progress in understanding the success of an evolutionary scandal

... hydrophobic interactions between the A–B loop of one monomer and the ˚ H strand of the opposite dimer, creating a 50 A central channel that contains the two binding sites for thyroxine [81] The four binding ... inside of the protein [98] Dislocation of the C and D strands from their native edge region may result in the formation of a new interface involving A and B strands which is open for intermolecular ... to lipid membranes In the model, binding to the lipid membrane disrupts the structure of the lipid rafts, thereby inducing changes in the membrane, which lead to activation and calcium entry through...

Ngày tải lên: 07/03/2014, 10:20

... definition of patients and follow up unraveling the intriguing balance between inflammation and ossification in the pathogenesis of AS The classification, genetic susceptibility, pathology, and ... Amsterdam, The Netherlands Competing interests The authors declare that they have no competing interests Published: 18 January 2010 References Sharma SM, Choi D, Planck SR, Harrington CA, Austin CR, ... profiling in human autoimmunity Immunol Rev 2006, 210:120-137 doi:10.1186/ar2895 Cite this article as: van der Horst-Bruinsma IE, Crusius JBA: New insights in understanding the pathogenesis of...

Ngày tải lên: 12/08/2014, 11:22

... illustration of the domain structure of PPARs The most conserved region is C, which consists of a highly conserved DNA-binding domain The E/F domain is the ligand-binding domain, which contains the AF2 ... of a link between PPARγ and the insulin signaling has been reinforced by the finding that the c-Cbl-associated protein, a signaling protein interacting with the insulin receptor, could be encoded ... ligand-dependent activation domain The amino-terminal A/B domain contains the AF1 ligand-independent activation domain The D domain consists of a highly flexible hinge region and non-rodent animal...

Ngày tải lên: 13/08/2014, 13:20

... Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation-and progression-linked discriminants of malignancy Cancer ... [23,33–36,45] Therefore, the variation in the concentrations of ATP, ADP and AMP was determined under the conditions of the experiments shown in Fig The results indicate that none of the adenine nucleotides ... determining the effect of the branching pathways on the main flux and on the concentration of the connecting metabolite [23] To determine the elasticity coefficients of the consumer block for the common metabolite...

Ngày tải lên: 30/03/2014, 11:20

... perspective has a significant impact in the success of any micro financing model Realizing the importance of the borrowers’ perspective for a successful and sustainable financing model, the research reviews ... influence on the behavior of borrowers If the income and savings of the individual is high then he/she is least attracted to debt financing On the other hand, the individual with low income and ... and savings is more attracted towards debt financing The selection of income group and the means of income are very important The main function of the MFIs is to enhance the capacity of the borrowers...

Ngày tải lên: 06/09/2013, 05:48

... explained on the basis of the instructions to the Russian readers, which were to use any ingenuity or knowledge of Russian they might have to divine the meaning of the translations The rankings of ... to the original because of the writer’s relative lack of expertness in the Russian language) and sorted by the writer into nine piles of ascending degrees of “informativeness” of the original ... the meaning intended by the original For the purposes of this experiment, the question of the fidelity of a translation was converted into the complementary question of whether the original could...

Ngày tải lên: 19/02/2014, 19:20

... also important Our review of the literature is organized to highlight these two points: the value of the MBA, and the motives for choosing a particular type of MBA program The Value of the MBA To ... and an over-emphasis on functional skills at the expense of integrative learning (Mintzberg, 2004) Other critiques question the value of the degree even in the face of continuing program expansion ... acquired in the process of earning the degree Some research has reported specific age and experience effects on the value of the MBA in skill acquisition and in career progression For example, in one...

Ngày tải lên: 08/03/2014, 01:20

... biosynthesis of androstadienol in humans (A) and pigs (B) does not require prior formation of 17a-OH-preg and DHEA The lack of androstadienol synthesis in the presence of lM of ketoconazole (C), an inhibitor ... P450c17 is involved in the biosynthesis of androstadienol Effect of cyt b5 on DHEA and androstadienol biosynthesis In order to determine the effect of cyt b5 in P450c17 16-ene-synthase and 17a-hydroxylase/17,20-lyase ... pick them up On the other hand, the orphan receptor ligands are most probably produced locally in the various tissues Because of the small volume of the cell, the production of a little amount of...

Ngày tải lên: 08/03/2014, 08:20

... proper understanding of the ISA, and definitions The entire text of an ISA, therefore, is relevant to an understanding of the objectives stated in an ISA and the proper application of the requirements ... application and other explanatory material The purpose and intended use of an appendix are explained in the body of the related ISA or within the title and introduction of the appendix itself A61 Introductory ... OBJECTIVES OF THE INDEPENDENT AUDITOR AND THE CONDUCT OF AN AUDIT IN ACCORDANCE WITH INTERNATIONAL STANDARDS ON AUDITING Application and Other Explanatory Material An Audit of Financial Statements...

Ngày tải lên: 29/03/2014, 18:20

... control substance in this context, because it is an inhibitor of P-glycoprotein rather than MPTP, and is devoid of calcineurin-inhibiting properties [23] We hypothesized that an increase in steady-state ... at 37 °C in an atmosphere of 5% CO2 Immunocytochemical staining of P-glycoprotein Cytospins of GLC4 and GLC4 ⁄ P-glycoprotein cells were incubated for with hematoxylin for staining of nuclei ... bovine pituitary extract and 20 lgÆmL)1 gentamicin (Centafarm Services, EttenLeur, the Netherlands) The human small cell lung cancer (GLC4) cell line and GLC4 cell line transfected the human...

