psychosocial influences in oncology an expanded model of biobehavioral mechanisms

... thank you I want to introduce our first two speakers today, Dr Sandra Horning and Dr Fitzhugh Mullan Both of them are cancer survivors Dr Sandra Horning is Professor of Medicine, Oncology and ... of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in ... implementing the cancer survivorship care plan and coordinating care; (3) developing guidelines, instituting quality improvement, and strengthening professional education programs; and (4) addressing...

Ngày tải lên: 22/03/2014, 20:21

... previously analyzed, including LPS and LBP plasma concentrations and TLR4 and MD-2 expression and mRNA levels In this vein, of special relevance is the finding that antibiotic intestinal decontamination ... the brain (A) Brain levels of the pro-inflammatory prostaglandin PGE2 (B), the anti-inflammatory one 15d-PGJ2 (C), and interleukin-1b (IL-1b) mRNA levels in control and after CMS in the brain (D) ... exposed to an animal model of depression This activation occurs with increased levels of the pro-inflammatory cytokine IL-1b and of one of the main enzymatic sources of inflammatory and oxidative...

Ngày tải lên: 19/06/2014, 22:20

... Blotting for biglycan identified intact core protein (43 kDa) and a number of fragments (39, 32, 28 and 26 kDa) in all of the specimens There was an increase in staining intensity for all biglycan ... Beavan L, Kresse H: Decorin-type I collagen interaction Presence of separate core protein-binding domains J Biol Chem 1995, 270:8877-8883 Hedbom E, Heinegard D: Binding of fibromodulin and decorin ... reported in both human OA [20] and spontaneous canine OA [52], but not in a canine cruciate ligament transection model of OA [52] The catabolites that were identified in meniscectomized cartilage in...

Ngày tải lên: 09/08/2014, 06:23

... 4:48 maintenance of anesthesia were achieved using an infusion of 0.15 mg/kg/min ketamine chloride and 0.01 mg/ kg/min pancuronium bromide (Pavulon®, N.V Organon, Oss, the Netherlands), or an infusion ... line indicates the infusion of shed blood surrogate The second dashed line indicates the infusion of epinephrine and Ringer's lactate return completely to baseline until after the infusion of ... pharmacologically increased blood flow and pressure After infusion of epinephrine and Ringer's lactate an increase in arterial blood pressure ensued (Figure 2), as shown by a significant increase in the AUC of...

Ngày tải lên: 10/08/2014, 10:20

... contains the RGD-binding motif present in ECM proteins like fibronectin, collagens and laminins [24,25] The specific role of laminins in ASM remodelling in vivo, however, remains to be determined ... epithelial integrity show increased laminin g2 chain expression in the airways [19] Laminins appear to be essential for lung development and are important determinants of ASM function Laminin a1 and ... Therefore, using a guinea pig model of chronic asthma, we explored the role of laminins in ASM remodelling in vivo, by treating the animals with the specific soluble laminin-competing peptide...

Ngày tải lên: 12/08/2014, 13:22

... bleomycin injection in WT mice, positive staining for IL-1 (A) was localized mainly in inflammatory cells and in vascular endothelium There was a marked reduction in the IL-1 immunostaining in the ... accumulation of water in lung as an indicator of lung edema, (Fig 1f) and neutrophils infiltration in the lung tissues in WT-animals The leukotrienes synthesis inhibition and the receptor blockade in bleomycin ... role of leukotrienes in vivo come from the experimental model of bleomycin-induced lung fibrosis Intratracheal instillation of the antitumour agent bleomycin is the most commonly used animal model...

Ngày tải lên: 12/08/2014, 16:20

... shows that longterm antinociceptive effects of HA preparations can be assessed in an animal model of joint pain based on the repeated intra-articular injection of bradykinin and PGE2 Boettger ... applicable and significant change in pain-related behavior as assessed employing different methods (see effects of saline and morphine injections) Although in principle, such models, mainly using bradykinin ... treatment of OA Here we report on the magnitude and long-term duration of antinociceptive effects of NASHA and other HA preparations in the bradykinin/PGE model of repetitive joint pain Materials and...

