prediction of response to neoadjuvant treatment
Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
Ngày tải lên :
09/08/2014, 09:20
... coefficient of 0.54 (p < 0.001) was found between predicted and measured treatment response (V30) (B) Predicted V30 V + PSA + Ktrans R = 0.66 2 10 12 14 Measured V30 Figure Prediction of treatment response ... individual tumor responses Thus, these factors may not enable prediction of treatment failure early in the course of treatment, when therapeutic adjustments still are feasible in terms of e.g radiation ... improves prediction of treatment response By combining all parameters (tumor volumes (V), prostate-specific antigen (PSA), apparent diffusion coefficients (ADC), Ktrans) and treatment groups, the treatment...
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Báo cáo sinh học: "Prediction of response to selection within families" potx
Ngày tải lên :
09/08/2014, 18:22
... number of individuals recorded of each sex, so X refers F the relationship of family members (r to the mean of one sex), r 1/2 for full-sib families), h heritability,t = intra-class correlation of ... population ten of each iT) sex = iT-!,/(l 1/4) = large If not, iT has to be calculated accordingly, taking account of the negative correlation, -1/(n - 1), of values of X - X of family members ... values distributed about true family means, say p of phenotypes and A of breeding values (A is the mean F F F breeding value of the parents, or of the sire for a half-sib family; a includes common...
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Báo cáo y học: "DAS28 best reflects the physician''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx
Ngày tải lên :
09/08/2014, 06:23
... ACR response not reaching the ACR20 criterion ('no ACR response' ) had a sensitivity of 69.6% (95% CI: 65.2–74.0) and a specificity of 64.2% (95% CI: 59.6–68.8) When we adapted the cut-off of the ... analyses (ranking of continuous variables, evaluation of the response scores and effects of change of scores over time on the physician's decision) allowed us to narrow the selection of variables ... score of this model had an AUC of 0.870 (95% CI: 0.828–0.912) with a sensitivity at the 95% specificity level of 45.5% (95% CI: 38.7–50.3) Evaluation of the discriminant score of the variables of...
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Báo cáo y học: "An alternative methodology for the prediction of adherence to anti HIV treatment" ppt
Ngày tải lên :
10/08/2014, 05:21
... The utilisation of VL data, with knowledge of the presence (or lack) of drug resistant mutations, should allow clinicians to form a more accurate picture of the adherence levels of their patients ... combination of drugs known as highly active anti-retroviral therapy (HAART) or combined anti-retroviral therapy, which works on the principle of using a combination of different classes of drugs ... range of viral targets The extent to which patients adhere to their therapy regime is pivotal to treatment success Although adherence-nonadherence occurs on a continuum, in the case of HIV treatment...
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Molecular mechanisms underlying the pathogenesis of nasal polyposis and its response to steroid treatment
Ngày tải lên :
10/09/2015, 15:49
... infiltration of eosinophils and survival of myofibroblasts [Devalia & Davies, 1993; Mullol et al., 1995; Shin et al., 2003] 1.4.5.6 Fibroblasts/Myofibroblasts Myofibroblasts are an activated phenotype of ... eosinophils often dominant The epithelium of polyps is often damaged followed by aberrant remodeling (such as squamous metaplasia) Other characteristics of nasal polyps include proliferation of stromal ... rate of positive skin prick test was 40% (24 out of 40) in patients with NP, while 20% (6 out of 30) in the control group [Pumhirun et al., 1999] Asero and Bottazzi found 40% (8 out of 20) of patients...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
Ngày tải lên :
18/06/2014, 16:20
... percentage of the untreated cell lines at the time of 24, 48 and 72 hours are showed in Figure 1a and p-values in Additional File In absence of the treatment, the percentage of viability at 72 hours of ... http://www.translational-medicine.com/content/8/1/15 Page of Table Comparative study of the percentage of viability among Caco-2, SW-480 and HT-29 cell lines at different time of treatments may be one of the genes responsible ... identification of additional genetic determining factors of the action mechanism of EGFRtargeted therapies in colorectal cancers (CRCs) is important at least for two reasons First, the understanding of the...
