pon1 in chronic liver impairment
Báo cáo y học: "Renal dysfunction in chronic liver disease" potx
Ngày tải lên :
13/08/2014, 20:21
... creatinine, which is associated with many problems Creatinine is a product of the metabolism of creatine, which is produced in the liver from three amino acids, methionine, arginine, and glycine, ... AKI staging does address the phenomenon of the lower baseline serum creatinine seen in patients with chronic liver disease The broadening of stage is beneficial in the setting of chronic liver disease, ... for detecting AKI, including two serum and three urine biomarkers: Serum neutrophil gelatinase lipocalin (sNGAL) and cystatin C, and urinary kidney injury molecule (KIM-1), interleukin-18 (IL-18)...
- 10
- 253
- 0
báo cáo hóa học: " Logistic feasibility of health related quality of life measurement in clinical practice: results of a prospective study in a large population of chronic liver patients" potx
Ngày tải lên :
18/06/2014, 19:20
... patients with chronic liver disease However, future studies should aim at including more liver specialists in order to substantiate these findings Expressed concerns of an increase in workload ... physicians in the experimental group requested the information in 92% of the consultations, discussing it with their patients in 58% of the consultations They indicated finding the HRQoL information ... widely implemented in clinical practice This may be explained by the initial lack of convincing data regarding the effectiveness of standardized HRQoL measurement in actually improving HRQoL or psychosocial...
- 9
- 477
- 0
báo cáo hóa học:" Logistic feasibility of health related quality of life measurement in clinical practice: results of a prospective study in a large population of chronic liver patients" pptx
Ngày tải lên :
20/06/2014, 16:20
... patients with chronic liver disease However, future studies should aim at including more liver specialists in order to substantiate these findings Expressed concerns of an increase in workload ... physicians in the experimental group requested the information in 92% of the consultations, discussing it with their patients in 58% of the consultations They indicated finding the HRQoL information ... widely implemented in clinical practice This may be explained by the initial lack of convincing data regarding the effectiveness of standardized HRQoL measurement in actually improving HRQoL or psychosocial...
- 9
- 370
- 0
Báo cáo khoa học: "Effect of extracorporeal liver support by MARS and Prometheus on serum cytokines in acute-on-chronic liver failure" docx
Ngày tải lên :
13/08/2014, 03:20
... samples, and was involved in revising the manuscript AJ was involved in data analysis and in revising the manuscript CL performed the histological analysis and was involved in revising the manuscript ... published in English are included ACLF, acute-on -chronic liver failure; ALF, acute liver failure; ELISA, enzyme-linked immunosorbent assay; FACS, fluorescence-activated cell sorting; IL, interleukin; ... any cytokine tested was found [19] This finding is consistent with a study in children with acute Wilson's disease reporting the transfer of TNF-α and IL-6 into the albumin circuit [21] In contrast,...
- 8
- 325
- 0
Bóa cáo y học: Economic evaluation of the artificial liver support system MARS in patients with acute-on-chronic liver failure pdf
Ngày tải lên :
13/08/2014, 11:22
... KH: [Acute liver failure] Internist (Berl) 2001, 42(4):545-54, 556-62 Lee WM: Acute liver failure in the United States Semin Liver Dis 2003, 23(3):217-226 Bauer M, Winning J, Kortgen A: Liver failure ... expressed in costs per life-years gained and costs per QALY over three years in patients with ACLF and an underlying alcoholic liver disease Methods Study design and population In a prospective clinical ... years Further inclusion criteria was a total bilirubin higher than 300 mmol/µl at any time during the hospital stay Exclusion criteria were severe gastrointestinal bleeding, carcinoma or other...
- 8
- 277
- 0
Báo cáo y học: "A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease" ppt
Ngày tải lên :
13/08/2014, 13:20
... details of the liver proteins and total bilirubin assays according to each patient and laboratory are outlined in Figure There were no significant differences according to testing center for ... error over the investigated range As previously observed, when ordinary linear regression (in combination with correlation analysis in the Passing Bablock method) gave poor estimates, in particular ... units), variations in the definition of normal may have important practical consequences Results The main characteristics of the included patients are outlined in Table According to each patient...
- 10
- 240
- 0
Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"
Ngày tải lên :
03/11/2012, 10:52
... Vainchenker W, Wendling F Prominent role of TGF-beta in thrombopoietin-induced myelofibrosis in mice Blood 2002;100:3495-503 32 Erusalimsky JD, Franklin R and Hong Y Is the platelet lowering activity ... the other, is in accordance with some previous results [13,19] This lack also suggests that interactions are rather complex or slow; thus, in samples obtained at a single time point it might not ... advocated as a protein susceptible to reductions during anagrelide treatment for MPD [30] We can not corroborate those findings here, despite using the same assay as those investigators At this...