Ngày tải lên: 12/08/2014, 17:22

... endotoxin injection in normal subjects J Clin Endocrinol Metab 1994, 79:1605-1608 35 Becker KL, Whang KT, Snider RH, et al: Relation between cytokines and procalcitonin peptides in an animal model of ... inflammation and sepsis References American College of Chest Physicians — Society of Critical Care Consensus Conference: Definitions of sepsis and organ failure and guidelines for the use of innovative ... as an index of inhalation injury in burns Horm Metab Res 1992, 24:439–443 12 Assicot M, Gendrel D, Carsin H, et al: High serum calcitonin concentrations in patients with sepsis and infection Lancet...

Ngày tải lên: 12/08/2014, 18:20

... de-staining in 20% isopropanol in 4% ethanol and 8% acetic acid The presence of gelatinases (MMP and 9) was shown by clear bands (no staining) corresponding to MMP standards (MMP and 9) run in leftmost ... site of action of the MMPs and a source of MMPs in this model will be important to determine the mechanism of action of this effect How MMPs are activated in the tissue is another important question ... 3500× (panels micrographs of control Scanning3electronC and D respectively) and MB-treated palates at a magnification of 400× (panels A and B respectively) and Scanning electron micrographs of control...

Ngày tải lên: 12/08/2014, 18:21

... Crs and PaO2 evolution in an experimental model of ARDS during a reversed sequential ramp procedure of PEEP changes to investigate the potential interest of combining FRC and Crs measurements in ... combination of FRC and Crs measurements obtained in this porcine model of ARDS may help to identify the optimal level of PEEP Indeed, by taking into account the value of both parameters, during ... of ventilator induced lung injury [10] Increasing the level of PEEP can be more harmful than beneficial since it will serve also to increase inflation of lung regions that are already open, increasing...

Ngày tải lên: 13/08/2014, 11:22

... underwent inhalation of placebo (5 ml isotonic saline solution) In a subsequent study, including 10 pigs, the effects of inhaled iloprost (Ilomedin®; Schering Deutschland GmbH, Berlin, Germany; 50 ... mg/kg) and atropine (0.5 mg), anaesthesia was induced with intravenous sodium pentobarbital (12 mg/kg) After endotracheal intubation, anaesthesia was maintained with a continuous intravenous infusion ... administered at a rate of ml/kg per hour Normothermia was maintained during the entire procedure using an infrared heating lamp A 7.5-Fr central venous catheter was inserted into the femoral vein...

Ngày tải lên: 13/08/2014, 11:22

... ischemia-reperfusion [18] in which there is activation of xanthine oxidase, leading to the formation free radicals and further imbalance between oxidants and antioxidants [4-6] The analysis of liver integrity ... exposed to intermittent hypoxia compared to SIH, demonstrating a reduced hepatic antioxidant defence in these animals The increase in TBARS and decrease in endogenous antioxidants observed in the ... livers of IH-35 mice confirms findings by other authors, who demonstrated a significant increase of nitric oxide in animals exposed to IH simulating OSA (6 min/6 min) during 120 days [48], and to...

Ngày tải lên: 13/08/2014, 13:20

... experiments, and analysed and interpreted the data KB contributed in the performance, analysis and interpretation of immunoblotting assays DLT contributed with grant support, study design and interpretation ... suspended in 30 mL of saline Using a bronchoscope (model FB-19H; Pentax, Japan), the solution was injected into the right lower, right middle and left lower lobes Anaesthesia was then discontinued and ... Traber D: Methicillin-resistant Staphylococcus aureus-induced sepsis: role of nitric oxide In Yearbook of Intensive Care and Emergency Medicine Edited by: Vincent JL Berlin: Springer; 2008:404-12...

