psychosocial factors in cancer initiation and progression

... embedded determines a different cell-environment interchange of matter, energy and information, thus inducing continuous qualitative and/ or quantitative changes in the shared properties and/ or behaviours ... Complexity and cancer Gastroenterology 2004, 126:630-631 Grizzi F, Chiriva-Internati M: Cancer: looking for simplicity and finding complexity Cancer Cell Int 2006, 1:4 Fearon ER, Vogelstein B: A genetic ... KA, Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease Cancer Cell 2005, 7:211-217 Casti JL: Complexification: explaining a paradoxical world...

Ngày tải lên: 13/08/2014, 16:21

... downregulated in the pre-inflamed joint but returned to a 'normal' level (as expressed in naive paws) during arthritis progression Clusters E and F included genes encoding Terf1-interacting nuclear ... found in joints during the first week of transfer, and a second cell transfer was needed to induce a significant influx of lymphocytes into the joints and cause subsequent inflammation In this ... in acute and chronic arthritis [47], dozens of cell signaling pathways and gene clusters were identified By further filtering of functional clusters, and by combining clusters encoding proteins...

Ngày tải lên: 09/08/2014, 06:22

... that initiating sexual activity before age sixteen increases the likelihood of having an unintended pregnancy, inducing pre-cancerous changes in the cervix, and contracting STDs, including HIV/AIDS ... participated in the design of the original study and was also instrumental in designing and administering the survey tool A Martin participated in the study design and helped to coordinate the manuscript ... the externalizing factors studied, increasing incidence of violent behavior (such as starting a fistfight, participating in a gang fight, hurting someone badly in a fight, and carrying a blade...

Ngày tải lên: 13/08/2014, 18:21

... effective inhibitor in cell lines and in mice with various types of cancer and was bioavailable when administered orally These data confirm that proteinprotein interactions between transcription factors ... Nutlin, an inhibitor of the interaction between the p53 tumor suppressor and its regulator Mdm2 This inhibitor binds selectively to the pocket of Mdm2, resulting in increased p53 levels Nutlin ... used for genome-wide mapping using ChIP-chip By correlating the binding profiles of all NRs, they found profile similarities and common binding sites between ER and retinoic acid receptor α; they...

Ngày tải lên: 14/08/2014, 21:20

... examples of the scoring performed on HDACs and staining Grade is defined as negative staining of the nucleus, while grades to represent increasing intensity of nuclear staining The upper panel ... colon cancer cases result from events which involve chromosomal instability (CIN), while the remaining 15% result from events which involve microsatellite instability (MSI) Cases involving CIN are ... plasmin upon activation Plasmin will in turn assist in the degradation of extracellular matrix (ECM) and activation of pro-MMPs in the extracellular space Signalling processes involving β1 integrin...

Ngày tải lên: 07/10/2015, 10:02

... the skin, non-Hodgkin lymphoma, oral (oral cavity and pharynx) cancer, ovarian cancer, pancreas cancer, prostate cancer, stomach cancer, thyroid cancer, and urinary bladder cancer To compare incidence ... Trends in Cancer Incidence and Mortality in New Jersey, 1979-2002; • Cancer Survival in New Jersey 1979-1997; • Cancer Prevalence in New Jersey on January 1, 2003; and • Childhood Cancer in New ... Risk factors for pancreatic cancer include increasing age and cigarette smoking Possible risk factors include diabetes, chronic pancreatitis (inflammation of the pancreas), obesity, and certain...

Ngày tải lên: 14/02/2014, 21:20

... smaller than most human cells Cancer Nanotechnology research is interdisciplinary and incorporates Biology, Chemistry, Engineering, Medicine, and Physics Properties of Cancer Cells • Epidermal Growth ... trials reveal that a single intravenous nanoparticle injection eradicated 100 percent of tumors in mice when exposed to near-infrared light Most work is being done with near-infrared light, which ... affinity to Cancer cells than healthy cells (EGFR binding) White light and simple, inexpensive microscope is all that’s necessary for powerful ex vivo Cancer detection The scattering is so strong...

Ngày tải lên: 15/02/2014, 05:20

... corresponds with apoptosis induction, a critical parameter impaired in cancer cells, and this induction is selectively exerted in cancer and transformed cell lines, while being less active toward ... with increasing dose of LA (E) Subcellular distribution of immunoreactive AIF and Cyt C in the cytosol, mitochondria and nucleus in control and 24 and 48 h LA-treated HL-60 cells Actin and histone ... to nucleus and promoting the caspase-independent induction of apoptosis chrome c in the activation caspase-independent apoptosis, as involving the nucleus accumulation of cytochrome c instead of...

Ngày tải lên: 10/08/2014, 22:20

... in development and disease follows Growth factors in development Growth factors are involved in virtually all aspects of lung development During the initial stages of lung bud morphogenesis and ... instillation of FGF7 in rats ameliorates radiation-induced and bleomycin-induced lung injury, reduces alveolar damage by hydrochloric acid instillation, and decreases hyperoxia-induced mortality ... Keratinocyte growth factor ameliorates radiationand bleomycin-induced lung injury and mortality Am J Pathol 1996, 149:1963-1970 Panos RJ, Bak PM, Simonet WS, Rubin JS, Smith LJ: Intratracheal instillation...

Ngày tải lên: 12/08/2014, 18:20

... of the Wnt signaling pathway and nuclear accumulation of b-catenin frequently occurs during gastrointestinal cancers, including colorectal cancer initiation and progression, and leads to an enhanced ... emphasis on brain, prostate, pancreatic and colorectal cancers were included in the review Potential applications of curcumin in cancer prevention and therapy Curcumin exhibits in vitro and in vivo ... cancer cells and antitumoral effect on MDA-MB-231 cell xenografts in vivo by inhibiting p21WAP1, survivin and NF-B and its downstream effectors, including cyclin D1 and Bcl-2, and activating caspase...

