qmc exp tsq to other supertree methods
Báo cáo y học: "Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an antiinflammatory cyclooxygenase-2 (COX-2) pathway" doc
Ngày tải lên :
12/08/2014, 17:21
... chondrocytes and we showed an inhibition of the IL-6 and IL-8 expression induced by inflammatory cytokines concomitant to an enhancement of the COX-2 expression The possible pathways involved in inflammation ... part of the inflammatory response in cartilage [16], we monitored the expression of COX-2 in Page of 12 Figure MGDG (monogalactosyldiacylglycerol) inhibits NF-kB (Nuclear Factor-kappaB) involved ... Veneto, Pietro d’Abano di Abano Terme e Montegrotto All the other authors did not have any interest or support from the Centro Studi Termali Veneto, Pietro d’Abano di Abano Terme e Montegrotto...
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báo cáo khoa học: " Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-a" doc
Ngày tải lên :
10/08/2014, 10:21
... cell apoptosis Compared to the control group (1.00), the level of apoptosis increased to 1.84 for the UTI group, 3.90 for the TAX group, and 6.79 for the UTI+TAX group (Table 2) 2.3 Expression ... that the expression of IL-8 in breast carcinoma cells is inversely proportional to the level of estrogen receptors (ER) Based on this relationship, decreased expression of ER increases the expression ... was added to each well with shaking for 10 The absorbance (A) at 570 nm was measured using an enzyme-linked immunosorbant assay (ELISA) plate reader to quantitate the inhibitory rate The experiment...
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Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
Ngày tải lên :
09/08/2014, 01:23
... leads to activation of MAPK cascades through the LPS receptor (CD14) or Toll-like receptors [9] The ability of bacterial toxins or super-antigens to induce proinflammatory responses leading to the ... Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers Clin Exp Immunol 2001, 124:16-20 Parasrampuria ... inhibitor IL-1β, IL-8, and COX-2 mRNA expression was reduced by 40.2%, 56.6%, and 65.0%, respectively, at µM MMP9 mRNA expression is not induced and not inhibited and proved to be constitutively expressed...
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Báo cáo y học: "Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont" ppsx
Ngày tải lên :
09/08/2014, 10:20
... immunohistochemistry to investigate the gene and protein expression of IL-1β, TNFα and their receptors in non-degenerate, degenerate and herniated human IVDs to investigate whether both cytokines ... TNFα and their receptors in human IVD Immunohistochemistry was used to localise IL-1β, TNFα and their active receptors in 39 IVD samples (Table 1) The immunohistochemistry protocol followed was ... in autopsy samples, no results were presented for TNF receptor expression in surgical samples, thus raising the question as to whether TNFα is biologically active in such samples [22] Thus, to...
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Báo cáo y học: "Primary effusion lymphoma associated with Human Herpes Virus-8 and Epstein Barr virus in an HIV-infected woman from Kampala, Uganda: a case repor" pptx
Ngày tải lên :
11/08/2014, 00:22
... and sent to the Department of Pathology, Makerere University, College of Health Sciences, Kampala, Uganda, where it was cytocentrifuged The sediment was made into a cell block and haematoxylin ... this patient is similar to what other authors have found in studies on HIV-positive PEL patients [14,16] HHV-8, by definition, has to be present in the tumor cells in order to make a diagnosis of ... Although immunohistochemical services are not routinely available in Uganda and other resource constrained countries, it is still possible to suspect PEL with available clinical and cytomorphologic...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
Ngày tải lên :
18/06/2014, 15:20
... reported to be highly expressed in hematopoietic stem cells (HSCs) from human umbilical cord blood, and it promotes differentiation of HSCs into progenitor cells by inhibiting ABCG2 expression[56] ... also be due to other miRNA regulatory function For instance, miR-373 induces the expression of E-cadherin and CSDC2 by targeting their promoter region and initiate their expression[73] Another mechanism ... Bioconductor project[81] The background-subtracted data were then subject to variance stabilization normalization[82] and imported into BRBArray Tools http://linus.nci.nih.gov/BRB-Array Tools.html...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
Ngày tải lên :
09/08/2014, 06:22
... used insensitive methods of RNA detection (northern blot) [9,11], or the methods were only semiquantitative [13,14] or failed to relate specific gene expression to the basic expression level ... changes to the histological scoring In order to directly correlate a certain histological outcome with gene expression scoring independent of the study group or the location, samples adjacent to sections ... semiquantitative methods have been used in these previous studies, the normalization of gene expression data will strongly influence the results [27] While others decided to express changes in mRNA expression...
