potential use of mmp inhibitors
Báo cáo khoa học: Combined use of selective inhibitors and fluorogenic substrates to study the specificity of somatic wild-type angiotensin-converting enzyme docx
... the use of selective inhibitors as convenient tools to study the specificity of the somatic form of ACE Thus, with this approach, the catalytic property of each domain towards the hydrolysis of ... enzyme The conservation of these residues was then checked, using aligned sequences of the N-domain and C-domain of human, mouse and rat enzymes The model of the N-domain of human ACE (ACE-N) was ... inhibition profile of mouse ACE, suggesting that the Mca-Ala substrate is mostly cleaved by the N-domain of mouse ACE 1774 To conclude this part, the inhibition profiles obtained with both RXP inhibitors...
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Báo cáo khoa học: "The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosis" pdf
... the fragility of agarose plugs, the corners tended to break off easily Therefore, to ensure that the same number of cells (DNA) per lane was loaded into a gel, we cut a section of the better ... to arbitrary units of optical density using a digital imaging analysis system (GelDoc 2000 and Quantity One software, Bio-Rad) The sum of fluorescence within DNA smears was used for calculations ... found that the pattern of DNA smears consisted of a compression zone (CZ) just below the wells, which was more patent in irradiated cells, followed with an area of distribution of DNA fragments ending...
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báo cáo khoa học: "Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy" ppsx
... (2 of patients with AMM and of patients with MCL), and SD/hematologic improvement occurred in 40% (4 of 22 patients with AML, of patients with MDS, of patients with AMM, of patients with CLL, of ... dysregulated in many different types of cancer, single-agent use of mTOR inhibitors could potentially result in anticancer activity in numerous tumor types Additionally, because mTOR is pivotal in the ... accumulation of HIF [11] mTOR regulates the synthesis of HIF-1α, and when loss of VHL function coincides with upregulation of mTOR activity, this scenario can drive overexpression of angiogenic...
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evaluate potential use of gut weed (enteromorpha sp.) as a food source for tilapia (oreochromis niloticus): affect on survival and growth
... 10.9 g/100 g of total fatty acid, respectively The protein of this seaweed has a high digestibility (98%) The findings of Banerjee et al (2009) on biochemical composition of three kinds of seaweeds ... environment and development stages of fish The growth of fish is an important factor used to assess the quality of fish feed intake In aquaculture, besides management of good water quality, feed is ... biochemical composition of Enteromorpha spp from the Gulf of Gdańsk on the southern Baltic Sea coast, Oceanologia 42, 19-28 Ho Tuyet Cuong 2012 Evaluating the potential use of dried gut weed (Enteromorpha...
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Potential use of lichens as an indicator of air polution in urban airshed
... This study made use of visual inspection of roof tops using binoculars to count lichen presences/absences and GPS to record the location of each house This was the enable the use of GIS to investigate ... include the type of roof substrate, the age of the building/roof and whether the roof had been cleaned recently (survey asked) The roof substrate will have an effect on the presence of lichens, as ... residential houses with clay rooves or asbestos-cement rooves were selected randomly At each house, a count of the presence/absence of lichen by a cumulative area of 5x5 quarter roof tile will...
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Integrated local knowledge in implementing forest allocation policy in Central Vietnam: potential use of local indicators in forest monitoring
... status of forest, conservation biologists have used concept of ‘surrogate species’ These species are often represented for several characteristics of a habitat or status of specific group of species ... local uses of these two species In survey, local uses of Ngat are more intensive for house construction and handle of production tools On the contrary, Chan chim seems not provide any use in ... number of naturally co-occurring species (Roberge 2004) In fact, umbrella species is often used for setting minimum size of area or group of species for conservation purpose Flagship species are used...
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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt
... toxicity of CuCNPs upon reduction of Cu content water, which has a neutral to slightly acidic pH While this feature is promising in terms of the stability of solutions of CuCNPs over long periods of ... pH The use of citrate buffer was less than ideal in this case due to the multiple acidic protons capable of generating four possible species in solution The use of acetate buffer in place of citrate ... effect of competing ligands on Cu release with the idea that the underlying principles governing release could be used in the design/optimization of this class of delivery vectors Release of Cu...
