protein drosophila disc large tumor suppressor zonula occludens 1 protein pdz

... including melanoma (11 1), ovarian cancer (11 2), prostate cancer (11 3), skin cancer (11 4), medulloblastoma (11 5), liver cancer (11 6 ,11 7), and endometrial cancer (11 8) Finally, AXIN1 mutations have ... helpful discussion References Weinberg, R A (19 91) Tumor suppressor genes Science 254, 11 38 11 46 Hinds, P W and Weinberg, R A (19 94) Tumor suppressor genes Curr Opin Genet Dev 4, 13 5 14 1 Paggi, ... as tumor suppressors Cytogenetically, Rb2/p130 maps to the region 16 q12.2 -13 , an area repeatedly altered in human cancers (10 ,11 ,42), whereas p107 maps to the human chromosome region 20q 11. 2,...

Ngày tải lên: 11/04/2014, 10:38

... complex assembly J Cell Sci 11 4, 3 219 –32 31 14 Nourry C, Grant SG & Borg JP (2003) PDZ domain proteins: plug and play! Sci STKE 2003, RE7 15 Sheng M & Sala C (20 01) PDZ domains and the organization ... multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling Cell Calcium 26, 16 5 17 1 13 Harris BZ & Lim WA (20 01) Mechanism and role of PDZ domains ... receptors, such as mOR167-4, mOR199 -1, M 71, M72 and mOR2 41- 1 B C D E Fig The C-terminus of OR2AG1 interacts with MUPP1 in vitro (A) Pie chart illustrating the abundance of classical PDZ motifs in human...

Ngày tải lên: 18/02/2014, 13:20

... (PvuII fragment of pPMG1 lacking CDRE) in 5% native PAA gel; concentrations of the oligonucleotide duplex and 2 513 -basepair fragment were 1. 6 and 10 lgÆmL )1 (1. 26 · 10 )7 and · 10 )9 M), respectively, ... Cancer 91, 16 14 16 23 12 Janus F, Albrechtsen N, Dornreiter I, Wiesmuller L, ¨ Grosse F & Deppert W (19 99) The dual role model for p53 in maintaining genomic integrity Cell Mol Life Sci 55, 12 –27 13 ... Brabec V (20 01) Different recognition of DNA modified by antitumor cisplatin and its clinically ineffective trans isomer by tumor suppressor protein p53 J Biol Chem 276, 16 064 16 069 14 Kasparkova...

Ngày tải lên: 16/03/2014, 14:20

... large FEBS Journal 278 (2 011 ) 2655–2665 ª 2 011 The Authors Journal compilation ª 2 011 FEBS PDZ3 PDZ -1- 2 PDZ3 PDZ- 1mut-2 PDZ -1- 2 kDa 50 Media Ct B PDZ -1- 2mut A PDZ -1- 2mut hDlg in ERK cascade PDZ- 1mut-2 ... (2 011 ) 2655–2665 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 2657 hDlg in ERK cascade O Maıga et al ¨ A L27 1 β2 CXC β3 1 GUK PDZ1 // // SH3 1 1 // 12 // // 13 Ι3 Ι2 Ι5 Ι4 14 15 ... 278 (2 011 ) 2655–2665 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 2659 hDlg in ERK cascade O Maıga et al ¨ WB 15 0 hDlg hDlg 10 0 50 10 0 50 MEK2 MEK2 37 37 C D 15 0 15 0 hDlg hDlg 10 0 50 10 0 50...

