protein in the presence or absence of pi3k inhibitors
Tài liệu Comparison of lung cancer cell lines representing four histopathological subtypes with gene expression profiling using quantitative real-time PCR pptx
... immunostaining of S100P in the cytoplasm and the nucleus, while SQ cells showed immunostaining of RAB25 in the cytoplasm The localization of S100P and RAB25 in tumor tissues was similar to that in ... SC) In Figure 2(C), which shows the principal component for the cell lines (PC1, PC2, and PC3), two of the three AD cells lines were close, whereas the third cell line was close in PC2 to the other ... modification; P, phosphorylation/dephosphorylation; PP, protein- protein binding; RB, regulation of binding) gene expression was not fully consistent among the subtypes, PCA with the present 12 genes...
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Tài liệu Báo cáo khoa học: A differential scanning calorimetry study of tetracycline repressor pptx
... repressor in the absence of Tc, whereas for the ligated protein, a slight increase was noted The Tmax is the increasing linear function of the scan rate of TetR (Fig 3) These results indicate ... at a protein concentration of 0.4 mgặmL)1 and scan rate of Kặmin)1 (Figs and 2) Therefore, under these experimental conditions, binding of Tc causes an increase in the Tmax of the protein of % ... radii The RH =Rtheo ratio higher than H (always % 1.15) indicates similar discrepancies in the spherical shape of the protein in the absence and presence of the ligand The increasing linear dependence...
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Applications of Calorimetry in a Wide Context - Differential Scanning Calorimetry, Isothermal Titration Calorimetry and Microcalorimetry docx
... accepted for the accuracy of information contained in the published chapters The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any ... 10°C/min, N2 atmosphere) The change of the annealing time influenced the value of the specific melting enthalpy (ΣΔH) due to the enabling of a growth of crystals (Table 5) The crystals morphology of ... comparable to that of annealed just for 10 min, however the crystal morphology is markedly different Furthermore, the change of the crystal morphology was indicated by the increase of the melting temperature...
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Báo cáo khoa học: Purification and structural study of the b form of human cAMP-dependent protein kinase inhibitor pdf
... structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitor protein J Biol Chem ... and hormonal regulation of the PKI and PKI isoforms of the inhibitor protein of the cAMP-dependent protein kinase J Biol Chem 272, 20011–20020 Byler, D.M & Susi, H (1986) Examination of the secondary ... protein kinase J Biol Chem 266, 11158–11162 Scarpetta, M.A & Uhler, M.D (1993) Evidence for two additional isoforms of the endogenous protein kinase inhibitor of cAMP-dependent protein kinase in mouse...
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Báo cáo Y học: Differential scanning calorimetric study of myosin subfragment 1 with tryptic cleavage at the N-terminal region of the heavy chain pdf
... domains, is of crucial importance for the structural integrity of the myosin head An important role of the N-terminal region of the myosin head in the communication between the motor domain and ... of actin to its binding sites, primarily to loop which is mainly responsible for the ÔweakÕ binding of S1 to F-actin Therefore we can expect that the actin-induced conformational changes in the ... Tm of 45.6 °C in the absence of nucleotides and 49.1 °C in the presence of ADP [17,20] These results are in favor of the above suggestion that the N-terminal region of myosin II is very important...
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selfridge, arnold, warnick. teaching electromagnetic field theory using differential forms
... those of dx in Fig 1a In general, the surfaces of a 1-form can curve, end, or meet each other, depending on the behavior of the coe cients of the form If surfaces of a 1-form not meet or end, the ... graphical interpretations A The Interior Product The interior product has the symbol Graphically, the interior product removes the surfaces of the rst form from those of the second The interior product ... pseudovector With forms, the distinction between a ^ b and a or b individually is clear The exterior product of a 1-form and a 2-form corresponds to the dot product The coe cient of the resulting 3-form...
