prediction of drug pharmacokinetics in different pediatric age groups

... Department of Internal Medicine, University of Turin, Turin, 10060, Italy 8Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, 53127, Germany 9Liver Research Group, Institute ... http://genomemedicine.com/content/3/8/57 in the African American population, where the linkage disequilibrium is lowest, allowing breaking up of the large haplotype block and thus allowing inference of the ... Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort Genome Medicine...

Ngày tải lên: 11/08/2014, 12:21

... Page of Number of ABVD cycles a Adriamycin, Bleomycin, Vinblastine, Decarbazine; bIfosfamide, Carboplatin, Etoposide; cEtoposide, Cisplatin, Cytarabine, Methylprednisolone; d Cyclophosphamide, Vincristine, ... median age is 30 years, were included in the study Fifty five percent are males and 47.7% have early stages of HL and complaining of B-symptoms Most of the patients (76.2%) received cycles of ABVD ... affecting drug transport to cancer cells MDR1 protein, called P-glycoprotein (P-gp), belongs to ATP-binding cassette superfamily [8] A number of polymorphisms in the MDR1 gene were found to be of...

Ngày tải lên: 10/08/2014, 10:21

... National Bureau of Statistics of China China statistical yearbook 2003 [in Chinese] Beijing: China Statistics Press 2003: 100-102 19 Chongqing Municipal Bureau of Statistics Chongqing statistical ... around age 8-9 and that, since this shift could be explained by an increased in myopia, ages and are the critical ages for occurrence of myopia Similarly, we found that age had a significant influence ... the time of selection were also included During door-to-door selection interviews, a parent or legal guardian of the child was informed of the study details, including the side effects of pupillary...

Ngày tải lên: 25/10/2012, 11:40

... cornfield increased the atrazine mass loss in runoff leaving the RBS increased (Table 4) Atrazine mass in runoff leaving the RBS were in the range of to 21% of the amount entering the RBS This implied ... manipulation of input data in each window session RESULTS AND DISCUSSIONS Simulation of atrazine fate, leaching and runoff loss As atrazine load into the RBS and the runoff depth from the cornfield increased ... literature The movement of atrazine in the RBS soil profile was examined under a worst-case scenario, where intense rainfall generated varying amounts of atrazine loss in runoff from the cornfield...

Ngày tải lên: 05/09/2013, 09:08

... the beginning of leaching, decreased after a peak, and then increased and decreased again This behavior indicates that the initial leaching is like Na+ leaching, and the surplus Ca2+ is drained ... and a height of 20 mm (Fig 2) This structure exposes 18 mm of the point of the current supply electrode and 12 mm of the point of the voltage measurement electrode while insulating the other ... observe the runoff rate of salts The four-electrode sensor consisted of four stainless steel rods inserted in parallel into an acrylic column with an inner diameter of 50 mm, outer diameter of 60 mm,...

Ngày tải lên: 05/09/2013, 09:38

... degree in Agricultural Machinery Engineering from Tarbiat Modares University, Iran He is currently an Associate Professor in Department of Agricultural Machinery Engineering in University of Tehran ... Use Pattern Analysis of Sunflower Production in Golestan Province of Iran In Proceedings of International Agricultural Engineering Conference 2010 Sept 16-20, Shanghai, China 2010, 369-375 Kallivroussis ... currently an Associate Professor in Department of Agricultural Machinery Engineering in University of Tehran His current research interest is mechanics of agricultural machinery E-mail address:...

Ngày tải lên: 05/09/2013, 16:30

... combinations of language-pair and domain, each with fourteen distinct training sets of increasing size and tested these instances on multiple in- domain datasets, generating 96 learning curves BLEU ... 10K point is not an extrapolation point but lies within the range of the set of initial points However, it does give a measure of the closeness of the curve fit using only the initial points with ... from data The training data for fitting these linear models is obtained in the following way For each configuration (combination of language pair and domain) c and test set t in Table 2, a gold...

Ngày tải lên: 07/03/2014, 18:20

... wild strains of human type that have never come into contact with the drugs (Mitchison, 1984) Monoresistance is defined as resistance to one of the first-line drugs Any drug resistance is indicated ... for a drug with and without accompanying other drug resistance Polydrug resistance is resistance of M tuberculosis strain to two or more of the first-line drugs MDR is a special subgroup of polyresistance, ... was expressed as the percentage of colonies that grew on critical concentrations of the drugs The ratio between the number of colonies growing on drugcontaining and drug free medium should be...

Ngày tải lên: 29/03/2014, 03:20

... or on a point-by-point basis (at individual frequencies) In the frame of the Kirchhoff method, the average coefficient of light scattering by surface fractal structures was calculated in chapter ... mode-matching technique, method of moments and finite difference method defined in the frequency domain was proposed for electromagnetic wave scattering from structures containing complex cylindrical ... explosion in the research with metamaterials according to two different mathematical viewpoints Finally, in the last chapter, beamforming of antenna arrays focused in near field zone or intermediate-field...

Ngày tải lên: 19/06/2014, 19:20

... electric field of the scattering wave in complex  that the problem of a finding I s is reduced to a finding of the scattered field Es The scattered field we shall find behind Kirchhoff method [16], ... on the area of rough surface - the removed wave scattering not only in direction of floppy, and, in general speaking, in different directions Intensity of the radiation dissipated in that or other ... becomes complicated Independence of the type of scattering surface there is dependence of the scattering coefficient from the incidence angle of light wave As far as an increase of the incidence angle...

