phase ii and phase iii

Ngày tải lên: 14/11/2014, 12:48

... [3-5], and treatment often follows the management of other dermatoses There are a number of reports from prospective controlled clinical studies for breast cancer patients including phase II and III ... radiation dermatitis In one Phase III trial, 194 female patients receiving breast or chest-wall irradiation were randomized to receive an aloe vera gel or placebo gel, and 108 female patients undergoing ... and propylparaben The gel was applied in a manner identical to that described above for the APP cream Statistical considerations The study was designed as a prospective and randomized Phase III...

Ngày tải lên: 09/08/2014, 10:21

... CCII or MTX in a randomized, doubleblind, multicenter, and controlled phase III clinical trial Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by pain, swelling, and ... patients with RA In this phase III trial, CCII at 0.1 mg daily and MTX at 10 mg once weekly effectively alleviated signs and symptoms of active RA However, the efficacy of CCII did not exceed that ... double-blind, double-dummy, randomized, and MTX-controlled trial comparing efficacy and safety of CCII and MTX in the treatment of RA Patients were randomly assigned to a CCII (n = 326) or MTX (n =...

Ngày tải lên: 12/08/2014, 11:22

... for the solid phase extraction studies In this work, a simple and accurate procedure for cadmium (II) and lead (II) ions that is based on solid phase extraction of cadmium (II) and lead (II) as their ... Microprobe Tech 15, 197–204 Soylak, M., 2004 Solid phase extraction of Cu (II) , Pb (II) , Fe (III) , Co (II) and Cr (III) on Chelex 100 Column prior to their flame atomic absorption spectrometric determinations ... effects of sample and eluent flow rates on the recoveries of Cd (II) and Pb (II) -1-phenyl-1H-tetrazole-5-thiol chelates in the range of 1.5–6.0 ml minÀ1 The recoveries of Cd (II) and Pb (II) were quantitative...

Ngày tải lên: 02/09/2015, 13:45

... of GCPIII-specific therapeutics and ligands, as well as in the investigation of the diverse biological functions of GCPIII and GCPII Experimental procedures rhGCPIII and rhGCPII expression and purification ... portions of human GCPII and GCPIII (rhGCPII and rhGCPIII; amino acids 44–750 and 36–740, respectively), were expressed and purified as described previously [25,38] Briefly, rhGCPIII was heterologously ... displacement parameters was used in the case of the rhGCPIII ⁄ EPE and rhGCPIII ⁄ Glu complexes, whereas the rhGCPIII ⁄ QA and rhGCPIII ⁄ ‘pseudo-unliganded’ complexes were refined using the isotropic...

Ngày tải lên: 23/03/2014, 05:22

... Phase III, randomized, double-blind, placebo-controlled trial, adalimumab improved HRQOL outcomes in patients with psoriasis, as measured with both the Dermatology Life Quality Index (DLQI) and ... assisted Abbott Laboratories with the original Phase III study design and acquisition of data All authors were involved in drafting the manuscript and critically reviewing it for intellectual content ... moderate to severe psoriasis: A randomized, controlled phase III trial J Am Acad Dermatol 2008, 58(1):106-115 Ware JE, Kosinski M, Keller SD: The SF-36 Physical and Mental Health Summary Scales:...

Ngày tải lên: 18/06/2014, 19:20

... Figure Alignment of human, murine and viral ligands for the human and the murine lymphotactin receptor Alignment of human, murine and viral ligands for the human and the murine lymphotactin receptor ... mXCL1 and XCL1 are very similar (60 % identity and 84 % similarity using BLASTP 2.2.17 at the NCBI website)(Figure 1) In contrast, vCCL2 and vCCL3 have only 31 and 32 % identity and 50 and 54 ... CCR1, CCR2, and CCR5 ligands However, vCCL2 also targets XCR1, CX3CR1 and CXCR4 and it does not cluster with the ligands of these receptors This sequence divergence between viral and human chemokines...

