phase i ii studies in patients with acute leukemia

... mechanical intubation, need for non-invasive ventilation, need for catecholamine and admission medical treatment (diuretics, nitrates, angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor ... mortality in individuals with and without cardiovascular disease [24] Angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARB) and beta-blockers build the mainstay ... respiratory failure While early diagnosis is often difficult to perform in ICU patients presenting with acute respiratory failure, this finding may be of major clinical importance Roughly one-third of...

Ngày tải lên: 13/08/2014, 21:21

... imaging is crucial to identify ischemic tissue 7, 24-29 In principle, our findings are confirming previously published studies about infarct detection and size, who described significant differences ... Int J Med Sci 2011, ability by the deformation indices two-dimensional strain (2DS) and strain rate (SR), might be an alternative approach in clinical routine Tissue Doppler Imaging (TDI) ... CABG In the 11 patients with vessel disease a stenosis > 50% was found in the circumflex artery in patients and in the right coronary artery in patients Complete revascularization in the patients...

Ngày tải lên: 25/10/2012, 11:15

... plasminogen activator inhibitor-2 (PAI2) was only found in patients E and F with the subtyp FAB M0 and M4, respectively This finding is inline with data from the PAI-2 serum levels of patients with hematological ... and maintenance of the histo-architecture Plasmonogen activator inhibitor-2 (PAI-2) Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator and its receptor, ... using 2D-electrophoresis Furthermore, protein expression profiling is likely to further impact the analysis of mechanisms involved in acute leukemia by examining routinely available biological...

Ngày tải lên: 18/06/2014, 15:20

... related to the inhibition of tPA-mediated mechanisms of excitotoxicity, inflammation, as well as blood brain barrier disruption that occur after acute ischemic stroke This is in line with recent ... Translational Medicine 2011, 9:58 http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information ... of Science and Innovation CIT-090100-2007-42, PI081472 and (Instituto de Salud Carlos III) RETICS-RD06/0026; Xunta de Galicia (Consellería de Innovación, Industria e Comercio: PGIDIT06PXIB918316PR;...

Ngày tải lên: 18/06/2014, 19:20

... related to the inhibition of tPA-mediated mechanisms of excitotoxicity, inflammation, as well as blood brain barrier disruption that occur after acute ischemic stroke This is in line with recent ... Translational Medicine 2011, 9:58 http://www.translational-medicine.com/content/9/1/58 our group obtained after investigating neuroserpin effects using an in vitro model of brain ischemia [40] The information ... of Science and Innovation CIT-090100-2007-42, PI081472 and (Instituto de Salud Carlos III) RETICS-RD06/0026; Xunta de Galicia (Consellería de Innovación, Industria e Comercio: PGIDIT06PXIB918316PR;...

Ngày tải lên: 20/06/2014, 03:20

... Immediate publication on acceptance Open access: articles freely available online High visibility within the field Retaining the copyright to your article Submit your next manuscript at springeropen.com ... to elucidate the other metabolic effects and control for complex medication regimens The results of this investigation are in line with a previous study that found minimal change in QTc intervals ... obtained from Medical Isotopes, Inc., Pelham, NH) as internal standard In brief, the samples were 60-min post-initial test 51 (21-69) 60 (31-78) Total rac-albuterol utilisation in preceding 24...

Ngày tải lên: 21/06/2014, 03:20

... population of patients with ALI Conclusions The diagnostic utility of BNP is not well established in critically ill patients with hypoxemic respiratory failure attributed to ALI We examined the ... association of BNP levels with RV dilatation and with patient outcomes (mortality) in patients with ALI Although BNP levels were elevated in patients with ALI, there was no association with RV dilatation ... 342:1301-1308 doi:10.1186/2110-5820-1-18 Cite this article as: Cepkova et al.: Clinical significance of elevated Btype natriuretic peptide in patients with acute lung injury with or without right ventricular...

Ngày tải lên: 21/06/2014, 03:20

... submission Rigorous peer review Immediate publication on acceptance Open access: articles freely available online High visibility within the field Retaining the copyright to your article Submit ... small increases in serum creatinine level during hospitalization for acute myocardial infarction Arch Intern Med 2008, 168:609-616 Ishani A, Xue JL, Himmelfarb J, Eggers PW, Kimmel PL, Molitoris ... Kilpatrick RD, Shinaberger CS, McAllister CJ, Budoff MJ, Salusky IB, Kopple JD: Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients Kidney Int 2006,...

Ngày tải lên: 21/06/2014, 03:20

... number of limitations The patients were recruited in daily, routine clinical practice at admittance to the acute ward It is difficult to imagine how a blinded research design regarding inclusion could ... questionnaire consists of ten items designed to identify patients with harmful alcohol use [23] It has a scoring range 0-40 with scorings ≥8 indicating problem drinking The questionnaire was administered ... were significant group differences in seizures in clinical history and EEG pathology, and a significant difference with regard to number of patients fulfilling clinical criteria for epilepsy...

Ngày tải lên: 11/08/2014, 17:20

... has an intrinsic limitation, in that exploratory sampling in the lung is limited Additional study measuring KL-6 in ELF from different sampling sites in the lungs of each ARDS patient is necessary ... Conclusion Concentrations of KL-6 in pulmonary ELF early after ARDS diagnosis were found to be significantly higher in nonsurviving patients than in surviving patients Furthermore, ARDS patients with ... fluid (ELF) In the normal lung, this glycoprotein can be predominantly found on alveolar type II epithelial cells, and its expression is greatly increased in proliferating, regenerating, or injured...

