proteins workers in the cellular factory
Báo cáo khoa học: Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast ppt
... for the latter, indicating that in the absence of an N-terminal domain distinct localization is lacking Finally, the Lsm1p Sm domain by itself (LsmDN1DCp) accumulates in both the nucleus and the ... hybrid proteins We deleted or exchanged their N- and ⁄ or C-terminal domains, exchanged the central Sm domains or, in the case of Lsm8p, made point mutations in putative RNA-binding residues We investigated ... N-terminus has the biggest effect on localization; the C-terminus plays a secondary role, determining the preferred localization in the absence of the N-terminus and the Sm Lsm1 and -8 domains involved...
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prevalence and influencing factors of the lower reproductive tract infections among sex workers in the centre for treatment - education- labour ii hanoi and evaluation of the intervention
... being in the Center II The thesis has proved the evidence on effectiveness of interventions by training, LRTI screening for FSW and performance on training to improve knowledge on managing LRTI ... that to expand this intervention model for other centers over the nation The layout of the thesis The thesis is presented in 124 pages, excluding appendixes and is divided into: Introduction: pages ... Gonorrhea in FSW The Gonorrhea ratio in the neiboring contries are 5.7 % in Cambodia and 9.5 % in China Syphilis: caused by Treponema pallidum Research in border provinces of Vietnam showed the incidence...
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Báo cáo y học: "Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor b pathway in patients with systemic sclerosis" pot
... protein (far upstream element-binding protein 2); LMNA: lamin A/C; PCBP2: poly(rC)-binding protein 2; PRDX2: peroxiredoxin 2; RB1: retinoblastoma-associated protein; RBBP4: retinoblastomabinding ... these proteins can be either increased or decreased by TGF-b Interestingly, some of these proteins are involved in the pathophysiological process of SSc Bussone et al Arthritis Research & Therapy ... recognised with high intensity by IgG from SSc patients were analysed by using Pathway Studio software Interestingly, most of these proteins were involved in the transforming growth factor b (TGF-b)...
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Báo cáo khoa học: Cellular response to unfolded proteins in the endoplasmic reticulum of plants pptx
... signal peptide in the 24-kDa a-zein and the 19-kDa a-zein endosperm storage proteins, respectively These mutant proteins are translocated into the lumen of the ER, but remain anchored to the membranes ... pivotal role of the UPR is to maintain ER homeostasis Therefore, the presence of mutated proteins that are unable to fold into their native conformation in the ER induces the UPR in an effort to ... its luminal domain is bound by BiP Upon accumulation of unfolded proteins in the ER, BiP is competitively titrated from the luminal domain of IRE1 by the abundant unfolded proteins in the ER...
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Báo cáo y học: " Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins" doc
... concluded that the biotinylated tag at the C-terminus of the IN protein, which can be detected in virions, becomes inaccessible for streptavidin binding after entry into the cell Biotinylation and ... this interaction is DNA independent, and we observe that it limits the accessibility of the IN C-terminus The Integrase Binding Domain (IBD) of LEDGF/p75 interacts with the IN- CCD, but no interaction ... amino-acid biotin acceptor domain (BAD) (Fig 1A) [16] was introduced in the pCMVΔR8.74 [43] either at the C-terminus of IN (pCMVΔR8.74 -IN- BAD) or in the N-terminal region of MA For pCMVΔR8.74 -IN- BAD,...
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Forms of resistance against the capitalist discipline female factory workers in batam
... further point out that the uncontrolled inflow of migrants from other parts of Indonesia poses an increasing threat to the economy of Batam Since there is little investment in low-income housing, ... industrial estate, BatamIndo Industrial Park is located in the Muka Kuning area, in the heart of the island, and is still the largest and most developed industrial estate on the island BatamIndo ... BatamIndo Industrial Park Chapter outlines the profile of factory workers in the manufacturing sector, who are mostly young, single females, between the ages of 18-22 Based on my in- depth field interviews...
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The graphs below show the numbers of male and female workers in 1975 and 1995 in several employment sectors of the republic of Freedonia
... made gains in both the finance/banking industries and in the defence-related public sector Whereas some 125 000 women worked in finance and banking institutions in 1975, the number increased to ... 000 women worked in the communications sector Twenty years later, though the number of men remained unchanged, the number of women rose to 550 000 A similar situation was seen in the wholesale and ... the number of women rose from about 550 000 in 1975 to almost 800 000 two decades later The number of men in this sector remained stable over the period, at around 700 000 Women also made gains...
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Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
... a puzzling question remains unanswered: how are these peptides distributed in the different cells of the X organ–sinus gland system? In other words, what is the cellular specificity of the isomerization ... microscopy study of the neuronal endings in the sinus gland to determine the subcellular localization of the different epimers Taken together, these results allow a discussion of the existence of ... the results obtained in the crayfish Orconectes limosus, showing that l-isomer of CHH is always present in the different parts of the d-CHH cells, in decreasing amounts from the cell body to the...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... one subcellular compartment [10–12] Protein targeting to the microsomes requires the cotranslational insertion of the newly synthesized protein into the microsomal membrane, where the N-terminal ... located inside the innermembrane compartment In the third approach, we used alkaline Na2CO3 extraction to determine whether mitochondrial CYP2E1 is a membrane-intrinsic or membrane-extrinsic protein ... Role of PKA in the mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches The first approach involved measuring the level of...
