pten as a marker for drug response and resistance

... KRAS MT has worse RR and TTP KRAS MT has worse RR KRAS MT has worse RR, TTP, and OS KRAS MT has worse RR, TTP, and OS KRAS WT has worse OS KRAS WT did not respond KRAS MT has worse RR Escalated ... signaling pathway KRAS encodes a membrane-associated GTPase that is an early player in many signal transduction pathways KRAS acts as a molecular on/off switch for the recruitment and activation of ... overcome KRAS MT CTX also improved quality of life in KRAS WT patients KRAS MT did not have impact on response KRAS MT has worse RR and TTP.b KRAS MT has worse RR, TTP, and OS KRAS MT has worse...

Ngày tải lên: 10/08/2014, 22:20

... Preliminary data analysis revealed no significant main effects and only one significant interaction of day and aroma on the pleasantness ratings of the young, implicating an increase in pleasantness ... samples was created by a laboratory panel (n ¼ 9; females, males, aged 25 –41 years) trained to evaluate attributes selected in advance The attributes were evaluated on a 9-point scale that was ... Hedonic ratings In the pleasantness ratings, the aroma concentration had a similar effect on both age groups in the first tasting session: the heightened aroma sample was rated as less pleasant than...

Ngày tải lên: 03/04/2013, 21:06

... a CD34+ hESC-derived starting population has been considered as a potential AIDS therapy, and as a way to alleviate secondary effects produced by anti-retroviral drugs [16] Various studies have ... Nature 460, 909–913 89 Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, Okita K & Yamanaka S (2009) Suppression of induced pluripotent stem cell generation by the p53–p21 pathway ... from Leukemia and Lymphoma UK, Fanconi New advances in human hematopoiesis from human ESCs Hope UK and the Fanconi Anemia Research Fund USA, and funds for research in the field of regenerative medicine...

Ngày tải lên: 22/03/2014, 17:20

... greater, or as nonresponders if the increase in SVITD was under 10% Statistical analysis For statistical analysis, all volume variables were indexed to body surface area Statistical analysis was ... However, validation of a variable as an indicator of preload requires, in addition to demonstrations that the variable increases with fluid loading and that the increase is related to an increase in ... 21 patients (17 male; aged 53–78 years, mean 65.7 years) undergoing elective coronary artery bypass grafting Patients with valvular heart disease, intracardiac shunts, regional myocardial asynchrony,...

Ngày tải lên: 12/08/2014, 22:21

... vascular defects abnormal vasculature o abnormal vascular dilation noted at E8.5 o vascular dilation was associated with an increased endothelial proliferation rate o in addition to the dilation, ... [14] In addition, MGD has adopted the Mouse Embryo Anatomy Nomenclature Database [15] and the Anatomical Dictionary for the Adult Mouse [16] for annotating data that include anatomical attributes, ... serves as the authoritative source for the names and symbols associated with mouse genes, alleles and strains The advantage of applying such nomenclatures has been increasingly recognized as genomes...

Ngày tải lên: 14/08/2014, 14:21

... broadband’s impact was delayed compared with Asia, and the evidence relates to the early years of the 2000s, before the higher speeds and lower prices for broadband became widely available and ... Telecommunication Indicators Database and AT&T 10 Broadband 2002 2007 2008 DRAFT Broadband and economic growth The example of China catching up with the United States, and of other developing Asian nations prospering ... a wider range of devices, and as machines and objects rather than humans become the main users, then broadband will give birth to a wide range of devices and applications, as yet unimagined Again,...

Ngày tải lên: 21/08/2014, 15:25

... that glial cells also play a part in exaggerated pain states created by inflammation and neuropathy (Hashizume et al., 2000; Watkins and Maier, 2002) Astrocytes, in particular, play an important ... my days as a researcher Thank you both so much for all the fun and laughter you have brought to my days in the laboratory I am also very grateful to Ms Jeyapriya Raja Sundaram for her help and ... hyperalgesia and allodynia when administered intrathecally in mice NST, on the other hand, blocks nociceptin-induced allodynia and hyperalgesia, and also attenuates pain due to prostaglandins In addition,...

