... under stress. The mutated phosphorylation sites were the four sites regulated by stresses (S1 58, T209, S4 31 and S4 42), one site constitutively phosphorylated in cells (S1 22) and one site phosphorylated ... we have shown that hDlg is hyperphosphorylated in response to cellular stress such as osmotic shock or UV radiation. This phosphoryla- tion is mediated by p38c MAPK and triggers its dissociation ... Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation Francisco A. In ˜ esta-Vaquera 1 , Francisco Centeno 2 ,...
Ngày tải lên: 23/03/2014, 06:20
... signal transduction systems governing bacterial responses and adaptation to environmental changes is the two-component system (TCS) A typical TCS consists of an autophosphorylating sensor histidine ... heterologous expression in Escherichia coli In vitro, SenSc is autophosphorylated to SenScP at the histidine residue at position 199, transfers the phosphate group to the aspartic acid residue at position ... revealed that SenR binds specifically to up-furS1 and up-hbpS1, and the phosphorylation of SenR by SenSP substantially alters its DNA-binding characteristics Further bandshift assays using different...
Ngày tải lên: 07/03/2014, 10:20
THE ECB’S RESPONSE TO THE FINANCIAL CRISIS pdf
... bank deposits as deposit holders shift their investments from deposits towards assets offering a higher return. Unless banks can compensate for the decline in deposits via other sources of funding, ... transmission of its monetary policy stance. 3 THE ECB? ?S RESPONSE IN THE VARIOUS STAGES OF THE CRISIS This section illustrates in detail the way that the ECB has responded to the various phases ... strategy. To put the ECB? ?s response to the crisis into perspective, Section 2 illustrates how monetary policy works under normal circumstances. Section 3 describes in some detail the measures...
Ngày tải lên: 22/03/2014, 17:20
Audit and Accountability in Central Government: The Government’s response to Lord Sharman’s report “Holding to Account” pdf
... priorities into departmental strategies and budgets, and then reports to Parliament on the efficiency and effectiveness of the services provided The results of this process assist the ... this, the C&AG, the bodies involved, their regulators, and other auditors should produce protocols for the exercise of these new statutory... measures included in the guide are tools ... Government? ?s response to Lord Sharman? ?s report “Holding to Account” March 2002 Cm 5456 £10.75 This document can be accessed from the Treasury? ?s Internet Site: http://www.hm-treasury.gov.uk Published...
Ngày tải lên: 29/03/2014, 22:20
THE RELUCTANT HOUSEWIFE’S GUIDE TO COUPONING By Kimberley Springer docx
... stores to shop at in order to save money. So, the stores I don’t shop at, the ads go straight in the recycle bin without being opened. Besides, driving to different stores costs money in gas ... are store coupons or manufacturer coupons.) You can use store coupons together with manufacture coupons (usually) to increase your savings STEP 9 – KNOW THE RULES As with any game (and this ... it first to ensure the coupon insert you need is inside Some items go on sale seasonally (like sunscreen or weed killer) and you should stock up while you can, but others (like toothpaste......
Ngày tải lên: 27/06/2014, 23:20
Báo cáo khoa học: "Scots pine susceptibility to attack by Tomicus piniperda (L) as related to pruning date and attack density" pps
... density classes (see below) prior to analysing resin acids and starch as previously described by Långström et al (1992). Statistics Data were analysed using the SAS statistical ... aggressor in resin-soaked lesions (for an overview, see Christiansen et al, 1987). Successful colonisation by bark beetles occurs when the beetles can exhaust the defence system ... article Scots pine susceptibility to attack by Tomicus piniperda (L) as related to pruning date and attack density B Långström C Hellqvist Swedish University of Agricultural Sciences,...
Ngày tải lên: 08/08/2014, 23:22
Báo cáo y học: "volution of an adenocarcinoma in response to selection by targeted kinase inhibitors" potx
... mechanisms of drug resistance accrual. Background Large-scale sequence analysis of cancer transcriptomes, predominantly using expressed sequence tags (ESTs) [1] or serial analysis of gene expression ... processing for transcriptome analysis was con- ducted as previously described [15,16,40]. The relapse sample was obtained by surgical excision of the skin metastasis under local anesthetic 5 days ... expressed. Consistent with our observations, administration of sunitinib was associated with stable disease lasting 4 months, after which the lung lesions began to grow. Administration of sorafenib...