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Tài liệu Báo cáo khoa học: Bone morphogenetic proteins in the early development of zebrafish pptx
... Follistatin, Chordin and Noggin [12] These proteins are antagonists of BMP and other members of the TGF-b family, binding to and inhibiting these signaling molecules from binding to their receptors in ... the extracellular space, thus inhibiting ventralizing activities Of these proteins, Chordin has a long-range effect In Xenopus, expression of the chordin gene is localized to the dorsal marginal ... Other factors affecting the BMP pathway Factors inhibiting BMP2b, other than direct binding proteins such as Noggin and Chordin, also affect dorsoventral patterning One example is found from the...
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Tài liệu Báo cáo khoa học: Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae docx
... the proteins of the outer membrane, we set out to determine what proportion was integral and to identify the major protein species To determine whether the major outer membrane proteins were integral ... the proteins present in the aqueous extract (‘Aq’), the detergent phase (‘D’) and the phospholipid-rich pellet (‘P’) Arrowheads designate the size of proteins enriched in the lipid-rich pellet including ... containing peripheral membrane proteins, a detergent-phase in which proteins with a-helical transmembrane domains are soluble and a ‘phospholipid-enriched’ pellet fraction containing proteins...
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Tài liệu Báo cáo khóa học: A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA Potential role in mRNA stabilization pptx
... containing CSD proteins can therefore bind the VEGF 5¢-UTR To further support a role for CSD proteins binding the VEGF 5¢-UTR, it was observed that a recombinant CSD protein GST-dbpB/YB-1 could bind ... contains the multifunctional singlestrand RNA/DNA binding protein, PTB [43–46,52–57], and that the binding of this complex may be involved in general VEGF mRNA stabilization The CSD/PTB-containing ... CSD proteins may direct the binding of the multiprotein complex to the VEGF RNA, as discussed above Consistent with this, using recombinant proteins, we have found that dbpB/YB-1 enhances the binding...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... signaling via the trk receptor in PC12 cells involves caveolin [51], and that caveolin associates with LDs [52] Therefore, NPs may induce the accumulation of lipids in PC12 cells by disturbing the ... factors in the cellular medium Serum, a mixture of proteins isolated from the blood (in this study, from the blood of bovine fetus), is a source of trophic factors The PI3K ⁄ Akt signaling pathway ... stopper into each flask with a syringe, and the flasks were then shaken gently for 24 h at room temperature The filters were then removed and placed into scintillation vials containing scintillation...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ... occurring C-terminal 100 kDa fragment of filamin, interacting with the motor protein dynein, may exert its inhibitory effect by interfering with interactions between the N- and C-terminal domains, ... LXXAA) both bind to the AR, but the mutant form shows much weaker binding than wild-type a-actinin-2 That is to say, the LXXLL motif in a-actinin-2 has a major role in the interaction with the AR However,...
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Báo cáo khoa học: Interaction of human stefin B in the prefibrillar oligomeric form with membranes Correlation with cellular toxicity doc
... surface-seeking potential Insertion into lipid monolayers was next measured using monolayers composed of DOPC or DOPG The insertion of proteins into the monolayer generated an increase in surface ... bound to any membrane used as the signal hardly changes during the injection and was the same as before the injection during the dissociation phases Weak binding at the micromolar range was observed ... confirm the binding of the aggregated forms, albeit to a much smaller extent than that observed for some proteins that bind specifically to membranes, such as the small membrane-binding domains involved...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
... of the genes encoding Cg-BMPR1 and Cg-TGFbsfR2 is shown in Fig 2C The serine ⁄ threonine kinase domain in both proteins is encoded by two exons equivalent to kinase subdomains X and XI [22] In ... clarify the binding properties of each of these domains we generated synthetic mRNA encoding only the C1 or C2 domains Expression of only the C1 domain resulted in the dorsalization of embryos in ... of the TGFb superfamily type I receptors are in bold and underlined, and the cysteine knot is boxed Also boxed are the transmembrane domain, the ATP binding site, the L45 loop and the serine...
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ANTIBIOTIC RESISTANCE OF ESCHERICHIA COLI ISOLATED FORM POULTRY WORKERS, PATIENTS AND CHICKEN IN THE EASTERN PROVINCE OF SAUDI ARABIA ppt
... Ampicillin, gentamicin Ampicillin, spectinomycin Ampicillin, tetracycline Ampicillin, TMPϩSMX Ampicillin, gentamicin, tetracycline & TMPϩSMX Ampicillin, gentamicin, spectinomycin, tetracycline & TMPϩSMX ... tetracycline and spectinomycin This might be explained by the fact that both are heavily used in the poultry industry in Saudi Arabia and could be the result of misuse or antagonism effect between the ... high individual and multiple resistance to antibiotics in E coli, reflecting the misuse of these agents in the poultry industry Since chicken may act as a possible source of pathogenic organisms in...
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Báo cáo Y học: The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli doc
... exposing the signal-anchor domain just outside the ribosome To compensate for the loss of methionines from the deleted domains of the proteins, both constructs contain a C-terminal tetra-methionine ... of the targeting signal is the parameter discriminating between SRP-dependent and SRP-independent pathways [14] On the other hand, in vitro cross-linking studies have revealed that the binding ... charged N domain, the hydrophobic H domain and the C-terminal C domain The a-helix in the H domain is predicted to extend up to the Gly at position )10 in the signal sequence Introduction of an...
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... determined whether the cells were insulin unresponsive in our study at the dose and period of TNFa preincubation prior to insulin treatment used Akt is one of the most important insulin signalling intermediates, ... that the nuclear corepressor is required in the TNFa-mediated inhibition of PEPCK [54] Therefore, in cells preincubated with TNFa prior to insulin, insulin signalling is prevented, resulting in ... in Foxa2 occupancy of the PEPCK promoter This decrease was significantly (P < 0.01) attenuated in cells preincubated in the presence of TNFa prior to insulin incubation In cells incubated in the...
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