prediction of the gel point

... advantage of p53 mutation analysis, and a unique feature of this database, is the availability of the residual activity of the majority of p53 missense mutants The biological activity of mutant ... the cross indicates the cut-off value used in PREDMUT The limit between the classes was set to the activity value of 25%, because this value was observed to be a natural divider of the data The ... favour of a severe mutant At the other end of the spectrum, where we have low energy, there is 75% probability for the mutation to be nonsevere if the energy is 0.125 or lower Thus, on the basis of...

Ngày tải lên: 18/02/2014, 11:20

... 7) The mathematical treatment of LaPorte et al [2] is reproduced here for the Phser branch -point When the branch -point is in steady-state, the ux of Phser (JPhser) is equal to the sum of the ... model of the steady-state in the branch -point The mathematical procedure published previously for the study of the isocitrate branch -point in E coli [2] was adapted to model the Phser branch -point ... are the TS catalytic constant in the absence and presence of a saturating concentration of AdoMet, respectively K1K2 is the product of the binding constants for the association of the rst and the...

Ngày tải lên: 20/02/2014, 02:21

... mentioning that the conditions of our theorems are easily to verify, so they are applicable to a variety of problems, see Examples 4.1 and 4.2 The proof of our main results is based upon the following ... t∈[η,1] β(1 − η) , η} − βη Proof Note that u“ (t) ≤ 0, by applying the concavity of u, the proof is easy So we omit it where γ = min{βη, Proofs of main theorems Define the operator T : C[0, 1] ® ... http://www.advancesindifferenceequations.com/content/2011/1/2 Page of 11 as an important area of investigation For the general theory and applications of integer order differential equations with deviated arguments, we refer the reader to the references...

Ngày tải lên: 21/06/2014, 03:20

... improve some of the conditions and results in the mentioned papers, especially those of Song and Xu 11 Preliminaries Let S : {x ∈ X : x 1} be the unit sphere of the Banach space X The space X ... fixed point x ∈ C, which is the unique solution in C to the variational inequality VI∗ F, C , that is Fx∗ , J x − x∗ ≥ 0, ∀x ∈ C 3.6 Fixed Point Theory and Applications Proof We divide the proof ... C1 , then condition ii in Theorem 4.2 holds Proof From 1.9 , C1 , and the boundedness of {xn }, we conclude that xn − T tn xn λn xn − T tn xn − μFxn −→ 0, 4.20 as n → ∞ On the other hand, the...

Ngày tải lên: 21/06/2014, 11:20

... 2.2 k then T has a fixed point in C This result generalizes Lifshitz’s Theorem in case of a Hilbert space and shows that the theorem admits certain perturbations in the behavior of the norm of successive ... 1.2 F and the Lipschitz constant of T tends to if ε ↓ For more information on the structure of fixed point sets see 4, and references therein In 1973, Goebel and Kirk introduced the class of uniformly ... ε ↓ and using the continuity of δH , we conclude that 1 − δH ε0 R0 This contradiction proves the continuity of mapping A < 2.20 Fixed Point Theory and Applications The Methods of Hilbert Spaces...

Ngày tải lên: 21/06/2014, 20:20

... elementary proof of the uniqueness of the fixed point index, Pacific J Math 35 (1970), 549–558 , The Lefschetz Fixed Point Theorem, Scott, Foresman and Company, London, 1971 A Granas, The Leray-Schauder ... and the set Fix( f ,U) := x ∈ U : f (x) = x (2.2) of the fixed points of f in U is compact In particular, ( f ,U) is admissible if the closure U of U is a compact subset of Ᏸ( f ) and f is fixed -point- free ... admissible because of the compactness of V We will show that the properties of normalization, additivity, and homotopy invariance imply a formula for the computation of the fixed point index that...

Ngày tải lên: 23/06/2014, 00:20

... perturbation If only the linear part of the data is subject to perturbation, then the upper semicontinuity of the KKT point set mapping can be studied via a theorem of Robinson [9] on the upper Lipschitz ... proved that the assertion of Theorem 2.2 remains valid if instead of (c1)–(c4) we use (c1)–(c5) The method of dealing with (c5) is similar to that of dealing with (c4) in the proof of Theorem 2.2 ... the usefulness of (c5) in characterizing the lower semicontinuity property of the multifunction S(·) is to be investigated furthermore This is the reason why we omit (c5) in the formulation of...

Ngày tải lên: 06/08/2014, 05:20

... performances of the offspring of the candidate for selection The selection criterion (21) is then a true measure of the candidate’s value, and can be considered as an approximation of the criterion ... of interest, E!(X) its expectation in the selected part in the candidate population, and Ed (X ) the expectation of phenotypes among the offspring of the w-selected parents The numerator is the ... w, then calculate the corresponding distribution in the offspring population Let f (y) be the unconditional distribution of Y, and f (u, v) the joint density of u and v The density of Y in the...

Ngày tải lên: 09/08/2014, 18:21

... at the mitochondria Pro-apoptotic and anti-apoptotic members of the Bcl-2 family of apoptotic regulators meet at the surface of mitochondria, where they compete to regulate the release of the ... by the removal of the prodomain after another cleavage event on the large subunit The large subunit and small subunit then associate with each other to form a heterodimer which unites with another ... Horvitz, 1990) Later, the cloning of the ced-3 gene by Yuan and co-workers led to the identification of the gene as a C elegans homologue of the mammalian ICE (Yuan et al., 1993) These observations...

