properties of agonist cd40 antibodies and potential toxicities
Báo cáo khoa học: Studies on the regulatory properties of the pterin cofactor and dopamine bound at the active site of human phenylalanine hydroxylase pptx
Ngày tải lên :
17/03/2014, 09:20
... (SPR) analyses, and (c) on the rate of phosphorylation of Ser16 by PKA Effect of ligands on the limited proteolysis of recombinant wt-hPAH and its catalytic core Limited proteolysis of rPAH by chymotrypsin ... redox states of the cofactor and that the distances from Ser23O to O1Â and O2Â are slightly different (Table 1) because of the different positions and hybridizations of the C6 atom of the pyrazine ... displacement of the cofactor results in a loss of stabilizing hydrogen bonds between O1Â and O2Â of the dihydroxypropyl side-chain and Ser23O in the autoregulatory sequence (Fig 4C and Table 1) and thus...
- 10
- 470
- 0
Báo cáo khoa học: Cytokine properties of prokineticins Justin Monnier and Michel Samson pptx
Ngày tải lên :
23/03/2014, 07:20
... heparin–sepharose, and PROK2 and PROK2L are predicted to be highly basic with a pI of 8.85 and a pI of 10.68, respectively Thus, prokineticin activity may Cytokine properties of prokineticins also ... activities as cytokines were overviewed Comparison of gene and protein structure of prokineticins and prokineticin receptors with chemokines Ligands PROK1 and PROK2 The gene that encodes PROK1 (86 amino ... Monnier and M Samson mechanisms, and chemotactic and immunomodulatory activities Therefore, in the present study we first described the gene, protein structure, signaling and biochemical properties of...
- 8
- 439
- 0
Báo cáo khoa học: "FACTORING RECURSION AND DEPENDENCIES: AN ASPECT OF TREE ADJOINING GRAMMARS (TAG) AND A COMPARISON OF SOME FORMAL PROPERTIES OF TAGS, GPSGS, PLGS, AND LPGS " pot
Ngày tải lên :
24/03/2014, 01:21
... n ~ 0}, w is a string of a's and b's such that (1) the number of a's = the number of b's and (2) for any initial substrlng o f w, t h e n u m b e r of a's ~ t h e number of b ' s } -r S A ~z" ... the base and the transformations essentially carry out the checking of the dependencies The PiG's and LFG's share this aspect 'of TG,i.e., tee.talon builds up a set of structures, some of w h i ... g i n a PiG, and by the constraints i n t r o d u c e d via functional structures in LFG In a GPSG on the other hand, recurslon and the checking of the dependencies go hand in hand in a sense...
- 9
- 354
- 0
Báo cáo khoa học: Kininogen-derived peptides for investigating the putative vasoactive properties of human cathepsins K and L docx
Ngày tải lên :
31/03/2014, 07:20
... produces BK(5–9) from BK and Lys-BK, and suggests that cathepsin K is a new member of the kininase family Both the kininogenase activity of cathepsin L and/ or the kininase activity of cathepsin K may ... nM), K (4 nM) and B (3.7 nM), and hK1 (4 nM) The Michaelis constants for hydrolysis of N-BK peptide by hK1 and cathepsin B were determined similarly, while the Km for cathepsins L and K were determined ... 4–5, and 0.1 M NaCl/Pi for pH 6–8 Results and discussion Processing of HMWK by cathepsins We reported previously that adding kininogen or cystatin to cathepsins results in supplementary bands of...
- 8
- 482
- 0
Tensile properties of cooked meat sausages and their correlation with texture profile analysis (TPA) parameters and physico chemical characteristics
Ngày tải lên :
05/05/2014, 08:43
... times (January, May and October) maintaining brands and meat sausage type At every time of purchase, eight samples were of chopped (CH), nine of mortadella (MT), and seven of galantines (GL) Chopped ... profiles and with similar (p > 0.05) values of BS and hardness to textural profile 1, and similar values (p > 0.05) of cohesiveness and springiness to profile 3, and intermediate values of adhesiveness ... mortadella; GL, galantines and 0.68 and 18.35 N mm, respectively The most representative values of BS and EF were those in the range of 1–3 N/cm2 and 4– 12 N mm, respectively About 50% of cooked meat sausages...
- 7
- 445
- 0
Báo cáo hóa học: "Research Article Weighted Estimates of a Measure of Noncompactness for Maximal and Potential Operators" pot
Ngày tải lên :
22/06/2014, 03:20
... 2 Journal of Inequalities and Applications see, e.g., 18 and for fractional maximal functions and Riesz potentials by Muckenhoupt and Wheeden 19 Two-weight criteria ... κ where Cα,Q and A1 are defined in Theorem 3.4 ≥ Cα,Q A1 , 3.17 12 Journal of Inequalities and Applications Proof of Theorem 3.4 By Lemma E, we have that for λ > Iα κ Lp G ,Lq G and a ∈ G, there ... functions; potential operators are discussed in Sections 3.2 and 3.3 Section 3.4 is devoted to the partial sums of Fourier series Constants often different constants in the same series of inequalities...
