potential causes of glutamatergic dysfunction in schizophrenia

... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... transport of cholesterol to post-lysosomal destinations Cells from NPC subjects show a decrease in acid sphingomyelinase activity, leading to the accumulation of sphingomyelin [27] Because one of the ... should have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This...

Ngày tải lên: 18/02/2014, 14:20

... for limiting the influence resulting to the Crown by an indefinite power of granting pensions—a Place Bill, to secure the independence of the House of Commons, by making the acceptance of office ... possessing means of the most extensive and corrupting influence, strained them to the utmost; and gaining ground from that moment on the sense of the nation on that main point, have continued ... of Charlemont, from the office of Governor of the County of Armagh—an office which might be considered as hereditary in his family, and to which his estate in that county gave him a kind of indefeasible...

Ngày tải lên: 29/03/2014, 12:20

... backgrounds, schooling in a rural area, having parents living in a rural area, motivation by an interest in medicine, intended specialization in medicine, intended specialization in public health, ... with specialist training in family or rural medicine Rural practice during the training Most students had some exposure to rural areas during medical training as shown in Row of Table The few (20% ... having a rural background [24] The influence of training institutions In a survey of 189 medical students at Monash University in Australia, Somers (2000) finds that the intention to practice in...

Ngày tải lên: 18/06/2014, 17:20

... is indispensable for information intake and processing within the central nervous system Glutamate neurotransmission is crucial in information intake and information processing within the brain ... blood brain barrier (BBB) is seen early in neuroinflammation, and parallels the release of proinflammatory cytokines [26-28] Mechanisms for disruption of the BBB in neuroinflammation are incompletely ... signal-to-noise ratio) in the glutamatergic transmission As a consequence, the information taken into the brain will be less distinct In addition, activation of astroglial networks, with induction of Ca2+ oscillations,...

Ngày tải lên: 19/06/2014, 22:20

... Committee of the West China University Medical School Page of Exposure Assessment The factory was established in 1950 Since the 1970s some engineering control measures were in place, but in most ... studies, finding excess obstruction among asbestos exposed workers, but remaining inconclusive as to how much of the effect is independent from smoking Kilburn reported significant differences in FEV1/FVC ... long period of time Therefore, the individual cumulative duration of work in exposed areas was used as surrogate measure of total asbestos exposure Clinical Evaluation Using a Chinese standardized...

Ngày tải lên: 20/06/2014, 00:20

... substitution of an arginine by a histidine (R101H) In affected members of both families there was no MMP-2 activity detected in serum by gelatin zymography, in contrast to measurable levels in unaffected ... disruption of the MMP13 gene The strategy employed involved the deletion of the critical zinc-binding region in the catalytic domain that resulted in markedly decreased transcription of the MMP13 ... demonstration of a spontaneous mutation in a MMP gene resulting in a human disease We look forward to descriptions of mutations and the resultant phenotype in other MMP genes geting mutations in Col1a1...

Ngày tải lên: 09/08/2014, 01:21

... Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere ... senescence Our findings clearly show the presence of oxidative stress in degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role ... A: Detection of nitrotyrosine in aging and osteoarthritic cartilage: Correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth...

Ngày tải lên: 09/08/2014, 06:22

... estimations included fasting lipids, complete serum biochemistry (including UA), fasting glucose, fasting insulin and C-reactive protein (CRP) Reference ranges for UA were established in our Clinical ... discontinuation of allopurinol led to a significant acceleration of the rate of loss of kidney function [42] The above studies highlight the role of UA as an independent predictor of renal dysfunction in ... In that study, UA was shown to associate with renal dysfunction in patients with RA In this study, we focus on the potential association of UA with renal dysfunction in patients with RA and investigate...

Ngày tải lên: 09/08/2014, 14:22

... massive pain in his left buttock A clinical examination revealed massive swelling that was extremely tender to touch The increasing pain necessitated the use of continuous intravenous morphine Computed ... we therefore continued a single-agent treatment strategy with imatinib in an outpatient setting No further episodes of bleeding occurred during the follow-up of the patient During that time, the ... large hematoma in the left gluteal region One day after the onset of symptoms surgery became necessary because of increasing swelling accompanied by a drop of the hemoglobin and impending compartment...

Ngày tải lên: 10/08/2014, 23:21

... concentration of endogenous DA significantly [22,34] Comparing the BP before and after the administration of AMPT, we have BP Methods BPAMPT Receptor binding Binding potential (BP) of D2 receptors ... of D2 receptors at the glutamatergic terminals of the frontostriatal projection and the autoreceptors on the dopaminergic terminals in the striatum The dynamics of the population activities of ... hypofrontality and working memory dysfunction in schizophrenia Am J Psychiatry 1998, 155:1285-1287 Perlstein WM, Carter CS, Noll DC, Cohen JD: Relation of prefrontal cortex dysfunction to working...

