pharmacovigilance inspections in the european union

Veterinary Pharmacovigilance Adverse Reactions to Veterinary Medicinal Products docx

Ngày tải lên : 06/03/2014, 16:20

... syringe when ﬁlling or giving the injection, and animals should always be properly restrained when administering the medicine The VPC published a letter in the Veterinary Record highlighting the ... the SARSS received ten reports of blindness in cats involving the use of enroﬂoxacin and eight of these cases involved the administration of an overdose Unauthorised use in the feline of canine ... Acknowledgements Introduction D Skilton Elements of veterinary pharmacovigilance K.N Woodward Veterinary pharmacovigilance in the European Union K.N Woodward Pharmacovigilance and the European Medicines...

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safety assessment of roundup readycorn event nk603

Ngày tải lên : 01/07/2014, 18:01

... are intact; an inversely linked 217 bp piece of DNA containing a portion of the enhancer region of the rice actin promoter at the 3’ end of the inserted DNA Sequencing of the DNA inserted into ... regulated by the E35S promoter contained two nucleotide changes, one of which results in a change of the amino acid leucine to proline at position 214 in the protein The CP4 EPSPS protein containing this ... to initiate in either one of the two promoters of the NK603 insert and proceed through the NOS 3’ polyadenylation sequence and continue into the corn genomic DNA flanking the 3’ end of the insert...

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Báo cáo y học: " Safety assessment of inhaled xylitol in mice and healthy volunteers" ppsx

Ngày tải lên : 12/08/2014, 18:21

... enhance innate immunity by increasing the potency of the natural antimicrobial peptides In addition to increasing the activity of individual ASL factors, lowering the NaCl concentration also independently ... synergistic interactions [36] Thus, lowering the salt concentration could improve the antimicrobial activity of the ASL in two ways: increasing the individual action of the factors, and augmenting synergism ... increased by low ionic strength [6-9] Lowering the ASL salt concentration might therefore increase the efficacy of the innate immune system and thereby decrease or prevent airway infections The...

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Báo cáo y học: "Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis" pot

Ngày tải lên : 12/08/2014, 19:22

... grateful to the clinical staff at the Vanderbilt Coordinating Center; to all of the investigators, study coordinators, and pharmacists who participated in the clinical trials reported; and to the product ... drotrecogin alfa (activated) infusion were included in this analysis hemorrhage serious bleeding events during the infusion period were exposed to heparin Serious bleeding events – intracranial ... receiving drotrecogin alfa (activated) in clinical trials, the ICH rate was 0.6% (16/2786) during the study drug infusion period and 0.6% (16/2786) during the postinfusion period The overall 28-day...

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safety assessment of sea dikes in vietnam a case study in namdinh province

Ngày tải lên : 03/10/2014, 13:14

... erosion is happening along the coastline from the southern coastline of Giao Thuy district to the coastline belonging to the HaiHau district and also taking part of northern coastline of the Nghia Hung ... the small grains causing the coarsening of the grain size of the beach According to the geology investigation document of the Hydraulics Engineering Survey and Design Service of Namdinh, strata ... area in Northern part of Vietnam In recent years there has been a number of studies aiming at understanding the situation of sea defences system in NamDinh, assess the safety of the and find the...

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Uncertainty and imprecision in safety assessment of offshore structures

Ngày tải lên : 10/09/2015, 08:39

... mathematicalo engineering modeling and the speciﬁcation of the involved parameters However, the numerical models and parameters must comply with the underlying real-world information to obtain ... Chapter Introduction 1.1 Uncertainty and Imprecision In order to achieve an appropriate modeling in accordance with the underlying nature of the available information, it is common in engineering ... describing the thickness of marine growth as interval variables This consideration results in the interval added mass eﬀects in the dynamical system and eventually leads to the development of an interval-based...

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Quality and safety assessment of sexual performance enhancement herbal medicines

Ngày tải lên : 13/10/2015, 15:55

... traditional use, including 15 years in the European Community (Dobos et al 2005, Gioacchino 2008) Taking into consideration the long medicinal use of these traditional products in the European 19 ... exploring new ways to bring the ancient practice of Chinese medicine in line with modern standards (Liu and Salmon 2010) The crucial issues relating to the safety of the herbal medicines in China ... prolonged the prothrombin time of warfarin, an indicator of anti-coagulation in the rat (Lo et al 1992) ; increased the bioavailability and decreased the elimination of warfarin in the rat (Chan...

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Tài liệu Assessment of the AHRQ Patient Safety Initiative pptx

Ngày tải lên : 18/02/2014, 01:20

... used in the remaining two model components, which contribute to practice implementation—building infrastructure and adopting effective practices (in the second row of the figure) FINDINGS FROM THE ... we should find increased AHRQ involvement in partnerships when this analysis is repeated in 2005–2006 The PSIC participants are bringing their new skills home to train others and put the techniques ... described in 10 Evaluation Report I, difficulties in accomplishing the intended functions were encountered early in the contract period, limiting the Coordinating Center’s ability to provide the proactive...