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Báo cáo sinh học: "Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy" doc
Ngày tải lên :
18/06/2014, 19:20
... vitro results Page of and clinical response was observed in 27 out of the 30 patients analyzed, with a predictivity of 85.7% in terms of sensitivity and of 91.3% in terms of resistance The important ... a molecular profile of chemosensitivity to all the drugs used in the clinical treatment was generated for each tumor Patients were subdivided into responders 22.7 (6-39) Type of treatment Carboplatin/taxol ... The use of the re-induction therapy in peritoneal carcinomatosis underlines the importance of studying these patients in terms of preclinical evaluation for response to platinum-containing treatments...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
Ngày tải lên :
18/06/2014, 22:20
... median EC50 of nM Since cancer cell death is a more desired phenotype, the in vitro response of 91 hematological cell lines were defined based on both time of response and degree of cell death ... http://www.translational-medicine.com/content/9/1/110 Page of 10 Figure Response vs Chromosome Number Response profile of GSK1070916 for various hematological cell line tumor types (n = 45) Those cell lines that were responsive to treatment ... with GSK1070916 for the majority of cells to contain sub2N DNA Furthermore, the Ymin (minimum response of the dose response curve) and the T = values (the number of cells at Time zero) were determined...
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báo cáo hóa học: " Saliva soluble HLA as a potential marker of response to interferon-β1a in multiple sclerosis: A preliminary study" pdf
Ngày tải lên :
19/06/2014, 22:20
... Results Demographics of study subjects are presented in Table Soluble HLA saliva levels Scatter plots of distribution of saliva levels of sHLA-II of MS patients pre- and post -treatment with IFN-β1a ... measurement of sHLA in CSF would be most likely to reflect CNS disease activity Measurement of such a biological marker of disease activity could potentially serve as a monitor of response to ... fluctuation in this form of MS Furthermore, response to interferon beta, the most common form of immunomodulating therapy, can vary with only 30 to 40% of patients reported to have a good response [20,21]...
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o cáo hóa học:" Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy" doc
Ngày tải lên :
20/06/2014, 04:20
... vitro results Page of and clinical response was observed in 27 out of the 30 patients analyzed, with a predictivity of 85.7% in terms of sensitivity and of 91.3% in terms of resistance The important ... a molecular profile of chemosensitivity to all the drugs used in the clinical treatment was generated for each tumor Patients were subdivided into responders 22.7 (6-39) Type of treatment Carboplatin/taxol ... The use of the re-induction therapy in peritoneal carcinomatosis underlines the importance of studying these patients in terms of preclinical evaluation for response to platinum-containing treatments...
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o cáo hóa học:" High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" ppt
Ngày tải lên :
20/06/2014, 04:20
... median EC50 of nM Since cancer cell death is a more desired phenotype, the in vitro response of 91 hematological cell lines were defined based on both time of response and degree of cell death ... http://www.translational-medicine.com/content/9/1/110 Page of 10 Figure Response vs Chromosome Number Response profile of GSK1070916 for various hematological cell line tumor types (n = 45) Those cell lines that were responsive to treatment ... with GSK1070916 for the majority of cells to contain sub2N DNA Furthermore, the Ymin (minimum response of the dose response curve) and the T = values (the number of cells at Time zero) were determined...
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Báo cáo khoa học: "A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study" potx
Ngày tải lên :
09/08/2014, 04:21
... Quantification of extent of change in these biomarkers of response to chemotherapy one day and 21 days after first cycle of chemotherapy http://www.wjso.com/content/7/1/35 d) Histopathological response ... the presence of residual disease and grading of pathological response to chemotherapy was done using MillerPayne criteria for assessment of response to chemotherapy [3] Miller-Payne response grade ... 40.0 Stage of disease at presentation Histological type Grade of tumor Miller-Payne response # Poor Grade I (no or
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
Ngày tải lên :
09/08/2014, 14:20
... according to response to therapy Effects of adalimumab therapy on synovial gene expression profiles Next, we investigated the effects of adalimumab therapy on global gene expression profiles of synovial ... distinct signature made of genes involved in the regulation of the cell cycle (28% of the GO annotated genes) and genes involved in the regulation of immune responses (15% of the GO annotated genes) ... of the genes of this panel, whereas the combination of TNF- and IL-1 had a significant stimulatory effect on the whole set of genes tested (Figure 6) Notably, the effects of the combination of...