Ngày tải lên: 02/10/2015, 17:15

... cell spectrum and spectral areas selected by genetic algorithm A smear of about · 105 cells was dried on an area of cm2 on the germanium surface as explained in Materials and methods Wavenumbers ... et al assigned the shoulders present at 1117 and 1020 cm)1 to RNA and DNA, respectively [18] Classification by LDA Classification by LDA on spectra reduced by PCA PCA was performed on the training ... final model Linear discriminant analysis (LDA) This statistical multivariate method is supervised It searches for the variables containing the greatest interclass variance and the smallest intraclass...

Ngày tải lên: 21/02/2014, 03:20

... PAGE (15% acrylamide) and PhosphorImager analysis To calculate reaction stoichiometries, radiolabeled reaction products and radioactive standards were quantitated using IMAGEQUANT software (Amersham ... Schizophrenia and Depression (JAB), the National Institute of Mental Health (ACN and RWG), the Department of Defense (JAB and AAF), the Department of Veterans A airs (RWG), and the Ella McFadden Charitable ... translational regulation, rate of turnover, subcellular localization, or association with as yet undefined regulatory factors The most abundant nucleoside kinase in mammals, AK has emerged as a key...

Ngày tải lên: 16/03/2014, 18:20

... waste was applied before planting as was 50 % of the inorganic P and K The remaining P and K was applied at panicle initiation stage at 35 days after sowing (DAS) while N was split times (7, 20 and ... (Page et al 1982), plant analysis (Chapman and Pratt, 1961); water and wastes samples analysis followed methods for chemical analysis of water and wastes (MCAWW) EPA/600/4/79-020 revised March ... within a Decade Catfish Aquaculture in Asia: Present Status and Challenges for Sustainable Development Handbook and Abstracts from Conference at CanTho University, CanTho City, Vietnam p 25 Pillay,...

Ngày tải lên: 21/06/2014, 04:20

... of the angle gauge (b) b a (a) α borderline Table Average values and their differences Diameter measured optically with wedge prism Diameter measured with calliper Difference Standard deviation ... method was also described for determining the tree diameter at breast height (Bitterlich 1996) For testing the accuracy of the method the laser telemeter was used and then the measured diameter was ... the distance when the blocks were on the borderline The distance was measured using the laser telemeter with half -a- meter scale The diameter was calculated and compared with the control measure...

Ngày tải lên: 07/08/2014, 10:21

... tsom si ydalam siht dna sulahpecordyh latinegnoc ot desopsiderp era sauhauhihC aixata htiw detneserp saw muiravlac depahs-emod a htiw god auhauhihC a ,esac siht nI ]3[ erusserp lainarcartni eht ... .)daehworra( ytivac laenotirep eht dna )worra( elcirtnev laretal tfel eht otni decalp saw tnuhs PV ehT edimalozateca ,enosahtemaxed htiw detaert saw god ehT ]01[ ellenatnof tnetsisrep a ro daeh ... tcudeuqa cilahpecnesem deworran a evlovni sulahpecordyh latinegnoc fo sesac rehtO etar etauqeda na ta FSC brosbaer ot illiv dionhcara eht fo eruliaf ot eud yltnerappa giF si sulahpecordyh )latinegnoc(...

Ngày tải lên: 07/08/2014, 18:21

... self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease J Exp Med 1985, 161:72-87 Kuniyasu Y, Takahashi T, Itoh M, Shimizu J, Toda G, Sakaguchi S: Naturally anergic and ... allogeneic organ transplants Acknowledgements This research was supported in part by National Institutes of Health grant AI 41768, The Nora Eccles Treadwell Foundation, and the Arthritis Foundation-Southern ... Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T: Organ-specific autoimmune diseases induced in mice by elimination of T cell subset I Evidence for the active participation of T cells in natural...