- 5
- 498
- 0
Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
Ngày tải lên :
18/02/2014, 18:20
... Desbuquois et al Insulin-induced translocation of Grb14 in rat liver A H N B M LP S PM GE –ins Grb14 – ins Grb14 + ins –ins + ins + ins – ins EEA1 + ins Na+K+ATPase Calnexin + ins number: 10 11 ... of liver insulin signaling, and that it may represent an interesting molecule with which to regulate liver insulin action Experimental procedures Materials Porcine insulin, recombinant human insulin, ... and IR proteins in liver subcellular fractions of control and insulin-injected rats (A) Liver homogenates (H) prepared from five control ()ins) and five insulin-injected (+ins, postinjection) rats...
- 15
- 497
- 0
Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
Ngày tải lên :
20/02/2014, 11:20
... Protein alteration in mitochondrial matrix with aging (Eur J Biochem 270) 2299 Western blotting of modified proteins Fig Determination of CML-protein content in liver mitochondrial matrix with aging ... efficiency in relation to damaged protein and/or a decrease in the amount of this protein in the matrix We have not detected any significant modification in the amount of this protein in the matrix ... proteins and their immunological signals increased with aging These findings are consistent with previous reports showing an increase in carbonyl proteins in mitochondria from different tissues...
- 8
- 412
- 0
Management of Complications of Chronic Liver Disease: “When to Refer to Transplant?” docx
Ngày tải lên :
05/03/2014, 10:20
... utilizing the creatinine-height index, dietary protein intake, trauma, and infection must be considered since they all can alter creatinine excretion Nutritional Assessment of the Child with Liver ... transferrin, prealbumin, and retinol-binding protein that are synthesized by the liver has been used to determine visceral protein nutriture • Diminished serum levels of these proteins may not accurately ... Cholestyramine and colestipol, bile acid binding resins, may deplete enteral bile acids and interfere with fat-soluble vitamin absorption from the intestines • Vitamin A and vitamin E require...
- 59
- 1.9K
- 0
Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
Ngày tải lên :
08/03/2014, 08:20
... is increased in chronic- vitamin A deficiency when compared to control rats Using Western blot analysis it was also found that p53 protein was increased and c-Jun protein was decreased in liver chronic- vitamin ... p53 protein was significantly increased in the liver and lung from vitamin A-deficient rats that in controls c-Jun protein was significantly decreased in vitamin A-deficient rats In the liver of ... p53 and c-Jun in liver and lung Total protein extracts were obtained as described in experimental procedures A single band of about 53 kDa was detected in liver and lung indicating that the amount...
- 9
- 508
- 0
Báo cáo khoa học: Supramolecular calsequestrin complex Protein–protein interactions in chronic low-frequency stimulated muscle, postnatal development and ageing pot
Ngày tải lên :
08/03/2014, 10:20
... method in determining protein linkage Its greatest advantage is the direct visualization of protein–protein interactions under controlled conditions In contrast, other established protein biochemical ... chemical crosslinking analysis might introduce artifacts by random protein linkage Although gel filtration chromatography, domain binding studies with recombinant or isolated peptide domains, differential ... heterogeneous protein–protein interactions Slow CSQ might be involved in a more indirect type of physiological coupling process in transformed fibers, while fast CSQ appears to be a directly interacting endogenous...
- 10
- 342
- 0
EDUCATING TO IMPROVE POPULATION HEALTH OUTCOMES IN CHRONIC DISEASE ppt
Ngày tải lên :
14/03/2014, 20:20
... This domain includes: core clinical skills, applying knowledge of chronic conditions to clinical decision-making, physical examination skills, investigations and the rational use of medicine Note: ... nutrition etc Smoking Individual – Brief interventions in each consultation Community – Smoke free zones in public buildings • Conducting education to school kids about smoking • Running smoking education ... multidisciplinary teamwork, maintaining medical records; confidentiality; ethics in managing chronic disease; duty of care; professional standards, self-care, disciplinary scope of practice Clinical...
- 54
- 346
- 0
Báo cáo khoa học: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet pdf
Ngày tải lên :
16/03/2014, 04:20
... Acbd6 (acyl-CoA-binding domain containing 6), Scd2 (stearoyl-CoA desaturase 2) or associated genes, Sorbs3 (sorbin and SH3 domain containing 3) and Etnk1_predicted (ethanolamine kinase 1) were downregulated ... reticulum protein that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SREBP cleavage-activating protein, thus preventing the latter from escorting SREBPs ... for sarcosine dehydrogenase (Sardh), a flavoenzyme involved in the oxidative degradation of choline to glycine in rat [22], was upregulated Transcriptome remodeling in group HG rat liver In group...
