... stability of PANs was studied in the aqueous medium, and the acute toxicity of PANs was evaluated in mice Morever, EPI was loaded into PANs and its pharmacokinetics was also assessed in rats to ... of 200 mg/kg In vivo pharmacokinetics The plasma levels of EPI were determined following a single i.v injection of EPI or PA/EPI (10 mg/kg EPI equiv.) in female Wistar rats The plasma levels over ... study, the terminal elimination half-life of free EPI was 8.129 h (Table 5), which was consistent with that of 7.3 h of doxorubucin (Gustafson et al., 2002; Bibby et al., 2005) In contrast, PA/EPI...
Ngày tải lên: 23/04/2013, 21:38
... also has an awareness of how individuals and groups are thinking and feeling within his class He actively responds to this in his planning and working methods and in building effective working ... discipline is referred to as ‘the training or control, often using a system of punishment, aimed at producing obedience to rules’ Webster’s New World Dictionary defines Discipline as “training that ... look of a disciplined classroom (p 259): ‘ The phrase ‘classroom discipline’ has for most teachers as immediate clear meaning, but it is in fact quite a complex concept, and hard to define in word...
Ngày tải lên: 07/09/2013, 13:06
Tài liệu Aesthetic preferences and the attribution of meaning: Environmental categorization processes in the evaluation of urban scenes ppt
... evidence of the existence of this association in urban settings Within this framework, the overview guiding the design of this study is establishing categories of urban places from the perspective of ... on the construction of an instrument to measure the restorative capacity of a specific place in terms of the ART—(Hartig, Korpela, Evans, & Garling, ¨ 1997) as well as analysing the role that this ... recreational places, and housing areas) agree with the characterization made in Galindo’s (1994) study, which was used as a provisional instrument in this study In our opinion, this suggests that...
Ngày tải lên: 19/02/2014, 17:20
Comparison of the obstetric anesthesia activity index with total delivery numbers as a single denominator of workload demand in Israeli maternity units doc
... in Israel has increased due to both an increase in the requests for labor analgesia and a marked increase in the cesarean delivery rate We propose a new workload-driven performance indicator, ... a single workload denominator Competing interests There are no competing interests declared for any author Author information Yehuda Ginosar is Senior Lecturer of Anesthesia and Director of ... workload in Israel has increased due to both an increase in the cesarean delivery rate (rising from 9.6% in 1992 [2] to 17–18% by 2004 [3]) and epidural labor analgesia Laboring women may be disproportionately...
Ngày tải lên: 05/03/2014, 15:20
Báo cáo khoa học: Subcellular compartmentalization of FADD as a new level of regulation in death receptor signaling pdf
... Whether, in the absence of caspase-8 activation, FADD shuttles back to the nucleus or is degraded in the cytoplasm remains to be investigated As treatment of cells with caspase inhibitors has been ... domain of INP54p was cloned into the modified pEGFP-C1 (Clontech, Mountain View, CA, USA) vector following the C-terminus of GFP The first 10 amino acids of Fyn were engineered in frame N-terminal ... the amount of FADD in the cytoplasmic fraction of cells expressing wild-type CD95 (Fig 4D, lanes and 5) A similar increase in cytoplasmic FADD was also observed in CD95(Y291F)-expressing cells...
Ngày tải lên: 07/03/2014, 02:20
atlas of cyberspaceatlas of cyberspaceMartin Dodge and Rob Kitchin What does cyberspace look like?For thousands of years, people have created maps of the world around them – cave paintings, drawings in the sand, pencil sketches, lavish manuscripts, 3- pot
... networking and laid the foundations of the Internet as we know it today, developing both the technical and the social infrastructure of Internet working It was conceived as a method to link several ... reading of them could easily provide a distorted view of the global spread of the Internet As discussed in full in chapter 1, whilst most of the world is connected to the Internet, this level of ... longest-serving cartographer of the Internet is undoubtedly John S Quarterman Through his research consultancy, Matrix.Net, based in Austin, Texas, he has been actively measuring, analyzing and mapping...
