preclinical models of pancreatic cancer

Mouse models of breast cancer metastasis: Anna Fantozzi and Gerhard Christofori pdf

Ngày tải lên : 22/03/2014, 17:20

... Amplification of the gene encoding ErbB2, a member of the EGF receptor gene family, is associated with 15 to 20% of human breast cancers, and in about 30% of cases the increased expression of an activated ... close similarity of this Page of 11 (page number not for citation purposes) Available online http://breast -cancer- research.com/content/8/4/212 Table Transgenic mouse models of breast cancer metastasis ... expression of alternatively spliced isoforms v6 and v9 of CD44 in breast cancer cells, leading to an increase in cell migration [84] In a similar approach, sublines of the breast cancer cell...

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báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt

Ngày tải lên : 18/06/2014, 15:20

... phase of pancreatic cancer cells in vitro The sigma-2 The sigma-2 ligand SV119 induces moderate apoptosis in both G0 and G1 to G2/S phase of pancreatic cancer cells in vitro The murine pancreatic ... selected sigma-2 ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animal models of cancer including pancreas cancer [12,13,15] The mechanisms ... both G0 and G1 to G2/S phase of pancreatic cancer cells in vitro Next, in order to further characterize this effect, we evaluated the growth phase of these pancreatic cancer cells under these conditions...

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báo cáo hóa học:" Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis" doc

Ngày tải lên : 18/06/2014, 15:20

... set of biomarkers used to fit models of pancreatic cancer diagnosis, we used the R distribution of the Prediction Analysis of Microarrays statistical technique, PAMR Logistic regression models ... plasma of pancreatic cancer patients, we investigated whether a panel of tumor markers could diagnose the presence of pancreatic cancer more accurately than the current standard tumor marker for pancreatic ... of pancreatic cancer more A tumor marker panel consisting of CA19-9, OPN, and CHI3L1 predicts the presence of pancreatic cancer more accurately than CA19-9 alone (A) Each row corresponds to of...

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Báo cáo hóa học: " Ezrin promotes invasion and metastasis of pancreatic cancer cells" ppt

Ngày tải lên : 18/06/2014, 16:20

... study, we investigated the effect of ezrin on the motility and invasion ability of the pancreatic cancer cell line MiaPaCa-2, as well as the expression of ezrin in pancreatic duct adenocarcinoma, ... with cortactin to form podosomal rosettes in pancreatic cancer cells, thereby playing a role in pancreatic cancer invasion [28] However, the mechanisms of ezrin-mediated tumor development still ... percentage of labeled tumor cells as follows: score 0, < 25% positive cancer cells; score +, 25-50% positive cancer cells; score ++, 50-75% positive cancer cells; and score +++, > 75% positive cancer...

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Báo cáo sinh học: "Pro-apoptotic activity of a-bisabolol in preclinical models of primary human acute leukemia cells" pptx

Ngày tải lên : 18/06/2014, 19:20

... Department of Sciences of Life and Reproduction, Section of Biochemistry, University of Verona, Italy 2Department of Medicine, Section of Hematology, University of Verona, Italy 3Department of Biochemistry ... in preclinical models of primary human acute leukemia cells Journal of Translational Medicine 2011 9:45 Page 13 of 13 Submit your next manuscript to BioMed Central and take full advantage of: ... three subgroups of leukemias with different sensitivities over 24 hours a-bisabolol was effective with an IC50 of 14 ± μM in a substantial proportion of Ph-B-ALL, and with an IC50 of 45 ± μM in...

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s Membrane proteomic analysis of pancreatic cancer cells docx

Ngày tải lên : 10/08/2014, 05:21

... RH, Pandey A: A Compendium of Potential Biomarkers of Pancreatic Cancer PLoS Med 2009, 6(4):e1000046 33 Grote T, Logsdon CD: Progress on molecular markers of pancreatic cancer Curr Opin Gastroenterol ... of pancreatic cancer in an orthotopic murine model1 J Surg Res 2004, 120(2):295-303 22 Walsh N, O’Donovan N, Kennedy S, Henry M, Meleady P, Clynes M, Dowling P: Identification of pancreatic cancer ... the identification of new tPA receptors in pancreatic cancer cells Proteomics 2006, 6(S1):S36-S41 25 Rathinam R, Alahari S: Important role of integrins in the cancer biology Cancer Metastasis...