- 9
- 506
- 0
Báo cáo khoa học: Pyruvate metabolism in rat liver mitochondria What is optimized at steady state? pptx
Ngày tải lên :
16/03/2014, 14:20
... input ⁄ output relationship Note that by constructing the conversion cone one 6252 loses no information because all other, less interesting, details are contained in the current matrix Assuming ... molecules in large excess and thus as being essentially constant Because we are not interested in tracking these four metabolites they were ignored in the stoichiometry matrix For the intramitochondrial ... only Hence, in analysing the model, we consider only conversions between the external metabolites, in effect treating the mitochondria as a black box input ⁄ output system Obtaining a description...
- 10
- 324
- 0
Báo cáo khoa học: The )148 to )124 region of c-jun interacts with a positive regulatory factor in rat liver and enhances transcription Dipali Sharma*, Sujata Ohri and Aparna Dixit ppt
Ngày tải lên :
23/03/2014, 20:22
... fragmented calf thymus DNA was packed in a 3-mL syringe column followed by washing with binding buffer and was eluted with binding buffer containing increasing concentrations of NaCl at a flow rate ... membrane was then blocked for h in blocking buffer (5% BSA in · binding buffer) and washed four times with · binding buffer for 10 each Finally, · binding buffer consisting of labelled tetramer of ... kDa in UV cross-linking studies whereas the purified protein is only 40 kDa, suggesting that it binds only as a dimer Absence of an 40 kDa DNA-protein adduct in UV cross-linking studies indicates...
- 9
- 449
- 0
Báo cáo hóa học: " Immune and hemorheological changes in Chronic Fatigue Syndrome" pdf
Ngày tải lên :
18/06/2014, 16:20
... severity of chronic fatigue syndrome Clin Infect Dis 1994, 18(Suppl 1):157-159 Maher KJ, Klimas NG, Fletcher MA: Chronic fatigue syndrome is associated with diminished intracellular perforin Clin Exp ... Belch JJF: Increased neutrophil apoptosis in chronic fatigue syndrome J Clin Pathol 2004, 57:891-893 Streeten DHP, Bell DS: Circulating blood volume in Chronic Fatigue Syndrome J Chronic Fatigue ... correlated with decreases in perforin and granzyme production [6] and changes in granzyme gene (GZMA) expression [8] These deficiencies in NK activity may increase viral load in CFS, incidentally a recent...
- 10
- 470
- 0
Báo cáo hóa học: " Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells" pot
Ngày tải lên :
18/06/2014, 16:20
... Becton-Dickinson, San Jose, CA) for 20 minutes, then treated with fixing and permeabilizing reagents (Fix&Perm kit, Caltag, Burlingame, CA) according to the manufacturer’s instructions, and finally stained ... following National Cancer Institute-Working Group guidelines [16] The concordance index (c index) was used to determine the predictive ability of ZAP-70 positivity in a TTT model Briefly, the c index ... expressing ZAP-70 according to T/B Ratiomethod (73), or expressing ZAP-70 according to either ISO- or Tmethods (30) Institution, in which ZAP-70 staining and analyses were performed utilizing a...
- 11
- 688
- 0
Báo cáo sinh học: " Serum levels of preS antigen (HBpreSAg) in chronic hepatitis B virus infected patients" potx
Ngày tải lên :
18/06/2014, 18:20
... fusion during entry [20] Since preS mainly exist in the DNAcontaining Dane HBV particles, detection of HBpreSAg present in serum of HBV patients may have a clinical value in management of HBV infection ... recombinant S proteins was used to plot a standard curve The amount of HBsAg present in serum was determined according to the amount of recombinant S protein The result shown in Fig 1B indicated ... shown) Since the amount of spheres viral particles containing HBsAg is much more than that of infectious Dane particles (infectious particles containing L-M-S antigens and viral DNA) containing full...
- 11
- 540
- 0
Báo cáo sinh học: "Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis" ppt
Ngày tải lên :
18/06/2014, 19:20
... recent data on cytokine distribution in CFS/ME patients point towards an increase in pro-inflammatory cytokines suggesting the presence of an underlying viral prevalence in these patients [17,18] ... element DNA binding complex pathway, therefore changes in VNs such as elevations in VPACR2 may suggest an increase in IL-10 [45] Further, an increase in TNF-a and IFN-g suggests an inability of ... (Th)1, Th2 and Th17 cytokine expressions were investigated using the cytometric bead array kit (BD Pharmingen, San Diego, CA) [25] for determining levels of interleukin (IL)-2, IL-4, IL-6, IL10,...
- 9
- 380
- 0