promoter methylation in head and neck tumorigenesis

... extracellular ligand-binding domain, a hydrophobic transmembrane segment, and an intracellular tyrosine kinase (TK) domain The extracellular domain provides a binding site for the endogenous ligand, epidermal ... cigarette smoking in never drinkers, and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium Journal Of the National Cancer Institute 2007; ... TGF-α, and the binding interaction induces subsequent receptor-mediated internalization and auto-activation of intracellular tyrosine kinase (TK), which is closely related to other vital intracellular

Ngày tải lên: 15/01/2020, 16:59

... Radiology in Head and Neck Presenter : Kanato T INTRODUCTION Radiology is a continually evolving medical specialty  Since the discovery of x-rays  Resulting in the numerous imaging modalities ... bear in mind that most imaging techniques utilizing ionizing radiation, including plain films, computed tomography (CT) and nuclear medicine  Carry with them a lifetime risk of developing cancer ... Otorhinolaryngology, Head and Neck Surgery 7th edition  Surgery of ear Glasscock Shambaugh 6th edition  Mohan Bansal Disease of Ear, Nose and Throat  Head and Neck Imaging, Peter M Som  Internet

Ngày tải lên: 19/01/2020, 23:29

... risk and provide new insights into the mechanisms underlying LOI in HNSCC In addition, the small molecular agents appear promising for LOI treatment Keywords: Lymphovascular invasion, Head and neck ... screening; we found that five drug–module interactions (XL844, AT7519, AT9283, alvocidib, and nelarabine) in the turquoise module and three drug–module interactions (benzamidine, Lglutamine, and zinc) ... LOI and predict OS Finally, we report that benzamidine, L-glutamine, zinc, XL844, AT7519, AT9283, alvocidib, and nelarabine are novel candidate drugs for controlling LOI in HNSCC Supplementary information

Ngày tải lên: 17/06/2020, 11:24

... fibronectin-1 and insoluble cellular fibronectin-1 The insoluble cellular fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, host defence and ... YAP1 and POLR2A) on paired margin and tumour core tissue samples Individual gene expressions were determined in each margin and core tumour tissue pairs In order to obtain a clinically meaningful ... with distinct clinical presentations that may also require stratified treatment approaches Through bioinformatics data mining and validation using a panel of normal oral keratinocyte lines and 10

Ngày tải lên: 17/06/2020, 17:43

... weekly during CRT, every or days during hospitalizations, and and 12 months after CRT in patients with LA-SCCHN AKI was defined as increase in serum creatinine (sCr) of ≥1.5 times baseline or by ... chemotherapy-induced nausea and vomiting (CINV) was prescribed according to international guidelines [13, 14], containing a three-drug regimen, which included dexamethasone, the serotonin receptor ... squamous cell head and neck cancer J Clin Oncol 2003;21:92–8 Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al Defining risk levels in locally advanced head and neck cancers:

Ngày tải lên: 17/06/2020, 18:48

... of BORIS in (d) Ye Head- Neck and (e) Slebos Head- Neck cancer analyzed by using Oncomine database (f) Western blot showing the protein level of PKM2, PKM1, and BORIS in paired normal and tumor ... genes MeDIP in curcumin-PEC treated and control-PEC in H157 cells and qRT-PCR in respective genes relative to input ChIP in curcumin-PEC treated and PEC-control H157 cells using RNA Pol II and BORIS ... + curcumin combination for 48 h using the indicated primers (c) MeDIP in HNC cells treated with Aza + curcumin combination for 48 h and qRT-PCR relative to input and control IgG Three independent

Ngày tải lên: 17/06/2020, 18:58

... recovery and well-being Patients liked the combination of talking, visualising issues using a whiteboard and other applied techniques, and concrete goal setting ‘Maybe it should be part of the initial ... be more frequent in the early stages of CB-EST x x x x x To adjust to life without eating and drinking (n = 1) x x x x x x x x Feel better about changes to eating and drinking (n = 2) x x x ... Feasibility and acceptability of combining cognitive behavioural therapy techniques with swallowing therapy in head and neck cancer dysphagia J M Patterson1,2*, M Fay, C Exley3, E McColl1, M Breckons1 and

