propagation of lesions in alzheimer s disease
Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... Authors Journal compilation ª 2010 FEBS 1391 Animal models of Alzheimer s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... models of human disease generally have similar pathological findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, ... and proteins in the Alzheimer' s disease brain Brain Res Mol Brain Res 2000, 81:7-18 Janus C, Phinney AL, Chishti MA, Westaway D: New developments in animal models of Alzheimer' s disease Curr Neurol ... celecoxib in the treatment of progression of Alzheimer' s disease [abstract] Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy 2000:180 Van Gool WA, Weinstein HC, Scheltens...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... Increased neuronal COX-2 expression leads to increased expression of cell cycle mediators in post mitotic neurons, as shown using a transgenic mouse model with increased neuronal COX-2 expression ... 25 26 Pasinetti GM, Aisen PS: Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer' s disease brain Neuroscience 1998, 87:319-324 Combrinck M, Williams J, De Berardinis MA, Warden...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible ... engagement of an ensemble of cell surface receptors initiates a tyrosine kinase-based signaling cascade Tyrosine phosphorylation of the Vav-GEF results in the activation of downstream Rac1 GTPase Recently, ... functional events in Alzheimer' s disease J Alzheimers Dis 2004, 6:171-175 Markesbery WR: Oxidative stress hypothesis in Alzheimer' s disease Free Radic Biol Med 1997, 23:134-147 Shimohama S, Tanino H,...
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Báo cáo hóa học: " Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study" doc
... severity to assess changes after an intervention using videotaped sessions of five 10-meter walks including turns A previous study reported the directionally restricted effects of gait training ... clinician-rated measures assessing frequency and severity of FOG, as well as situations that elicit freezing, such as walking through narrow spaces and turning, since very few freezing events ... Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted a longer survival of AD patients (CPHR, co-varying MMSE scores, ... deficit, we used the MMSE scores as proxy of status (control vs AD) and of disease progression Subjects were divided into three mutually exclusive groups ranked by increasing MMSE scores [below 20 ... Alzheimer' s disease (AD), oxidative stress is one of the earliest events occurring prior to the onset of symptoms and it has been recognised as an essential contributor to the pathogenesis and progression...
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báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
... years is 29% compared to 7% in older control cases For AD cases, the incidence of APOE4 in cases younger than 80 years is 57% compared to 29% in older AD cases Page of Discussion In this study, ... quantified using Image-Pro Plus analysis software (Media Cybernetics, Silver Spring, MD) Using this method the percentage of the area of interest that is immunoreactive for a specific antibody is measured ... demographic information, disease duration, neuropathological staging and APOE genotype of control and AD cases used in this study Case Diagnosis Sex Age (years) GDS Braak Brain weight (grs) PMD (hours:...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... symptoms as distinct and different diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are ... errors in separating idiopathic Parkinson 's disease from other causes of the akinetic-rigid syndrome, or errors in differentiating dementia from confusional states, depression and even ageing, ... finally addressing dementia itself So, the diagnostic process in patients with PD and suspected dementia involves two steps: the diagnosis of dementia and differential diagnosis of its cause A deficit...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... role of apolipoprotein E in Alzheimer s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models [In Process Citation] Neurobiol Aging ... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... alertness, parkinsonism, and visual hallucinations DLB may be difficult to distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, ... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive ... depression symptoms such as changes or disruptions in sleep, appetite, concentration, interest in activities, libido, and energy level; the presence of feelings of guilt, hopelessness, helplessness;...
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Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot
... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting regions for further studies These regions included ... shown to bind to and inhibit the serine–threonine protein phosphatase calcineurin [5] The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is...
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Alterations of matrix metalloproteinases in the healthy elderly with increased risk of prodromal Alzheimer’s disease pot
... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups Spearman ... levels of different MMPs in plasma of AD patients [30] The increased levels of several MMPs in the CSF of individuals with increased risk for AD, as observed in the current study, could be explained...
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Báo cáo khoa học: Implication of calpain in neuronal apoptosis A possible regulation of Alzheimer’s disease doc
... Cross-talk between calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation ... Ca2+-mediated apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is observed These findings indicate that, in this case, NF-jB acts as a death-promoting ... mechanism associated with the proteolysis of several MAPs and leading to neuronal apoptosis in AD Conclusion In summary, the ubiquitous expression of calpains in distinct subcellular compartments at...
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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx
... of increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page ... brain slice cultures from transgenic mouse models of Alzheimer' s disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity ... numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... with this approach Methods Serum samples Serum samples were obtained from the Rush Alzheimer s Disease Center (Chicago, IL) from individuals whose diagnosis on the basis of post-mortem clinical ... encouraging results were obtained in two clinical trials in which IvIg was administered to AD patients [22,23] and a multi-site phase trial is in progress In our ELISA studies we found that in addition ... concentrations of these antibodies tended to be increased in AD vs NCI sera (by 20% in undissociated samples and 29% in dissociated samples) 95% Tukey confidence intervals for differences in the mean...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... features of the complex responsible for discriminating these two closely-related cholinesterases Background Alzheimer' s disease (AD) or Senile Dementia of the Alzheimer Type (SDAT) is an irreversible ... been classified into two types, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), on the basis of distinct substrate specificities and inhibitor sensitivities AChE (EC 3.1.1.7) is a key ... calculated using the MPI SANDER module of AMBER installed on cluster computing facility at PCMD, ICCBS, University of Karachi, consisting of 10 nodes Results and discussion Selection of docking protocol...
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Báo cáo y học: "Variations in the transcriptome of Alzheimer''''s disease reveal molecular networks involved in cardiovascular diseases" potx
... helps in comparing results across studies and obtaining a global overview of the disease pathogenesis In this paper, we perform a transcriptomebased study by combining the analysis of co-expressed ... meaning co-expressionlinks expressed co-expression at since profiles number We are This of over-represented 6.4% shows biological ID of in disease- asso- Acknowledgements pcc − mpcc Zscore = spcc ... categories Check for genes associated with Alzheimer s disease and other human diseases WordSpy Identify significant cis-regulatory elements in disease associated genes Figure Steps taken to analyze Alzheimer' s...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
... cm)1 Assessment of aggregation using thioflavin T binding and electron microscopy The kinetics of fibril formation was determined using a continuous ThT assay [49] Solutions of Ab isolated by SEC ... containing m urea Mass spectrometry, amino acid analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed ... coverage of structural assignments to the N-terminus of Ab Moreover, the procedures described here are also suitable for expression and purification of mutant versions of Alzheimer s disease- associated...
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