protein glycation and oxidative stress in diabetes mellitus and ageing

... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this...

Ngày tải lên: 26/10/2012, 09:07

... element binding protein, iso- citrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84]. Mitochondria from different brain regions contain different ... provided by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with...

Ngày tải lên: 07/03/2014, 12:20

... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductions of soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the dep- osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...

Ngày tải lên: 19/06/2014, 22:20

... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi- dative stress also promotes angiogenesis [13]. The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1. Endothelium injury is critical in SSc and is ... VEGF signalling is impaired in SSc. However, more experimental evidence is needed to determine whether the VEGF pathway is intrinsically defective in SSc. Keywords: nifedipine, oxidative stress, ...

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Ngày tải lên: 11/08/2014, 07:21

... phos- phoproteins such as zonula occludens protein 1, zonula occludens protein 2, and P-130. Other possible signal- ing molecules include Ga subunits, tyrosine kinase, small GTPases (Rab ⁄ Rho), and ... In Chang cells, stained occludin was observed in the cytoplasmic region. Additionally, in Occ WT -overexpressing Hep3B and Huh7 cells, regions stained with antibody to hem- agglutinin (HA), indicating ... level increased in Occ WT -overexpressing cells, and that 2-APB inhibited the effects of Occ WT . Therefore, the increase in intracellular calcium may explain the induction of apoptosis and reduction...

Ngày tải lên: 18/02/2014, 18:20

... PilA4 competence proteins and raised antisera against these proteins to visualize the proteins in the T. thermophilus wild-type strain. This is the first report on the detection of competence proteins in T. ... secretin-like PilQ was detected in sufficient amounts in the inner and outer membranes. The pres- ence of PilQ in inner membranes is interesting, because secretin-like proteins of type IV pili and ... fatty acylation and, thereby, be involved in membrane anchoring of the pilin. Since PilA4 is similar to the meningococcal pilin and contains several central serine residues, it is tempting to speculate...

Ngày tải lên: 07/03/2014, 12:20

... Processing, Electrical Systems, Fault Diagnosis and Monitoring, Image Processing and Applications in Engineering. The wavelet method is used in this book to extract more information than the standard ... of interest in red (b), the LP candidate in yellow (b), the 2D Haar WT edges (c) and post - processed 2D Haar WT edges (d) Advances in Wavelet Theory and Their Applications in Engineering, ... THEIR APPLICATIONS IN ENGINEERING, PHYSICS AND TECHNOLOGY Edited by Dumitru Baleanu Advances in Wavelet Theory and Their Applications in Engineering, Physics and Technology 38 ...

Ngày tải lên: 27/06/2014, 00:20

... year. During follow up, patients were evaluated b y history and physical examination, including digital rectal examination and CEA level every three months. A chest radiograph and trans-abdominal ... 8:82 http://www.wjso.com/content/8/1/82 Page 4 of 11 In our analysis, other variables such as gender, tumour location, tumour characteristics - invasion margin (pushing vs. infiltrative), perineural and lymphovascular invasion - did ... States [9], 3% in France [9] and 5.5% in New Zealand [ 6,15]. The high percentage reported in devel- oping countries may be due, in part, to the higher popu- lation of younger people in these countries. Young...

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Ngày tải lên: 12/08/2014, 16:20

... 559-65. 18. Cronin CC, Shanahan F. Insulin-dependent diabetes melli- tus and coeliac disease. Lancet 1997; 349: 1096-7. 19. Pocecco M, Ventura A. Coeliac disease and insulin-depen- dent diabetes mellitus: ... osteoporosis, infertility, ma- lignancy or other autoimmune disorders. Based on our study and a literature review, we think that routine screening should be carried out in diabetic children, and long-term ... IgA- tTG. Serum total IgA levels were within normal li- mits in these subjects. Intestinal histopathology showed sub-total villous atrophy in the sibling (Marsh type 3c). Both parents refused...

Ngày tải lên: 05/03/2014, 12:20

... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) ... accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses. (A) Virus infec- tion-induced H 2 O 2 accumulation detected by DAB staining. (B) Abi- otic stress- induced...

Ngày tải lên: 14/03/2014, 23:20

... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... solubilized extract were incubated in such buffers for 4 h on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N 2 -saturated buffer in the absence or presence of...

Ngày tải lên: 15/03/2014, 23:20

... 100% open chain that modifies proteins more rapidly than glucose by an interaction with arginine and cysteine, in addition to lysine [2]. It has been shown to cross-link proteins during glycation ... a-crys- tallin in a more physiological system in which a-crystallin was incorporated into red cell ÔghostsÕ. Its ability to protect the intrinsic membrane protein Na/K-ATPase from external stresses ... ghost cells and the supernatants were taken for scintillation counting. Creatine kinase determination Creatine kinase activity was assayed following the method of Bernt and Bergmeyer [24], in the...

Ngày tải lên: 17/03/2014, 03:20