Ngày tải lên: 09/08/2014, 03:24

... decreased DNA methyltransferase activity [89] secondary to cellular activation [116] Interestingly, medications that can cause drug- induced lupus (e.g hydralazine and procainamide) are capable ... 34 Tan EM: Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology Adv Immunol 1989, 44:93-151 35 Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted ... chromatin complexes, aberrant DNA methylation, oxidative DNA damage, differential cleavage of DNA, and histone phosphorylation are just a few modifications that may result in increased TLR stimulation...

Ngày tải lên: 09/08/2014, 07:20

... manuscript; and provided statistical analysis LWK and TN acquired data and drafted the manuscript NLW acquired, analyzed, and interpreted data; provided administrative, technical, or material support; and ... statistical analysis AH analyzed and interpreted data as well as critically revised the manuscript MT critically revised the manuscript JAM acquired, analyzed, and interpreted data; drafted the manuscript; ... of care measures and seldom improved patient outcomes Lack of clear patient benefit and lack of data on harms and costs preclude a recommendation to adopt CCDSSs for drug therapy management Additional...

Ngày tải lên: 10/08/2014, 11:20

... Membrane current was measured via homemade Ag/AgCl electrodes One electrode was used as ground and the other connected to the headstage of an Axopatch 200B amplifier (Axon Instruments, USA), allowing ... side of Maltoporin addition The average residence time is 5.0 ms (C) First, M6-ANDS was injected to the trans-side and no variation in the ion current occurs As control, maltohexaose was added to ... used for a fundamental analysis to probe e.g the individual energy barrier and it seems that nature has optimized this channel to have the best turnover number On the other hand these channels can...

Ngày tải lên: 11/08/2014, 00:22

... as well as current and past alcohol and/ or drug treatment Participants were also asked about whether they use cannabis as a substitute for alcohol, illicit drugs or prescription drugs and why ... information, cannabis use pattern, alcohol and drug use and service utilization Participants were asked the quantity and frequency of alcohol, tobacco and drug (prescription and illicit) use as ... [12] Cannabis substitution has also been discussed as part of a harm reduction framework A record review of 92 medical cannabis patients who used marijuana as a substitute for alcohol was conducted...

Ngày tải lên: 11/08/2014, 18:20

... nonasthmatic and an asthmatic subject Typical trace of respiratory system resistance (Rrs) at Hz and relative inhaled volume (above functional residual volume) for a nonasthmatic (H09) and asthmatic (A0 4) ... Base Post-alb Day Base Post-mch Post-alb Day Figure Plot of R % predicted for asthmatic and nonasthmatic subjects Rmin %predicted for all 34 nonasthmatic (black) and 35 asthmatic (hatched) participants ... acquisition of data, analysis and interpretation of data, and drafting and revising the manuscript GTO contributed to study design, acquisition of data, analysis and interpretation of data, and...

Ngày tải lên: 12/08/2014, 13:22

... i ntrad ers arri ' val rate onmeas resof ark perf ane (the averag s u m et orm c e pread an the averag w n d e ti g c os t) .For b revi tyw e res c t ou atten on the c as nw hi trad ershave d ... nthi ec ti ,w e arg e that the i pac t of ss on u m a d ec reas i e nthe ord er arri valrate onm ark qu i samb i u s tu l d ec reas et altyi g ou Ac alya e i nthe ord er arri valrate i d u eslqu ... ook an q b e the l g ofthe b ook af the d ec reas i en th d ~ en th ter e ntrad ers ' arri valrate P roposti i on9 A d ec reas i e ntrad ers arrivalrate (aninreas ind ) : ' c e 1.d ec reas esor...

Ngày tải lên: 31/10/2014, 12:11

... trader arrivals as a period Patient and Impatient Traders Each trader arrives as either a buyer or a seller for one share of security Upon arrival, a trader observes the limit order book Traders ... informational asymmetries appear to be large in practice For instance Huang and Stoll (1997) estimate that 88.8% of the bid-ask spread on average is due to non-informational frictions (so called ... between market and limit orders In fact we are not aware of any such dynamic models.11 10 Harris and Hasbrouck (1996) and Harris (1998) also argue that optimal order placement strategies for liquidity...

Ngày tải lên: 31/10/2014, 12:12