physiologically based pharmacokinetics and pharmacodynamics of skin

... scheme for danaparoid, based on a mathematical model aiming at a peak anti-Xa level of less than 1.0 and a maintenance level of between 0.5 and 0.7 anti-Xa-U/mL Lindhoff-Last and colleagues [5] have ... high (6 to 8) probability of HIT With the exception of patient 2, all patients had positive antibodies against the heparin/PF4 complex Pharmacokinetics and pharmacodynamics of danaparoid during continuous ... is the first time the pharmacokinetics and pharmacodynamics of danaparoid have been studied during CVVH A limitation of this study is that we used an ultrafiltration rate of L/hour, which is lower...

Ngày tải lên: 13/08/2014, 08:20

... themselves, and the variation is given by the number of times the data points appear Another type of bootstrap is based on a model M1, and on analysis of the corresponding residuals In such residual -based ... The number of runs Ru is defined as the number of sign changes in the sequence of residuals, and it is compared to the expected number of runs, N/2 (because it is assumed that the mean of the uncorrelated ... modeling is often used to achieve a characterization of which of these mechanisms that are significantly active, and independently important, and which mechanisms are present but not significantly and/ or...

Ngày tải lên: 23/03/2014, 06:20

... determination of IMPDH activity, analyses of IMPDH and expression and characterization of T cell subpopulations The PK and PD profiles of MPA changed with time after transplantation Materials and methods ... range of total observations Profiles of patients in the belatacept group (n = 3) at weeks 1, and 13 (A, B and C) and the cyclosporine group (n = 3) at weeks 1, and 13 (D, E and F) Page 10 of 14 ... represent the range of total observations Profiles of patients in the belatacept group (n = 3) at weeks 1, and 13 (A, B and C) and the cyclosporine group (n = 3) at weeks 1, and 13 (D, E and F) (Observe...

Ngày tải lên: 18/06/2014, 15:20

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Ngày tải lên: 07/08/2014, 18:21

... in the conception of the study and interpretation of data VJ performed conception and design of the study and substantially contributed to interpretation of data, drafting of the manuscript, ... preparation and mass spectrometry measurements, respectively JW performed many of the animal experiments ACM and MB performed critical revision of the manuscript HE synthesized and provided ErPC and ... period of one day, urine was collected every 24hours for days under water-saturated oil and stored at 20°C Analysis of ErPC3 in body fluids and tissues For the quantitative measurement of Erufosine...

Ngày tải lên: 09/08/2014, 10:20

... included incidence, severity, and treatment relationship of adverse and serious adverse events and the regular monitoring of hematology, serum and urine chemistry, vital signs, and physical condition ... design of the study, carried out parts of the study, wrote the manuscript, and contributed equally to this study; LS and DY carried out parts of the study and contributed to critical review of the ... E, Alexandre J, Faivre S, Vera K, Materman E, Boni J, Leister C, Korth-Bradley J, Hanauske A, Armand JP: Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779,...

Ngày tải lên: 10/08/2014, 21:23

... between sample -based clustering and metabolite -based clustering Illustration of differences between sample -based clustering and metabolite -based clustering A toy example matrix of intensity measurements ... associates the intensity profile of JA and its precursor OPC-4 (blue dot at rt 0.98 in the rt-m/z plane in figure 5) with the profile of a group of marker candidates of high molecular weight (m/z ... Eigenvalue spectrum of sample -based PCA Eigenvalue spectrum of sample -based PCA Eigenvalue spectrum of sample -based PCA showing variance of the first 20 principal components Page 14 of 18 (page number...

Ngày tải lên: 12/08/2014, 17:20

... the concept of virtual reality (VR) and computer haptics; the surface -based and volume -based modeling approach of virtual objects; haptic rendering methods; and the current state of VR and haptic ... APIs and DLLs to control the behaviors of the graphic and haptic hardware The software layer is composed of a data access module to manipulate the data structures of the voxel -based oral model and ... LIST OF TABLES Table 4.1 Summary of CBCT imaging of the patient 37 Table 5.1 Summary of CBCT imaging of the jaw segment 55 Table 6.1 List of control points for the registration of CT...

Ngày tải lên: 09/09/2015, 10:07

... circulation and utilization of knowledge require people’s participation and seldom automatically follow the availability of technology support (Brown and Duguid 1991; Davenport and Prusak 1998; Vandenbosch ... advocates the adoption of KM tools and practices (Purvis et al 2001) It can occur through articulation of the importance of KM, assignment of knowledge champions, and encouragement of employees’ participation ... advantage (Eisenhardt and Martin 2000; Wade and Hulland 2004) Effective KM can support the processes of consolidating existing knowledge and generating new and unforeseen means of improving organizational...

Ngày tải lên: 11/09/2015, 10:06

... data of MPA and MPAG 101 Table 4.4 Apparent clearance values and elimination half-lives of MPA and MPAG, and apparent volume of distribution for MPA obtained based on the five-compartment drug and ... UGT1A7, 1A8, 1A9 and 1A10 polymorphisms on the steady-state PK of MPA and MPAG 249 5.3.2.2 Haplotype analysis of UGT1A7, 1A8, 1A9 and 1A10 polymorphisms and impact of haplotypes and diplotypes ... representation of the de novo and salvage pathways of guanosine nucleotide biosynthesis, showing the mechanism of action of MPA by inhibition of the de novo pathway 10 Figure 3.1 The influence of pH of running...

Ngày tải lên: 12/09/2015, 08:18

... encouragement and tremendous help offered I am grateful for his trust and belief in me I am thankful to Prof Teoh Swee Hin for his advice and assistance I thank all the staff and research scholars of Biosignal ... intelligence and robotics 2.1.1 Simulation and Planning A surgical plan in reconstructive surgery needs information of the shape, symmetry, dimension, and function of hard and soft tissue At ... potential source of errors Therefore, validation should involve the study of the performance and validity of the overall system, the performance and validity of the individual components, and error-propagation...