Ngày tải lên: 13/08/2014, 15:21

... and antiinflammatory cytokines, decreasing CINC-1 and IL-6 in BALF and PLF at 18 hours, and increasing IL-10 in PLF at 18 hours and BALF at 48 hours We used a CLP model of sepsis for the following ... reduced pro-inflammatory cytokines (CINC-1 and IL-6) with an increase in anti-inflammatory cytokine (IL-10) in BALF and PLF (Figure 7) It has been reported that CINC-1 plays an important role in the ... macrophage inflammatory protein-2 On the other hand, the lack of endogenous IL-10, a prototypic anti-inflammatory cytokine, resulted in increased levels of TNF and enhanced mortality in mouse models of...

Ngày tải lên: 13/08/2014, 16:20

... creatinine at t = 180 minutes (b) Creatinine clearance was measured over t = 120 minutes to t = 180 minutes Creatinine clearance = UCr × V/PCr, where UCr represents the creatinine concentration in ... attenuates VILI and renal hypoperfusion and dysfunction, by maintaining endotheliumdependent vasodilation and decreasing inflammation and tissue injury, in the rat kidney during LPS-induced lung injury ... creatinine, and urea (Modular Analytics, Roche Diagnostics, Mannheim, Germany) In rats with preserved urinary production, creatinine clearance was calculated using the formula UCr × V/PCr In this...

Ngày tải lên: 13/08/2014, 20:21

... Longstaff, and Pan (2003) and Das and Uppal (2001) Dufresne and Hugonnier (2001) study the impact of event risk on pricing and hedging of contingent claims 132 An Equilibrium Model of Rare-Event ... fundamental risks in the economy Among others, recent studies include Gilboa and Schmeidler (1989), Epstein and Wang (1994), Anderson, Hansen, and Sargent (2000), Chen and Epstein (2002), Hansen and Sargent ... reference model only in terms of jump size An agent who searches over P b instead of P finds the jump-magnitude aspect of the model unreliable, while having full faith in the jump-timing aspect of the...

Ngày tải lên: 07/03/2014, 10:20

... mind when interpreting the estimation results in Table The results in panel B indicate that infants in rural areas are about 135-148 grams lighter than infants born in urban areas The IV and Heckit/control ... signs and sizes of effects of commodity prices on health depend on (a) magnitudes of changes in demand for health inputs following price changes and on (b) sizes of the marginal products of health ... demand for tetanus vaccination is affected differently by wealth portfolio of the household The probability of tetanus vaccination increases with land holding and with rent income but declines...

Ngày tải lên: 14/03/2014, 09:20

... understanding and production of domain and control utterances are closely linked; they thus cannot be implemented as independent mechanisms in an SLS For example, giving directions involves presenting ... utterances in unconstrained dialogues contain many instances of acknowledgment In interpreting these utterances, identification of the appropriate acknowledgment function affects the state of the ... scheme into a task-based model of acknowledgment acts This model formalizes the meaning and usage characteristics of acknowledgments, based On an analysis of what acknowledgments mean and when...

Ngày tải lên: 17/03/2014, 09:20

... is shown in Figure 4, and is virtually identical to that of the PS Module (in Figure 3) However rather than recovering branches of phrase structure, it recovers links of chains, determining their ... on GB-Parsing, Geneva, Switzerland, 1990 [4] M Crocker Multiple Meta-Interpreters in a Logical Model of Sentence Processing In Brown and Koch, editors, Natural Language Understanding and Logic ... operation shown in Figure For the partial input "What did John put ~, we can recover the partial phrase structure, including the trace in Infl2 In addition, we can recover the chain linking the did...

Ngày tải lên: 18/03/2014, 02:20

... process of selecting informants The aim of semi-structured interviews was to gain a deeper understanding of the living and working conditions on the plantation and the factors influencing those ... Assessment of Living and Working Conditions, with Special Attention to Forced Labor 11 Tapping rubber trees The clearing of land, breeding in the nursery, and the weeding and pruning of fields and young ... sugar in the Dominican Republic; coffee in Guatemala; fish in Indonesia; rubber in Liberia; and tuna in the Philippines The following report is based on research on living and working conditions in...

Ngày tải lên: 31/03/2014, 09:21