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Báo cáo y học: " DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines" ppt
Ngày tải lên :
09/08/2014, 22:23
... genes into quartiles from high to low gene expression and observed that the drop in methylation levels near to the TSS (Figure 1b) was only seen in (a) Methylation vs gene−expression High expression ... gene expression (a) Methylation levels are low in the top quartile of highly expressed genes (left), and high in the bottom quartile of lowly expressed genes (right), looking across 12,670 autosomal ... with respect to the TSS in sets of genes categorized by gene expression levels, from highest (red) to lowest (blue), using the quartiles of gene expression with respect to gene expression means,...
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Báo cáo y học: " The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis" pps
Ngày tải lên :
12/08/2014, 11:22
... CAT2deficient mice to test the net effect of reducing transport of arginine in experimental asthma and experimental lung fibrosis Methods Page of Additionally, fibrosis was evaluated histologically ... analysis revealed Niese et al Respiratory Research 2010, 11:87 http://respiratory-research.com/content/11/1/87 very specific expression of CAT2 compared with other CAT genes For example, the hybridization ... demonstrate appropriate inflammatory responses in the lung in response to allergic stimuli CAT2 expression is required for collagen deposition following bleomycin exposure Figure CAT2 induction...
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Báo cáo y học: "Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis" pps
Ngày tải lên :
12/08/2014, 14:21
... proinflammatory cytokines upregulate NGF/TrkA in FLSs, NGF/TrkA is upregulated in FLSs of inflammatory arthritis (Table 1), and NGF is mitogenic to FLSs (Figure 1) These observations suggest an autocrine ... growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis Arthritis Res Ther 2009, 11:R82 Raychaudhuri SP, Raychaudhuri SK: The regulatory role of nerve growth factor and ... cultured in DMEM with cytokines tumor necrosis factor-alpha (TNF-α) (1 ng/mL) and interleukin-1-beta (IL-1β) (1 ng/mL) Data are expressed as mean ± standard deviation Nerve growth factor (NGF), TrkA,...
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Báo cáo y học: "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis" pot
Ngày tải lên :
12/08/2014, 17:22
... TNF-a is a proinflammatory cytokine, activating the NF-B pathway, leading to a downstream cascade of other proinflammatory cytokines [12,13] Moreover, it is known to increase mitochondrial ROS production ... necrosis factor cytotoxicity by protease inhibitors Cell Immunol 1987, 107:317-325 29 Dealtry GB, Naylor MS, Fiers W, Balkwill FR: DNA fragmentation and cytotoxicity caused by tumor necrosis factor is ... graded using to scale, where represented no stained cells, was to 25% stained cells, was 25 to 50% stained cells, was 50 to 75% stained cells, and was 75 to 100% stained cells Mitochondrial random...
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Báo cáo sinh học: "Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues" docx
Ngày tải lên :
14/08/2014, 13:21
... correlation corresponds to 0, no correlation to and a perfect negative correlation to on the y axis (Figure 1b) To facilitate the comparison with the dendrograms built with gene expression data, only ... and their receptors have been shown to stimulate reverse cholesterol transport in animal models [27] Multiple-tissue network To explore the connections between tissues at the gene expression level, ... KEGG for Kyoto Encyclopedia of Genes and Genomes category) clustered at the top or the bottom of the ranks is calculated for each gene set The normalized enrichment scores were used to measure...