Ngày tải lên: 09/08/2014, 20:22
The World Bank Group’s Response to the Global Economic Crisisch03
... response and a smaller IDA response? ??is similar to the Bank? ?s response to the East Asian crisis (fiscal 1998–99) The increase in Bank disbursements—a more relevant measure of the Bank? ?s crisis ... provides details on the social protection and infrastructure sectors, because they are also covered by Bank special crisis -response initiatives It also describes the Global Food Response Program ... hedging strategies, as well as consideration of how advisory services could be deployed in support of investment clients (IFC 2008) As in past crises, IFC? ?s initial core business response was largely...
Ngày tải lên: 30/08/2016, 15:38
Combined transcriptome and metabolome analyses to understand the dynamic responses of rice plants to attack by the rice stem borer Chilo suppressalis (Lepidoptera: Crambidae)
... was used to assess the similarity of the expression of rice genes induced by C suppressalis with indexed data sets of those elicited by exogenous application of phytohormones to Arabidopsis as ... carbohydrates such as galactose, fructose, and mannose The genes in class IV are mainly related to the metabolism of starch and sucrose, and to the biosynthesis of photosynthesis-antenna proteins, flavone, ... dynamic responses of rice plants to attack by C suppressalis, with the expectation to provide a better understanding of rice defense mechanisms to C suppressalis infestation and clues for the...
Ngày tải lên: 22/05/2020, 05:04
Dissection of the style’s response to pollination using transcriptome profiling in self-compatible (Solanum pimpinellifolium) and self-incompatible (Solanum chilense) tomato species
... responses, such as defense response to fungus, response to fungus, immune response, and immune system process in the SCP vs SCUP comparison This result is consistent with other plant pollination studies, ... showed significant (P-value < 0.05) differences in counts between Page of 14 SCP vs SCUP styles and SIP vs SIUP styles These results suggested that despite certain mechanisms of SC and SI appear to ... transcriptome-level studies Thus, to the best of our knowledge, this is the first study to perform comparative transcriptome analyses of SC and SI tomato unpollinated/pollinated styles using RNA-seq The results...
Ngày tải lên: 26/05/2020, 20:56
Can functional traits predict plant community response to global change?
... grass Woody shrub GL CSS CSS and GL CSS and GL CSS and GL CSS and GL CSS and GL CSS and GL CSS and GL CSS CSS and GL CSS CSS CSS and GL CSS CSS Note: Invasive species are denoted with an asterisk ... et al 2006) We measured traits of dominant species in adjacent Southern California grassland and coastal sage scrub ecosystems and related those traits to species responses to precipitation and ... composition, and by scaling trait responses to the community level Specifically, we addressed the following questions: (1) Do traits related to water and nitrogen use determine species’ responses to water...
Ngày tải lên: 19/11/2022, 11:41
parathyroid hormone s enhancement of bones osteogenic response to loading is affected by ageing in a dose and time dependent manner
... Lanyon, Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition, ... according to ASBMR guidelines.[23] Previously-validated, freely available site-specificity software was used to analyze whole bones and allow comparisons of the effects of treatment across all sites ... effect of PTH.[12] Sclerostin down regulation is also a necessary step in bone? ?s anabolic response to mechanical stimulation[13] suggesting some commonality between the mechanisms of action of iPTH...
Ngày tải lên: 04/12/2022, 15:59
Tài liệu REPORT BY THE DIRECTOR-GENERAL ON THE UNITED NATIONS DECADE OF EDUCATION FOR SUSTAINABLE DEVELOPMENT: INTERNATIONAL IMPLEMENTATION SCHEME AND UNESCO’S CONTRIBUTION TO THE IMPLEMENTATION OF THE DECADE doc
... environmental NGOs Private local business clans and families individuals private sector businesses business associations regional business associations international associations of businesses (e.g in ... at all levels are necessary to initiate such processes This section makes several proposals in response to these questions, beginning with a focus on mechanisms which will give voice to the local ... outlines UNESCO? ?s leadership tasks The IIS also lists key milestones for the DESD It then lays out seven strategies for moving forward with ESD and describes how this wide range of partners can...
