prognostic+nomograms+in+localized+disease

... BM examination and pathology; and no evidence of CNS disease by cerebrospinal fluid analysis The disease course was assessed by ranking patients according to their response to treatment into categories; ... metaphase and on the interphase nuclei of leukemic cells It was measured in newly diagnosed cases (Table 1) and it was positive in 30/80 (37.5%) determining its frequency in B-lineage ALL positive ... frequency of MRD positivity is high after induction and decreases gradually during consolidation and maintenance phase being in some genes 88% during early induction to 13% at week 52 [19] If MRD...

Ngày tải lên: 10/08/2014, 22:20

... resulting in cell death These findings raise the possibility that BRCA1 accumulates in neurons early in the disease and only in those cases in the early stages of AD and may or may not be independent ... implicated to play a role in maintaining genomic integrity in mitochondria and in the nucleus [40] Recent work has related these functions specifically to telomere maintenance In BRCA1 -/- cells, telomere ... fixed either in 10% buffered formalin or in methacarn (methanol:chloroform:acetic acid, 6:3:1), and embedded in paraffin 6μm sections were deparaffinized in xylene and rehydrated in graded alcohol,...

Ngày tải lên: 26/10/2012, 10:04

... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ ... aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding of the modified protein to filaments increases ... coexpression, indicating R120G aB-crystallin is chaperoned R120G aB-crystallin is disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion...

Ngày tải lên: 19/02/2014, 18:20

... 5¢ss recognition in the normal splicing process [55] First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of ... splicesupporting intronic mutation in the last bp position of a cryptic exon within intron of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD) ... many of the ‘new’ exons in our genome originate from the insertion of transposable sequence elements belonging to the SINE and LINE classes in the eukaryotic genome [23–25] In particular, exonization...

Ngày tải lên: 06/03/2014, 09:22

... nutrition etc Smoking Individual – Brief interventions in each consultation Community – Smoke free zones in public buildings • Conducting education to school kids about smoking • Running smoking education ... chronic disease They are relevant to every patient, community or interaction These domains were developed by combining the existing domains of the various health disciplines listed on page 14 They include: ... multidisciplinary teamwork, maintaining medical records; confidentiality; ethics in managing chronic disease; duty of care; professional standards, self-care, disciplinary scope of practice Clinical...

Ngày tải lên: 14/03/2014, 20:20

... made in identifying genetic factors contributing to PD in recent years [135] Low concordance for clinical disease in monozygotic twins indicates environmental in uences on PD [136], and the finding ... Gene–environment interactions in neurodegenerative disease Table Environmental in uences on neurodegenerative disease AD, Alzheimer’s disease; HD, Huntington’s disease; PD, Parkinson’s disease Disease ... neurodegenerative diseases caused by CAG repeat expansions, encoding polyglutamine tracts in different proteins, suggesting that these diseases may involve overlapping molecular mechanisms of pathogenesis involving...

Ngày tải lên: 16/03/2014, 19:20

... the insulin receptor tyrosine kinase substrate protein of 53 kDa (IRSp53) IRSp53 is an SH3 domain-containing adaptor protein originally identified as a substrate of the insulin receptor kinase ... d-catenin The armadillo, ARM, domains, predicted 14-3-3 binding site and a PDZ binding motif are indicated (B) d-catenin complexes in adherens junction targeting and interaction with cadherin FEBS ... Mochizuki N (2004) A novel actin bundling ⁄ filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein J Biol Chem 279, 14929–14936...

Ngày tải lên: 16/03/2014, 22:20

... as a 15-kDa band, containing both the N- and C-terminal chains that are identical in size (band A) Activation of double-chain trypsinogen to double-chain trypsin results in the appearance of band ... chance for premature trypsinogen activation inside the pancreas, while maintaining acceptable trypsin function in the duodenum In other words, increased anionic trypsinogen levels not cause or ... anionic trypsinogen resulted in lower trypsin generation in pathological mixtures of the two human trypsinogens Finally, at pH 5.0 cationic trypsinogen was completely activated to trypsin in the physiological...

Ngày tải lên: 17/03/2014, 03:20

... protein at the sites that are phosphorylated in AD In NFTs, tau protein is phosphorylated by several protein kinases, including GSK-3b, cyclin-dependent kinase5 (CDK5), c-Jun N-terminal kinase, ... common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson’s disease, Pick’s disease, and Alzheimer’s disease, as well as Rosenthal fibers in cerebellar ... hyperphosphorylated in the DS brain Gene dosage-related increases in DYRK1A levels in DS appear to be the major factor distinguishing the pattern and consequences of tau protein hyperphosphorylation in DS and in...

Ngày tải lên: 22/03/2014, 16:21

... whether the initiating process is direct or indirect Injury to this membrane allows fluid to spill into the lung, thus hindering or preventing gas exchange The aspiration of stomach contents into the ... combine with resident cells to produce more chemicals (called cytokines and chemokines), which induce a variety of actions involved in the in ammatory process In ammation is usually beneficial, in ... controllers in the brainstem The controllers help direct the respiratory muscles, triggering inspiration and expiration and regulating the depth of breathing By expelling carbon dioxide, the lungs eliminate...

Ngày tải lên: 28/03/2014, 09:20

... domain for basolateral sorting of PrPC Moreover, Dpl, containing either the whole N-terminal domain of PrPC or the HD only, was sorted basolaterally, indicating that this domain acts as a dominant ... mediate an interaction of PrPC with accessory proteins, such as transmembrane proteins involved in PrP-induced signaling Alternatively, deletion of the HD could indirectly affect intermolecular interactions ... or a combination of both (Fig 1) In the following, such in vivo models are described which address certain aspects of membrane topology, folding, intracellular targeting and trafficking of PrP...

