properties of the elements and inorganic compounds
Tài liệu MECHANICAL PROPERTIES OF THE HEART AND ITS INTERACTION WITH THE VASCULAR SYSTEM ppt
Ngày tải lên :
22/02/2014, 09:20
... understanding and will be the focus and repeating theme throughout the text A sound understanding of cardiac physiology begins with basic understanding of cardiac anatomy and of the physiology of ... contraction and instantaneous atrial volume) The pressure of the point at the bottom right corner of the loop is the pressure in the ventricle at the end of the cardiac cycle and is called the end-diastolic ... ongoing contraction process of the cardiac muscles and the properties of the arterial system and is beyond the scope of this lecture As the contraction process of the cardiac muscle reaches its...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
Ngày tải lên :
23/03/2014, 21:20
... kinetic properties of NR1, and as we have shown for CPR and P450 BM3 (23,24,28) the properties of the flavin binding domains of NR1 are likely to mimic the redox properties of the domains in full-length ... spectroelectrochemical titrations of the isolated FAD/NADPH and FMN domains of NR1 enabled the determination of the midpoint reduction potentials for the oxidized/semiquinone (E1) and semiquinone/hydroquinone ... FAD/NADPH domain and the oxidized FMN domain The lack of a second order dependence of the observed rate for interdomain electron transfer as the Ó FEBS 2003 Redox properties of human NR1 (Eur...
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Báo cáo y học: "Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptases" pptx
Ngày tải lên :
12/08/2014, 23:22
... is the reverse transcription of the genomic RNA into double stranded (ds) DNA For formation of dsDNA, the RT catalyzes RNAand DNA-dependent DNA polymerization to synthesize the (-) and (+)-strand, ... substrate containing a fluorescent dye on the 3’ end of the RNA and a quencher on the 5’ end of the DNA Upon cleavage of the RNA the fluorescent dye is released from the quencher resulting in an increase ... detection of the fluorescence emission of the RNA template strand at 670 nm upon excitation at 633 nm The cleavage sites are indicated on the left The first nucleotide of the RNA hybridized to the...
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Thermal properties of the vernacular buildings envelopes: the case of the "Sassi di Matera" and "Trulli di Alberobello
Ngày tải lên :
05/09/2013, 14:58
... characteristics of the "Sassi of Matera" and "Trulli of Alberobello" In the South of Italy, the sites of the "Sassi of Matera" (Figure 1a) (classified as humanity world heritage in 1993) and "Trulli of Alberobello" ... namely, “Tufo of Matera” for the structures of the "Sassi of Matera," and “Stone of Fasano” for the structures of the "Trulli of Alberobello," they are different with regard to form and constructive ... and the knowledge of the temperature coefficient of the material of which it is made A single measure allows for the determination of diffusivity, thermal conductivity, and specific heat of the...
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Tài liệu Psychometric properties of the quality of life scale Child Health and Illness Profile-Child Edition in a combined analysis of five atomoxetine trials pdf
Ngày tải lên :
12/02/2014, 19:20
... smaller The RA and the PA sub-domains had lower correlations with their domains than most of the other domains at baseline, at endpoint, and Psychometric properties of the CHIP-CE also for the change ... the SH sub-domain (item 1: ‘‘How often does your child have a lot of fun?’’ and item 4: ‘‘How often does your child feel happy?’’) The items of the SPS sub-domain Psychometric properties of the ... as well as for the domains and sub-domains Furthermore, the sub-domains were correlated with the domains and the total score, and the domains were correlated with the total score The items/sub-domains/domains...
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Tài liệu Báo cáo khoa học: Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle doc
Ngày tải lên :
18/02/2014, 11:20
... by presenting the pulse of Src activity in the plane of the inactive and active fractions, si and s1 If the duration of the stimulus exceeds the critical value, the trajectory in the (si, s1) ... by number in the plane of the Csk and RPTP concentrations Within these two regions of monostability, there are parameter sets where the QSS dependence of the active Src fraction on the inactive ... transition from the Off state to On state (in the bistability domain) Regardless of the slope, the active Src fractions increase during the Off to On transition, whereas the value of the inactive...
