precision of parameter estimates in linear models

... criterion concerning a linear combination of estimates The CD of a linear combination u’u will be a function of the ratio of the variance of x’u after the experiment to the variance of x’u before ... experiment, ie: The CD of individual is a particular form of this formula In an individual that x’u All the CDs, of both individuals and linear combinations, are then ratios of quadratic forms x’(A ... singular, Mixed model equations estimator) of b and following equation system (Henderson, 1984): BLUE (Best linear unbiased M is a projector, orthogonal or, if x is a linear combination of X Precision...

Ngày tải lên: 14/08/2014, 19:22

... unique) set of points in the parameter space Individual parameters within this set could have a very large domain, resulting in a large variation within the individual parameter, i.e the parameter ... each parameter in the bar chart of Figure The first bar represents the actual value of the parameter as determined in [12] The remaining bars represent the estimated values of the corresponding parameter, ... (L being the iteration number), in the order of the highest to the lowest sensitivity To make the adjustment of the net influence of each of the remaining parameters on the already selected parameters,...

Ngày tải lên: 20/06/2014, 22:20

... to the incidence of (or connectedness of due to the incidence of 0) in a model including 0, and A using the terminology of Foulley et al (1984, 1990) This terminology is also in agreement with ... different numbers of parameters In that § respect q can be interpreted as a kind of average measure of connectedness for (0i,!) among all pairs of levels of the factor9 due to the incidence of the nuisance ... the definition of an objective criterion for measuring the degree of connectedness between factors involved in Gaussian linear models of genetic evaluation The procedure proposed herein is based...

Ngày tải lên: 14/08/2014, 20:20

... but were mainly clustered with intermediate sensitivity AML Interestingly, introducing both CD34+ and CD33+my cell sensitivity to a-bisabolol (as the mean value of cases) in clustering analysis ... proliferation of the cell line Means ± SD of experiments Right side Plot showing the corrisponding combination index (CI) vs the fraction affected (Fa) CI values are

Ngày tải lên: 18/06/2014, 19:20

... Murine LN showing recruited cells (red fluorescent staining, see arrow) (g) Merger of (e) and (f ) showing a lack of nonspecific cellular staining (h) DAPI staining showing cell nuclei (original ... inflammation during an acute response that may offer insight into early proinflammatory cytokine release in the initial phases of the inflammatory response This is often lost by using models such ... critical in acute inflammation of murine joints in as early as 24 hours after zymosan injection (n = number of joints analyzed) in EL4/6.1 thymoma cells [31,64] From our previous findings, we...

Ngày tải lên: 12/08/2014, 14:22

... often performed in the early stages of care Although physician input is known to increase triage precision [8,9], triage is often performed independently by paramedics with limited training in ... the introduction of trauma triage guidelines (Fig 1) The continuous process of performance improvement as proposed by ACS-COT [14] refers to a cycle of monitoring, finding, fixing, and monitoring ... unexpected lack of increased triage precision These results indicate that paramedics need further training in evaluating trauma victims We also call for improved routines in communicating patient...

Ngày tải lên: 13/08/2014, 23:20

... selection intensity and CD the coefficient of determination of the animal selection index p plays the same role in [21] as CD in (22] The increase of i induces a decrease of R, initially because of ... measure of connectedness Lalo6 (1993) introduced the concept of generalized coefficient of determination (CD), the CD of a linear combination of genetic values, and suggested a new definition of disconnectedness ... source of a decrease of precision, and its study has no inherent interest Its study may permit the choice of a strategy for precision increase, either by connectedness increase or by an increase of...

Ngày tải lên: 09/08/2014, 18:22

... partially linear models for longitudinal data with only -mixing and r-mixing In fact, our results with other mixing-dependent structures, such as a-mixing, *-mixing and r*-mixing, can also be obtained ... Heckman, N: Spline smoothing in a partly linear models J R Stat Soc B 48, 244–248 (1986) Speckman, P: Kernel smoothing in partial linear models J R Stat Soc B 50, 413–436 (1988) Robinson, PM: Root-n-consistent ... properties of the estimators In practice, a great deal of the data in econometrics, engineering and natural sciences occur in the form of time series in which observations are not independent and often...

Ngày tải lên: 20/06/2014, 22:20

... for each trait within each level pointing to the beginning of first trait in the respective effect level For convenience of programming the actual address minus is used For linear = = = = = covariables ... results in a factorization step as in the following In the presence of rounding errors (or in case of near dependence) we obtain entries of order eB in place of the diagonal zero (This even holds ... estimation package, in: Proceedings of an EC Symposium on Application of Mixed Linear Models in the Prediction of Genetic Merit in Pigs, Mariensee, 1994 Groeneveld E., A reparameterization to...