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Báo cáo khoa học: "Beneficial effects of erythropoietin in preclinical models of shock and organ failure" ppsx

Ngày tải lên : 13/08/2014, 03:21

... period of days [12] The reported beneficial effects of EPO in preclinical models of shock, trauma and haemorrhage are exciting, but further studies are warranted to determine the effects of EPO ... effects of EPO in murine endotoxaemia are secondary to both antioxidant and anti-inflammatory effects of EPO, which have been reported in other models of disease [11] Thus, the beneficial effects of ... beneficial effects of EPO in rodent models of endotoxaemia may vary with doses of EPO and LPS, as well as species (rat or mouse) used Interestingly, higher doses of EPO reduce both the systemic inflammation...

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ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER

Ngày tải lên : 12/10/2015, 17:35

... ELUCIDATING THE ROLE OF AUTOPHAGY IN ZEBRAFISH MODELS OF LIVER CANCER SIM HUEY FEN, TINA (B.Sc.(Hons.)), NUS A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF BIOLOGICAL SCIENCES ... Table of contents Table of contents Acknowledgements i Table of Contents ii-iv Summary v-vi List of Tables vii List of Figures viii-x List of Common Abbreviations xi-xii Introduction The use of ... the study of cancer 1.1 The use of zebrafish as a model organism in vertebrate developmental biology studies 1.2 The use of zebrafish as a model organism in cancer studies 1.3 Generation of inducible...

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Báo cáo sinh học: "Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" doc

Ngày tải lên : 18/06/2014, 19:20

... advantage of upregulation of IL-13Ra2 in pancreatic cancer cell lines and hypothesized that HDAC inhibitors may enhance the sensitivity of IL-13 receptortargeted immunotoxin, IL-13-PE, in pancreatic cancers ... combination of HDAC inhibitors and IL-13-PE may have a prominent role in pancreatic cancer or other cancer therapies in the clinic Materials and methods Cell culture and reagents Pancreatic cancer ... IL-13Ra2 expression in pancreatic cancer cell lines Eleven pancreatic cancer cell lines and three types of normal cell lines (fibroblast, umbilical vein endothelial cells and pancreatic ductal epithelial...

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báo cáo hóa học:" Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer" pot

Ngày tải lên : 20/06/2014, 03:20

... advantage of upregulation of IL-13Ra2 in pancreatic cancer cell lines and hypothesized that HDAC inhibitors may enhance the sensitivity of IL-13 receptortargeted immunotoxin, IL-13-PE, in pancreatic cancers ... combination of HDAC inhibitors and IL-13-PE may have a prominent role in pancreatic cancer or other cancer therapies in the clinic Materials and methods Cell culture and reagents Pancreatic cancer ... IL-13Ra2 expression in pancreatic cancer cell lines Eleven pancreatic cancer cell lines and three types of normal cell lines (fibroblast, umbilical vein endothelial cells and pancreatic ductal epithelial...

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Báo cáo khoa học: "Proposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence" ppsx

Ngày tải lên : 09/08/2014, 08:23

... Frequency of lymph nodal metastasis of pancreatic cancer Page of 13 treatment of pancreatic cancer has not been addressed With more effective chemotherapy for systemic treatment of pancreatic cancer, ... http://www.ro-journal.com/content/5/1/28 Page of 13 Figure Flowchart of studies to final number of eligible studies Table Classification of regional lymph nodes of the pancreas No of Study Studies Year Location of Tumors No of Patients ... rates of pancreatic head cancer; cancer of body/tail of pancreas in only Sun et al Radiation Oncology 2010, 5:28 http://www.ro-journal.com/content/5/1/28 Page of 13 Figure JPS Classification of...

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Báo cáo khoa học: "Helical tomotherapy with concurrent capecitabine for the treatment of inoperable pancreatic cancer" doc

Ngày tải lên : 09/08/2014, 09:20

... of the clinical application of helical tomotherapy for locally advanced pancreatic cancer [35] To the best of our knowledge, this is first comprehensive analysis of the clinical application of ... each day of radiation and continued for the duration of the radiation therapy [3] Figure Distribution of isodoses in the planning of helical tomotherapy in patients with advanced pancreatic cancer; ... Treatment of Cancer (EORTC) International journal of radiation oncology, biology, physics 1995, 31:1341-1346 Shankar A, Russell RC: Recent advances in the surgical treatment of pancreatic cancer...

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Báo cáo khoa học: "Gemcitabine/cisplatin versus 5-fluorouracil/ mitomycin C chemoradiotherapy in locally advanced pancreatic cancer: a retrospective analysis of 93 patients" pptx

Ngày tải lên : 09/08/2014, 09:20

... calculated for analysis of survival Survival was calculated from date of diagnosis to date of death or date of last contact Pair wise log-rank test was employed for comparison of the differences in ... July 2011 Published: 27 July 2011 References UK cancer mortality statistics for common cancers [http://info cancerresearchuk.org/cancerstats/mortality/cancerdeaths/?a=5441] Malvezzi M, Arfe A, Bertuccio ... treated in pancreatic head and body tumours were the regions 8, 9, 12, 13, 14, 16a2, 16b1, 17, and 18 to the right of the left edge of the aorta according to the Japanese Gastric Cancer Association...