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Differential scanning calorimetrycalorimetry
... polymorph induce solid-state transition below the melting temperature of the low melting polymorph EYP 2006 Outline Brief history of thermal analysis Theory of thermal analysis techniques – Thermal ... differential thermal power is supplied to the heaters to maintain the temperature of the sample and reference at the program value EYP 2006 Outline Brief history of thermal analysis Theory of thermal ... used for the sample and the reference material should completely cover the bottom of the pan to ensure good thermal contact avoid overfilling the pan to minimize thermal lag from the bulk of the...
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báo cáo hóa học:" Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines" pptx
... combination with chemotherapy The effect of dasatinib in combination with chemotherapy was examined in the three dasatinib responsive cell lines, Lox-IMVI, HT144 and Malme-3M and in one of the ... evidence for evaluation of dasatinib in clinical trials in melanoma patients Two clinical trials of dasatinib in melanoma are currently underway, including a phase I/II study of dasatinib in combination ... multi-target tyrosine kinase inhibitor, targets Src kinase, in addition to BCR-Abl, c-KIT, PDGFR and ephrin-A receptor kinases It is the most potent Src kinase inhibitor currently in clinical development...
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Báo cáo hóa học: " Temperature-Dependent Site Control of InAs/GaAs (001) Quantum Dots Using a Scanning Tunneling " pptx
... After the InAs WL growth, we applied voltage on the InAs WL without As4 Figure 1a–c was the STM images of surface structure before applying voltage at 50 and 150°C White points were indicating the ... considered as the Ga-rich sites compared with other InAs WL region [15] After fabricating the hole structure, we started supplying In flux again The amount of InAs supply was estimated at 0.02 ML in every ... fabrication, c congregating In atoms in this site, and d exceeding critical thickness partially, forming an InAs dot 50 to 430°C After 1.5 ML of the InAs WL growth by ordinal S–K dot fabrication...
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Báo cáo vật lý: "EXOTHERMIC TRANSITIONS ON COOLING OF GELATINIZED NATIVE RICE STARCH STUDIED BY DIFFERENTIAL SCANNING CALORIMETRY" doc
... retrogradation of starchcontaining food.2,11 With the increase in application of rice starch in various food products, (e.g as a fat replacer in food), the aim of the present work was to investigate the ... multiple melting thermal profiles on the DSC heating curves It is believed that native amylose-lipid complexes formed during cooking or processing affect the storage stability, for example retrogradation ... Effects of Cooling Rate Endothermic heat flow (W g–1) Figure gives a comparison of the DSC thermograms obtained using cooling rates of 1, and 10oC min–1 on the 1:2 system Generally, the transitions...
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Báo cáo y học: " Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation" pot
... 20 for hour Detection of phosphorylated (ph) and unphosphorylated proteins was performed by incubating the membranes with a primary antibody against the protein of interest overnight at 4°C The ... locations in the joint to minimize sampling error) were cultured intact in DMEM/10% FCS in a humidified 5% CO2 atmosphere in the presence or absence of NBD peptides (100 µM) and after 2hour pre-incubation ... ameliorates arthritis Intra-articular injection of the NBD peptide at the onset of disease ameliorates arthritis (a) Dose-finding experiments To determine the optimal dose of the NBD peptide for...
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Báo cáo y học: "Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis" pot
... inhibitor, Dec-RVKR-CH2Cl, or the general trypsin-like serine proteinase inhibitor, alpha1-proteinase inhibitor, can block the activation of pro-collagenases and degradation of collagen in the bovine ... point in the breakdown of the cartilage collagen matrix ase inhibitors in resorbing cartilage Relative differential expression of MMPs, ADAMTS, and metalloproteinase inhibitors in resorbing cartilage ... 10 of culture IL-1+OSM also causes a net reduction in metalloproteinase inhibitors, favouring the destructive potential of the plethora of metalloproteinases that this potent cytokine combination...