- 19
- 210
- 0
Báo cáo khoa học: "Comparison of flexural and shear properties of southern pine LVL and lumber from young plantation and natural stands*" ppsx
Ngày tải lên :
08/08/2014, 18:21
... veneers of older natural stands The average MOR and MOE values of LVL from the 20-year-old trees are only 54 and 63%, respectively, of the properties of LVL from 40-year-old trees from natural stands ... Testing and Materials (ASTM) (1991) Standard methods of static tests of timbers in standard sizes, D 198-84 Standard method of testing small clear specimens of timber D 143-83 In: American Book of ... 28-year-old natural stands improves the properties and design = = = values of sawn lumber from trees of these stands Table IIIalso shows that 67% of the tested LVL specimens of composite have design...
- 9
- 253
- 0
Báo cáo y học: "Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity" docx
Ngày tải lên :
09/08/2014, 08:22
... edema and deformity of the hindpaws; however, SIA is primarily an enthesopathy characterized by the proliferation of fibroblasts and the formation of periarticular enthesophytes of cartilage and ... the severity of arthritis Conclusion To understand the importance of CIX for cartilage integrity and stability and in the disease process of arthritis, we used a transgenic disruption of the col9a1 ... sign of OA or other pathology in a large number of normal young and old (more than one year) mice of either strain Samples were also taken from CIA and SIA experiments with littermate controls of...
- 8
- 615
- 0
Báo cáo y học: "Immediate determination of ACPA and rheumatoid factor - a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassay" pdf
Ngày tải lên :
12/08/2014, 14:22
... MCV antibodies and of 55.6% for RF-IgG as well as to a specificity of 99.7% for MCV and of 97.2% for RFIgG Overall, correlation between both methods was 93% regarding detection of anti-MCV antibodies ... with a reactivity of approximately 100 U/ml in both standardized anti-MCV and RF-ELISA (Orgentec, Mainz, Germany) The ratio of applied antigens and serum anti-MCV antibodies and/ or RF was such ... the limit of quantification of the ELISA (cut-off anti-MCV 40 U/ml, cut-off RF-IgG 30 U/ml) for RF-IgG (Table 2) The positive POCT results were confirmed by ELISA in 98.3% and 95.1% of the cases,...
- 5
- 426
- 0
Structure, magnetic and transport properties of magnetic oxide materials and exploration of magnetic oxides semiconductor (zno) heterostructures
Ngày tải lên :
09/09/2015, 10:15
... of the CoFe2O4 / ZnO /SiO2, and the enlarged (333) diffraction of the CoFe2O4 films with different thicknesses 143 Figure In plane and out of plane hysteresis loops of the CoFe2O4 (40nm) ... 300K and 5K 116 XI LIST OF FIGURES Figure 1 The density of state of non-magnetic, ferromagnetic, and half metallic meterials Figure Schematic diagram of Spin filter tunneling Below the TC of ... (black) and out of plane (red) hysteresis loops of CoFe2O4 deposited at temperatures from 150° 250° 350° and 550° on glass substrates 90 C, C, C C Figure 10 In plane (black curve) and out of...
- 175
- 592
- 0
Electronic, magnetic and optical properties of oxide surfaces, heterostructures and interfaces role of defects
Ngày tải lên :
10/09/2015, 09:11
... lot of people have helped me to further my research and I am grateful to all of them Especially, I would like to sincerely thank my supervisors Prof Ariando and Prof T Venkatesan for educating and ... will ever be indebted to Prof Ariando and Prof T Venkatesan I would like to take this opportunity to thank Prof J M D Coey from Ireland, who has ever been a visiting professor in Nanocore for several ... with the Fermi level of NSTO such that the wave functions of electrons inside the QCB and the conduction band of NSTO can overlap and interact with each other The implications of this mechanism...
- 307
- 988
- 0
Effect of neuroinflammation on cognition and potential mechanisms involved
Ngày tải lên :
05/10/2015, 19:03
... Effect of single dose of 1mg/kg LPS in rotarod 49 3.8 Effect of three doses of 1mg/kg LPS in MWM 50 3.9 Effect of three doses of 1mg/kg LPS on body temperature 51 3.10 Effect of three doses of 1mg/kg ... Effect of constant dose of 1mg/kg LPS in MWM 53 3.12 Effect of increasing dose of LPS in MWM 54 3.13 Effect of increasing dose of LPS in MWM (individual trials) 55 3.14 Effect of increasing dose of ... Effect of increasing dose of LPS in NOR T2 57 3.16 Effect of increasing dose of LPS in FC 58 3.17 Effect of increasing dose of LPS in LABORAS™ (2 hours) 59 3.18 Effect of increasing dose of LPS...