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Báo cáo y học: "Co-existence of a giant splenic hemangioma and multiple hepatic hemangiomas and the potential association with the use of oral contraceptives: a case report" potx
... because of the possibility of malignant transformation and of rupture and massive bleeding, complications which have been Figure oma and1liver hemangiomatosis Computed tomography appearance of ... not be employed because of the high risk of hemorrhage [10] The presence of central hematomas in the giant hemangioma we describe showed possible rupture Serious complications of hemangiomas include ... pattern because of complicating features such as hemorrhage, infarction and thrombosis Differentiation of a splenic hemangioma from malignancy may not be feasible solely on the basis of MRI The...
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Báo cáo y học: "The use of proton pump inhibitors for gastric acid suppression in critical illnes" pdf
... increasing the intragastric pH The principal means of directly protecting the gastric mucosa is the use of sucralfate Although the potential protective effect of enteral nutrition on the gastric mucosa ... headaches, diarrhoea, nausea, constipation and pruritis [59–61] The possibility of achieving a more profound and sustained acid suppression provides a rationale for the use of the PPIs in preference ... Table Use in organ dysfunction Given the prevalence of organ dysfunction or failure among ICU patients, ease of drug handling is an important factor in the choice of prophylaxis for SRMD Because...
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Báo cáo y học: "The therapeutic potential of a venomous lizard: the use of glucagon-like peptide-1 analogues in the critically ill" pdf
... the consequent potential for type errors The authors reported that the use of the GLP-1 analogue failed to reduce hypoglycaemic episodes and glycaemic variability However, the lack of effect on variability ... duration of action [12] Exenatide, a synthetic form of exendin-4, has been shown to reduce fasting and postprandial glucose via glucosedependent stimulation of insulin and suppression of glucagon ... significance of anti-exenatide antibiodies or mild increases in calcitonin concentrations is unclear [14] Albeit preliminary, the present study represents part of a growing interest in the use of incretins,...
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3 carbon isotope discrimination in roots and shoots of major weed species of southern u s rice fields and its potential use for analysis of rice–weed root interactions
... signalgrass Fall panicum Lemont rice PI 312777 rice Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field Shoot Root Corrected rootc Shoot minus corrected ... signalgrass Fall panicum Lemont rice PI 312777 rice Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field Greenhouse Field 40.7 f 41.5 d–f 42.5 a–d 43.5 ab 42.1 c–e 41.7 ... levels in the field primarily because of deployment of ceiling shades intended to maintain greenhouse temperatures within tolerable limits No supplemental lighting was used; thus, day lengths were...
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Laser surface structuring of biocompatible polymers films for potential use in tissue engineering applications
... the degree of Doctor of Philosophy in the Department of Mechanical Engineering at the National University of Singapore under the supervision of Professor Teoh Swee Hin and Associate Professor Hong ... and elongation (λ) of all types of PCL films (Page 52) Table 4.1 Thermal and optical properties of PCL (Page 67) xi List of Figures Fig 2.1 Comparison of moduli of elasticity of biomaterials [15] ... solvent-free method of hot roll-milling • The exploration of the use of lasers to modify the surface of PCL films and understanding the mechanisms behind it, and the effect of the physical and...
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Synthesis of guanidino analogues as potential nitric oxide synthase inhibitors
... result, the design of isoform specific inhibitors is suggested to be a great challenge However, the availability of existing isoform selective NOS inhibitors suggests that isoform selectivity ... lower towards an isoform over that of the other isoform is a selective inhibitor of the former isoform Since there are three NOS isoforms, for a compound to be considered as a NOS isoform selective ... Optimised SPOS of N1-monoalkyl-N2-(mono/di)alkylguanidine 90 13 Synthesis of N1-alkyl-N2-nitroguanidine 98 14 Synthesis of NGAA 113 15 Synthesis of TZN 116 16 Synthesis of TZA 119 17 Mechanism of Dimroth...