Ngày tải lên: 21/02/2014, 17:20
Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt
... potently suppressed autophagic flux in response to nutrient deprivation (Fig 5B) Bcl-2 overexpression inhibits autophagy due to depletion of sequestered S ⁄ ER Ca2+ stores The strong suppressive effect ... portions of the cytoplasm, such as mitochondria and protein aggregates, are surrounded by double-membrane vesicles called autophagosomes; delivery of autophagosomes and their contents to lysosomes; ... autophagy is suppressed [30,31] These results demonstrate that autophagic flux was substantially upregulated in HL-1 cells in response to nutrient deprivation, consistent with previous reports [32,33]...
Ngày tải lên: 07/03/2014, 09:20
Báo cáo " Thailand’s inadequate response to the 2008 Economic Crisis: Implications for Vietnam and other countries entering the East Asian economic model " pptx
... military to suppress workers’ rights, freedom of association and freedom of speech. As Studwell has observed: “The great discovery of south-east Asian governments in the late 196 0s was that ... these markets will swiftly or persistently return to pre-crisis levels, though, since many European nations have ignored the lessons provided by Keynes of avoiding economic recessions by ... rectitude. The crisis also had the more positive aspect of requiring certain banks to address the issues of non-performing loans and assets and forcing the revaluation of some assets which had...
Ngày tải lên: 22/03/2014, 13:20
plant physiological ecology (lambers et al 2008)
... Compounds The Plant s Response to Attack by Microorganisms Cross-Talk Between Induced Systemic Resistance and Defense Against Herbivores Messages from One Organism to Another References 9D Parasitic ... degree of stress resistance Mechanisms of The stress response is the immediate detrimental effect of a stress on a plant process This generally occurs over a time scale of seconds to days, resulting ... process Time Scale of Plant Response to Environment FIGURE Typical time course of plant response to environmental stress The immediate response to environmental stress is a reduction in physiological...
Ngày tải lên: 03/04/2015, 15:00
báo cáo hóa học:" Risk factor analysis for early femoral failure in metal-on-metal hip resurfacing arthroplasty: the effect of bone density and body mass index" potx
... dysplasia in 52 hips (14%), osteonecrosis in 14 cases (4%), post-traumatic arthritis in cases (2%), LeggCalve-Perthes in three cases (0.8%), slipped capital femoral epiphysis in three cases (0.8%), ... reported to be performed using resurfacing implants[1, 2] Clinical studies have demonstrated successful early to midterm results (1-10 years) with survivorship rates ranging from 93.2% to 99.8% ... logistic regression models were tested by changing the types and thresholds of these variables in order to find the best regression model to predict the early femoral failures The final regression...
Ngày tải lên: 20/06/2014, 07:20
Báo cáo khoa học: "Wood density traits in Norway spruce understorey: effects of growth rate and birch shelterwood densit" ppsx
... Norway spruce is considered to be a semi-shade tolerant species and can adapt to a wide variety of light conditions Stratified stand mixtures, composed of shade tolerant late successional species ... rate class separately, and differences were tested using dummy variables as described by Zar [53] All analyses were performed using SPSS 7.0 for Windows [47] RESULTS Radial fluctuations in annual ... densité minimale et le pourcentage de bois d’automne sont plus élev s pour les arbres dont le taux de croissance est le plus faible par rapport tous les autres arbres, tandis que l’on ne constate...
Ngày tải lên: 08/08/2014, 14:21
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... using the QuikChange XL Site Directed Mutagenesis Kit (Stratagene, La Jolla, CA, USA) Pull-down assay GST-fusion proteins were prepared and used for the pulldown assays, as described previously ... from the soma was decreased in neurons overexpressing v-KIND, but increased in neurons overexpressing either KIND2 or KIND2-1, compared to neurons expressing EGFP (Fig 5B) Neurons overexpressing ... v-KIND was specifically localized to dendrites and soma, although not to axons The expression of three other KIND2-containing constructs (DKIND1, DRasN and DGEF) was restricted to dendrites and soma...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Growth, Distribution, and Tax Reform: Thoughts on the Romney Proposal pdf
... seems to have gotten short shrift in the debate over the proposal To assess the effects of moving from tax system X to tax system Y, one needs to know what X and Y are In this case, X is the status ... assumed that no one s labor or savings behavior differed across various tax regimes Finally, it seems odd to assume away possible increases in incomes associated with a given tax reform proposal ... taxes on economic growth is uncertain To be sure, there is a lot of disagreement on this issue among professional economists But that is not sufficient cause to assume that the right answer is...
Ngày tải lên: 20/02/2014, 19:20