Ngày tải lên: 12/08/2014, 13:22

... ANP infusion in patients with severe chronic obstructive pulmonary diseases They found a deterioration in the ventilation–perfusion relationship during ANP infusion, with a decrease in arterial ... production of nitric oxide in patients infected with the European variant of hantavirus Scand J Infect Dis 1995, 27:453–456 Young JD, Dyar OJ: Delivery and monitoring of inhaled nitric oxide Intensive ... either during ANP infusion or during NO inhalation In patients who responded to NO inhalation with an increase in PaO2/FiO2 > 10%, EVLWI tended to be lower than in patients who did not show such...

Ngày tải lên: 12/08/2014, 18:21

... material may worsen lung injury, it appears prudent to limit this procedure to specific indications in patients with ALI undergoing a thoracic CT scan 10 11 12 13 14 condition of patients with ALI, ... messages • • In patients with ALI, administration of contrast material induces an apparent increase in lung tissue This apparent increase in lung tissue results from a true increase in extravascular ... characterizing each individual voxel is expressed in HU and is defined as the attenuation coefficient of the radiogram by the material being studied minus the attenuation coefficient of water divided...

Ngày tải lên: 12/08/2014, 19:21

... tracheostomy in patients with acute respiratory failure Physician belief in the utility of tracheostomy, patient selection and the lack of blinding may introduce bias, leading to difficulties in comparing ... their sole injury or in addition to torso and extremity injuries The remaining patients had various surgical problems including intra-abdominal sepsis and ruptured abdominal aortic aneurysm Patients ... Fatigue while weaning was defined by a combination of clinical evidence of respiratory distress accompanied by an ordered increase in positive pressure support (increased synchronized intermittent...

Ngày tải lên: 12/08/2014, 20:20

... Arteries (GUSTO) IIb investigators N Engl J Med 1996, 335:775-782 Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes The PURSUIT Trial Investigators ... in most critically ill patients with cardiovascular disease, with the possible exception of patients with acute myocardial infarction and unstable angina [3] Others studies have supported this ... transfusions to maintain hematocrit values in patients with ischemic heart disease The theory underlying this practice is that blood transfusion will increase oxygen delivery and improve outcomes in...

Ngày tải lên: 12/08/2014, 22:21

... commercial systems included in intensive-care-unit ventilators that may contribute to optimizing CO2 elimination [30], in particular in patients with severe acute respiratory syndrome associated with ... deterioration of gas exchange during endotracheal suctioning in hypoxaemic patients receiving mechanical ventilation with PEEP Conclusion Mechanical ventilation in patients with ALI/ARDS requires specific ... consequence, the administration of recruitment manoeuvres should be restricted to individualized clinical decisions aimed at improving arterial oxygenation in patients remaining severely hypoxaemic As an...

Ngày tải lên: 12/08/2014, 22:22

... significant increase in myocardial infarction in patients treated with BiPAP [21] Therefore, a small increase in risk for reducing cardiac output and/or inducing myocardial ischaemia with BiPAP ... attending physician who decided when to initiate invasive ventilation or to cease noninvasive ventilation with the assigned mode of noninvasive ventilation (for instance CPAP or BiPAP) was required ... using I2 statistics [12] Because hypercapnia is a predictor of requiring intubation in patients with cardiogenic pulmonary oedema [13], sensitivity analysis was conducted to include studies that involved...

Ngày tải lên: 12/08/2014, 23:23

... an institution using an intensive care unit benchmark Mayo Clin Proc 2005, 80:174-180 International Consensus Conferences in Intensive Care Medicine: noninvasive positive pressure ventilation in ... volumes, which is a major risk factor for ventilator induced lung injury in intubated patients, confers the same risk in patients receiving NIPPV Alternatively, the patients with metabolic acidosis or ... are initially treated with non-invasive ventilation needs to be tested in prospective clinical trials Carefully selected patients with ALI are successfully treated with non-invasive ventilation...

Ngày tải lên: 12/08/2014, 23:23

... The patients were lying on air-cushioned beds (Total Care®; Hill Rom Services Inc., Batesville, IN, USA) In the supine position and in the prone position without supports, the body of each patient ... patients were incompetent, was obtained in accordance with Italian national regulations (waived consent) Study design The patients were first studied in the supine position (1-hour baseline) Subsequently, ... volume increased in some patients after being moved from the supine to the prone position, whereas in others it decreased, suggesting different individual interactions between the opposite effects...

Ngày tải lên: 12/08/2014, 23:23

... fractional inspired oxygen; LIP, lower inflection point; M, male; Pao2, partial arterial oxygen tension; Pplat, plateau airway pressure; SAPS II, Simplified Acute Physiology Score II; UIP, upper inflection ... that is not followed by a change in PEEP level This finding is important because many clinical and experimental studies report early evaluation findings for therapeutic interventions that are initiated ... recruitment manoeuvre is less effective in pulmonary ARDS as well as in late ARDS (for example in patients with more consolidation or fibrosis) [12] In our study we included mainly patients with...

Ngày tải lên: 12/08/2014, 23:23

... result confirms that the initial portion of the P–V curve in ZEEP is essentially influenced by the inflation of previously normally aerated lung regions When the initial increase in lung volume ... Volpi A, Bricchi C, Rossi A: Lower inflection point and recruitment with PEEP in ventilated patients with acute respiratory failure J Appl Physiol 2001, 91:441-450 Lu Q, Vieira SR, Richecoeur ... Houltz E, Lundin S, Stenqvist O: Estimation of functional residual capacity at the bedside using standard monitoring equipment: a modified nitrogen washout/washin technique requiring a small change...

Ngày tải lên: 12/08/2014, 23:24