Ngày tải lên: 22/03/2014, 16:20

... –0.04 15 30 cm 1 1552 cm 1 1622 cm 1 16 51 cm 1 1.0 0.08 15 52 –0.06 0.8 0.6 0.4 0.2 0.0 16 51 –0.08 17 00 16 50 16 00 15 50 Wavenumber (cm 1) 20 30 D 50 60 70 40 Temperature (°C) 16 22 0 .12 0 .10 0.08 ... (kJÆmol )1) mol )1 M )1) (kJÆmol )1) (M) mol )1 M )1) (kJÆmol )1) (M) mol )1 M )1) (kJÆmol )1) mol )1) mol )1) Apo 4.7 +Zn2+ 2.5 +Ca2+ 3.9 89.9 35 .1 40.3 13 .0 3.5 2.9 – )14 .2 )5.2 4.5 4.0 4.8 78.9 50 .1 62.4 11 .2 ... 15 30 0.00 –0.02 –0.04 –0.06 –0.08 –0 .10 –0 .12 –0 .14 15 52 80 90 80 90 16 08 cm 1 1622 cm 1 1635 cm 1 1693 cm 1 1.0 % Variation second derivative ΔAbs (a.u.) C 0 .14 15 00 0.8 0.6 0.4 0.2 0.0 16 51...

Ngày tải lên: 30/03/2014, 02:20

... (Dlg1-) Tax1 Tax1 X Tax1 PBM C X PBM PBM C Dlg1 Tax1 Tax1 Tax1 PBM Dlg1 Tax1 PBM C X PBM Dlg1 Tax1 Tax1 C) Low transformation of Tax1 C in CTLL-2 X C Tax1 X Tax1 C C C Figure A model of Tax1 induced ... 3: 71 http://www.retrovirology.com/content/3 /1/ 71 IL-2 dependent CTLL-2 A) Dlg1 -1 Dlg1-3 CAT LUC IL-2 independent Tax1ΔC Δ IL-2 independent Tax1 Dlg1 -1 Dlg1-3 CAT LUC Dlg1 -1 Dlg1-3 CAT LUC Dlg1 ... of 13 (page number not for citation purposes) Retrovirology 2006, 3: 71 http://www.retrovirology.com/content/3 /1/ 71 B) A) 20 LUC Dlg1 Tubulin Dlg1 -1 Cell number (x105) Dlg1 -1 Dlg1-3 CAT 15 Dlg1-3...

Ngày tải lên: 13/08/2014, 09:20

... 11 12 13 14 15 16 Jiang G, Liu L, Buyse IM, Simon D, Huang S Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1 Int J Cancer 19 99; 83: 5 41- 6 Jiang ... superfamily Cancer Res 20 01; 61: 8094-9 Jiang GL, Huang S Adenovirus expressing RIZ1 in tumor suppressor gene therapy of microsatellite-unstable colorectal cancers Cancer Res 20 01; 61: 17 96-8 Deng Q, Huang ... Yokochi T Retinoblastoma protein- interacting zinc finger (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression Immunol Lett 2 010 ; 13 1 :16 6-9 25 Miyake H, Hara...

Ngày tải lên: 25/10/2012, 11:15

... between the pRB and p53 tumor suppressor pathways came from the discovery of p 21 Multiple groups identified p 21, as a p53-target gene (WAF1), a Cdk2-associated protein (p 21 or CIP1), a Cdk2 inhibitor ... RA (20 01) Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis Nature 413 :86– 91 Sherr CJ (19 96) Cancer cell cycles Science 274 :16 72 16 77 Sherr CJ (20 01) The INK4a/ARF network ... 19 96; LeCouter et al 19 98b) (Cobrinik et al 19 96) (Lee et al 19 96) (Tsai et al 19 98) (Ziebold et al 20 01) (Iavarone et al 2004; Lasorella et al 2000) (Macleod et al 19 96; Morgenbesser et al 19 94)...

Ngày tải lên: 25/10/2013, 21:20

... as inhibitors of protein- carbohydrate recognition using purified plant and mammalian lectins 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 11 3 11 4 11 5 and wild-type and lectin-gene-transfected tumor cells as ... pathways connecting protein FEBS Journal 274 (2007) 3233–3256 ª 2007 The Authors Journal compilation ª 2007 FEBS New function of p16INK4a ´ S Andre et al 10 11 12 13 14 15 16 17 18 glycan interaction ... Koenderman AH & van den Eijnden DH (19 86) Mucin synthesis Conversion of R1-b1–3Gal-R2 to R1-b1–3 (GlcNAc b1–6) Gal-R2 and of R1-b1–3GalNAc-R2 to R1-b1–3 (GlcNAc b1–6) GalNAc-R2 by a b6-N-acetylglucosaminyltransferase...