Ngày tải lên: 14/09/2015, 14:01

... the appearance of the object is known These spatial methods can be categorized into four major approaches: region -based, contour -based, model -based and feature -based Examples of 10 these approaches ... region -based and contour -based are not suitable for reliably detecting and tracking individuals in this scenario In this thesis, we propose a feature -based approach to detect the head of an individual, ... colleagues and friends for always inspiring and helping me in my times of personal and financial needs Finally, I would like to thank my parents and my wife for their endless love and support...

Ngày tải lên: 14/09/2015, 14:05

... Simulation and Emergence of Metabolic Network using the agent -based model 37 3.2 Illustration of Agent -based Execution of Metabolic Network 41 3.3 Application of Agent -based Model ... development of comparative tools and maintenance of databases for the analysis of genomics data in the domain of bioinformatics, as well as the construction of models for the analysis and integration of ... and specified environment (identification of fixed concentrations, inflows and outflows) The state of the network is represented by a complete set of concentrations of intermediates The set of...

Ngày tải lên: 26/11/2015, 13:02

... MDZ and metabolite profile was optimized and, followed by the addition of the ITZ data and models, was used to test the Page of 15 (page number not for citation purposes) Theoretical Biology and ... curves its Figure state standard deviation plots of the CYP3A5 *1/*1 (n = 6), and the *1/*3 (n = 6) and CYP3A5*3/*3 optimized sum of Mean ± standard deviation plots of the experimental observed ... al [29] and Shih & Huang [30] found no effect of the CYP3A5 genotype on the elimination of MDZ in a mixed population of healthy white and African American adults and Chinese volun- Page of 15 (page...

Ngày tải lên: 13/08/2014, 16:21

... mechanistic basis of the variability in pharmacokinetics and pharmacodynamics of this agent xi PUBLICATIONS AND ABSTRACTS Publications The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 ... haplotypes and diplotypes in healthy local populations* and Chinese NPC patients (N = 50) ABCB1, ABCC2 and ABCG2 polymorphisms and their relationships with pharmacokinetics and pharmacodynamics of docetaxel ... course of absorption, distribution, metabolism and excretion of a drug molecule and its metabolites Pharmacodynamics, on the other hand, is a study on the biochemical and physiological effects of...

Ngày tải lên: 10/09/2015, 09:08

... 5, 30 and 60 nM of icariside I and 71 icariside II, respectively and internal standard in pooled rat sera, were placed at the beginning and end of each assay for determination of accuracy and imprecision ... Accuracy and imprecision of the method were studied by using QC samples consisting of a high, medium and low concentration of the five analytes, containing 1, and 10 nM of icariin, icaritin and desmethylicaritin; ... Mixture of five analyte standards and internal standard were spiked into 0.1 mL of methanol (neat solution) and 0.5 mL of serum extract, respectively Neat solution samples were directly injected and...

Ngày tải lên: 10/09/2015, 15:48

... steroid 89 3.1.3 Validation of ERα and ERβ cell -based bioassays The inter- and intra-assay variations of both ERα and ERβ bioassays, were determined by using 0.1 nM and 0.5 nM of estradiol, respectively ... 175 200 [E2], pM 92 3.1.4 Isoform selectivity of DPN, PPT and genistein To assess the ER-isoform selectivity of ERα and ERβ bioassays, compounds such as, DPN, PPT and genistein, which are non-steroidal ... presence of 50 pM of estradiol for a duration of days Changes of cell culture media were carried out twice on the second and fourth day of incubation Similar to what was observed for ERα and ERβ...

Ngày tải lên: 10/09/2015, 15:54

... ex-vivo at close time points for pharmacokinetics and pharmacodynamics studies 199 4.2 Pharmacokinetics and pharmacodynamics of Epimedium compounds 4.2.1 Pharmacokinetics of unconjugated prenylflavonoid ... determined to be 8.1% and 16% respectively Detection limits for estradiol in ERα and ERβ bioassays were 8.4 and 13.1 pM, respectively This set of assays is simple and rapid to perform and offers highthroughput, ... differentiation of ERα and ERβ bioactivities We validated this aspect of our bioassays using well-known ER-isoform selective ligands, such as genistein, PPT and DPN Similar to the results reported by Escande...

Ngày tải lên: 10/09/2015, 15:54

... levels of estrone and estradiol by tandem mass spectrometry, for ERα and ERβ bioactivity and MCF-7 breast cancer cell proliferative effects The concentrations of icaritin and desmethylicaritin and ... methods coupled with cell -based bioassays that can measure global estrogenicity of sera of animals were employed to understand the levels and bioactivity of conjugated and unconjugated active compounds ... duration of two studies and the number of metabolites that were examined also differed The rat study reported the levels of total amounts of prenylflavonoids absorbed (sum of conjugated and unconjugated...

Ngày tải lên: 10/09/2015, 15:54

... C.X and Chen, Y.M 2009 Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials Bone 44(5):948–953 Liu, J., Ye, H and ... Jansen, H.J., Riteco, J.A., Brouwer, A and van der Burg, B 2005 Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line -based highly selective steroid-responsive ... S and Ishikawa, F 2006 Bioavailability of isoflavones after ingestion of soy beverages in healthy adults J Nutr 136(9):2291-6 Kanaze, F.I., Bounartzi, M.I., Georgarakis, M and Niopas, I 2007 Pharmacokinetics...

Ngày tải lên: 10/09/2015, 15:54