polymeric conjugates for angiogenesis targeted tumor imaging and therapy

... Chapter Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy 159 Amitava Mitra, Anjan Nan, Bruce R Line, and Hamidreza Ghandehari ... anti -tumor treatment, or tumor imaging, which is essential for tumor diagnosis and for monitoring the extent and timing of an individual patient’s response to anti -tumor therapy The first nanotechnology-based ... nanoplatforms for cancer therapeutics is a critical component to the successful use of nanovectors for anti -tumor therapy and tumor imaging, there are other necessary components for nanoplatforms to...

Ngày tải lên: 04/06/2014, 14:30

... “reversal” of the values for the T1/2 a and b values of the tumor and non -tumor bearing mice In the absence of a tumor burden, the T1/2a and b for IgG was approximately 5.2 and 3.8 times faster, ... plotted for each time point Imaging g-Scintigraphy was performed with tumor bearing mice to further validate the 111 In-CHX-A"-panitumumab F(ab’)2 tumor targeting Imaging studies were performed ... be useful in assessing tumor responses to therapy (i.e., estimating HER1 expression) and would provide accurate data for performing dosimetric calculations for radioimmunotherapy [36] The caveat...

Ngày tải lên: 21/06/2014, 02:20

... molecular imaging modalities, MRI is one of the best imaging modalities in both research and clinical fields for injury and disease diagnosis as it offers high spatial and temporal information ... than 41 oC Therefore, hyperthermia based on the generation of heat at the tumor site is a promising cancer therapy and is a supplementary treatment to chemotherapy, radiotherapy, and surgery (Lu ... be designed for the potential applications in targeted and controlled drug delivery 2.3 Biomedical Applications of SPIONs 2.3.1 MRI Molecular imaging, such as optical imaging, MRI, and positron...

Ngày tải lên: 09/09/2015, 10:14

... Bioluminescent Imaging of Gene Expression and of Tumor Progression and Metastasis C W G M Lowik, M G Cecchini, A Maggi, G van der Pluijm 193 Targeted Optical Imaging and Photodynamic ... and SPECT), radiotherapy, ultrasound imaging, optical imaging, and photodynamic therapy Feedback from the participants led to the conclusion that the interdisciplinary nature and scientific diversity ... 147 Imaging of Proteases for Tumor Detection and Differentiation C Bremer 153 Molecular Imaging with Targeted Ultrasound Contrast Microbubbles...

Ngày tải lên: 29/06/2014, 11:20

... uneven tissue contour for imaging (b) Histological tissue sections of the tumor after H & E staining for tumor without gold nanoshells (left) and tumor post i.v (middle) and intratumoral (right) gold ... tumor and the tumor- skin interface to be imaged…………………… 230 Figure 8.3 OCT images of the interface between normal peripheral skin and tumor tissue of mouse model prior to and after i.v and intratumoral ... images of normal skin (top row) and tumor tissue (bottom row) of mouse model prior to gold nanoshells delivery i.e tumor without gold nanoshells and after i.v and intratumoral gold nanoshells delivery...

Ngày tải lên: 11/09/2015, 09:02

... contributions Hou ZQ, Yi YF, and Zhang QQ conceived of the study and participated in the design of the study and performed the statistical analysis and drafted the manuscript Zhan CM and Jiang QW carried ... concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 1986, 46:6387 Duncan R: Polymer conjugates ... dark condition for h, and a yellow FA-NPs suspension was obtained The FA-NPs were collected by centrifugation at 12,000 rpm for 30 min, and the deposit was washed with distilled water and centrifuged...

Ngày tải lên: 20/06/2014, 22:20

... hyperuricemia, high tumor burden, high growth rate of tumor, high sensitivity to chemotherapy and renal impairment Standard measures to prevent and treat hyperuricemia include allopurinol and alkalinization, ... the purinic nucleotides useful for DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage ... with hydration and alkalinization, that are the standard proceedings of TLS management Hydration, that should be started before and continued for several days after the end of chemotherapy, helps...

Ngày tải lên: 31/10/2012, 14:59

... of tumor progression, combining enzymatic activity-dependent and -independent activities of heparanase and affecting two systems critical for tumor progression, namely tumor vascularization and ... density, and favorable prognosis of head and neck cancer patients (see text for details) (B) Heparanase expression associates with tumor cell invasion into lymph vessels Head and neck tumor specimen ... early stages of cancer and long before metastatic growth at distant sites can be detected [103] These cells can reinfiltrate and promote growth and angiogenesis of the primary tumor [102] The possible...

Ngày tải lên: 15/03/2014, 23:20

... stands for Digital Negative Group and was designed by Adobe as a common raw format option for photographers It maintains all the quality and nondestructive editing benefits of proprietary raw file formats; ... any form by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher For information on getting permission for reprints and ... #99: Saving for the Web 261 #100: Image Processor 263 Index 266 Foreword The year 2010 has been an exciting time for digital photographers and imaging professionals...

Ngày tải lên: 30/05/2014, 23:16

... exempt from the relevant protective laws and regulations and therefore free for general use While the advice and information in this book are believed to be true and accurate at the date of publication, ... the second and third columns of Fig 3.2, respectively V.M Patel and R Chellappa, Sparse Representations and Compressive Sensing for Imaging and Vision, SpringerBriefs in Electrical and Computer ... monograph and whose works could not be discussed Also known as compressive sensing or compressed sensing V.M Patel and R Chellappa, Sparse Representations and Compressive Sensing for Imaging and Vision,...