Ngày tải lên: 19/06/2014, 19:20

... containing the investigated element and then utilizing the analytical iterative model for determining scattering parameters of arbitrary configuration of objects The obtained solution can be combined ... a hybrid method of electromagnetic wave scattering from structures containing complex cylindrical or spherical objects is presented Depending of the investigated post geometry different numerical ... electromagnetic waves in uniaxial crystal; three kinds of electromagnetic waves in biaxial crystal and three kinds of distorted 72 Behaviour of Electromagnetic Waves in Different Media and Structures...

Ngày tải lên: 19/06/2014, 19:20

... and lines of electric flux pass from the inner to the outer surfaces In the principle mode of radial-line cavity only Ez , and H z are different from zero and these quantities are independent of ... currents circulating in the walls and is due to the finite conductivity of the metal of the walls The total energy of the oscillations is the integral over the volume of the cavity of the energy ... degree of excitation, are inversely proportional to the product of the effective depth of penetration of the fields and currents into the walls, the skin depth, and the conductivity of the metal of...

Ngày tải lên: 19/06/2014, 19:20

... material paintings Chinese ancient wall paintings can be generally distinguished according to different drawing site, such as palace paintings, temple paintings, grotto frescoes, coffin chamber ... wall paintings and palace wall paintings is achieved by distinguishing the tone when tapping wall paintings by hand, such experience is useful in determining the area and degree of delamination, ... profiles at different sampling frequency Detection of Delamination in Wall Paintings by Ground Penetrating Radar 129 In Fig 8, the length of the radar profile is about 2.1 m, the interval of...

Ngày tải lên: 19/06/2014, 19:20

... Presentation of GPR profile H5 Fig 29 Presentation of GPR profile V1 Detection of Delamination in Wall Paintings by Ground Penetrating Radar 139 Fig 30 Comprehensive interpretation of delamination in wall ... of a self-induced transparency submits to nonlinear equation of Schrödinger with logarithmic nonlinearity The way of connection of an average number filling and energy of the impulse taking into ... Let's find sinθ = sinθ'cosδ + sinδcosθ' Considering that δ is too small we find  p sinδcosθ'  ' ' sinθ = sinθ'  +  = sinθ  + cosθ  The law of sines for a triangle on fig is sinθ'  pe...

Ngày tải lên: 19/06/2014, 19:20

... acceleration; III: Intravalley scattering; IV: Intervalley scattering; (b) ideal acceleration of electrons in bulk GaAs Taking advantage of the novel experimental method, invaluable information on ... single layer The combined effect of gravitationally decreasing densities of neutral atoms and molecules and increasing intensity of ionizing solar ultraviolet radiation with increasing altitudes, gives ... understanding the nonequilibrium transport of carriers in bulk GaAs, the intrinsic property of the negative differential conductivity (NDC) in the THz region, which means the gain, can be clarified In...

Ngày tải lên: 19/06/2014, 19:20

... Even the linear sensing dipole, receives half of energy of circularly EMF radiation in any direction of transverse plane 217 Exposing to EMF Dosimetry According to a definition the amount of a substance ... ρm (15) The geometry of human body determines the type of induction In case of isolated feet from ground we consider an un-grounded case And in case of bare foot the image of human contributes ... can be defined as + Z ) −1 ≈ − Z2 The real and the imaginary part of the refractive index and the phase velocity of the polarized ordinary and extraordinary wave can be determined by using this...

Ngày tải lên: 19/06/2014, 19:20

... waveform of the PMOS FET on the second stage of the on-chip inverter In Fig b, Ea is the differential value of the drain-source voltage Vds according to the definition of the voltage potential in the ... than adults In addition, since they are in their growing age, their growth hormones are in high level, so any even low interfering to their organic system of adjusting hormones, remains the un-returnable ... EMF exposing clinical effects [17, 18] 3.2 Burning and shocking Burning or shocking can be seen by contacting to conductive materials inside of the EMF This effect can be separated from indirect...

Ngày tải lên: 19/06/2014, 19:20

... enough than it of the on-chip interconnect Fig 11 shows the analyzing model of the on-chip interconnect as the transmission line Fig 11 Analyzing model of the on-chip interconnect In Fig 11, this ... Improvement of Reduction of Decoupling on the PCB Impossible Numbers of Anode multiple Single Large Small Large Large Very Large Large Thickness of Aluminum foil Numbers of Aluminum foil Thickness of ... repetitions of the SEMW on SMC The wave shape of the signal voltage is got by integral of the wave shape of the SEW because the signal voltage is formed by the charging action of the SEW The timing analysis...

Ngày tải lên: 19/06/2014, 19:20

... confined electrons in a cylindrical quantum wire in the presence of a magnetic field with case of confined phonons The nonlinear absorption coefficient of a strong electromagnetic wave α in a cylindrical ... γ ,k z   We insert the  expression of n γ ,k ( t ) into the expression of jz (t) and then insert the z expression of jz (t) into the expression of α in Eq.(27) Using property of Bessel function ... is intrinsically right-handed, a particle which is intrinsically left-handed, or, by taking a linear combination of solutions, a particle such as the electron that has no intrinsic chirality In...

Ngày tải lên: 19/06/2014, 19:20

... embarked on the study of the underlying physics of the bigrating The main works, from the point of view of these authors, are gathered together in the following points according to the different theses ... Babinet’s principle can be invoked to obtain the propagation characteristics of an infinitely thin patch array As it has been indicated earlier, the reflection coefficient of an in nitely thin ... Response of Extraordinary Transmission Plates Inspired on Babinet’s Principle 333 To put this pedagogically in an example within the context of the topic of the chapter, let us show the response of...

Ngày tải lên: 19/06/2014, 19:20