Ngày tải lên: 15/03/2014, 13:20
Effect of cd and as in soil on growth availability to plant
... and Cd in agricultural products were significantly increased as the concentrations of As and Cd in soils were increased, basically Table shows that the contents of As in edible part of chinese ... As the concentrations of Cd and As in soils were increased, the contents of Cd and As in agricultural products were significantly increased, basically The contents of Cd in the edible parts of ... concentration of As because of 6.0 mg kg-1 of concern level and 15 mg kg-1 of countermeasure level for soil contamination designated by ‘Soil Environment Conservation Law’ in Korea (1996) In case of Cd,...
Ngày tải lên: 16/03/2014, 00:07
Báo cáo Y học: Mydj2 as a potent partner of hsc70 in mammalian cells doc
... protein (lanes 3, 3¢) In contrast, no binding between the immobilized dj2 protein and the inducible hsp70 protein was observed (Fig 6, lanes: 3, 3¢) Interestingly, the same results were obtained ... Using clone 5aI as a probe and RNAs from cell lines, we identified two different in size mRNAs The steady-state levels of both messages were examined in different cell lines and mouse tissues In ... with blocking medium, the cells were washed three times with NaCl/Pi and incubated for h with 20–30 lL of the primary antibody diluted as indicated in NaCl/Pi/3% BSA Following washings (three...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... treatment of leaf disks with H2O or a solution of mM SA As shown in Fig 3B, inducibility of GUS activity was maintained with any plant containing either of the as- 1[GUS] transgenes Surprisingly, ... transcription factor TGA2.2 is the main component of as- 1binding factor ASF-1 and is involved in salicylic acid- and auxininducible expression of as- 1-containing target promoters J Biol Chem 275, ... which contains an authentic as- 1 element as found in the CaMV 35S RNA promoter (in bold letters) The as- 1 element was inserted at position )591 in the PR-1a promoter The as- 1 containing )906 bp...
Ngày tải lên: 23/03/2014, 15:21
networks of innovation change and meaning in the age of the internet
... increasing complexity of new and continuously changing components using Internet newsgroups As sociologists have often argued, the development of modern society creates increasingly complex interrelationships ... of relationships in an ecology of communities At the level of ecology of communities of practice, the speed of recombination has therefore increased The space of recombination has become an increasingly ... who was part of which project In Enquire, information was stored as a ‘node’ in a linked network Each page of information was a node A new node was created by creating a link from an existing...
Ngày tải lên: 01/06/2014, 10:08
coats & schauberger - nature as teacher - new principles in the working of nature (1998)
... we are increasingly forced to become aware of certain life-threatening irregularities in the functioning of Nature's household Record catastrophes of increasing violence and extent are being reported ... increasingly unstable; an instability that is also reflected in the growing instability of human institutions These alarming events, however, will continue to increase in scope and magnitude in ... for life in Nature The reason people mistake their cultural and economic decline for a passing crisis and strive in vain to master the increasingly widespread misery, lies mainly in the intellectual...
Ngày tải lên: 04/06/2014, 12:23
nanotalk. conversations with scientists and engineers about ethics, meaning, and belief in the development of nanotechnology, 2006, p.378
... and engineers, but those distinctions are becoming increasingly vague in the nanotechnology initiative Both scientists and engineers work as principal investigators within laboratory settings Both ... to increasing shareholder value in the long run He felt that in some cases they had neglected basic research over the last or years, increasing shareholder value in the short run but leaving ... federal hearings Drexler was not included in the 2003 hearings on nanotechnology appropriations (a time during which there was a significant increase in funds being proposed and in a climate of highly...
Ngày tải lên: 04/06/2014, 15:19
báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf
... brain scan results Of particular interest, the increase in sHLA-II values was associated with a decline on brain MRI activity as demonstrated by post-contrast T1-weighted axial brain images Initially, ... well as response to therapy, must be reliable, noninvasive, and preferably of reasonable cost in order to be performed in a serial fashion reflective of the natural history of the relapsing/remitting ... examination at baseline as well as at three and six months and this included expanded disability status scores (EDSS) during each visit MRI protocol Brain MRI was performed using a 1.5 T machine...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... the introduction of chloride increased the rate of Cu release in acetate buffer (Figure 3C) Again, Cu release was highly dependent on the identity of competing ligand as illustrated by comparing ... effect of competing ligands on Cu release with the idea that the underlying principles governing release could be used in the design/optimization of this class of delivery vectors Release of Cu ... amount released at 48 h and that contained in the original loading solution determined Cu loading, resulting in values ranging between 12 and 16 wt.% based on these reactions conditions XPS was used...