Ngày tải lên: 09/08/2014, 18:22

... sex in threshold linear models, i.e estimating one parameter for each score Thus, this is a useful way to improve the goodness -of- fit of the models with a small increase in the number of parameters ... threshold linear models, a threshold log -linear Weibull model, and a grouped data model for the analysis of carcass conformation and fat cover in beef cattle The three threshold linear models were ... participating in the Yield Recording Scheme of the breed Two traits were analysed in this study: the CON score, which describes the development of essential parts of the carcass profile according to...

Ngày tải lên: 14/08/2014, 13:21

... the parameter of interest In the classical sense, this is equivalent to taking into account errors in estimation of all other parameters in the model when inferences about a parameter of interest ... BLUP is the linear function of the data that minimizes mean square error of prediction in the class of linear unbiased predictors Bulmer (1980), Gianola and Goffinet (1982), Goffinet (1983) and ... that uncertainty about the remaining parameters is fully taken into account The starting point is the joint posterior density of all unknowns From the joint distribution, the marginal posterior...

Ngày tải lên: 14/08/2014, 19:22

... using regression splines, the model is linear, where as non-parametric estimation using smoothing splines, leads to an additive model In this paper we investigate the efficacy of using Bayesian dynamic ... generalised linear models (DGLMs, West et al (1985) and Fahrmeir and Tutz (2001)) to analyse air pollution and health data Dynamic generalised linear models extend generalised linear models by allowing ... the hyperparameters are estimated using Akaike Information Criterion (AIC) The remainder of this subsection describes the model building process, including justifications for the choice of models...

Ngày tải lên: 17/02/2014, 10:20

... be used interchangeably in this document, reflecting common usage In all cases externalities are calculated to give marginal figures, or figures cose to being marginal The dominance of health ... applied in the future External costs of air pollution vary according to a variety of environmental factors, including overall levels of pollution, geographic location of emission sources, height of ... arise because of the non -linear nature of the atmospheric chemistry of ozone Indeed, this is so non -linear that at high NOx concentrations, NOx emissions will reduce, rather than increase ozone...

Ngày tải lên: 17/02/2014, 22:20

... connected to Σ3 in Br0 −20 h (y) ∩ Σ, with ∂γ3 ⊂ ∂Σ, such that ∂Br0 −10 h (y) ∩ γ3 consists of an odd number of points in each of two distinct components of H ∩ Σ To that, we begin by applying Lemma ... The space of minimal embeddings of a surface into a three-dimensional manifold of positive Ricci curvature, Invent Math 81 (1985), 387–394 [CM1] T H Colding and W P Minicozzi II, Minimal Surfaces, ... space of embedded minimal surfaces of fixed genus in a 3-manifold III; Planar domains, Ann of Math., to appear; math.AP/0210141 [CM6] ——— , The space of embedded minimal surfaces of fixed genus in...

Ngày tải lên: 14/03/2014, 22:20

... cells, independently of CD81 expression [51,52] The limited involvement of CD81 in the binding process was further illustrated by the poor binding inhibition achieved in the presence of mAbs ... culture of infected hepatocytes To succeed in obtaining HCV infection in primary human hepatocytes, an existing model of hepatitis B virus infection was used to determine optimal infection conditions ... mutations are at the N-terminus of the NS3 helicase, in two distinct positions of NS4B, in the centre of NS5A and in the C-terminal region of NS5B [3–6] The significance of these mutations has been...

Ngày tải lên: 16/03/2014, 05:20

... For the first time since this monitoring task began, the data indicate a decline in both the poverty rate and the number of poor in all six regions of the developing world  Between 2005 ... Development Goal of halving the 1990 incidence of extreme poverty by 2015  Using the $1.25 a day line, the developing world as a whole reached the MDG1 in 2010, despite the global financial crisis ... standards of middle-income developing countries, and certainly by the standards of what poverty means in rich countries  There has been less long-run progress in getting over the $2 per day hurdle Indeed,...

Ngày tải lên: 29/03/2014, 09:20

Ngày tải lên: 24/04/2014, 17:20

... NI, Husain SR, Kreitman RJ, Haas GP, Pastan I, Debinski W: Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 ... HDAC inhibition increases the anti-cancer effect of IL-13PE targeting IL-13Ra2 in vitro and in vivo As HDAC inhibition increased IL-13Ra2 expression in IL-13Ra2-negative but not in normal cell lines, ... variability of IL-13Ra2 expression in cancer cells The role of histone acetylation was explored further using histone deacetylase (HDAC) inhibitors Interestingly, in the presence of HDAC inhibitors...

Ngày tải lên: 18/06/2014, 19:20