... diagnosis of limited or diffuse SSc according to the criteria ofthe American College of Rheumatology (ACR) (1980) [18] were recruited from the Rheumatology Clinics ofthe University of Tennessee ... = 0.359) None ofthe SSc-related disease manifestations was predictive of an immuneresponse to CI in vitro, except for a trend toward more lung fibrosis in the CI responders Ofthe CI responders, ... characterization ofthe autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in...
... ticks The plots show the frequency distribution ofthe contacts as log10 ofthe number of nodes vs the log10 ofthe number of links per node for the first 400 ticks ofthe simulation for the given ... distributions of contacts for each immune agent type at 1000 ticks The plots show the frequency distribution ofthe contacts as log10 ofthe number of nodes vs the log10 ofthe number of links per ... “engaged” in theimmune response, and the extent of engagement of each agent type for theresponse duration was determined Zero percent ofthe agents were engaged at the start of a simulation run The...
... causing the ulcerative disease in grouper Study on the effect of oral administration β-glucan on the native immuneresponseof orange-spotted grouper Study on the specific immuneresponseof orange-spotted ... and contents of research 2.1 Aims of research Study theimmuneresponseof orange-spotted grouper to Vibrio parahaemolyticus 2.2 Contents of research Study on characteristics of V parahaemolyticus ... killed cells of V parahaemolyticus Significance and new conclusions from this dissertation The results ofthe dissertation contribute with scientific information about theimmuneresponseof orange-spotted...
... and this occurred even in the presence of antigen These encounters of rapidly migrating T cells with DCs occurred preferentially in the vicinity of HEVs [25] The role of these early and short-lived ... as the method of choice Fluorophores are excited by the near-simultaneous absorption of two infrared photons, rather than by a single photon of visible light as in confocal microscopy Each ofthe ... became sessile The higher motility of mature DCs probably functions to distribute DCs and the antigen(s) they carry throughout the T cell zones, thereby maximizing the likelihood of antigen-specific...
... elucidated The efficacy of phytol and PHIS-01 as adjuvants is also evident in the quality of protection that the vaccines pro- Page of 10 (page number not for citation purposes) Journal ofImmune ... prepared under the supervision and oversight ofthe Indiana State University Animal Care and Use Committee Page of 10 (page number not for citation purposes) Journal ofImmune Based Therapies and ... anti-bacterial antibody responses Sera of immunized mice collected over the course of three immunizations were analyzed by ELISA to determine the induction and duration of antibody response Low but...
... supervised the genetic analyses and the writing ofthe manuscript WHMP performed the GSTA1-1 and GSTP1-1 analyses PP, NPR, and PS supervised the conduct ofthe study and the writing ofthe paper ... the tip ofthe syringe After blood was mixed with the ‘blocker solution’ and collected in the collection syringe with a total volume of mL, the hematocrit value was Page of 10 determined in the ... (vascular cell adhesion molecule), indicators of shedding from the endothelium, were used as markers of endothelial dysfunction To determine the concentration ofthe various cytokines and adhesion molecules,...
... expression was mainly confined to the subcapsular region ofthe LN The heparin-binding carboxyl-domain ofthe predominant VEGF-A isoform, VEGF164 may bound the molecule to the extracellular matrix and ... through the LN could influence the spatial-temporal distribution of VEGF-A during the course of inflammation and, as a consequence, modulate the remodeling of cortical and medullary sinuses As other ... unlikely that they were the only cells driving the process Depletion of monocytes and macrophages by the use of AFS98 MAb inhibited lymphangiogenesis in the µMT LNs, indicating that these cells...
... reabsorbed at the venous side ofthe capillary bed, where the colloid osmotic pressure ofthe blood exceeds the blood pressure The main function ofthe lymphatic vasculature is to return the remaining ... shall focus on the other stromal components- the BECs and the FRCs in this section 22 Figure 1.4 Organization ofthe lymph node (A) Schematic representation ofthe organization of a LN Afferent ... lymph to the SCS, which forms a channel around the periphery ofthe LN Lymphatic sinuses run from the SCS through the cortex to the medulla and exit the LN via efferent lymphatic vessels on the opposite...
... On the basis of classical theories ofimmune surveillance and more recent awareness ofthe tumour-promoting properties of innate immune cells, researchers are now investigating the efficacy of ... history of alcohol and tobacco use66,67 On the other hand, the RR for the most common non-viral-associated solid tumours of epithelial origin is decreased in immune- suppressed patients; some of these ... adaptive immune cells Acute activation of innate immunity sets the stage for activation ofthe more sophisticated adaptive immune system Induction of efficient primary adaptive immune responses...