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báo cáo khoa học: " Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome " pptx

Ngày tải lên : 10/08/2014, 10:21

... and primary cultures, induction of apoptosis of pancreatic cancer with traditional Chinese anti -cancer drugs would be probably a promising approach of pancreatic cancer Multiple signal pathways ... apoptosis in human pancreatic cancer As this Figure The inhibitory effect of oxymatrine on the growth of PANC-1, BxPc-3 and AsPC-1cells The inhibitory effects of oxymatrine on the growth of PANC-1, BxPc-3 ... Figure The effect of oxymatrine on release of mitochondrial cytochrome c and activation of caspase-3 The effect of oxymatrine on release of mitochondrial cytochrome c and activation of caspase-3 PANC-1...

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báo cáo khoa học: "Dysregulation of miR-15a and miR-214 in human pancreatic cancer" potx

Ngày tải lên : 10/08/2014, 22:21

... development of the disease Overexpression of exogenous miR-15a inhibited the viability of pancreatic cancer cells, suggesting that downregulation of miR-15a might be involved in the progression of pancreatic ... calculated to indicate the frequency of a miRNA expression downregulated or upregulated in pancreatic cancer Page of development or in the chemoresistance of pancreatic cancer This is the first report ... function of miR-214 in human pancreas Table Expression of miRNAs in pancreatic cancer specimens compared with adjacent benign pancreatic tissues miRNA Median valve Upregulated in pancreatic cancer...

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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc

Ngày tải lên : 11/08/2014, 00:23

... BRCA1-associated breast cancer, increased expression of several components of the IGF axis is seen in liver, normal mammary tissue and mammary tumors of these mice along with increased levels of IGF-1 in ... therapeutic potential of candidate biomarkers, such as IGF-1 for the early detection of breast cancer These studies are important since the breast cancers from populations of women at high risk ... breast cancer in young women: a pooled re-analysis of three prospective studies Eur J Cancer Prev 2005, 14:493-6 Renehan AG, Frystyk J, Flyvbjerg A: Obesity and cancer risk: the role of the insulin-IGF...

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Báo cáo y học: "MALDI-TOF MS Combined With Magnetic Beads for Detecting Serum Protein Biomarkers and Establishment of Boosting Decision Tree Model for Diagnosis of Colorectal Cancer"

Ngày tải lên : 25/10/2012, 11:18

... al Genetic models of human cancer as a multistep process Paradigm models of colorectal cancer, breast cancer, and chronic myelogenous and acute lymphoblastic leukaemia J Exp Clin Cancer Res.2005; ... based on a first pass of signal-noise ratio of and a minimum peak threshold of 20% of all spectra This process was completed with a second pass of peak selection at 0.2% of the mass window, and ... (AIHW), Australasian Association of Cancer Registries (AACR) Cancer in Australia In: Cancer in Australia 2001; Cancer series number 28 Canberra: Australian Institute of Health and Welfare 2004: 6-25...

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Models of motherhood in the abortion debate - self-sacrifice versus self-defence

Ngày tải lên : 01/11/2013, 08:20

... women in the form of the right to an abortion as an instrument of care-giving not to the fetus, of course, but to others We can see a good example of the use of a traditional model of motherhood ... model of motherhood and abortion rights Underlying the problem deWnition of abortion rights is a traditional view of motherhood – one that rests upon a relational view of women, deWned in terms of ... Clause of the Fourteenth Amendment of the Constitution prohibits the state from depriving ‘any person of life, liberty, or property without due process of law’ This Due Process right of privacy...

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Tài liệu The Early Detection Research Network: Investing in Translational Research on Biomarkers of Early Cancer and Cancer Risk docx

Ngày tải lên : 14/02/2014, 21:20

... presence of colorectal cancer using serum, stool and urine Definition of colon cancer: Cancer that forms in the tissues of the colon (the longest part of the large intestine) Most colon cancers ... on Biomarkers of Early Cancer and Cancer Risk One of the most consistent properties of lung cancers is their high level of chromosome instability that is reflected in imbalance of chromosome ... prevalent cancers in the United States (colorectal cancer) , a cancer with the fastest rising incidence (liver cancer) and two of the most deadly malignancies (esophageal and pancreatic cancers)...

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