of Iceland Press and Centre for Ethics, 2004), pp 111–119 ´ 199 200 ´ Sigurdur Kristinsson and ... method of not seeking genuine informed consent is that of presuming the consent of those who not opt out of a database An example of this is the law about the Icelandic Health Sector Database, ... Beauchamp and Childress, Principles, p 83 Informed consent and human genetic database research 205 background knowledge can limit understanding of the conceptual and causal implications of propositions...

Ngày tải lên: 05/08/2014, 13:20

... (eds.), Blood and Data: Ethical, Legal ¨ ´ and Social Aspects of Human Genetic Databases (Reykjavık: University of Iceland Press and ´ Centre for Ethics, 2004), pp 175–179; Sue Weldon and Mairi Levitt, ... ‘Public Databases and Privat(ized) Property? A UK Study of Public Perceptions of Privacy in Relation to ´ ´ Population Based Human Genetic Databases’, in Arnason, Nordal and Arnason, Blood and Data, ... problem of genetic databases: endangering freedom of an individual in and against the state and society he or she lives in Genetic databases are inherently endangering this freedom because of fundamental...

Ngày tải lên: 05/08/2014, 13:20