Ngày tải lên: 20/06/2014, 01:20

... three -phase study Phases I and II resulted in two NRC letter reports: one in 2009 and one in 2010.1 This is the Phase III report Findings and recommendations from the Phase I and Phase II reports ... standard The recommendations of the Phase II committee are contained in Appendix L In this final report, the Phase III committee has carried out the Phase III tasks and consolidated and expanded ... Body Armor Materials: Phase III Testing of Body Armor Materials Phase III Committee on Testing of Body Armor Materials for Use by the U.S Army— Phase III Board on Army Science and Technology Division...

Ngày tải lên: 29/06/2014, 09:21

... Despite its use, data on outcomes with NCR for Stage II and III extremity STS are limited A prospective, randomized trial comparing NCR to NR and SA is needed to provide more robust knowledge In ... nor NR appeared to improve LR-RFS compared to SA Previous phase III randomized trials have shown pre- and post-operative EBRT [14-19] and peri-operative brachytherapy [20-22] improve LR-RFS compared ... neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities Radiation Oncology 2011 6:91 Submit your next manuscript to BioMed Central and take full advantage...

Ngày tải lên: 09/08/2014, 09:20

... studies, to stimulate and improve the implementation of stereotactic techniques in clinical practice and to improve the comparability of results Methods A randomized phase III trial of Radiosurgery ... Amsterdam and the Dutch Lung Cancer Research Group The primary study objectives are to compare local and regional control, quality of life and treatment costs at and years in patients who are randomized ... end-inspiration and end-expiration phase bins using axial, sagittal and coronal views In addition to the MIP contouring, the GTV should also be contoured in a single phase (preferably the end-expiration phase, ...

Ngày tải lên: 09/08/2014, 09:22

... number of LNs removed for both Stage II (R = -0.692, p = 0.0004) (Figure 1A) and III (R = -0.774, p < 0.0001) (Figure 1B) patients; however, for Stage II and III colon cancer patients, there was ... staging of Stage II and III colon cancer patients Collection of ≥ 20 LNs, however, was associated with reduced risk of recurrence and improved survival for Stage II but not for Stage III colon cancer ... 5-year survival of Stage II patients who had ≤ LNs examined was similar to that for Stage III patients (51.8%) Sixteen of 17 studies of Stage II and of studies of Stage III showed improved patient...

Ngày tải lên: 10/08/2014, 21:23

... of donor segment II and III bile ducts that are less prone to stricturing due to their larger caliber However, this advantage may be lost in cases where the segment II and III bile ducts join ... prone to strictures and leaks as the liver regenerates [1] In our report, the left lateral segment was split along a non-anatomical plane and the confluence of segments II and III bile ducts provided ... umbilical portion of the left portal vein and the segment IV duct, then joined medial to umbilical portion This confluence of segment II and III ducts was divided and used for anastomosis in the recipient...

Ngày tải lên: 11/08/2014, 02:22

... participated in phase II, which will end at least six months prior to the onset of phase III We believe there will be little or no carry-over effect on physician behavior in phase III because physicians ... Implementation study Why we need to conduct this proposed phase III implementation study, especially after the large and successful phase I derivation and phase II validation studies? First, physician behaviour ... implementation, such as whether our simple and inexpensive implementation strategy can be expected to have a long-term effect Will incorporation of phase II sites in phase III lead to contamination? Seven...

Ngày tải lên: 11/08/2014, 05:22

... injury, may be efficacious, and that expanded multicenter trials are necessary The challenge moving forward will be the design of an appropriate multicenter phase III trial with several questions ... results of phase III trials with progesterone in traumatic brain injury In the meantime, the scientific community needs to continue to pursue similar, early phase trials with other candidate neuroprotective ... 11 hours following their injury Would earlier enrollment and administration of the drug improve efficacy? Would enrollment of patients and administration of drug in the pre-hospital setting further...

Ngày tải lên: 13/08/2014, 11:22

... crisis would occur, those unfamiliar with the procedures would not know how to handle the situation A B C D 23 Standing among so many strangers, the frightened child began to sob uncontrollable ... sought with his company A B C D 32 Ms Thoa and her children hope go hiking in the mountains this weekend if the weather permits A B C D 33 The political candidate talked as if she has already been ... house was infested with termites A B C D ANSWERS AND EXPLANATIONS (B) should be ghost Ghost is an adjective in this sentence modifying the noun stories and thus cannot be in the plural form (B) should...