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Tài liệu Báo cáo Y học: Electrochemical, FT-IR and UV/VIS spectroscopic properties of the caa3 oxidase from T. thermophilus docx
Ngày tải lên :
21/02/2014, 15:20
... c the Soret band was reported to absorb at 418 nm, the b-band at 520 nm and the a–band at 550 nm [18] The deviations of approximately nm between the signals of horse heart cytochrome c and the ... at 415 and 442 nm, and for the oxidized form at 403 and 422 nm The b–band can be seen at 517 nm and the a–band at 547 nm and 603 nm The difference signals that can be observed between 400 and 700 ... work we study the electrochemical, UV-VIS and FT-IR spectroscopic properties of the caa3oxidase from T thermophilus in the presence and absence of cyanide, and compare the observed properties to...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
Ngày tải lên :
22/02/2014, 04:20
... complexes of GGH, where the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component dd bands and of CT transitions are relatively constant, their ... albumins On the other hand, the direct thermodynamic and kinetic characterization of Ni(II) binding at site I in HSA and BSA was obtained These data can be very useful in further studies of the toxicologically ... values) of Ni(II) and Cu(II) complexes of peptides at I = 0.1 M (KNO3) and 25 C Standard deviations on the last digits are given in parentheses EPR The X-band EPR spectra of Cu(II) complexes of VIHN...
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Tài liệu Báo cáo Y học: The effects of low pH on the properties of protochlorophyllide oxidoreductase and the organization of prolamellar bodies of maize (Zea mays) pot
Ngày tải lên :
22/02/2014, 04:20
... The two phenomena are clearly related and strongly point to the importance of changes in the surface properties of the PLB membrane The obvious candidates for the driving forces in the case of ... kinase therefore still remains unclear The main line of evidence for the existence of a PORphosphatase is the observation by Wiktorsson et al [9] of an inhibition, by NaF and ATP, of the loss of the ... spectral changes in POR and structural changes in PLB The existence of a correlation between the presence of the cubic membrane structure of the PLB and the presence of POR-PChlide650 has long...
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Báo cáo khoa học: Structure analysis of the flavoredoxin from Desulfovibrio vulgaris Miyazaki F reveals key residues that discriminate the functions and properties of the flavin reductase family pdf
Ngày tải lên :
07/03/2014, 02:20
... Resolution of the structure of NADP+-bound FeR revealed that the nicotinamide moiety of NADP+ faces the re-side of the isoalloxazine ring, and that the 2Â-P-AMP moiety is held in the groove between the ... Pro154, Ile156 and Pro161 of the other monomer Similarly, Gly175Ala181 forms an anti-parallel intermolecular b sheet with the b12 of the other monomer, and towards the C-terminus, the subsequent ... of the logarithms of the concentration ratios for oxidized and reduced forms of the mediator versus that of recombinant avoredoxin Reduction titration of avoredoxin by NAD(P)H The reduction of...
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Báo cáo khoa học: Spectroscopic and kinetic properties of the horseradish peroxidase mutant T171S Evidence for selective effects on the reduced state of the enzyme potx
Ngày tải lên :
07/03/2014, 21:20
... comparison of the electronic absorption and RR spectra of the wild type and Thr171Ser either in the presence of the aromatic donor BHA or at alkaline pH Addition of saturating amounts of BHA did ... between the magnitude of the changes in Fe-His band frequencies and the redox potential values This is exemplied by the case of CCP and its mutants D235E, D235N and D235A [27] The H-bond between the ... between the proximal His and Asp residues that is weakened at alkaline pH Therefore, on the basis of their sensitivity to pH, the bands at 220 and 247 cm)1 are assigned to two m(Fe-Im) modes The band...
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Báo cáo Y học: Properties of the Na+/H+ exchanger protein Detergent-resistant aggregation and membrane microdistribution potx
Ngày tải lên :
08/03/2014, 16:20
... amount at the 105–110 kDa size The amount of 105–110 kDa protein was reduced and in many instances evidence of aggregation was evident at the top of the gels The amount of aggregate present at the ... glycosphingolipid- and caveolin-enriched fractions To test this hypothesis, we isolated membrane fractions from mammalian cells and examined the distribution of the Na+/H+ exchanger and of caveolin, a marker of ... by standard procedures in the presence of Triton X-100 The results are shown in Fig 3E,F The Na+/H+ exchanger was present in the low density fractions (4 and 5) and was again present in the higher...
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Báo cáo Y học: Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIa doc
Ngày tải lên :
08/03/2014, 22:20
... Cc of Asp and Cd of Glu, and Og of Tyr Positive unit charges were added at the following atoms: Nt of the N-terminus, Nf of Lys, Cf of Arg, and Nd or Ne of His (depending on the position of the ... associated error of ± 30° These values were deduced using the combined information of the intensities of Jab couplings from the 2D DQF-COSY spectrum and the NOE intensities of the HN-Hb and Ha-Hb cross ... contain the well-defined elements of secondary structure, helices I, II of monomer (yellow traces) and helices I¢, II¢ of monomer (grey traces) The location of the four helices and the amino and C-termini...
