principles+of+clinical+pharmacology+by+arthur+j+atkinson

... level of 1.4 ng/mL when measured by the immunoassays 11 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION CHAPTER 3 Compartmental Analysis of Drug Distribution ARTHUR J. ATKINSON, JR. Clinical ... basic principles of clinical phar- macology currently are being applied in the process of drug development. Journals Clinical Pharmacology and Therapeutics British Journal of Clinical Pharmacology Journal ... 502 Impact of Regulation on Clinical Development Programs 504 Goal and Objectives of Clinical Drug Development 505 Objective 1 — Clinical Pharmacology and Pharma- cometrics 506 Objective 2 —...

Ngày tải lên: 22/03/2014, 23:20

... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...

Ngày tải lên: 06/07/2014, 08:20

... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... administered by a nonintravenous route, the peak concentration occurs later and is lower than after the same dose given by rapid intravenous injection, reflecting absorption from the site of administration ... and CYP2E1, and each drug may be a substrate for one or more of these enzymes. "Phase II" metabolism involves conjugation of specific other routes is termed bioavailability. Bioavailability...

Ngày tải lên: 06/07/2014, 08:20

... amount of drug administered per unit time equals drug eliminated per unit time. With a continuous intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... (Chap. 226) to prevent elimination by very rapid (t 1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous...

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

... The Project Gutenberg EBook of The Business of Mining, by Arthur J. Hoskin This eBook is for the use of anyone anywhere at no cost and with almost no ... operation of mines Author: Arthur J. Hoskin Release Date: February 16, 2012 [EBook #38903] Language: English Throughout the subject, we see the inseparable idea of profit. The work of carrying ... BUSINESS OF MINING A BRIEF, NON- TECHNICAL EXPOSITION OF THE PRINCIPLES INVOLVED IN THE PROFITABLE OPERATION OF MINES BY Consolidated Copper Co., Coram, Cal. 114 Washoe Reduction Works of the Anaconda...

Ngày tải lên: 28/06/2014, 17:20

... have rendered further work unremunerative. The Project Gutenberg EBook of The Business of Mining, by Arthur J. Hoskin This eBook is for the use of anyone anywhere at no cost and with almost no ... PRINCIPLES INVOLVED IN THE PROFITABLE OPERATION OF MINES BY number of years and which, of late, has been met and forcibly applied by the best men in the profession of mining engineering. An excavation that ... Ariz. 161 Diagram of Metal Market for One-third of a Century 178 Florence Mine and Mill, Goldfield, Nev. 201 *** START OF THIS PROJECT GUTENBERG EBOOK THE BUSINESS OF MINING *** Produced by Eric Skeet...

Ngày tải lên: 28/06/2014, 17:20

... The worm and the pro hacker • Everyone is online • Horrible levels of vulnerability • Exposure of data and professionalization of cybercrime • Venture community pulls up stakes • Lawmakers stake ... CEO of NFR 1997 • CSO, consultant, teacher, writer Some History • The early days of computer security: • Audit function - oversight • Mainframe usage accounting and system log analysis • Often ... the “disaster of the day” TopHeavy • $1 bn among 190 start-ups • “That’s not a market; that’s a hobby” (Peter Kuper, Morgan Stanley) • Further pressure on the “little guys” • Think of Checkpoint...

Ngày tải lên: 14/02/2014, 16:20

... Glossary of Common Project Management Terms at the following web site http://www.pmforum.org/ 12 Bing, John, A. Principles of Project Management, PMNETwork, PMI, January 1994, p40 13 Contributed by ... of a project in terms of key and measurable criteria upon which the relative success or failure of the project may be judged. For example, those that 11 : • Meet key objectives of the project such ... content. First Principles of Project Management Based on the foregoing criteria, the following ‘First principles are proposed. These principles build extensively on the work of John Bing 12 . All the principles...

Ngày tải lên: 18/02/2014, 07:20