Ngày tải lên: 11/09/2015, 09:05

... apply to the other types of agents as well 1.3 Two statements This thesis consists of two parts For each of these two parts a separate statement will be formulated The first part of the thesis ... needs, and for the connection of the user with the agent(s) that will help him solve his problem The number of types of agents the Interface Agent has to deal with, depends on the aims of the system ... in the other-half population rather than the upstream population These particular other-half consumers report the highest degree of frustration with the Web of any population segment Although they...

Ngày tải lên: 08/10/2012, 15:22

... the Strum Farm in the southern half of the Bear Creek channel system The elevation of the site is 318 m The aspect from true north is 200 degrees and the latitude is 42 degrees The slope of the ... that the organic matter for the rest of the soil profile (the third layer to the eighth layer) were half of the previous layer We did not have field measurements for the microbial pools; therefore ... runoff loss As atrazine load into the RBS and the runoff depth from the cornfield increased the atrazine mass loss in runoff leaving the RBS increased (Table 4) Atrazine mass in runoff leaving the...

Ngày tải lên: 05/09/2013, 09:08

... apply to the other types of agents as well 1.3 Two statements This thesis consists of two parts For each of these two parts a separate statement will be formulated The first part of the thesis ... needs, and for the connection of the user with the agent(s) that will help him solve his problem The number of types of agents the Interface Agent has to deal with, depends on the aims of the system ... in the other-half population rather than the upstream population These particular other-half consumers report the highest degree of frustration with the Web of any population segment Although they...

Ngày tải lên: 26/10/2013, 17:15

... components of double curves in X; • fn : the number of n-faces of G, i.e the number of En -points of X, for n 3; • f := n fn , the number of faces of G, i.e the total number of En -points of X, for ... rn : the number of open n-faces of G, i.e the number of Rn -points of X, for n 3; • r:= n rn , the total number of Rn -points of X, for all n 3; • sn : the number of n-angles of G, i.e the number ... respectively] the number of En -points [Rn -points and Sn -points, respectively] of X along γ Denote by dγ the number of double points of the total space X along γ, off the Zappatic singularities of X Then:...

Ngày tải lên: 16/02/2014, 06:20

... To overcome the fact that the prosa z-score is dependant of the length of the amino acid sequence, the z-score was normalized using the natural logarithm of the sequence length [39] The resulting ... distribution of the percentage best model, for each of the 672 best models, is presented in the left panel Of the six template structures used, 54% of the sequences give the best model with the FixL ... portions of the Fa helix and the subsequent FG loop were poorly defined in this structural ensemble [1] The Fa helix and the FG loop correspond to that region of the PAS fold that is part of the region...

Ngày tải lên: 19/02/2014, 12:20

... are the seeds that later produce knowledge and wisdom, then the emotions and the impressions of the senses are the fertile soil in which the seeds must grow The years of early childhood are the ... time to prepare the soil Once the emotions have been aroused a sense of the beautiful, the excitement of the new and the unknown, a feeling of sympathy, pity, admiration or love then we wish ... nature The cycle can follow the whole process, or it may only complete parts of the process The more elements of the process used deepens the depth of engagement and subsequent understanding Further...

Ngày tải lên: 19/02/2014, 17:20

... evaluated the accuracy of the prediction using ROC scores, defined as the area under the receiver operating curve (ROC), that is, the area under the plot of true positives as a function of false ... j is defined by the number of nucleotides between the end of the i-th gene and the start of the j-th gene along the chromosomes We then derived a distance kernel using the formula Kposition (xi,xj) ... parameter In this study the parameter h is set to 105 This means that, the larger the distance between two genes along the chromosome, the smaller the value of the similarity score The resulting kernel...

Ngày tải lên: 07/03/2014, 09:20

... modifications of chromatin [9] Little is known, however, of the functional role of the remaining subclass members In this study, the yeast protein SPP1 (alias cps40), a member of the COMPASS complex ... constitute CGBP homologues The presence of a TFS2M domain is also indicative of a possible function for the DIDO1 long isoform (Figs and S2) It is the second domain of the elongation factor, TFSII ... in the tree (Fig 1), the branch of the FEBS Journal 272 (2005) 3505–3511 ª 2005 FEBS A M Rojas et al fungal sequences is clearly distant from the other branches, which was indeed predicted The...

Ngày tải lên: 07/03/2014, 21:20

... E/Cdk2:p27 For each of the intermediates, the ratio of its gradient in the correlation plot and the gradient of cyclin E/Cdk2:p27 was close to the value of the co-control coefficient of the intermediate ... absolute time point, then the sum of control coefficients would add up to )1 (as they for the control on the cell division time) The four steps delaying the RP the most (i.e with the highest positive ... (A), with the points denoting the time point of RP (x-axis) and the concentration of cyclin E/Cdk2:p27 (y-axis) For each simulation, the perturbed variable is indicated (B) The results of similar...

Ngày tải lên: 15/03/2014, 09:20

... • Taken together, the binding of oxygen to ferrous PGIS is similar to that of other P450s with respect to the transient formation of the oxyferrous form, followed by restoration of the resting ... nm In the presence of substrate, the secondorder rate constant of oxygen binding at °C was · 105 m)1Æs)1, and the auto-oxidation rate of the oxyferrous complex was 0.37 s)1 In the absence of substrate, ... sity of the Soret peak, suggesting that the redox process may cause bleaching of the enzyme We then added a small amount of dithionite to the solution containing re-oxidized PGIS and sealed the...

Ngày tải lên: 23/03/2014, 07:20

... to the strategy of the proof of Theorem 1.3.9 At the n-th stage of the induction over the period we consider the family of polynomial ˜ perturbations {fε

Ngày tải lên: 29/03/2014, 07:20