- 140
- 299
- 0
Tài liệu PHYSICAL, CHEMICAL, AND MECHANICAL PROPERTIES OF BAMBOO AND ITS UTILIZATION POTENTIAL FOR FIBERBOARD MANUFACTURING docx
Ngày tải lên :
22/02/2014, 09:20
... utilization The physical and mechanical properties of bamboo vary with the age of the bamboo and the height of the culm [Chauhan 2000] In general, SG and the properties of bamboo drop from the ... bending properties, along longitudinal and radial directions of one, three, and five year old bamboo and determine the correlation between SG and bending properties, and (5) compressive strength of ... characteristics and mechanical properties of bamboo Dissertation, Chinese Academy of Forestry, Beijing, China pp 147 Yusoff, M.N.M, A Abd.Kadir, and A.H Mohamed 1992 Utilization of bamboo for pulp and paper...
- 76
- 579
- 0
báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
Ngày tải lên :
18/06/2014, 15:20
... T cells and platelets [10,11] The interaction of CD40 and CD40L represents a major component of T cell help Ligation of CD40 on DC, for example, induces increased surface expression of costimulatory ... analyzed the effects of co-stimulating B cells with the TLR9 agonist CpG ODN 2006 Materials and methods In mice, agonist CD40 antibodies have been shown to mimic the signal of CD40L and substitute ... ** Discussion CD40 activation of APC plays an important role in driving anti-tumor T cell-mediated immune responses, and agonist CD40 antibodies which mimic the action of CD40 ligand are thought...
- 10
- 624
- 0
Báo cáo y học: "Expression and functional properties of antibodies to tissue inhibitors of metalloproteinases (TIMPs) in rheumatoid arthritis" docx
Ngày tải lên :
09/08/2014, 06:23
... Several functional properties of TIMPs are of potential importance in the pathogenesis of arthritis Overexpression of TIMP-1 and TIMP-2 is associated with inhibition of apoptosis and invasive tumour ... protein of molecular weight 22 kDa corresponding to TIMP-2 forming a band in the blotting membrane Relation of TIMP antibodies to clinical features of RA Antibodies against TIMPs in blood and/ or ... patients with RA Samples of blood and synovial fluid from 89 patients with RA were tested for the presence of autoantibodies against all four types of TIMP (TIMP-1, -2, -3, and -4) and compared with...
- 9
- 392
- 0
Thermal properties of the vernacular buildings envelopes: the case of the "Sassi di Matera" and "Trulli di Alberobello
Ngày tải lên :
05/09/2013, 14:58
... characteristics of the "Sassi of Matera" and "Trulli of Alberobello" In the South of Italy, the sites of the "Sassi of Matera" (Figure 1a) (classified as humanity world heritage in 1993) and "Trulli of Alberobello" ... Polytechnic of Bari, were performed on some samples of calcarenite sandstone and calcareous stone of Fasano The goal of the laboratory tests was to experimentally find the thermophysical properties of ... typologies of building wall: a wall in blocks of calcarenite sandstone assembled with mortar, typical of the constructions of "Sassi of Matera," and a masonry made with dry calcareous stones of Fasano,...
- 10
- 507
- 0
Tài liệu Nature and Properties of Micro-organisms doc
Ngày tải lên :
12/12/2013, 17:15
... (VZV) VZV: Chickenpox VZV: Shingles Re-activation of latent infection Suppression of cell mediated immunity Bacteria Unicellular, DNA and RNA Binary No prokaryotes fission mitochondria ... reducing opsonisation and protecting from phagocytosis E.g Streptococcus pneumoniae in RTI vaccination: pneumococcal; meningococcal A and C GLYCOCALYX loose meshwork of fibrils extending ... cephalosporins and vancomycin lipoteichoic acid, septic shock Beta-lactamases hydrolyse penicillins and cephalosporins secreted by Gram positive bacteria Within periplasm of Gram negative...
- 35
- 528
- 0
Electronic and Optoelectronic Properties of Semiconductor Structures
Ngày tải lên :
24/01/2014, 17:34
... principles and actual devices Electronic and Optoelectronic Properties of Semiconductor Structures provides engineering and physics students and practitioners with complete and coherent coverage of key ... manual and set of viewgraphs for use in lectures is available for instructors received his Ph.D from the University of Chicago and is Professor of Electrical Engineering and Computer ... University of Michigan, Ann Arbor He has held visiting positions at the University of California, Santa Barbara and the University of Tokyo He is the author of over 250 technical papers and of seven...
- 559
- 435
- 0