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Báo cáo khoa học: " The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells" ppt
... targeting HGF or c-Met expression using ribozyme radiosensitizers in GBM cells in vitro and xenograft tumor in vivo [10], demonstration of clinically useful inhibitors of the tyrosine kinase ... was defined as the number of days for tumors in the radiation-only and the MP470 + radiation groups to reach 1,500 mm3 minus the number of days for tumors in the control group to reach the same ... the same size Normalized growth delay (NGD) was calculated as the number of days for tumors in the combined-therapy group to reach 1,500 mm3 minus the number of days for tumors in the MP470only...
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Báo cáo y học: "Reliability of capturing foot parameters using digital scanning and the neutral suspension casting technique" ppt
... need to determine the reliability of measuring foot parameters that the clinician views as important for the manufacture of, and successful outcome of, orthotic intervention The clinician should ... estimates for the plaster casting of 0.43 and 0.41 for the foam boxes] In summary, the current evidence suggests that there is conflicting evidence relating to the inter-rater reliability of traditional ... be aware of the potentially small measurement errors when utilising digital scanning Therefore, the aims of this study were to assess the intra-rater reliability (within-rater) and the inter-rater...
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báo cáo khoa học: "ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside" doc
... Collectively, these results indicate a prominent role of FLT3 ligand in mediating the resistance to FLT3 inhibitors Survivin (encoded by BIRC5), the smallest member of the inhibitor of apoptosis protein ... Figure Kinase inhibition profile of ABT-869 against a broader range of kinases Kinase inhibition profile of ABT-869 against a broader range of kinases Nonclinical in vivo activity of ABT-869 Initial ... Glaser KB: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors Mol Cancer Ther 2006,...
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Báo cáo y học: "Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice" pot
... cultured in the presence of RANKL and TNF-α in the presence or absence of ZSTK474 The number of TRAP staining-positive multinucleated cells was counted Amelioration of CIA in mice with oral administration ... incubated for 72 hours in the presence or absence of ZSTK474 and other PI3-K inhibitors The dentin slices were stained with hematoxylin, and the pits formed in the resorbed area on the slices were observed ... containing 10-7 M 1α,25(OH)2D3 (Wako Pure Chemical Industries, Ltd., Osaka, Japan) for five to six days in the presence or absence of varying concentrations of ZSTK474 or other PI3-K inhibitors Otherwise,...
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Báo cáo y học: " Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction" pps
... in the absence of the Rho-kinase inhibitor (Fig 1B) Interestingly, the AHR after the LAR was even fully reversed to the basal responsiveness in the presence of Y-27632 (Fig 1B) Saline inhalations ... assisted in performing the experiments JZ participated in the design of the study and the interpretation of results HM supervised the study, participated in its design and in interpretation of results ... of PGF2α in saline, respectively OA-provocations were performed by inhalation of increasing aerosol concentrations of 0.5 and 1.0 mg/ml OA in saline for min, separated by intervals Allergen inhalations...
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Báo cáo sinh học: "Characteristics of predictor sets found using differential prioritization" docx
... set indicates the amount of similarity among the members of the predictor set, or rather, the amount of repetitions in terms of the information conveyed by the members of the predictor set Previous ... terms of the Euclidean distance The value of the DDP leading to the best separation of classes in terms of the Manhattan distance in original feature space The value of the DDP giving the largest ... predictor sets in the original projection, we investigate the characteristics of the predictor sets after transformation by PCA In the original form, the data are characterized along axes representing...
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Báo cáo y học: "The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells" ppsx
... paw Clinical score assessment was made using the following criteria: = normal; = one hind paw or fore paw joint affected or minimal diffuse erythema and swelling; = two hind or fore paw joints ... protected the bones of the mice, especially in the joint areas (Figure 5c) MicroCT analysis of forelimbs of the CAIA mice showed a major reduction of J scores measuring bone intensity in the PCI-32765 ... using the aforementioned scoring criteria by a scientist blinded to the study The J scores were tabulated and analyzed for statistical significance Lesions in the forelimb or hindlimb were scored...
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