polyphenols in cocoa from in vitro digestion to in vivo bioavailability
Báo cáo khoa học: The mitochondrial permeability transition from in vitro artifact to disease target ppt
Ngày tải lên :
30/03/2014, 11:20
... devoted to identifying the signaling pathways linking myocardial protection to PTP inhibition, which may involve protein kinase Ce [217] and mitogen-activated protein kinase kinase [218] An integrated ... step in steroid synthesis [159] The PBR also binds some porphyrins, including protoporphyrin IX, a potent inducer of the PTP [160], and is thought to be involved in transport of porphyrins into ... course of apoptosis, cytochrome c is released into the cytosol [72], together with apoptosis-inducing factor [73] and a set of proteins involved in the effector phase of apoptosis [74–77] A rigorous...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf
Ngày tải lên :
14/02/2014, 21:20
... discover of obtaining information regarding several of viil INTRODUCTION them, was to write to persons bearing the same name in this country Moreover when I had actually succeeded in obtaining the addresses ... In all cases, therefore, where rowing was not supposed to be attended with injurious results, I decided to yield to their wishes and to insert the names, taking care at the same time to obtain ... fit state of health; in others, to the rowers being by nature constitutionally delicate; and in others again, to their having thoroughly overdone it, to their being in boating language "stale."...
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Tài liệu Báo cáo khoa học: Quantitative estimation of channeling from early glycolytic intermediates to CO2 in intact Escherichia coli pdf
Ngày tải lên :
19/02/2014, 18:20
... investigations of channeling may be divided into two categories: in vitro and in vivo The former include experiments with cell extracts and purified enzymes These are inherently unsatisfying In ... 3H in protein was insignificant, showing that the aminoacyltRNA made from amino acids and tRNA did not mix with the introduced aminoacyl-tRNA; i.e there was perfect channeling from free amino ... bear little relation to the conditions under which enzymes must act in vivo Among tools used for investigating channeling are the following In vitro experiments (a) Chromatographic techniques...
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Báo cáo "Evolution of holocene depositional environments in the coastal area from the Tien river to the Hau river mouths " pot
Ngày tải lên :
05/03/2014, 16:20
... a distance from each other about 3-10km They are evidences of paleocoast existence during delta progradation from delta front into delta plain Due to these sand ridges delta plain in study area ... River mouth changes In study area, a continental regime was dominated during time from 20Ky Bp to 12Ky Bp A presence of alluvial deposits during 10Ky Bp from the depth 50-80m in boreholes had proved ... depositional environments in coastal and nearshore area from 12Ky Bp to present Study on facies changing in time and space helps to determine river mouth changes and paleocoasts during the Holocene Based...
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Báo cáo khoa học: Activator-binding domains of the SWI ⁄ SNF chromatin remodeling complex characterized in vitro are required for its recruitment to promoters in vivo pot
Ngày tải lên :
07/03/2014, 00:20
... galactose To determine whether the activator-binding domains of the SWI ⁄ SNF complex are important for its recruitment to promoters in vivo and to determine whether the Swi1 and Snf5 domains ... lacking the Snf5 activator-binding domain (SNF5D2-327) and strain YPP247 (dark grey bars, DABDswi1) lacking the Swi1 activator-binding domain (SWI1D329-655), relative to the wild-type tested in ... function of the increasingly large group of proteins that have been shown to contain intrinsically unstructured regions The intrinsic conformation flexibility that is inherent in this binding mechanism...
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Comparing HIV prevalence estimates from prevention of mother-to-child HIV transmission programme and the antenatal HIV surveillance in Addis Ababa docx
Ngày tải lên :
15/03/2014, 10:20
... decline from 10.0% in 2004 to 4.5% in 2009 There were five antenatal surveillance sites from 2003 to 2007 in Addis Ababa and they increased to seven by 2009 Four rounds of surveillance data from ... PMTCT services In early 2008, the HIV testing approach was shifted from opt -in (voluntary testing) to opt-out (routine testing) [10] In the programme HIV counselling and testing is offered as ... Consistent with our findings, several studies from resource poor settings including Ethiopia have reported dramatic increases in the proportions of women testing in PMTCT programmes following the WHO...
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Báo cáo khoa học: Oxidative stress induces a reversible flux of cysteine from tissues to blood in vivo in the rat pptx
Ngày tải lên :
16/03/2014, 02:20
... Cys from the liver and other organs to maintain the cysteine pool GSH is known to be a critical source for maintaining a steady Cys availability as it is continuously exported out of cells into ... cysteine from other tissues towards RBCs Figure 3C shows the change in total cysteine and total glutathione in RBCs with respect to their basal levels It is evident that the levels of total cysteine, ... Propargylglycine is an inhibitor of cystathionase, the enzyme that forms cysteine from cystathionine in the TSP; in this case, treatment should eliminate the supply of Cys derived from methionine [28]...
