psychosocial interventions in bipolar disorder theories mechanisms and key clinical trials

... structured clinical interview for DSM-IV (SCID) All patients also had a physical examination including weight and blood pressure, biochemical screening including full blood count, urea and electrolytes, ... personal and family history was obtained and diagnosis was made using Diagnostic and Statistical Manual of Mental Disorders version IV (DSM-IV) criteria for bipolar disorder [11], using a the ... significant medical findings, were excluded from the study Depressed symptomatology was determined by clinical interview using DSM-IV criteria Symptom severity for depression was determined using the 17-item...

Ngày tải lên: 08/08/2014, 21:20

... schizophrenia or bipolar disorder as established by the Structured Clinical Interview for DSM-IV, being clinically stable (defined as having had no changes in severity or new treatments initiated in the ... afford greater insight in describing and grading the impact of side effects associated to antipsychotic drugs [15,16] A brief instrument is preferred for use in clinical practice and in investigations ... 10.9), and 63% were males (n = 151) Sociodemographic and clinical characteristics of the sample are shown in Tables and The percentage of missing values in each of the items contained in the...

Ngày tải lên: 09/08/2014, 01:21

... hospitalization and associated treatment costs in commercially insured patients with bipolar disorder newly treated with aripiprazole, ziprasidone, olanzapine, quetiapine or risperidone, alone or in combination ... aripiprazole and quetiapine patients; and 771 aripiprazole and risperidone patients Baseline characteristics after matching are shown in Table 1, demonstrating that comparable baseline characteristics ... studies can provide important insights into the outcomes of clinical practice in real-world settings, where dosing, titration and concomitant medications are not constrained by trial protocols Such...

Ngày tải lên: 11/08/2014, 16:22

... according to the following equation, %m = mm + mr/2, by using the observed mm and mr values The solid lines indicate the fitting of the data and the dashed lines indicate the theoretical lines ... chain initiating radical as shown in Figure The smaller hfc value of phosphorous nucleus than that in diphenylphosphinoyl radical is reasonable for the distant interaction in the chain initiating ... radical concentration and to essentially the same number (concentration) of terminated chains Typically, the fraction of terminated chains is between and 10% The remaining chains are in the dormant...

Ngày tải lên: 14/03/2014, 09:20

... there is growing interest in characterizing QoL in bipolar disorder populations, and determining the impact of treatment interventions upon life quality The scientific quality of research in this ... group in Canada, and will be dealt with in unison Following this, six other studies (one comparing QoL in patients with during different phases of the disorder, a recent study assessing QoL in bipolar ... welldesigned longitudinal research and research into the impact of psychosocial interventions upon QoL, and the development of a disease-specific measure for use in bipolar populations Bipolar disorder creates...

Ngày tải lên: 20/06/2014, 15:20

... dysfunction in bipolar disorder Research on neuropsychological functioning in bipolar disorder reveals deficits in several cognitive domains, including attention, learning and memory, and executive ... negative self-appraisal and rumination A final related hypothesis explaining the link between the tendency to ruminate and mania in bipolar disorder is rooted in the possibility that individuals with ... present in patients with bipolar disorder in euthymic states is exacerbated in mania and depression In fact, in studies using tests of executive functioning, including attentional setshifting [65,...

Ngày tải lên: 21/06/2014, 19:20

... search included a keyword search of Medline and the internet via Google with the words 'aripiprazole' and 'bipolar' The second step included search of the BMS site http:// www.bms.com /clinical_ trials/ ... as several relevant online repositories including http://clinicaltrials.gov, http://www.clinicalstudyresults.org and http:// www.cochrane.org The third step included scanning of the reference lists ... standard deviation of the ith sample, and k is the number of samples being combined Although psychotic symptoms are common in bipolar patients, not all randomised controlled trials (RCTs) include...

Ngày tải lên: 08/08/2014, 23:21

... SGAs against acute mania and SGAs in maintenance protecting from mania) Four effect cases are not adequately studied (FGAs against acute bipolar depression and in maintenance protecting from ... medicine has seemed to dominate medical scientific thinking in the last few decades, this is not true for wider clinical practice The evidence is limited and hard to interpret and to carry over into ... disorders, and especially for bipolar disorder The ‘class effect’ provides the clinician with fast and simple rules to determine treatment, but in the case of bipolar disorder it might provide the clinician...

Ngày tải lên: 09/08/2014, 01:21

... (MDGs) as a gold standard of measuring outcomes in global population health and of international funding and monitoring initiatives such as the Global Fund is a recent case in point In many African ... an MSc in International Primary Health Care She specialises in research on media messaging and health and applies her research and education through advice giving in the media and training journalists ... The CAMBoD project was also influential in reducing the prices of insulin and diabetes related products such as testing kits in across the country For instance insulin was reduced from £15 to...

Ngày tải lên: 11/08/2014, 14:21

... study, covering both in- and outpatient units including substance abuse clinics Conclusions The current findings show that there is a significant increase in illicit substance use in BD compared ... 0.010) Clinical assessment Clinical assessment was carried out by trained clinical psychologists and psychiatrists Diagnoses were established using the Structured Clinical Interview for DSMIV, modules ... the mechanisms involved in the increased substance use in BD are not known Several studies have found increased impulsivity and novelty seeking in BD patients [76,77], which have also been linked...