Ngày tải lên: 30/03/2014, 08:20

... (x1 and y; x2 and y; x3 and y; and x4 and y) The intensity of the relationship is indicated by the clustering of points and the spread of the data Moreover, although the satisfaction rating is ... asymmetric The mean of population is in the range of 2.37 and 2.54 P a g e | 16 1.2 Investigate the relationship between students’ feelings of safety and gender, origin and postcode In the comparison ... shape with the skewness of 0.538 Furthermore, the mean of 2.96 and the median of are not much different The standard deviation is 1.845, therefore; the mean of population is between 2.77 and 3.14...

Ngày tải lên: 03/04/2014, 09:20

... than the poliovirus IRES Including the extension into the coding region into the SD-1 IRES resulted in 1.5–3 fold increase in translational efficiencies irrespective whether the cell line is of ... in which the mutation was introduced (Fig 6) In mutant M7 disrupting base changes of mutant M6 were repaired by introducing complementary bases in the opposite strand (Fig 6) Interestingly, the ... mutational analysis of stem and stem of the putative pseudoknot indicate the relevance of this region of tertiary structure for BVDV translation Strength of the BVDV strain SD-1 IRES in cell lines of...

Ngày tải lên: 18/06/2014, 18:20

... addressed in the Hankins' paper, and there is no explanation for how the use of Ferguson's Delta would enhance interpretability Although the use of Ferguson's Delta may someday improve our understanding ... encompasses the intent of the taxonomy, integrates the relevant properties described above, and reflects the McMaster authors' goal for evidence of its of success Publish with Bio Med Central and every ... reliability Yet in none of the Hankins examples is this type of reliability calculated or reported The first example uses an intraclass correlation between two different measures as the estimate of reliability,...

Ngày tải lên: 18/06/2014, 19:20

... not serve the purpose of quantifying the degree of discrimination offered by an instrument They do, however, establish the consistency with which discriminations are made Both Norman and Wyrwich ... raise the interesting issue of what constitutes a meaningful discrimination, and whether Delta is an index of such discriminations This happens to be a valid point, but not as argued here Norman ... 'Understanding the Role of Discriminative Instruments in HRQoL Research: Can Ferguson's Delta Help?' to which the answer is a definitive yes, subject to the constraints previously discussed Finally,...

Ngày tải lên: 18/06/2014, 19:20

... provide information on a wide range of potentially relevant issues) and allows easy administration of general instructions in any language It has the inherent advantage of determining and rating ... the scoring points at 10, to allow 12 spending points and to allow the mother and child counselors to administer the index if requested by the subject To further simplify the concept for administration ... subjects from the LSEC to complete the questionnaire The original mother generated index was modified in the context of the problems observed in the pilot study limiting the comparability of the results...

Ngày tải lên: 18/06/2014, 19:20

... (the unity line) in each panel indicates what would be expected if there were no change due to the medication Points below the line indicate decreases following the administration of tizanidine, ... properties in spinal cord injured subjects remain unknown The objective of this study was therefore to address this deficit by quantifying the effect of single dose tizanidine on reflex and intrinsic ... able to quantify the effects of tizanidine since they did not routinely differentiate intrinsic and reflex contributions to spastic hypertonia Thus, the mechanisms of action of tizanidine on neuromuscular...

Ngày tải lên: 19/06/2014, 08:20

... than the poliovirus IRES Including the extension into the coding region into the SD-1 IRES resulted in 1.5–3 fold increase in translational efficiencies irrespective whether the cell line is of ... in which the mutation was introduced (Fig 6) In mutant M7 disrupting base changes of mutant M6 were repaired by introducing complementary bases in the opposite strand (Fig 6) Interestingly, the ... mutational analysis of stem and stem of the putative pseudoknot indicate the relevance of this region of tertiary structure for BVDV translation Strength of the BVDV strain SD-1 IRES in cell lines of...

Ngày tải lên: 20/06/2014, 01:20

... islands, the interior Amazon River basin and certain parts of the Caribbean (Haiti and the Dominican Republic) [2] In Italy, the prevalence of HBV infection is set under 2% from the beginning of ... number of join-points in the final model The joinpoint analysis showed a statistically significant decrease of HBV infection incidence rates too, in particular in 0–14 and 15–24 age groups For the ... screening for pregnant women during the last trimester of pregnancy since 1984 [20] In low/intermediate endemic areas, such as Italy as a whole, and such as the other Southern Mediterranean European...

Ngày tải lên: 20/06/2014, 01:20

... years later In January 2005 the patient began to develop similar medial pain and swelling in the left knee A bone scan showed increased activity in the medial femoral condyle indicating possible ... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis in the femur and the tibia, and a CT scan ... surveillance Figure Fluoroscopic image of the left knee showing the introducing cannula and simultaneous venting of the medial tibial condylar cyst Discussion When dealing with massive periprosthetic...

Ngày tải lên: 20/06/2014, 04:20

... enter the vagina, anus, or mouth.[43] For the purposes of this article, however, dry sex is the drying and/or tightening of the vagina using various methods of douching and/ or application of caustic ... lack of lubrication results in lacerations of the epithelial lining of the vagina, creating a portal for HIV entry In addition, condoms break easily due to the increased friction, exposing woman ... in nations in which leadership was exercised such as in Senegal and Uganda has the incidence of HIV declined We should learn from the experience of the gay community in the United States in the...

Ngày tải lên: 20/06/2014, 08:20