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Báo cáo khoa hoc:"Analysis of response to 20 generations of selection for body composition in mice: fit to infinitesimal model assumptions" pdf
Ngày tải lên :
09/08/2014, 18:21
... different sources of information, and estimate the magnitude of the initial rates of response to selection Long-term experiments are useful for measurement of changes in the rates of response or variances ... study of the inheritance of complex traits and allow the evaluation of theoretical predictions by testing observations against expectations Depending on the time scale, the objectives of selection ... generations of the three replicates of those lines selected divergently for high and low proportion of body fat, and in particular on changes in the variances of fat proportion during the course of selection...
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Báo cáo y học: "The long-term prediction of return to work following serious accidental injuries: A follow up study" docx
Ngày tải lên :
11/08/2014, 15:22
... analyses Time taken off work was calculated as the number of days of leave taken from the time of the injury (including time in hospital), with a week off work equaling seven days of leave Where subjects ... appraisals of the injury severity and of their coping abilities These two variables were entered in the second step accounting for an additional 11.2% of the variance of the time off work three ... http://www.biomedcentral.com/1471-244X/11/53 Page of Table Prediction of time off work year years Predictor variable Beta p Beta Injury Severity Score (ISS) 21
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Leaching of arsenic in response to organic matter contamination in groundwater treatment practice
Ngày tải lên :
05/09/2013, 09:38
... 66.6% of the water samples from wells have arsenic levels of >50 μg/L (Tun, et al., 2002) In 1987, skin manifestations of chronic poisoning of arsenic were first diagnosed among the residents of ... areas of Bangladesh Moreover, the concentration of organic matter is sometimes unnoticed in the installation process of the treatment unit Several techniques were reported for the removal of arsenic ... period of 100 bed volumes of effluent water (standard deviation < 0.6% of removal efficiency) Slightly, higher removal performance with increased bed volume of treated water was due to deposition of...
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Báo cáo sinh học: "The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil" pdf
Ngày tải lên :
18/06/2014, 19:20
... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... determination of the rates of aerobic glycolysis, 0.1 mL aliquots of culture media were collected and used for enzymatic determination of lactate [11] Cell death assays Exposure of phosphatidylserine ... 5-FU treatment of G-, M- and especially SM-cells resulted in a significant percentage of annexin-positive stained cells compared to controls (Figure 2), suggesting induction of apoptosis in response...
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báo cáo hóa học:" The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil" ppt
Ngày tải lên :
20/06/2014, 03:20
... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... determination of the rates of aerobic glycolysis, 0.1 mL aliquots of culture media were collected and used for enzymatic determination of lactate [11] Cell death assays Exposure of phosphatidylserine ... 5-FU treatment of G-, M- and especially SM-cells resulted in a significant percentage of annexin-positive stained cells compared to controls (Figure 2), suggesting induction of apoptosis in response...
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báo cáo hóa học:" Immunological response to highly active antiretroviral therapy following treatment for prevention of mother to child transmission of HIV-1: a study in Côte d’Ivoire" pdf
Ngày tải lên :
20/06/2014, 08:20
... up of each patient at the date of last visit, or death, or date of switch to a protease inhibitor (PI) to evaluate the response to non-nucleoside reverse transcriptase inhibitor (NNRTI)-based treatment ... al.: Immunological response to highly active antiretroviral therapy following treatment for prevention of mother to child transmission of HIV-1: a study in Côte d’Ivoire Journal of the International ... understand the dynamics and rate of treatment failure in our population Switching treatments without using viral load data for making these decisions is indeed of utmost concern [10,11] Second,...
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Báo cáo y học: "Clinical response to discontinuation of anti-TNF therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab" ppsx
Ngày tải lên :
09/08/2014, 06:22
... intervals) of retreatment after discontinuation of infliximab in patients treated for ankylosing spondylitis Retreatment depended on the duration of response to the initial treatment Of the 42 ... candidates for R442 ation of infliximab treatment Kaplan-Meier analysis of time to relapse in AS patients after discontinuation of infliximab treatment (a) Cumulative probability of relapse analyzed ... clinical remission and disease activity and response to discontinuation of treatment Patients in partial remission at TP1 (n = 15) had a longer duration of response than patients who did not fulfill...
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