... digesting the fragment with HindIII and Bgl II and the plasmid with HindIII and Bam HI The fragment was ligated into the plasmid and the integrity ofthe insertion was validated by digesting the plasmid ... contributing to the phosphorylation ofthe wild-type siglec tail by Lck and Jak3 kinases By comparison, the mutation ofthe tyrosine at position 641 did not significantly affect the degree of phosphorylation ... final pH of 8.0 Siglec-10 –hIg was then dialysed against NaCl/Pi To construct the GST fusion ofthe siglec-10 cytoplasmic domain (GST– siglec-10cyto-wt) the cytoplasmic domain (KRRTQTE…VFQ) of siglec-10...
... behaviour of packed columns for the development of a new method for the standard presentation ofthe fluid dynamics of columns with any type of packing design The basic principlesofthe method ... for the calculation ofthe maximum loading capacity at a given specific liquid load uL The higher the loading capacity ofthe column in the case of countercurrent flow ofthe phases, i.e the higher ... the bottom tW and at the top tD ofthe column, and on the price ofthe heating steam CH , the optimum operating temperature tD,opt of a condenser operated with cooling water is in the range of...
... illustrates the spectral dependence ofthe bowtie’s near-field emission on its outline dimensions (a and b) The field is sampled at the center ofthe aperture on the exit plane (the free-space side ofthe ... its direction Figure shows the sum ofthe energy density stored in the electric and magnetic field and the magnitude ofthe Poynting vector at the center ofthe gap in the exit plane for different ... resonant peaks ofthe various sized bowties are all above the cutoff wavelength ofthe circular hole in the probe This leads to the resolution of only the shortest wavelength resonant peaks The signals...
... 631004 THE ORCE RF PRINCIPLESOFTHE ALGEBRA OF LOGIC THE ORCE RF A generation will arise in which the leaders of education will know the value of logic, the value of mathematics, the value of logic ... in the practical or theoretical activities of mankind The properties ofthe symbol of Quality are not laws of thought in the common acceptation of that term For the properties ofthe symbol of ... ALGEBRA OF LOGIC THE ORCE RF THE ORCE RF I THE SCIENCE OF FORMAL LOGIC AN ALGEBRA THOUGH it is evident a priori to one who reflects on the matter, that the theory of Necessity and the theory of...
... no clinical signs of infection over the period of observation (Table 1) Mice vaccinated with the mixture of rHA proteins lost ~15% of their original body weight by day and then began to recover ... formulation The clade VLP elicited a high degree of cross-protection than the clade VLP (Figure 3) The cross-reactivity ofthe single-strain vaccines is more limited than that ofthe mixed vaccine ... pathogenicity The isotype ofthe antibody may play as an important a role in protection as the antibody titer Whether mixed together or individually, these VLPs elicited an IgG2a antibody profile (data...
... potential of nanomaterials [12,13] However, the role ofthe different physical characteristics of nanomaterials in the production of allergic responses has not been elucidated Here, we examined whether ... responses of silica particles To clarify the mechanism by which nSP30 elicited an immune response, we analyzed the profiles of cytokines released from splenocytes of OVA-exposed mice The splenocytes ... nanosilica particles has the capacity to promote allergic immune responses in mice In addition, we investigated the relationship between the size of silica particles and allergic immune responses Materials...
... establishment) the P-CSCF asserts the identity ofthe user to the rest ofthe nodes in the network This way, other nodes not need to further authenticate the user, because they trust the P-CSCF The rest of ... is GPRS, the location ofthe P-CSCF is subordinated to the location ofthe GGSN In roaming scenarios, GPRS allows location ofthe GGSN either in the home or in the visited network (the SGSN is ... interface to the HSS The main reasons to interface the HSS are as follows • To download the authentication vectors ofthe user who is trying to access the IMS from the HSS The S-CSCF uses these vectors...
... well recognized for the regulation ofimmune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression ... between pathogen species These graduated effects may, in turn, have driven quantitative polymorphisms in the contemporary immune system that control the strength oftheimmune response, exemplified ... controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in terms ofthe hygiene hypothesis) out of alleles known to predispose...
... administration ofthe ApxIIA We first confirmed the immunogenicity ofthe yeast-derived ApxIA antigen We then investigated the local and systemic immune responses, bacterial clearance, and inflammatory responses ... to the involvement of IL-6 in Immune responses with S cerevisiae expressing rApxIA or rApxIIA 391 the production of IgA and the induction of TNF-α by IgA [23] Moreover, the dual capacities of ... antibodies and the number of IgA-secreting cells in the intestine and lung Based on the findings of other reports [7,8,34], these results strongly suggest that mucosal immune responses at remote...
... controls The two main hypotheses ofthe study were the following: (1) that the virtual exposure elicits emotional responses comparable to those produced by the real exposure, and (2) the sense of presence ... second hypothesis, we found an effect of subjects' degree of presence experienced in the VR condition on their level of perceived anxiety (STAI-S and VASA): the higher the sense of presence, the higher ... the room and to stand in front ofthe six plates covered by the red lids (the same used in the real food (RF) and photograph (PH) conditions) indicated by the yellow arrow on the right side of...