Ngày tải lên: 16/03/2014, 10:20

... Authors Journal compilation ª 2 011 FEBS A L Cavatorta et al 10 11 12 13 14 15 16 17 18 and differentiation of human intestinal epithelial cells J Biol Chem 279, 10 157 10 166 Assemat E, Bazellieres ... efficiency A F3 +35 F5 –36 –27 11 +1 R3 +54 16 2 43 19 1 5′UTR DLG Large 5’UTR DLG Large ATG G R Exon B Exon A Exon C F5 R3 F4 +35 –56 –36 –27 –22 11 +17 3 +1 162 43 19 1 5′UTR DLG Short 5’UTR DLG ... cytoskeleton J Cell Sci 11 1, 10 71 10 80 Laprise P, Viel A & Rivard N (2004) Human homolog of disc- large is required for adherens junction assembly FEBS Journal 278 (2 011 ) 2596–2608 ª 2 011 The Authors Journal...

Ngày tải lên: 22/03/2014, 16:20

... 1. 3 6.5 ± 1. 0 1. 8 ± 0.4 3.0 ± 1. 6 19 000 ± 2000 2700 ± 600 > 400 000 A )12 .4 ± 0.3 )11 .2 ± 0.2 )11 .1 ± 0.3 )11 .0 ± 0.3 )11 .7 ± 0 .1 )11 .4 ± 0.3 )6.3 ± 0 .1 )7.5 ± 0 .1 – B DG was calculated as DG ... (kcalÆmol )1) E7b E7( 21- 29) (LXCXE)b E7 (16 - 31) (LXCXE)b E7 (16 -40) (CR2)b E7 (16 -40)PP (CR2PP)b E7 (1- 40) (E7N)b E7 (1- 20) (CR1) E7(40-98) (E7C) BPV (1- 43) (BPV-N) 0.6 ± 0.3 4.7 ± 1. 7 5 .1 ± 1. 3 6.5 ± 1. 0 1. 8 ... HPV E7 proteins Fragment DGa (kcalÆmol )1) KD (nM) Full-length protein HPV16 E7 2.4 ± 0.2 HPV18 E7 7.8 ± 0.5 HPV 11 E7 10 8 ± N-terminal domain HPV16 E7 8.6 ± 1. 3 HPV18 E7 12 .2 ± 0.8 HPV 11 E7 366...

Ngày tải lên: 22/03/2014, 21:20

... used included EGFR (10 05, sc-03), CD 71 (i.e TfR, 3B8 2A1, sc-32272), LAMP1 (H5G 11, sc -18 8 21) , caveolin -1 (N-20, sc-894) and HA (Y -11 , sc-805) FEBS Journal 276 (2009) 22 01 2 212 ª 2009 The Authors ... IR HCT 116 wt HCT 116 -p53null D EGFR CAV1 Merge 0h C H460 H1299 + +DO -1 Input + + 300 bp 200 bp b c e f g – +DO -1 a d M No Ab h i j k l IR 4h CAV1 10 0 bp Relative luciferase activity 12 0 6h 10 0 80 ... expression level H460 3.5 2.5 2 1. 5 1 No treatment No treatment 0.5 IR 0 p 21 in H460 p53 in H460 CHMP4C in H460 250 2.5 200 15 0 1. 5 10 0 0.5 C siRNA-NS - 300 bp 200 bp +DO -1 -1 H1299 + +IgG M Input H460...

