principles of clinical pharmacology atkinson pdf
PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
... basic principles of clinical phar-macology currently are being applied in the process of drugdevelopment.Journals Clinical Pharmacology and TherapeuticsBritish Journal of Clinical Pharmacology Journal ... effective use of medicine can be traced back at least to RudolphBucheim (1820–1879), who has been credited with1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION20 Principles of Clinical Pharmacology Therefore, ... 6 Principles of Clinical Pharmacology TABLE 1.1 Status of Renal Function in 44 Patients withDigoxin ToxicityaSerum creatinine(mg/dL)No. of patients with CLCR of Percentage of group50...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... aInhibitors affect the molecular pathway, and thus may affect substrate. bClinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...
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Tài liệu Ten Principles of Economics - Part 6 pdf
... pound of potatoes costs the rancher 8 pounds of meat,1 pound of meat costs the rancher 1/8 pound of potatoes. Similarly, because 1pound of potatoes costs the farmer 1/2 pound of meat, 1 pound of ... opportunitycost of producing 1 pound of meat is 2 pounds of potatoes. Explain why the rancher’s opportunity cost of producing 1 pound of meat is 1/8 pound of potatoes.2. Maria can read 20 pages of economics ... The rancher buys 1pound of potatoes for a price of 3 pounds of meat. This price of potatoes is lowerthan her opportunity cost of 1 pound of potatoes, which is 8 pounds of meat. Thus,the rancher...
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Tài liệu Ten Principles of Economics - Part 8 pdf
... quantity of ice cream you are willing to produceand offer for sale? Here are some possible answers.PriceThe price of ice cream is one determinant of the quantity supplied. Whenthe price of ice ... MARKET FORCES OF SUPPLY AND DEMAND 77MARKET SUPPLY VERSUS INDIVIDUAL SUPPLYJust as market demand is the sum of the demands of all buyers, market supply isthe sum of the supplies of all sellers. ... the price of the good. Thisrelationship between price and quantity supplied is called the law of supply:Other things equal, when the price of a good rises, the quantity supplied of thegood...
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Tài liệu Ten Principles of Economics - Part 9 pdf
... responsiveness of quantity demanded or quantitysupplied to one of its determinantsprice elasticity of demanda measure of how much the quantitydemanded of a good responds to achange in the price of that ... price of flour or a fall inthe price of milk? Illustrate and explain youranswer.b. Suppose instead that the equilibrium price of cream cheese has risen but the equilibrium quantity of bagels ... eventscertainly raise the price of ice cream, but their impact on the amount of icecream sold is ambiguous.Price of Ice-CreamCone2.00$2.50047Quantity of Ice-Cream ConesDemandNewequilibriumInitial...
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Tài liệu Ten Principles of Economics - Part 11 pdf
... THEPRICEELASTICITY OF SUPPLYCANVARY. Becausefirms often have a maximumcapacity for production, theelasticity of supply may be veryhigh at low levels of quantitysupplied and very low at highlevels of ... Concepts1. Define the price elasticity of demand and the incomeelasticity of demand.2. List and explain some of the determinants of the priceelasticity of demand.3. If the elasticity is greater ... reducing the supply of farm products may raise the in-comes of farmers, but it does so at the expense of consumers.WHY DID OPEC FAIL TO KEEP THE PRICE OF OIL HIGH?Many of the most disruptive...
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Tài liệu Ten Principles of Economics - Part 56 pdf
... Second, debt financing of wars shifts part of the cost of wars to fu-ture generations, who will have to pay off the government debt. This is argu-ably a fair distribution of the burden, for future ... THE FINANCIAL SYSTEM 577size of the changes to the $20 billion of extragovernment borrowing.c. How does the elasticity of supply of loanablefunds affect the size of these changes? (Hint: SeeChapter ... source of the supply of loanable funds—is composed of private saving and public saving.A change in the government budget deficit represents a change in public savingand, thereby, in the supply of...
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