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Báo cáo khoa học: Recent contributions of in vitro models to our understanding of hepatitis C virus life cycle pdf
Ngày tải lên :
16/03/2014, 05:20
... culture of infected hepatocytes To succeed in obtaining HCV infection in primary human hepatocytes, an existing model of hepatitis B virus infection was used to determine optimal infection conditions ... virions that were infectious in primary human hepatocytes and lymphocytes in vitro In summary, use of HCV-containing sera to reconstitute the entire life cycle of HCV in vitro has proved to be very ... the poor binding inhibition achieved in the presence of mAbs directed against CD81 In contrast, heparin sulfate seemed to mediate this interaction [53] Taking advantage of this binding model,...
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Báo cáo khoa học: "Learning From Collective Human Behavior to Introduce Diversity in Lexical Choice" potx
Ngày tải lên :
30/03/2014, 21:20
... the information content in the summaries that are generated automatically Finally, recent research on analyzing online social media shown a growing interest in mining news stories and headlines ... headlines, and 926 citations The annotators were asked to follow precise guidelines in nugget extraction Our guidelines instructed annotators to extract non-overlapping phrases from each headline ... phrasal information as nuggets is an essential element to our experiments, since some headline writers often try to use uncommon terms to refer to a factoid For instance, two headlines from the...
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báo cáo hóa học: " A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices" potx
Ngày tải lên :
19/06/2014, 22:20
... during the culture Next, we wanted to see if either proinflammatory histone deacetylase inhibitor TSA or anti-inflammatory NF-κB inhibitor helenalin could influence the LPS-induced response Interestingly, ... (n = in each group) preclinical in vivo experiments Therefore, we also wanted to study the possibility of refining the model itself by taking into the account the experimental design involving ... importance to pay attention to the factors that contribute to the consistency of in vitro models used to mimic in vivo situations In the present study, we used hippocampus tissue slices in serum-free...
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Báo cáo hóa học: " Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug " pot
Ngày tải lên :
20/06/2014, 01:20
... evaluated in cell culture and in intranasally infected mice The deletion of F2L had a minimal impact on viral replication in vitro and did not appear to significantly reduce the virulence in vivo ... models including route of infection In HSV, direct intracranial inoculation resulted in a 10-fold reduction in virulence of the mutant, whereas footpad inoculation increased the LD50 from approximately ... F2L-gfp The F2L gene in VV strain WR (shaded arrow in the top line) was replaced with the gfp gene driven by the synthetic E/L promoter (black arrow in the bottom line) The resulting virus was designated...
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Báo cáo hóa học: " Research Article Array Iterators in Lustre: From a Language Extension to Its Exploitation in Validation Lionel Morel" doc
Ngày tải lên :
22/06/2014, 22:20
... elt T4 init Q true P ok init res4 init elt tab in init R res3 init propRankN ok inv accIn T S elt T1 inv varOut inv accIn R elt tab in inv R res3 inv accIn Q elt T2 inv elt T3 inv Q res4 inv elt ... the value of all instances of accu in during the current instant (declared at line (4)), and one for storing the previous values corresponding to pre(accu in) (line (5)) Line (6) initializes the ... out=accu in- > (3) int accu out; pre(accu in) ; (4) int accu in[ 10]; t=accu in; tel (5) int PREaccu in[ 10]; node Tenlast(V:int) //Initializing returns (T:intˆ10); // the iteration var:foo:int;let...
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PROGRESS IN MOLECULAR AND ENVIRONMENTAL BIOENGINEERING – FROM ANALYSIS AND MODELING TO TECHNOLOGY APPLICATIONS_2 pps
Ngày tải lên :
29/06/2014, 13:20
... l-tryptophan l-glycine l-alanine l-cysteine l-histidine l-lysine l-arginine 1.0 nf, mol/m h l-glutamic acid l-aspartic acid l-tryptophan l-glycine l-alanine l-cysteine l-histidine l-lysine l-arginine ... l-tryptophan l-glycine l-alanine l-cysteine l-histidine l-lysine l-arginine 0.6 0.4 0.2 0.0 pHF=4 1.0 P 0.8 0.6 l-tryptophan l-glycine l-alanine l-cysteine l-lysine l-arginine 0.4 0.2 pH of stripping ... sulphopropyl-Toyopearl, to separate lactoperoxidase and lactoferrin α-Lactalbumin and β -lactoglobulin were adsorbed onto quaternary aminoethylToyopearl α-Lactalbumin was eluted using a linear (0–0.15...