Ngày tải lên: 30/03/2014, 09:20

... generating increased collateral flow But documented clinical success in reducing angina scores and improving myocardial perfusion in otherwise untreatable patients has been observed In a porcine ... transfer into vein grafts using viral vectors The vast majority of vein graft failures that have been linked to the neointimal disease is part of graft remodeling after surgery Although neointimal ... fluorescent-labeled ODN to saphenous vein graft cells See color insert (A) Hoechst 33,342 nuclear chromatin staining of vein graft in cross section, illustrating location of nuclei within the graft wall (100¥)...

Ngày tải lên: 10/04/2014, 22:11

... for 10 minutes to block nonspecific binding and then with the primary antibodies in moist chamber for 60 minutes After rinsed with PBS for minutes, the sections were incubated with the biotinylated ... hematoxylin Serum blocking solution (Reagent A) in place of the primary antibody was used as a negative control A brown particle in nuclei was considered as positive labeling Immunostaining labeling intensities ... higher than that in HCC tissues, indicating that its expression might represent a form of cyclin dependent kinase (CDK) inhibitor dysfunction involved in tumorigenesis However, Qin [28] reported...

Ngày tải lên: 18/06/2014, 15:20

... proteins: alpha-1-microglobulin (a1m), a low molecular weight plasma glycoprotein, and an inter-alpha-trypsin inhibitor light chain (bikunin) that is further cleaved to trypstatin [17] All protein ... and protein AMBP In apoA1, a known marker of CVD, we assessed its plasma levels, including proportional representation of isoforms Vitamin D-binding protein is a multifunctional protein, which ... VDBP in the AMI group or by other coidentified proteins in the spot Protein AMBP is a complex glycoprotein secreted in plasma Its precursor is proteolytically processed into distinct functioning...

Ngày tải lên: 18/06/2014, 19:20

... proteins: alpha-1-microglobulin (a1m), a low molecular weight plasma glycoprotein, and an inter-alpha-trypsin inhibitor light chain (bikunin) that is further cleaved to trypstatin [17] All protein ... and protein AMBP In apoA1, a known marker of CVD, we assessed its plasma levels, including proportional representation of isoforms Vitamin D-binding protein is a multifunctional protein, which ... VDBP in the AMI group or by other coidentified proteins in the spot Protein AMBP is a complex glycoprotein secreted in plasma Its precursor is proteolytically processed into distinct functioning...

Ngày tải lên: 20/06/2014, 03:20

... carcinoma [reviewed in 4] These findings point to survivin expression as an unfavourable prognostic factor However, the majority of research groups evaluating the clinical importance of survivin ... survivin is involved in the spindle checkpoint activation and mitotic arrest [14,15] Survivin, expressed during foetal development [16], and undetectable in most adult tissues [17] has been found in ... different ovarian carcinomas (400×, hematoxylin counterstain): a) negative survivin expression (clear cell carcinoma; FIGO IIIC), b) survivin expression absent in the nucleus but present in the cytoplasm...

Ngày tải lên: 20/06/2014, 08:20

... fulfilling United Kingdom Brain Bank Criteria [18] for idiopathic PD (IPD) were included in the database Information abstracted from the medical record included age of disease onset, disease ... instruments in predicting change in criterion indices of disease severity and quality of life (measured with a visual analogue scale); disease- specific measures outperformed generic measures in explaining ... life in Parkinson’s disease: a prospective longitudinal study J Neurol Neurosurg Psychiatry 2000, 69:584-589 38 Rahman S, Griffin HJ, Quinn NP, Jahanshahi M: Quality of life in Parkinson’s disease: ...

Ngày tải lên: 20/06/2014, 16:20

... 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org Echocardiography – In Specific Diseases, ... Preface An integral part of clinical cardiology, echocardiography is becoming a routine examination for all cardiac patients This is due to its role not only in diagnosing cardiovascular diseases, ... discontinuing inotropic agents in order to decrease contractility and heart rate, volume loading to increase preload, and augmenting afterload with pure α-agonists (such as phenylephrine) (Benea,...

Ngày tải lên: 27/06/2014, 16:20

... reabsorption increase Aquaporin activities Studies show that – Prenatal Glucocorticoid administration increases Na+ transporter and aquaporin maturation and activities Collecting Duct: Final sodium ... • High intake and protein metabolism acid 2-3 meq/k/day Aggressive Total Parenteral Nutrition (TPN) may cause acidosis Large amount of Arginine in TPN for premature infants can result in metabolic ... (Arginine is a source of HCl) Why is neonate not acidotic if excretion is decreased? Mother’s milk contains base equivalents to maintain acid/base balance Premature milk contains higher proteins,...

Ngày tải lên: 26/07/2014, 17:21

... then rinsed in PBS In p53 staining, slides were digested in 0.1% porcine trypsin for 20 minutes at 37oC and rinsed three times with PBS Endogenous peroxidase present within the tissue was inactivated ... suitable prognostic markers in canine mammary carcinoma and female breast cancer [20,34] Positive staining of p53 protein was detected in two benign mammary tumors accompanied by increased index ... 20 minutes in the streptavidin- p53 as a prognostic factor in cmt peroxidase conjugate solution (Histostain SP kit, Zymed Lab Inc.) for detection of bound primary antibody After washing in PBS...

Ngày tải lên: 07/08/2014, 17:22