Ngày tải lên: 23/03/2014, 04:21

... 10 (29%) 2d 10 (29%) 1d D4Mit302 (85.2) 21 ( 31% ) 17 D4Mit9 (94.7) A+B 34 10 11 (32%) D4Mit9 (94.7) B (C x C.S302–9)F1 11 (32%) D4Mit 31 (10 6.8) 21 ( 31% ) 19 (C x S)F1 D4Mit 31 (10 6.8) 11 (28%) 10 ... of tumors (CXS)F1 74 Chr Marker (Mb)b LOH (%) Reference [37] a 81 42 (57%) D19Mit 11 (42.5) 37 (50%) D4Mit54 (13 7.4) (25%) D12Mit233 (10 9.5) 12 (60%) 12 D12Mit1 81 (11 0.0) 53 (65%) 16 (CXM)F1 d ... putative tumor susceptibility gene Lyr Micea Number of tumors Marker (Mb)b LOH (%) S loss C loss A (C x C.S163– 31) F1 34 D4Mit17 (63.0) 11 (32%) 2c D4Mit302 (85.2) 11 (32%) 2c 1c D4Mit9 (94.7) 68 10 1c...

Ngày tải lên: 23/03/2014, 17:20

... assays B p16INK4a negatively affects Gal-3 mRNA availability 10 0 10 0 0 10 0 C 10 1 10 2 10 3 10 4 10 0 10 1 10 2 10 3 10 4 Fig p16INK4a restitution inhibits Gal-3 expression (A) Western blot after 1D SDS ... Sanchez-Ruderisch et al G -1 + G al G 80 C 40 Counts 12 0 B 10 0 10 1 10 2 Gal-3 binding (log fluorescence) 80 40 Counts 12 0 C 10 0 10 1 10 2 Gal -1 binding (log fluorescence) Fig Gal-3 inhibits Gal -1- stimulated anoikis ... 600 12 20 40 60 80 0 600 200 400 FL2-H 600 30 60 90 12 0 0 200 400 FL2-H 600 12 40 80 12 0 16 0 400 FL2-H 200 200 400 FL2-H 16 600 200 400 FL2-H 600 31 10 20 30 40 50 60 0 Counts p16-3 0 40 80 12 016 0...

Ngày tải lên: 29/03/2014, 21:20

... Lefebvre et al (Eur J Biochem 2 71) 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 nuclear forms of Pax-6 products in quail neuroretina cells J Cell Biochem 85, 208– 218 Lamarre-Vincent, N & Hsieh-Wilson, ... TATA binding -protein- associated factor, TAFII 110 or holo-Sp1 [18 ] This protein protein interaction is inhibited by O-GlcNAc, thus reducing the RNA-polymerase II-dependent transcription [18 ] In addition, ... complexes [11 ] In terms of protein stability, the glycosylation of the full-length HIC1 protein could also contribute to its stabilization as shown for Sp1 [16 ] or the beta-estrogen receptor [17 ] Examination...

Ngày tải lên: 30/03/2014, 15:20

... disulfide-linked homo-dimer of human Tff1 (66) PDB ID 1SAE, 1SAF, 1SAG, 1SAH, 1SAI, 1SAJ, 1SAK, 1SAL 1AU1 1HS5 1COK 1BU9 1A5E, 2A5E 1DC2 1D9S 1PS2 1HI7 1. 1 NMR of Soluble Proteins Solution NMR methods ... four tumor suppressor proteins, p15, p16, p18, and p19, ranging in size from 13 .7 to 18 kDa (50–53) Among these, mutations in p16 have been tied to the development of cancer, and the tumor suppressor ... P M (19 90) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 Cell 63, 11 29 11 36 17 Huibregtse, J M., Scheffner, M., and Howley, P M (19 91) A cellular...

