processing and cognitive deficits in rodent animal models of neuropsychiatric disorders

... activation and IL8 production [25,26] CARR injection in the hind paw of the mouse is one of the most commonly used models of inflammation and inflammatory pain and it has a biphasic profile [27] ... the FERM (band 4.1, ezrin, radixin, moesin) domain of PTPH1 is necessary for the inhibition of Mek, Erk, Jnk and AP-1 and also for localization of the phosphatase on the plasma membrane of Jurkat ... after mg/kg LPS injection Genotype-related difference in MCP-1 and IL10 between WT and KO LPS-treated animals WT animals displayed a LPS-induced increase in IL10 and IL6; dot line indicates the...

Ngày tải lên: 11/08/2014, 03:20

... 4’,7-O-glucopyranoside, puerarin, 6’-O- xylosylpuerarin, mirificin, daidzin, 3’-methoxypuerarin, genistin, sophoraside A, ononin, daidzein, genistein and formononetin Among them, the abundance of puerarin was highest ... 4’,7-O-glucopyranoside, puerarin, 6’-O- xylosylpuerarin, mirificin, daidzin, 3’-methoxypuerarin, genistin, sophoraside A, ononin, daidzein, genistein and formononetin, were purchased from the National Institute ... al Chinese Medicine 2010, 5:36 http://www.cmjournal.org/content/5/1/36 to both alcohol metabolism and the reward circuits in the brain [11] Isoflavones including daidzein, daidzin and puerarin...

Ngày tải lên: 13/08/2014, 14:20

... angiogenesis and neuronal signaling in the brain and are implicated in aging-induced cognitive deficits in SAMP8 Considering a role of the VEGFVEGFR2 signaling systems in cognitive function, we, in this ... for aging-related cognitive deficits To this end, we investigated the effects of CTS on emotional and cognitive deficits in an animal model of aging, namely SAMP8, with and without ischemic insult ... variety of diseases including deterioration of brain function [4] One of the prominent symptoms due to aging-induced brain dysfunction is cognitive deficits such as in Alzheimer disease (AD) and...

Ngày tải lên: 13/08/2014, 14:20

... is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic models produce mainly full-length ... important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining stable phenotypes We would argue that a single ... the N-terminus of the Ab domain in APP It was identified in 1992 [47] and shown to increase Ab levels by six- to eightfold [4] These discoveries created intense interest in APP processing and paved...

Ngày tải lên: 16/02/2014, 09:20

... Retain Retain Retain Retain Retain Retain Delete Retain Delete Delete Retain Retain Delete Retain Retain Retain Delete Retain Delete Retain Appendix 2: Item analysis for the extended listening ... -0.267** 0.551** -0.483** Delete/Retain Retain Retain Retain Retain Retain Retain Retain Retain Retain Retain Retain Retain Retain 654 Australasian Journal of Educational Technology, 2011, 27(4) ... performance by increasing working memory load and interrupting information processing (Sweller, 2007) Multimedia instructional systems have been widely applied in teaching and learning, but the media...

Ngày tải lên: 24/02/2014, 18:20

... included in the study These individuals were family caregivers of demented patients followed at the Behavioral and Cognitive Neurology Unit of the Faculty of Medicine of the Federal University of Minas ... greater risk of future cognitive decline.2 Indeed, the diagnosis of mild cognitive impairment (MCI), which entails an increased likelihood of conversion to dementia, demands the existence of SMCs, ... topic in a group of cognitively healthy Brazilian elderly subjects which were divided into two subgroups according to the presence of SMCs and submitted to brief cognitive tests Methods Sixty cognitively...

Ngày tải lên: 05/03/2014, 21:20

... biochemistry of the CCM genes left a considerable gap in understanding between protein function and lesion biology By exploring the function of the CCM genes in animal models this gap is being CCM animal ... phenotype was seen in only a small percentage of fish Combining this low dose of rap1b morpholino with a similarly low dose of san morpholino resulted in a synergistic increase in both the intracerebral ... caused by the loss of Ccm3 interaction with the kinases serine ⁄ threonine kinase 25 (STK25) and mammalian sterile twenty-like (MST4), giving a hint to the signaling pathway in which Ccm3 belongs,...

Ngày tải lên: 15/03/2014, 10:20

... control of metabolism of a strain of C.utilis (viz RQ = 4-5) and the sustained feeding of benzaldehyde while maintaining a concentration of g 1- ~ in the bioreactor 1-35] The results of a typical ... bleaching chemicals containing chlorine, e.g chlorine gas and/ or chlorine dioxide The amount of chlorine in the bleaching process can be substantially reduced by subjecting the pulp to preliminary ... amounts of chlorine-containing compounds and affords the opportunity to eliminate the use of elemental chlorine, thereby reducing the pollution load Realities and Trends in EnzymaticPrebleachingof...

Ngày tải lên: 01/04/2014, 10:20

... possible An alternative mode of imaging is the use of single photon imaging of γ-emitting isotopes like 11 1In or 99Tc Imaging of γ-emitting isotopes is referred to as single photon emission commuted ... be collected in a couple of minutes of recording, the migration of leukocytes in tissues is relatively slow and requires many minutes of recording to track cells This longer imaging period requires ... EC, Constantin G: Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand1 and heterotrimeric G(i)-linked receptors...

Ngày tải lên: 09/08/2014, 01:22

... reduction in local production of proinflammatory cytokines, thereby reducing their circulating levels and abolishing a sensitizing effect on naïve joints A conflicting finding was the protection of ... remissions and exacerbations of chronic inflammation in the joint Expression profiles in experimental arthritis models showed that the relative amounts of cytokines present in the joint vary according ... feedback loop and prevented influx of inflammatory cells and swelling of the arthritic joints We used this system to elicit adenoviral overexpression of human IL-1Ra in knee joints of CIA mice and compared...