Ngày tải lên: 21/06/2014, 02:20
Screening of Bacillus strains as potential probiotics and subsequent confirmation of the in vivo effectiveness of Bacillus subtilis MA139 in pigs doc
... type of exogenous spore-forming bacteria, are not normally found in the gastrointestinal tract but have also been shown to be effective in keeping a favorable balance of microflora in the gastrointestinal ... antimicrobial activity screening assay was repeated in triplicate for these six strains 141 at 37°C Simulated small intestinal fluid without inoculation was used as a control Determination of total spore counts ... count of the washed bacterial spore suspension was determined prior to the gastrointestinal tract tolerance test Simulated gastric fluid tolerance test A pH of was selected as the critical point...
Ngày tải lên: 07/07/2014, 19:20
Báo cáo lâm nghiệp: "New insights in the recognition of the European ash species Fraxinus excelsior L. and Fraxinus angustifolia Vahl as useful tools for forest management" pdf
... germination of stratified seeds of three ash species, Seed Sci Technol 22 (1994) 519–529 [17] Preece J.E., Bates S.A., Van Sambeek J.W., Germination of cut seeds and seedling growth of ash (Fraxinus ... microsatellite-derived marker Then we assessed the utility of two of them, together with germination tests of intact untreated seeds and embryo/seed length ratios measurements, for distinguishing between these two ... respectively) with Primer3 software [22] Preliminary PCR tests were performed with 10 individuals of each species in 20 µl solution containing 0.5 units of Q-BIOgene Taq DNA Pol, 100 µM of each dNTP, 1.5...
Ngày tải lên: 07/08/2014, 16:20
Báo cáo y học: "Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis" pptx
... expressing granulocytes, most of these infiltrating PR-3 mRNA expressing cells were macrophages (Supplementary Fig 4) We found this kind of distribution of PR-3 mRNA expressing cells at sites of inflammatory ... expressing granulocytes, most of the infiltrating PR-3 expressing cells were macrophages One explanation for the occurrence of PR-3-positive macrophages in inflammatory tissue is the invasion of ... 7.6) and incubated in Tris–NaCl containing 2% normal goat serum (to block nonspecific binding) for 30 at room temperature, followed by incubation with antidigoxigenin–alkaline phosphatase–antibody...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo lâm nghiệp: "Seasonal variations in photosynthetic activity of spruces as determined by chlorophyll fluorescence" ppsx
... using different fluorescence methods 1) The red laser-induced chlorophyll fluorescence kinetics (determination of Rfd-values as a vitality index of needles) measured near 690 and near 730 nm in ... apparatus as seen from the lower Rfd-values In contrast, the Rfd-values as a vitality index and as an index of the intactness of the photosynthetic apparatus, showed a different behavior There was a ... degree in the youngest needle year 1987 With the start of the new vegetation period, the chlorophyll content increased again This increase was particularly strong in the 1987 needles, which in the...
Ngày tải lên: 09/08/2014, 04:20
Báo cáo y học: "Correspondence in relation to the case report "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note." published in May issue of Journal of Brachial Plexus and Peripheral Nerve Injury" potx
... possibility in the case report Even nothing was mentioned about occurrence of hiccup, which is usually seen in case of phrenic nerve stimulation [5] This is a possibility in case of electrical ... mentioned anything about the ventilator rate and tidal volume setting in their particular case in relation to capnogram recording Hypocarbia can result from several causes Most common of them is ... this case report is a little bit inadequate in ruling out other possibilities of diaphragmatic contractions rather than elicited by electrical stimulation of phrenic nerve Thus before accepting...
Ngày tải lên: 10/08/2014, 10:20
báo cáo khoa học: " Using the theory of planned behaviour as a process evaluation tool in randomised trials of knowledge translation strategies: A case study from UK primary care" pot
... of three of the targeted laboratory tests – the measurement of serum ferritin in the assessment of microcytic anaemia (ferritin), the measurement of serum follicle stimulating hormone (FSH) in ... This is akin to measuring intermediate endpoints in clinical trials to further understand the biological basis of any observed effects (for example, measuring cholesterol alongside trials of lipid-lowering ... effect was modified in the presence of different barriers and enablers There is increasing recognition of the value of process evaluations alongside trials of complex interventions such as professional...
Ngày tải lên: 10/08/2014, 10:23