Ngày tải lên: 23/07/2020, 23:44

... altering tumor growth and drug resistance in HNSCC Page of 11 A very interesting recent study on the inhibition of NRF2, glutathione (GSH), and thioredoxin (Trx) in head and neck cancer (HNC) strongly ... alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk Int J Epidemiol 2010;39(1):182–96 Leemans CR, Braakhuis BJ, Brakenhoff RH The molecular biology of head and neck cancer ... mutations in KEAP1 and CUL3), and copy-number changes (amplification of NRF2 and deletion of KEAP1 and CUL3) leads to oncogenesis and drug- and radio-resistance in different types of cancers including

Ngày tải lên: 23/07/2020, 23:49

... mRNlA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis Lancet Oncol 2014;15(12):1319–31 Venuti A, Paolini F HPV detection methods in head and neck cancer Head ... Routine use of IHC for the status of p53, pRb and cyclin D1, does not seem to be indicated Abbreviations FFPE: Formalin fixed paraffin embedded; HNC : Head and neck cancer; HNSCC: Head and neck ... common cancer in males in Bangladesh, surpassing lung cancer [15] As extensive use of tobacco (in smoking and smokeless forms) and chewing of areca nut dominate the risks for head and neck cancer

Ngày tải lên: 06/08/2020, 03:19

... approach is integrated with extensive biological sampling and exploration into cytokines and mechanisms involved The current paper discusses decisions and methods behind exercise in head and neck cancer ... resistance training in head and neck cancer patients during concomitant chemoradiotherapy – design of the DAHANCA 31 randomized trial Camilla K Lonkvist1, Simon Lønbro2,3, Anders Vinther4, Bo Zerahn5, ... retrospectively at ClinicalTrials.gov (NCT02557529) September 11th 2015 Keywords: Head and neck cancer, Head and neck squamous cell carcinoma, Chemoradiotherapy, Progressive resistance training, Exercise,

Ngày tải lên: 06/08/2020, 07:25

... Kevin J Harrington1,2, Emma Hall2 and Christopher M Nutting1* Abstract Background: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating ... a phase III randomised multicentre study of dysphagia- optimised intensitymodulated radiotherapy (Do-IMRT) versus standard intensity- modulated radiotherapy (S-IMRT) in head and neck cancer Imran ... endpoints include prospective and longitudinal evaluation of swallow outcomes incorporating a range of subjective and objective assessments, quality of life measures, locoregional control and overall

Ngày tải lên: 20/09/2020, 18:12

... Cetuximab plus platinum-based chemotherapy in head and neck squamous cell carcinoma: a randomized, double-blind safety study comparing cetuximab produced from two manufacturing processes using the EXTREME ... 2010) Randomization was carried out using a computergenerated random sequence and a centralized interactive voice response system (IVRS) To maintain the blinding of patients and the personnel involved ... study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck J Clin Oncol 2006;24:2866–72

Ngày tải lên: 21/09/2020, 11:15

... cells against virally infected squamous cell carcinoma of the head and neck Cancer Res 2005;65(23):11146–55 10 Ragin CC, Taioli E Survival of squamous cell carcinoma of the head and neck in relation ... cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN Keywords: Squamous cell carcinoma of the head and neck, Human papillomavirus, ... result in early lymphatic spread [73–75] The heterogeneity of head and neck tumors in combination with HPV infection may cause complex molecular perturbations in the cell and differences in survival