Ngày tải lên: 11/08/2014, 16:22

... recruiting centres 132 patients fulfilling the criteria below will be included into this study by nine centres in Norway All the patients will first be included in the Bipolar Research And Innovation ... 15-30 minutes to complete The YMRS has been used in clinical practice since 1978 Ratings are based on self-reporting and clinician observation The MSIF [46] is a new instrument for rating functional ... the reports, the clinician’s observations are given more weight than patient reports UKU is designed for use in both clinical trials and routine clinical practice Rating is independent of whether...

Ngày tải lên: 11/08/2014, 16:22

... to evaluate the incidence of synchronous appendiceal neoplasm in patients with resectable CRC in a university hospital, and to determine the clinical significance of these findings Methods Pathological ... demonstrate the clinical significance of these findings The study was approved by the Institutional Ethics Committee Results Two hundred and ninety-three patients were included in this study The ... were 1–5 mm in diameter; primarily located in the subserosal area All appendices with neoplasms did not appear abnormal in the preoperative imaging and during the intraoperative examination However,...

Ngày tải lên: 09/08/2014, 04:21

... abdominal adiposity increases more quickly in HIV-infected men with clinical lipodystophy, compared to those HIV-infected men without lipodsytrophy and HIV-uninfected men The mechanisms underlying ... study comparing body composition in men and women with and without HIV infection, reported similar amounts of VAT in 926 HIV-infected and 258 HIV-uninfected subjects[20] Body mass index, however, ... and -uninfected persons after matching, adjusting, or stratifying on BMI may be inflated, the FRAM investigators did not directly adjust for BMI in their analyses, noting that "BMI is being influenced...

Ngày tải lên: 10/08/2014, 05:21

... influencing obesity in bipolar patients include nutrient intake and physical activity In assessing the nutrient intake of persons with bipolar disorder, Elmslie and colleagues found that they had increased ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks ... (Tegretal and others), clozapine (Clozaril), droperidol (Inapsine and others), gabapentin (Neurontin), haloperidol (Haldol and others), lamotrigine (Lamictal), lithium (Eskalith and others), metformin...

Ngày tải lên: 25/10/2012, 10:51

... the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, quetiapine and aripiprazole for the maintenance phase This ... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman ... Grunze H, Martinez MI, Post RM: Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion...

Ngày tải lên: 08/08/2014, 23:21

... bovine serum (GIBCO) and a mixture of penicillin-streptomycinglutamine (PSG from GIBCO) Puromycin-resistant MEF lines were grown, maintained, serum shocked, and serum starved in medium containing ... states, segregating in time those which are mutually incompatible, thus integrating neurotransmitter, endocrine and behavioural mechanisms whose dysregulation may be involved in the pathophysiology ... nature of bipolar disorder itself, and clinical features of depression such as premature early morning awakening from sleep and diurnal variation in mood, shortened REM sleep latency, advances in hormonal...

Ngày tải lên: 10/08/2014, 09:20

... medicines, including Saint-John’s-wort and S-adenosyl-L-methionine (SAMe) The next two chapters examine the importance of including psychosocial interventions in the treatment plan for children and ... articles and book chapters on bipolar disorder and schizophrenia, and five books, including The Bipolar Disorder Survival Guide Kimberley L Mullen, MA, is a doctoral candidate in clinical psychology ... using psychosocial interventions that include families of patients Next, the authors review the role of psychosocial interventions and incorporating families in treatments for patients with bipolar...

Ngày tải lên: 11/08/2014, 04:20

... 1949) Clinical trials in adult patients with bipolar disorder have established the efficacy of lithium in acute mania and bipolar depression and as a maintenance therapy (reviewed in Goodwin & ... exercised in translating the in vitro and animal findings to humans Lithium and Neurotransmission Preclinical studies and information from adult human studies have provided information regarding the ... bipolar offspring with and at high-risk for bipolar disorder Bipolar Disorders, 7, 589–597 Gelenberg, A J., & Pies, R (2003) Matching the bipolar patient and the mood stabilizer Annals of Clinical...

Ngày tải lên: 11/08/2014, 04:20

... have been positive in the treatment of bipolar disorder, including treatmentresistant and rapid-cycling bipolar disorder An early case series of female inpatients with bipolar disorder showed improvement ... ultradian-cycling bipolar disorder with nimodipine by Davanzo, Krah, Kleiner, and McCracken (1999) This 13-year-old boy had failed trials of lithium, clonidine, fluoxetine, and levothyroxine Trials ... placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder Journal of Clinical Psychiatry, 65(3), 432–441 Isojarvi, J I., Laatikainen, T J., Pakarinen, A J., Juntunen,...

Ngày tải lên: 11/08/2014, 04:20

... Feelings and triggers, tool kit, taking charge of mad, sad, bad feelings Negative family cycles; thinking, feeling, doing Thinking, feeling, doing Problem solving for parents Problem-solving ... against stress once he or she has discontinued taking them In contrast, psychosocial interventions have two interrelated goals: decreasing the intensity of environmental stressors and increasing ... ROLE OF EARLY PSYCHOSOCIAL INTERVENTION IN BIPOLAR DISORDER Interventions early in the course of bipolar disorder may alter the subsequent course of the disorder Some of these interventions are...

Ngày tải lên: 11/08/2014, 04:20