Ngày tải lên: 11/04/2014, 10:38

... (0) (18 .5) (18 .2) (12 .5) CACNA1A 18 (33.3) 11 (50.0) ( 21. 9) 13 (28.3) (66.7) (29.6) 11 (50.0) ( 21. 9) TIMP3 10 (18 .5) ( 31. 8) (9.4) (19 .6) (1. 7) (18 .5) ( 31. 8) (9.4) TIMP3-2 11 (20.4) ( 31. 8) (12 .5) ... (55.5) 14 (63.6) 15 (46.9) CACNA1G 21 (38.9) 12 (54.5) (28 .1) 19 ( 41. 3) (1. 7) 12 (44.4) 12 (54.5) (28 .1) TGIF 10 (18 .5) (22.7) (15 .6) (19 .5) (1. 7) (22.2) (22.7) (15 .6) BCL2 (14 .8) (18 .2) (12 .5) (17 .4) ... (18 .5) ( 31. 8) (9.4) (19 .5) (1. 7) (18 .5) ( 31. 8) (9.4) SFRP4-2 16 (29.6) 11 (50.0) (15 .6) 12 (26.0) (50.0) (29.6) 11 (50.0) (15 .6) DLC1 22 (40.7) 12 (54.5) 10 ( 31. 2) 18 (39 .1) (50.0) 13 (48 .1) 12 (54.5)...

Ngày tải lên: 18/06/2014, 16:20

... pp (4608-4 614 ) 0008-5472 Eilers M., Schirm, S & Bishop, J.M (19 91) "The MYC protein activates transcription of the alpha-prothymosin gene Embo J, Vol 10 , No .1, pp (13 3 -14 1) 02 61- 418 9 Emig R., ... Beach, D & Dracopoli, N.C (19 95) "Mutations associated with familial melanoma impair p16INK4 function Nat Genet, Vol 10 , No .1, pp (11 4 -11 6) 10 61- 4036 Rao S.S & Kohtz, D.S (19 95) "Positive and negative ... No.6456, pp (704707) 0028-0836 Serrano M (19 97) "The tumor suppressor protein p16INK4a Exp Cell Res, Vol 237, No .1, pp (7 -13 ) 0 014 -4827 Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell...

Ngày tải lên: 27/06/2014, 13:20

... details Pak1p with Snf1p is enhanced under the low glucose conditions in which Snf1p is activated [17 ] Pak1p, Tos3p and Elm1p can all phosphorylate Snf1p at Thr 210 [17 -19 ] (indeed, Elm1p was selected ... mammalian p 21- activated kinase -1, also abbreviated Pak1), Tos3p and Elm1p, were recently identified as Snf1p kinases [17 -19 ] Thus, massspectrometric analysis of proteins associated with the Snf1p complex ... Am J Physiol 19 99, 277:E1-E10 Goodyear LJ: AMP-activated protein kinase: a critical signaling intermediary for exercise-stimulated glucose uptake? Exerc Sport Sci Rev 2000, 28 :11 3 -11 6 Mu J, Brozinick...

Ngày tải lên: 06/08/2014, 18:20

... (%) 10 0 50 Anti-LKB1: Control IgG: AMPKK1 AMPKK2 + + + + LKB1 + + 0.02 0. 01 Anti-LKB1: Control IgG: (b) AMPKK1 AMPKK2 + + + + (d) GST-LKB1 LKB1 + + AMPKK1 AMPKK2 LKB1 LKB1 STRADα Anti-LKB1 SN: ... AMPKK1 ) ) AMPKK2 ) 10 0 30 50 14 16 18 20 22 24 26 28 30 32 34 36 (b) Conductivity (mS) ( 60 A280 ( Activity (units per ml) ( 15 0 LKB1 STRADα MO25α LKB1 STRADα MO25α (c) AMPKK1 AMPKK2 AMPK LKB1 ... Article 28 + pT172 1/ α2 AMPKK1: AMPKK2: LKB1 complex: + + + + (b) GST-LKB1 ? LKB1 AMPKK1: + AMPKK2: + LKB1 complex: + (c) FLAG-STRADα STRADα Myc-MO25α MO25α AMPKK1: + AMPKK2: + LKB1 complex: +...

Ngày tải lên: 06/08/2014, 18:20