Ngày tải lên: 09/08/2014, 01:24

... identified intact core protein (43 kDa) and a number of fragments (39, 32, 28 and 26 kDa) in all of the specimens There was an increase in staining intensity for all biglycan core protein species in ... Kresse H: Decorin-type I collagen interaction Presence of separate core protein-binding domains J Biol Chem 1995, 270:8877-8883 Hedbom E, Heinegard D: Binding of fibromodulin and decorin to separate ... important insights into potential regulatory steps in this process Animal models of OA have permitted longitudinal evaluation of spatial and temporal changes in joint tissues that occur during the...

Ngày tải lên: 09/08/2014, 06:23

... increased in an experimental model of OA in rabbits FGF8 induced production of MMP-3 and PGE2, and caused degradation of the ECM in vitro Degradation of S-GAG was detected by intraarticular injection ... FGF8b and FGF8f specifically out of the four human FGF8 isoforms, and showed little binding to other members of the FGF family Neutralizing activity of KM1334 was shown by the blocking of FGF8b binding ... For the saline group, 50 μl sterile saline was injected into the knee joint and sterile saline was administered intraperitoneally instead of the antibody solution Each group consisted of five rats...

Ngày tải lên: 09/08/2014, 10:23

... proteoglycan-induced spondylitis and to determine expression patterns of a panel of relevant genes in a large number of distinct colonies of the susceptible mouse strain BALB/c Although induction of disease ... any differences in incidence and severity, the sub-lines of BALB/c mice showed modest but significant differences in immune parameters such as cytokine and antibody responses and clinical scores ... No Robinson same inbred strain of mouse, the universally studied BALB/c, which is the most susceptible to PGIA The goal of the research was to compare the incidence and severity of PGIA and proteoglycan-induced...

Ngày tải lên: 09/08/2014, 14:20

... as CD in (22] The increase of i induces a decrease of R, initially because of the decrease in the selection intensity, noted by Kennedy and Trus (1993), and secondly because of a decrease in the ... selection index and made on a large population of unrelated animals: where ip is the selection intensity and CD the coefficient of determination of the animal selection index p plays the same role in ... measure of connectedness Lalo6 (1993) introduced the concept of generalized coefficient of determination (CD), the CD of a linear combination of genetic values, and suggested a new definition of disconnectedness...

Ngày tải lên: 09/08/2014, 18:22

... possible role of MPO polymorphism in the development of cognitive decline in MS This study was mainly designed to investigate whether some clinical and individual variables and the occurrence of the ... Ratios and CI were estimated using logistic regression adjusted for age and sex gene being involved in AD pathology, possibly through oxidation of Aβ or ApoE, promoting their aggregation into insoluble ... VA, DP and RC partecipated to acquisition of data AQ conceived the study and partecipated in its design and coordination and drafted the manuscript Rao SM, Leo GJ, Bernardin L, Unverzagt F: Cognitive...

Ngày tải lên: 11/08/2014, 08:20

... Activity of Daily Living (ADL) [10] assesses the ability of patients to perform the daily activities of bathing, dressing, toileting, transferring, continence and feeding This index correlates with ... the best was (complete independence) The cognitive score includes the individual components of the Lawton index of Daily Living: ability to Daubin et al Health and Quality of Life Outcomes 2011, ... ADL index and cognitive score, respectively, 57% and 40% of the patients were completely independent (ADL index = 6, cognitive score = 0) and only 1% and 7% were completely dependent (ADL index...

Ngày tải lên: 12/08/2014, 01:22

... maintaining endotheliumdependent vasodilation and decreasing inflammation and tissue injury, in the rat kidney during LPS-induced lung injury aggravated by MV Key messages • VILI complicating ... creatinine at t = 180 minutes (b) Creatinine clearance was measured over t = 120 minutes to t = 180 minutes Creatinine clearance = UCr × V/PCr, where UCr represents the creatinine concentration in ... staining: wheat germ agglutinin; blue staining: nuclei; green staining: (c) CD45, (d) NGAL These observations may warrant a discussion of potential cause-effect relations in a complex model of inter-organ...

Ngày tải lên: 13/08/2014, 20:21

Ngày tải lên: 14/11/2014, 12:00

... investigated the link between homocysteine, folate, vitamin B-12 and the risk of dementia and cognitive impairment in older adults The thiol-containing amino acid homocysteine links the methionine cycle ... albumin, hemoglobin, low BMI, chronic comorbidity and low BMI * chronic comorbidity interaction 44 Odds Ratios (95% CI) of Association of Quintiles of Haemoglobin and Albumin and low BMI -and- Chronic ... relationships between body mass index, albumin, hemoglobin and cognitive performance Study II investigated the effect of serum albumin on cognitive performance and cognitive decline and the effect modification...

Ngày tải lên: 11/09/2015, 16:02

... proteins include protein serine-threonine kinases (Akt and phosphoinositidedependent kinase (PDK1)), protein tyrosine kinases (Btk and Tec family), exchange factor for GTP-binding proteins (Grp1 and ... and IgE inducing expression of the FcεRII and MHC class II enhancing the expression of integrins, including CD11b, CD11c, CD18, and CD29 inducing MHC class II and CD23 expression Inhibiting the ... sensitizing them (Busse and Lemanske, 2001) Crosslinking of FcεRI with IgE and antigen is the triggering event of the activation of protein-tyrosine kinases (PTK), including those of the Src, Syk and...

Ngày tải lên: 15/09/2015, 22:09