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Báo cáo khoa học: Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant Mark Wehner and Christian Herrmann doc
Ngày tải lên :
15/03/2014, 10:20
... coefficients of 2.4 and 1.9 and dissociation constants (KdHill) of and lm for hGBP5a ⁄ b and hGBP5ta, respectively The proteins are very similar in terms of their enzymatic activity, so the activity ... hGBP5, and the enzymatic hydrolysis of GTP leads to GDP rather than GMP The nucleotide affinities of hGBP5 are grossly similar to those of hGBP1, but there are differences in thermodynamic and kinetic ... transfer to the mant-group of the nucleotide) to minimize excitation of unbound nucleotide and thereby loss of signal quality The traces were fitted using a single rate constant, and the resulting...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
Ngày tải lên :
15/03/2014, 11:20
... Schematic representation of the roles of the FadD proteins encoded by the DIM + PGL locus in the biosynthesis of DIMs and related compounds in Mycobacterium tuberculosis The role of the activation enzymes ... promote the transfer of the p-HB moiety onto PKS15 ⁄ [16,18] To examine the involvement of FadD29 in the biosynthesis of DIMs and PGLs, we took advantage of the existence in the laboratory of an ... knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of FadD26 in the...
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Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx
Ngày tải lên :
16/03/2014, 18:20
... for the wild type (WT) and mutant Tms The uncertainties listed are the standard errors of the mean and included the uncertainty in the determination of protein concentrations The values are the ... parameters for the thermal-induced unfolding of wild type (WT) and mutant Tms The values are the mean ± standard deviation of at least three experiments Tm1 is the midpoint of the thermal transition ... indicate that the main effects of mutations A63V, K70T and E180G are mainly related to the overall stability of the protein as a whole, rather than on the position of the mutation in the polypeptide...
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Báo cáo khoa học: Conformational properties of bacterial DnaK and yeast mitochondrial Hsp70 Role of the divergent C-terminal a-helical subdomain pdf
Ngày tải lên :
16/03/2014, 22:20
... that of DnaK The twofold reduction of the KSV values estimated for mtHsp70 both in the absence and the presence of ATP (Table 2) supports the existence of differences in the Trp environment of ... that the endotherm at 51.6 °C could represent the unfolding of a more stable ATPase domain The Tm values of the high-temperature endotherms, which are similar to those of KKCC and KCCC and clearly ... temperatures, e.g 42 °C Therefore, the functionality of the peptide-binding site depends on interactions between the b-sandwich and both the lid subdomain and the ATPase domain of the protein This structural...
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Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
Ngày tải lên :
17/03/2014, 09:20
... conformation and hydrogen bonding network of the pterin cofactor in the three structures Superpositions of the binary and ternary complexes of hPAH onto the crystal structure of the ligand-free dimeric ... features of its hysteretic properties Thus, the structures of the binary and ternary complexes of hPAH have provided a detailed picture of the protein contacts involved in the binding of biopterin cofactor ... required for the cofactor inhibition of phosphorylation (data not shown) The molecular basis for the negative modulatory effects of the pterin cofactor and dopamine binding to wt-hPAH and their reversal...
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Báo cáo Y học: Trehalose-phosphate synthase of Mycobacterium tuberculosis Cloning, expression and properties of the recombinant enzyme pdf
Ngày tải lên :
17/03/2014, 10:20
... describe the cloning and expression of the M tuberculosis tps gene in E coli, and the production of active TPS in these cells The properties of the recombinant enzyme have been determined, and are ... on the activity of the TPS was determined as shown in Figs and Fig shows the effect of increasing concentrations of either UDP– glucose or GDP–glucose in the presence of saturating levels of ... for the four substrates shown in the reaction It seems likely that under the appropriate conditions in the cell, the enzyme can catalyze either the synthesis or the degradation of trehalose Another...
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Báo cáo Y học: The Fe-only nitrogenase and the Mo nitrogenase from Rhodobacter capsulatus A comparative study on the redox properties of the metal clusters present in the dinitrogenase components doc
Ngày tải lên :
18/03/2014, 01:20
... in the EPR tube They contained 24 mg Rc1Fe per mL and 0.6 mg Rc2Fe per mL in the case of the Fe nitrogenase and 28 mg Rc1Mo per mL and 0.7 mg Rc2Mo per mL in the case of the Mo nitrogenase The ... type of nitrogenase cluster [27–31] In view of the lack of analogous studies on the cofactor and the P-cluster of the MoFe protein from R capsulatus (Rc1Mo), as well as our intention to use the ... stems from the P3+ cluster, then the g ¼ 2.27 feature derives from the FeFe cofactor On the other hand, if the broad signal, despite its unusual properties, represents the P1+ cluster, the narrow...
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