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Báo cáo sinh học: " Genetic effects of static magnetic fields. Body size increase and lethal mutations induced in populations of Drosophila melanogaster after chronic exposure" potx
Ngày tải lên :
14/08/2014, 20:20
... MATERIALS AND METHODS Exposure system The exposure system consisted of a function generator and a power amplifier (50 Hz) (generator stabilized by a continuous current) connected to several coils ... different laboratory animals have varied widely in relation to the organism and the experimental protocol, providing contrasting results Mutagenic effects have been investigated Exposure of adults ... subjected to the effect of the geomagnetic field alone while the other were exposed to the induced magnetic field Control lines were maintained within coils the same size as those adopted for the experiment...
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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
Ngày tải lên :
09/08/2014, 01:23
... are often transduced to downstream targets via NF-κB [33], its activation is likely to have contributed to the increased binding of this inflammatory transcription factor to the promoter of IL-6 ... necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction J Exp Med 2000, 191:12331239 Handel, M, McMorrow L, Gravallese E: Nuclear factor-kappa B in rheumatoid synovium ... inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines J Immunol 1998, 161:409-414 Aggarwal S, Gurney A: IL-17: prototype member of an emerging cytokine...
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Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt
Ngày tải lên :
07/03/2014, 09:20
... proinflammatory cytokines in vivo and in vitro [22], by converting inactive precursors of cytokines such as pro-IL-1b and pro-IL-18 into their active forms [18,23], or by enhancing the expression of cytokine ... of FasL is to induce inflammation in vivo [15–18], and this inflammatory activity of FasL seems to play deleterious roles in inflammatory diseases [19–21] Consistent with its inflammatory activity, ... Matsumoto et al gene expression [7–11] The extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPKs) as well as nuclear factor jB (NF-jB) are reported to be...
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Báo cáo y học: " Glycine tomentella Hayata inhibits IL-1b and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells" docx
Ngày tải lên :
10/08/2014, 05:21
... white arrows the apoptotic cells In parallel, flow cytometry was used to detect the phagocytosis of (C) apoptotic cells and (D) latex beads The data was expressed as phagocytosis index indicating ... rheumatic diseases Recently, phagocytosis of apoptotic cells, also called efferocytosis, has attracted much attention because phagocyte clearance of apoptotic cells appears to be critical in the resolution ... clearance of apoptotic cells and is a potent IL-1b, IL-6 and MMP-9 inhibitor These findings may explain the anti-inflammatory effects of GTH Abbreviations Used (GTH): Glycine tomentella Hayata;...
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Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
Ngày tải lên :
11/08/2014, 03:20
... the context of mitogen-activated protein kinases (MAPKs) and the transcription factor, activator protein-1 (AP-1) in CF Three MAPK pathways are believed to contribute to IL-8 gene expression, the ... for activator protein-1 (AP-1), which is not essential for baseline expression but is required for maximal expression of IL-8 [16, 17, 24, 25] To understand how the two transcription factors might ... micro-inhibitory RNAs (miRNAs) has been shown to regulate protein expression mainly at the post-transcriptional level [43], and has been shown to be dysregulated in several inflammatory diseases...
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Báo cáo y học: " Augmentation of Pulmonary Epithelial Cell IL-8 Expression and Permeability by Pre-B-cell Colony Enhancing Factor" docx
Ngày tải lên :
11/08/2014, 08:22
... inflammatory process and damage to both endothelial and epithelial cell barriers, resulting in marked extravasation of vascular fluid into the alveolar airspace [3] A number of inflammatory cytokines ... pilot experiment provided evidence that PBEF expression could be induced by TNFα treatment in A549 cells (data not shown), we sought to determine the doseresponse and time-course to optimize the experimental ... PBEF expression in A549 cells are similar to those of IL-8 TNFα induction of IL-8 and PBEF expression at their mRNA levels in A549 cells To investigate whether TNFα augments IL-8 and PBEF expression...
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