Ngày tải lên: 27/06/2013, 11:46

... instructione', p 172 `Topographia Hibernica', distinctio iii, cap xlix-lii In Werner (ed.), `De principis instructione', distinctio ii, cap viii-xi, the same passages are reused, in a different order, ... ®n du VIIIe a la ®n du XIIe Á siecle, Angers, 1994, pp 529, 540 130 Duke Geoffrey, Henry II and the Angevin empire Henry II, especially after the death of the bride's father in 1171, and the ... p 115 Chronicle of Geoffrey de Vigeois (RHF, xviii, p 212); Actes de Henri II, no dcxvii; RH, ii, p 273; Gesta, p 291; RT, ii, p 117 131 Brittany and the Angevins It was in these circumstances...

Ngày tải lên: 01/11/2013, 07:20

... Stephen, Henry II and Richard I, Rolls Series, London, 1885, book ii, chs xvii-xxii and book iii, ch i RT, ii, pp 5±7; Ann ang., p 15; Actes d'Henri II, nos cclxxii and cclxxiii 45 Brittany and the ... d'Henri II, no.cccclxviii) Thereafter, he attested royal charters at Caen (Actes d'Henri II, nos cccclxxiii, cccclxxiv), Angers (Actes d'Henri II, nos diii and dix), Le Mans (Actes d'Henri II, no ... Petroc, Appendix III, `Lands of Roland de Dinan in the Pipe Rolls' Pipe Roll Henry II, 1160±1161, pp 34, 46, 48, 52±3 56 Henry II and Brittany Rolland made peace with Henry II soon afterwards,...

Ngày tải lên: 01/11/2013, 07:20

... quang 22 II. 3.2 Xác định đồng thời hàm lợng sắt (II) sắt (III) mẫu giả 23 II. 3.3 Xác định đồng thời hàm lợng sắt (II) sắt (III) nớc 26 ngầm khối khối - phờng Trung Đô- Thành phố Vinh Phần III: Kết ... tính Nhờ tính chất xác định đồng thời sắt (II) sắt (III) nớc II. 3.2 Xác định đồng thời hàm lợng sắt (II) sắt (III) mẫu giả Lấy 0,2ml Fe (II) 0,005ml Fe (III) nồng độ 10-3M cho vào bình định mức 25ml ... tơng đối từ (-2,4%) ữ (-5%) II. 3.2.2 Xác định đồng thời hàm lợng sắt (II) sắt (III) mẫu giả trình khử hoàn toàn sắt (III) xuống sắt (II) Gọi x2, y2 lần lợt nồng độ Fe (II) Fe (III) ban đầu, từ phơng trình(1)...

Ngày tải lên: 24/12/2013, 09:36

... affected, for Mn (III) heme–HSA and Mn (III) heme– HSA-myristate at : : 3, : : 4.5, and : : molar ratios Values of pK for the three titration steps, obtained at the different Mn (III) heme–HSA-myristate ... measured at 10 MHz and 25.0 °C of fatty acid-free Mn (III) heme– HSA and of Mn (III) heme–HSA-myristate pK values were obtained by fitting data in Fig according to Eqn (2) Mn (III) heme ⁄ HSA ⁄ fatty ... the other hand, both X-ray structures deposited in PDB so far for Fe (III) heme–HSA display the Tyr161 residue as the only axial ligand for Fe (III) [6,8] In the absence of myristate, Mn (III) heme–HSA...

Ngày tải lên: 20/02/2014, 02:22

... Fig RNA polymerase (pol) II and DNA polymerase (Pol) e co-immunoprecipitate and copurify Pol e, but not Pol a and Pol d, co-immunoprecipitates with RNA pol II, and RNA pol IIO co-immunoprecipitates ... II antibody N20, which recognizes both the IIA and the IIO form Although less RNA pol II appears to be recognized by the antibody in this application, the focal colocalization of RNA pol II and ... polymerase II Table Comparison of colocalization and focal staining of Pol e and RNA pol II by immunoelectron microscopy The number of gold particles representing Pol e (5 nm) and RNA pol II (10 nm), and...

Ngày tải lên: 07/03/2014, 11:20