Ngày tải lên: 22/09/2020, 23:35

... standards and guidelines On the other hand, cancer patients are considered partners in decision making in order to incorporate individual perspectives and needs Moreover, patients are better informed ... 3-year survival These findings should be taken into account when counselling patients in whom nonstandard treatment is considered Keywords: Head and neck cancer, Nonstandard treatment, Patient ... standard, curative treatment In addition doctors may propose alternative, nonstandard treatments Little attention is devoted, both in literature and in daily practice, to understanding why and

Ngày tải lên: 28/09/2020, 10:03

... PG has been proposed to influence migration and invasion of oral squamous cell carcinoma cells in vitro by interacting with the β1 integrin subunit and the laminin β1 chain [48] NG2/CSPG4 has been ... cancer cell-host microenvironment interactions and by enhancing drug resistance and protecting cells from stress-induced programmed cell death [49,50] In an increasing number of tumours, prognostic ... extraction and qPCR Total RNA from healthy specimens and 119 neoplastic specimens were extracted using Trizol® according to the manufacturer’s instructions and in combination with Qiagen RNAeasy Mini

Ngày tải lên: 29/09/2020, 16:16

... papillomavirus infection in head and neck cancers Ann Oncol 2010, 21 Suppl 7:vii243–vii245 OCIU: Profile of Head and Neck Cancers in England: Incidence, Mortality and Survival In Oxford Cancer Intelligence ... hpv-ahead_en.html] 21 International Symposium on HPV infection in Head and Neck Cancer, Poznan, Poland, 13–14 November 2014 [http://www.hpv2014-poznan.pl/] 22 Workshop on emerging findings in head ... the head and neck cancers and certain HPV types was investigated Results: Thirty-nine publications met the inclusion criteria The prevalence of HPV of any type in 3,649 patients with head and neck

Ngày tải lên: 30/09/2020, 13:25

... data; drafting and revising the manuscript JD: analysis and interpretation of data; drafting and revising the manuscript LMR: analysis and interpretation of data; drafting and revising the manuscript ... analysis and interpretation of data; drafting and revising the manuscript AP: analysis and interpretation of data; drafting and revising the manuscript ME: analysis and interpretation of data; drafting ... imaging, PET-MRI fusion, Retrospective image fusion, Side-by-side analysis, Head- and- neck cancer, Staging Background Clinical examination and imaging is routinely performed for the staging of head- and- neck

Ngày tải lên: 30/09/2020, 15:04

... of the developmental Notch signaling pathway links the CSC phenotype with the proteasome Musashi, a RNA binding protein crucial for maintaining Notch signaling, binds to the 3’-UTR of NF-YA mRNA, ... Christianson TJ, Spain K: The interaction of epidermal growth factor and radiation in human head and neck squamous cell carcinoma cell lines with vastly different radiosensitivities Int J Radiat Oncol ... cell lines contain cell populations with low proteasome activity and higher sphere-forming capacity HNSCC cell lines were engineered to express the fusion protein ZsGreen and the c-terminal of

Ngày tải lên: 05/11/2020, 01:29

... Actin-related protein 2/3 complex subunit (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma ... targets: Moesin contributes to cancer cell proliferation and invasion in head and neck squamous cell carcinoma Biochem Biophys Res Commun 2012, 418(2):378–383 Lund AH: miR-10 in development and cancer ... miR-10b in the cell lines SCC25, SCC9 and FaDu, and of miR-196a in normal keratinocytes following transfection with the specific miRNA precursor molecules A: Expression of miR-10b in the cell lines

Ngày tải lên: 05/11/2020, 05:32

... against infection and invading connective tissue There are still very few studies applying the methods of tissue engineering to produce tracheal replacements and to examine these in vitro and in ... this technique and bearing in mind the contraindications, more than 90% of the children can nowadays be extubated without problems In spite of the progress, in children undergoing single-step surgical ... intubation over several days as an intratracheal splinting An external splinting by metallic microplates in the surgical tracheal reconstruction was described first time by Zalzal and Deutch in...

Ngày tải lên: 25/10/2013, 08:20