Ngày tải lên: 11/08/2014, 16:22

... parametric study of frontostriatal abnormalities in schizophrenia patients BMC Psychiatry 2010 10:93 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission ... 2010 Published: 19 November 2010 Reference Tanaka S: Model-based parametric study of frontostriatal abnormalities in schizophrenia patients BMC Psychiatry 2010, 10:17, PMID: 20187970 Pre-publication ... http://www.biomedcentral.com/1471-244X/10/93 Page of Page 7: “Δ PANSS is the change” should be “Δ PANSS is the percent change” Page 10: Reference 35 should be removed from the list because of the reason provided in Correction #4...

Ngày tải lên: 11/08/2014, 16:22

... Subjective Scale To Investigate Cognition in Schizophrenia Competing interests The authors declare that they have no competing interests Heinrichs RW, Zakzanis KK: Neurocognitive deficits in schizophrenia: ... that our study included a majority of subjects scoring no more than on the PANSS insight item Only one patient had a score of Since insight could influence one's subjective perception of cognition, ... the Ependorff Inventory of Schizophrenia [25] What is significant is that these scales dealt with different aspects of subjective experiences in schizophrenia including cognitive dysfunctions...

Ngày tải lên: 11/08/2014, 17:20

... lack of demonstrated benefit and the finding of an increased risk of intracranial hemorrhage, especially in infants younger than 60 days of life [98] In addition to the potential risk for increased ... administration of medications that are primarily eliminated in the renal system This impact is pertinent in milrinone use, and therefore dosing is often renally adjusted in neonates In cases of ... efficacious in certain clinical scenarios in pediatric patients [78,79] Many of these studies, however, have been conducted by providing a loading dose of milrinone followed by a continuous infusion In...

Ngày tải lên: 13/08/2014, 08:20

... alkalinizing changes of several variables A decrease in albumin concentration had the strongest alkalinizing effect (+1.3 mEq/L) Increases in potassium and calcium concentration were of minor ... baseline at the different measuring points Baseline values were 350 ± 76 μg/dL concentrations in canine serum versus baseline at the different measuring points Values are mean ± standard error of ... endotoxin [31] In our canine model of hemorrhagic shock, serum concentrations of citrate were significantly increased after shock induction This is in accordance with a recent finding of Forni and...

Ngày tải lên: 13/08/2014, 08:21

Ngày tải lên: 28/08/2014, 01:12

... Pollutants arising from activities of maintaining and renewing infrastructures, roads, brigdes… are also the major cause of poor air quality in suburbs The next cause of air pollution in Ha Noi is ... has the potential to affect the environment by contaminating the air We still litter everyday but we don’t know how many tons garbage need disposing in hugo landfills It is steadily becoming harder ... living with toxic, breathing dirty air? In conclusion, the air pollution in Ha Noi is the difficult problem which can’t be solved in short time It is also the common problem of the global It's necessary...

Ngày tải lên: 11/10/2015, 07:35

... Pollutants arising from activities of maintaining and renewing infrastructures, roads, brigdes… are also the major cause of poor air quality in suburbs The next cause of air pollution in Ha Noi is ... has the potential to affect the environment by contaminating the air We still litter everyday but we don’t know how many tons garbage need disposing in hugo landfills It is steadily becoming harder ... living with toxic, breathing dirty air? In conclusion, the air pollution in Ha Noi is the difficult problem which can’t be solved in short time It is also the common problem of the global It's necessary...

Ngày tải lên: 11/10/2015, 07:48

... local interview data and forest survey data on list of potential indicator species In order to explore possibility of using local knowledge integrated in forest monitoring, we compare list of potential ... monitoring on specific forest type or a threatened wildlife species By using this source of knowledge, we can save our time in finding relationship among living things or non-living things in local ... relevance of indicator species with its indicating subjects are still remaining debated In sense of application, however, none of scientific research have searched indicator from the knowledge base of...

Ngày tải lên: 12/08/2016, 22:03

... demonstrating that fluvoxamine is effective in the treatment of aripiprazole-induced akathisia of patients with schizophrenia Furthermore, we have experienced that fluvoxamine is Page of also effective ... occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503 Biol Psychiatry 2007, 62:878-883 14 Kerwin R, ... which fluvoxamine was effective in treating aripiprazole-induced akathisia in patients with schizophrenia Written informed consents were obtained from the all patients in this case report Case reports...

Ngày tải lên: 08/08/2014, 23:21

... measurements of cytokine blood levels in severely ill patients not allow precise determinations of cytokine synthesis and secretion in vivo In addition, the interpretation of cytokine data is ... the overwhelming release of proinflammatory cytokines is one crucial initiating event in the posttraumatic acute phase response However, a comprehensive understanding of the underlying mechanisms ... effect [14] Furthermore, intracellular cytokine staining remains unaffected by the short half-life of the proinflammatory mediators or the presence of soluble cytokine inhibitors, such as sIL-1RA...

Ngày tải lên: 13/08/2014, 16:21