Ngày tải lên: 13/08/2014, 14:20

... regulatory protein 1, is a RNA binding protein that coordinates the expression of ferritin and transferrin receptor during iron metabolism by binding to iron-responsive elements in the 5’ and 3’ UTRs ... regulatory domains such as the 5’- and 3’ UTR, and TRS of leader (TRS-L) and each ORF (TRS-B), and this is mediated by protein-RNA and protein-protein interactions comprising of both viral and cellular ... systems involving viral RNA and replicase remains the choice approach for identifying cellular proteins to be involved in coronavirus infection, an increasing number of cellular proteins have...

Ngày tải lên: 09/09/2015, 10:07

... myosin, gelsolin, filamin, spectrins, microtubular proteins including tubulins, microtubule associated proteins, and intermediate filament proteins including vimentin keratin and nuclear lamins ... genes involved in lipid use and energy balance (AMP-activated protein kinase-gamma3, uncoupling protein (UCP)-3, GLUT4 in the case of silencing NR4A1 and FABP4, CAV3, UCP2 in the case of silencing ... it 116 kDa intact form into 85 kDa and 25 kDa fragments This process separates the aminoterminal DNA-binding domain of the enzyme from the carboxy-terminal catalytic domain resulting in the loss...

Ngày tải lên: 14/09/2015, 14:04

... processing (i.e., part of the “gain” in determining the central pain set point) In addition, descending pain inhibitory pathways depend upon adequate levels of norepinephrine, GABA, or serotonin, ... deconditioning, increasing pain, and disability Viewing arthritis pain through a biopsychosocial lens is critical to understanding the unique and complex issues associated with an individual’s pain coping ... cognitive and behavioral strategies for Understanding and Enhancing Pain Coping in Patients with Arthritis Pain managing psychological and social factors that negatively impact their pain The main tenet...

Ngày tải lên: 13/06/2016, 09:56

... their main roles focus on ectodomain shedding and nonproteolytic functions, such as binding to adhesion molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and ... [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming growth factor (TGF)-a and amphiregulin, was observed ... endostatin and endorepellin MMPs also modulate the cell–cell and cell–ECM interactions by processing E-cadherin and integrins, respectively, affecting both cell phenotype (EMT) and increasing cell...

Ngày tải lên: 15/03/2014, 00:20

... briefing will outline: The established risk factors for breast cancer, and The current thinking regarding the involvement of certain chemical exposures in breast cancer, and in particular, the ... smoke and breast cancer is clearly defined In the meantime, not smoking has other clear health benefits BREAST CANCER Factors in uencing the risk of breast cancer – established and emerging Other ... oestrogenmimicking chemicals and their involvement in breast cancer increasingly plausible Studies have been published which investigate the timing and nature of exposure to oestrogen-mimicking chemicals and...

Ngày tải lên: 15/03/2014, 01:20

... breast cancer risk On one hand, tobacco smoke contains chemicals that can cause breast cancer in animals and could thus be associated with an increase in breast cancer risk On the other hand, smoking ... this interplay is poorly understood Does quitting smoking affect breast cancer risk? Quitting smoking may lead to a temporary increase in breast cancer risk Most of the studies that have examined ... lung cancer risk and smoking; the risk of lung cancer increases with the dose or amount a person smokes Most breast cancer studies have not seen a dose relationship between smoking and breast cancer...

Ngày tải lên: 15/03/2014, 01:20

... domain ERM contains two DNA binding inhibitory domains flanking the Ets domain: the central 87 amino acid inhibitory domain is poorly conserved and virtually specific to ERM, and the C-terminal ... target sites in different genes In addition promoter sequences flanking the Ets motif determine activity through protein–protein interactions between Ets factors and factors binding at adjacent ... flanking the major transcription initiation site (+1) in SK-N-SH cells included in the PS1CAT reporter fusion vector are shown The binding sites for known transcription factors Sp1 and Ets are indicated...

Ngày tải lên: 16/03/2014, 18:20

... exposure in the UK DM Parkin and SC Darby Tobacco-attributable cancer burden in the UK in 2010 DM Parkin S14 11 Cancers attributable to infection in the UK in 2010 DM Parkin S77 S6 10 Cancers ... environmental factors in the UK in 2010: Summary and conclusions DM Parkin, L Boyd and LC Walker Cancers attributable to dietary factors in the UK in 2010: III Low consumption of fibre DM Parkin and L ... hormones in the UK in 2010 DM Parkin S73 The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010: Introduction DM Parkin S42 S70 S2 Cancers attributable to inadequate...

Ngày tải lên: 22/03/2014, 16:21

... patients and parents gave the same answer, at least that information could be included All of the interviews were conducted by authors They had been trained in interviewing and administering questionnaires ... tried to avoid exposing their chest in public places because of the fear of being teased, and ‘an unwillingness to be seen without a shirt while swimming and participating in sport or social activities’ ... [14,35,36] In this study, teasing was associated with significantly higher prevalence of psychosocial difficulties in patients This finding is not surprising given that our results indicate teasing...

Ngày tải lên: 20/06/2014, 15:20

... the testing set, and the remaining 914 cases and 967 controls formed the validation set After providing informed consent, each woman was personally interviewed face-to-face by trained interviewers ... University, Nanjing 210029, China; Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 210029, China * Corresponding ... also breast cancer marker SNPs in this Chinese population Then, we grouped the marker SNPs, and modeled them with clinical risk factors, to see the usage of these factors in breast cancer risk...

Ngày tải lên: 21/06/2014, 19:20