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Use of DDGS in Swine Diets
... Use of U.S DDGS in Swine Diets Historical Use of DDGS in Swine Diets Historically, limited amounts (less than 3% of total production) of distiller’s co-products were used in swine ... rates of 05 - Use of DDGS in Swine Diets 0, 15 and 30% without supplemental fat The second trial used the same dietary levels of DDGS as in the first trial, but also evaluated the effect of adding ... reference source Use of DDGS in starter diets Whitney and Shurson (2004) conducted two experiments to determine the effects of increasing dietary levels (0-25%) of DDGS on growth performance of early-weaned...
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Báo cáo y học: "Use of chinese and western over-the-counter medications in Hong Kong"
... non-significant (p > 0.05) Use of Chinese OTC medications and consultations with Chinese medicine practitioners A total of 19.0% of the population used Chinese OTC medications only whereas 7.2% used both Chinese ... level of health and possession of western or Chinese medicine insurance coverage patterns of OTC and medical service use as dependent variables Dependent variables were classified as ‘OTC use only’ ... variables and Use of western OTC medications and consultations with western medicine practitioners Among all respondents (n = 33,263), 9.4% used western OTC medications only whereas 41.4% used both...
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Báo cáo y học: "Use of the measure your medical outcome profile (MYMOP2) and W-BQ12 (Well-Being) outcomes measures to evaluate chiropractic treatment: an observational study"
... rate their general feeling of well-being over the last days on a scale of to 6, with being as bad as it could be Profile P Equals the mean of the scores recorded mental) of a specific problem they ... another section relating to medication [3] Page of (rs) as a measure of the responsiveness, validity, in terms of well-being, and clinical usefulness of the instruments in a chiropractic student ... The authors of this latter study attributed the lack of responsiveness of the W-QB12 to two possible causes: either the socioeconomically diverse population or the preponderance of musculoskeletal...
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Báo cáo y học: "The Versatile Use of Temporoparietal Fascial Flap"
... been used in reconstruction of various defects of 57 patients Each of them was assessed in terms of age, sex, etiologic factors, tumor type, follow-up time, and complications (Table 1) Most of ... reconstruction of the extremities.16 The TPFF can also be used in reconstruction of the oral cavity.17,18 Prefabrication of the TPPF with skin grafts and cartilage tissue gives chance for reconstruction of ... range of axis of rotation, minimal donor site morbidity are some features of the of the TPFF These advantages make this flap a good option in head and neck reconstruction The possibility of using...
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Báo cáo y học: "No increased risk of infant hypospadias after maternal use of loratadine in early pregnancy"
... and risk of hypospadias in offspring Int J Med Sci 2006; 3: 21-5 Källén B, Otterblad Olausson P Monitoring of maternal drug use and infant congenital malformations Does loratadine cause hypospadias? ... Sweden, to BK Conflict of interest The authors have declared that no conflict of interest exists References Pedersen L, Vinther Skriver M, Nørgaard M, Sørensen HT Maternal use of Loratadine during ... the earlier observed association between maternal use of loratadine in early pregnancy and birth of infants with hypospadias was the result of multiple testing Acknowledgments The study was supported...
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Báo cáo y học: "Maternal use of Loratadine during pregnancy and risk of hypospadias in offspring"
... infrequent maternal use of loratadine and the prevalence of hypospadias have a major impact on sample size requirements for providing the definitive assurances of the safety of loratadine to the ... height and weight of the neonate, and personal identifiers for both mother and child [24] Use of loratadine, other antihistamines, IVF drugs, antidiabetics and epileptics As a part of the tax-funded ... were used to link records from all registries Statistical analysis The association between use of loratadine and hypospadias was studied in a nested case-control design within the cohort of women...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... majority of these reports provide evidence of post-fertilisation transfer and maintenance of transgenes Several of the studies report the subsequent generation of viable progeny animals, the cells of ... gene therapy Traditional RVVs would be of minimal potential use, due to the high levels of mosaicism associated with these vectors However, the new generation of lentiviral vectors would avoid such ... Accordingly, even with hormonal induction of superovulation, the numbers of zygotes available per woman would be a strongly limiting factor in the potential use of pronuclear microinjection for human...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25