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PROGRESS IN MOLECULAR AND ENVIRONMENTAL BIOENGINEERING – FROM ANALYSIS AND MODELING TO TECHNOLOGY APPLICATIONS_1 ppsx
Ngày tải lên :
29/06/2014, 13:20
... this reason in the following we will drop the subscript a in the definition of the operators we consider, and use t, instead of x, to indicate the independent variable time Starting from equation ... Progress in Molecular and Environmental Bioengineering – From Analysis and Modeling to Technology Applications The concept of minimal cell in biology, however, is not new Looking at the astonishing ... itself from inside) 26 Progress in Molecular and Environmental Bioengineering – From Analysis and Modeling to Technology Applications The first attempts to create a minimal chemical autopoietic...
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Báo cáo y học: "Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series" doc
Ngày tải lên :
09/08/2014, 01:21
... availability of agomelatine, a novel antidepressant acting as a melatonin agonist and selective serotonin antagonist (MASSA; acting against melatonin (MT1) and MT2, and 5-hydroxytryptamine (HT)2C, respectively) ... symptoms consisted of religious obsessions, continuous rituals regarding touching holy pictures of saints in her pocket and continuative fear of cursing against God Both cognitive status and insight ... associated to refractoriness to agomelatine within months of 50 mg/day therapy This appears to be consistent with evidence in the current literature pointing out a lack of response to antidepressants...
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Báo cáo khoa học: "Scaling up from the individual tree to the stand level in Scots pine. I. Needle distribution, overall crown and root geometry" ppsx
Ngày tải lên :
09/08/2014, 04:20
... decreasing to 899 trees in 1987, 743 trees in 1990 and 716 trees in 1993 -1 -1 Due to windfall a remaining 672 trees -1 were still present in 1994 A new detailed forest inventory was made in spring ... original, homogeneous stocking density was very high (Van Looken, pers comm.) and the stand had been frequently thinned, with the most recent thinning in 1993 The stocking density was 390 trees in ... equation was modified by introducing the height of the top of the tree i ) top (h in addition to the h Only the Rayleigh equation, where the best fit for Scots pine in this study was observed,...
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Báo cáo khoa học: "Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo" ppsx
Ngày tải lên :
09/08/2014, 09:20
... the line abrogated in p21 results into increased sensitivity of this subline similar to the exaggerated response to 15 Gy by the S cell line abrogated in p21, or the other three cell lines in the ... mechanism that influences in vivo radiosensitivity We selected eight cells from the four in vitro radiosensitivity groups and these cell lines are shown in table In this table we list these lines by ... cells that vary in their in vitro radiosensitivity and genotype For each of the eight cell lines for which we determined in vitro radiosensitivity in figures and 2, we measured in vivo radiosensitivity...
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Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx
Ngày tải lên :
10/08/2014, 05:20
... aptamer or from an indirect effect on the conformation of a neighboring amino acid residue, increasing the template·primer affinity thus indirectly leading to altered susceptibility to the aptamer ... defect in Figure appears to be due to a loss in substrate affinity and not due to defect in the RNase H catalytic activity of these mutant RTs To determine whether these mutant RTs retained RNase ... them to interact with a similar binding surface on the RT protein Additional evidence in support of this is the presence of the characteristic interrupted helices present in all RT-binding aptamers...
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Báo cáo khoa hoc:" Multiple microvessels extending from the coronary arteries to the left ventricle in a middle aged female presenting with ischaemic chest pain: a case report" doc
Ngày tải lên :
11/08/2014, 10:22
... uneventfully from the right femoral artery, using lignocaine local anaesthesia Initial injections into the left coronary artery revealed diffuse direct shunting of contrast from all branches into the ... pain symptoms leading to angiographic triage The linkage to female gender may therefore be confounded by associa- Patients with multiple micro-channels extending from the coronary arteries to ... rarely in midlife in females presenting with troponin-negative ischaemic chest pain Given the increasingly common pattern of invasive triage despite negative biomarkers, and the possible non invasive...
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Báo cáo khoa học: "Production and purification of immunologically active core protein p24 from HIV-1 fused to ricin toxin B subunit in E. coli" ppt
Ngày tải lên :
12/08/2014, 04:21
... The history of ricin, abrin and related toxins Toxicon 2004, 44:361-370 Sandvig K, van Deurs B: Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin FEBS ... zidovudine, reinforcing the possibility for a p24-containing therapeutic vaccine against HIV in the presence of antiretroviral therapy [8] Ribosome inactivating proteins are a group of cytotoxic ... using the glycoprotein asialofetuin, in capture ELISA and sepharose affinity chromatography assays, we were able to demonstrate binding of the fused protein RTB/p24 to complex sugars, confirming...
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