Ngày tải lên: 05/06/2014, 12:05

... Ratios of tumor- to-blood and the tumor- to-muscle between unblocked and blocked mice decreased for this tracer The uptake in the blood, kidney, liver, spleen, lungs and tumor is higher for 64Cu/NOTA-dimer ... tumor- to-blood ratio after h and is also retained longer at the tumor site In addition, this tracer displays lower tumor- to-liver ratio and similar ratios of tumor- to-kidney and tumor- to-pancreas than ... Bio-distribution and tumor to non-target organ ratios for 64Cu/NOTA-monomer and 64Cu/NOTA-dimer Organ Blood Plasma Adrenal Fat Kidney Spleen Pancreas Liver Heart Lungs Muscle Bone Brain Tumor Tumor/blood Tumor/ muscle...

Ngày tải lên: 21/06/2014, 17:20

... staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen Most glycosaminoglycan staining was for chondroitin-4-sulfate, with less for keratan ... MRI, magnetic resonance imaging; n/a not applicable; N/A not available with standard and polarised light and images captured and digitised using a closed-circuit television and Image Grabber software ... bone and sometimes a very thin layer at the surface (see Fig 8) Staining for types III and VI collagens was cellassociated and for type X collagen was restricted to the R65 Arthritis Research and...

Ngày tải lên: 09/08/2014, 01:21

... emerged as an effective liverdirected therapy with a favorable therapeutic ratio SIRT, both as a stand-alone therapy and in conjunction with systemic or regional chemotherapy (chemo-SIRT), has been ... primary and metastatic liver tumors [1216] Y-90 microspheres, injected via the hepatic artery, are entrapped within the tumor (preferentially) and hepatic arterial microvasculature, and emit ... systemic chemotherapy for a total of courses with no significant toxicity noted At 3month follow-up evaluation, based on a favorable tumor response, the patient's improved performance status, and the...

Ngày tải lên: 09/08/2014, 04:21

... 62°C for ADAMs 8, 9, 10, 12, 17, 20, 21, 28 and 30, 67°C for ADAM15, 64°C for VEGFR-1, 63°C for VEGFR-2 and neuropilin-1 and 65°C for β-actin, and minute at 72°C, followed by minutes at 72°C for ... protocols Cycling conditions were 50°C for minutes, 95°C for 10 minutes, and then 40 cycles at 95°C for 15 seconds and 60°C for minute Primers were designed and selected using Primer Express software ... searches were performed to confirm the specificity of the probes Hybridization with the probes was performed at 42°C for 16 h, and the sections were washed in 2× standard saline citrate/50% formamide,...

Ngày tải lên: 09/08/2014, 07:20

... , S-I2 and A-P2 , and L-R1 , S-I1 and A-P1, represent during-treatment and pre-treatment (uncorrected) isocenter positions along the L-R, S-I and A-P axes respectively, and cL-R , cS-I and cA-P ... a): S-I and A-P axes, and b): S-I and L-R axes Ellipse shows 95% confidence intervals for CTV coverage in each direction PTV margins, from 0.57 cm, 0.79 cm and 0.77 cm to 0.36 cm, 0.37 cm and 0.37 ... larger along the L-R and S-I axes, and mm or larger along the A-P axis, effectively reduced the combined systematic and random error to within mm along the L-R and S-I axes and mm along the A-P...

Ngày tải lên: 09/08/2014, 09:20

... (hepatobiliary) phase (Figure 2c) Tumor Volume Assessment and ADC Calculation Assessment of tumor areas was performed with the OsiriX imaging software version 3.6.1 Tumor borders were segmented manually ... HDR-BT and 3D dosimetry 77-year-old man with colorectal liver metastasis in segment VII scheduled for high-dose-rate brachytherapy (HDR-BT) The implantation of one brachytherapy catheter was performed ... volume of nontreated and treated tumors at early and follow-up MRI compared to baseline MRI Boxplot shows changes of mean tumor volume (TV) of non-treated (*: p = 0.027) and treated colorectal...

Ngày tải lên: 09/08/2014, 09:20

... function and tumor movement was analyzed Thirteen and 10 tumors in the upper and lower lung fields, respectively, were in patients with normal pulmonary function Ten, and tumors each in the upper and ... than 80%, and as mixed dysfunction when both criteria were fulfilled A lung tumor is a movable target so that management of tumor motion is required for SBRT of lung tumors The lung tumor movement ... intrafractional tumor movement was not measured CT was taken just before the first and third fractions of SBRT to evaluate the accuracy of reproducibility of patient and tumor position, and any positioning...

Ngày tải lên: 09/08/2014, 09:22

... examination, by both the head and neck surgeon and the radiation oncologist, endoscopy and CT scan of the head and neck region A chest X-ray or chest CT and blood test were performed to rule out distant ... total dose prescribed to the primary tumor was 66-70 Gy for patients with gross disease and 54-64 Gy for patients treated in the adjuvant setting For elective radiotherapy, 50 Gy was administered ... Radiation oncologists and head and neck surgeons performed a clinical examination A head and neck CT or MRI, examination under general anesthesia and/ or biopsy were performed if recurrence was...

Ngày tải lên: 09/08/2014, 10:20

... constant, and cell number for that compartment and phase For the purposes of this model, we are interested in estimating tumor control and focus on the development of relatively small tumors Thus, ... to solid tumor and from solid tumor to CSF, γf and γt, respectively, which range in value from to Finally, the tumor cell growth rate in each phase is assumed to be a linear function of tumor cell ... and observed doubling times is due solely to cells shedding from the tumor (and not from, for example, cell growth slowing with increasing tumor size nor from host immunologic attack of the tumor) ,...

Ngày tải lên: 09/08/2014, 10:21