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Assessment of the AHRQ Patient Safety Initiative docx

Ngày tải lên : 15/03/2014, 22:20

... scale by coordinating the work of the Coordinating Center and the Resource Center, and integrating them whenever possible, including the joint conduct of the annual conferences for the two groups ... training a workforce skilled in safety) and adopting effective practices THE CHANGING CONTEXT DURING THE INITIATIVE The formation and funding of the AHRQ patient safety initiative occurred in ... findings Unless stated otherwise, the information presented in this report is current as of September 2006 The remaining seven chapters of this report are organized according to the context, input,...

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Báo cáo khoa học: "Safety margin in irradiation of colorectal liver metastases: assessment of the control dose of micrometastases" potx

Ngày tải lên : 09/08/2014, 08:23

... distance of the 3D isocenter of the micrometastases to the margin of the originating colorectal metastases was 8.75 mm (range 1-21 mm, Q25: mm, Q75: 15 mm) The dose in the 3D-isocenter of the micrometastases ... independent factors the distance between the isocenter and the initial tumor margin (the higher the distance the lower the dose, p = 0.0004) as well as the geometry of the initial liver lesion (oligonodular ... was acquired using breathhold technique after positioning of the brachytherapy catheters in the tumor Depending on tumor geometry and lesion size, a median of catheters was used in our patients...

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Báo cáo y học: " Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" doc

Ngày tải lên : 11/08/2014, 10:23

... Alhydrogel) Since phytol and PHIS-01 are structurally similar to the mineral oil constituents in IFA and CFA, we included pristane for comparison as the protype mineral oil in this study Most of these ... on the type of antibody subclasses induced, and adjuvants are known to play significant roles in vaccine efficacy In this study, we determined by isotyping the effects of various adjuvants on induction ... effector T cells Since induction of cytolytic effector cells is pivotal in ensuring the success of tumor vaccines, we investigated relative efficacy of phytols and known adjuvants in their ability...

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Báo cáo y học: "Correction: Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses" pot

Ngày tải lên : 11/08/2014, 10:23

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Assessment of source of air, water, and land pollution

Ngày tải lên : 23/09/2012, 16:00

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Báo cáo y học: " A retrospective quality assessment of pre-hospital emergency medical documentation in motor vehicle accidents in south-eastern Norway"

Ngày tải lên : 25/10/2012, 09:56

... analysis, and the drafting, revising, and final approval of the manuscript SS was involved in the study conception and design, data analysis, and in the revising and final approval of the manuscript ... the mechanism of injury for all patients According to local procedures and international Utstein Guidelines, key variables important in determining mechanism of injury (MOI) in MVA patients include ... recording the same time data in the ambulance records We registered the frequencies of completion of these Page of 11 patient encounter times, both in the electronic EMCC records and in the ambulance...

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Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"

Ngày tải lên : 03/11/2012, 11:06

... Int J Med Sci 2009, 134 aged This is particularly true with regards to T gondii, where the consequences of infection can be very severe, while the risk of living with one’s beloved ... immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma gondii infection and risk factors associated with seropositivity of pregnant women in Korea J ... 2008; 94: 963-965 Grant S and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org...

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USING THE ANALYTIC HIERARCHY PROCESS APPROACH FOR ASSESSMENT OF THE STRENGTH OF UNIVERSITY-INDUSTRY-GRI COOPERATION IN VIETNAM

Ngày tải lên : 23/04/2013, 10:29

... briefly explores the theory of the University-Industry-GRI linkages in the Innovation Triangle (Figure I.2) including linkage type in terms of formal as well as informal Then, a few points toward ... simple problem with the elements in a level being independent from those in succeeding levels, working downward from the focus in the top level, to criteria bearing on the focus in the second level, ... property in the level above, giving rise to the kind of matrix encountered above and its corresponding principal eigen-vector The third principle is that of synthesizing the priorities In the AHP...

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ASSESSMENT OF LISTENING

Ngày tải lên : 18/08/2013, 17:10

... for the listening Focus on assessing the listening skills, not spelling, grammar etc Include both detail questions and meaning questions Don’t expect full comprehension Consider integrating skills ... The Reading/Listening Connection • • How is the assessment of listening different from the assessment of reading?? How is it similar?? Micro-skills for Listening • • • • • • • ... discriminate among the distinctive sounds of English retain chunks of language in short-term memory recognize English stress patterns, rhythm, intonation recognize reduced forms of words distinguish...

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Assessment of Mercury Contamination in the Kahayan River, Central Kalimantan, Indonesia

Ngày tải lên : 05/09/2013, 09:38

... protein for many people living in the sampling watershed However, at the same time, levels of contaminants in fish are of considerable interest because of the potential effects on the fish themselves ... Technology, Vol 6, No.2, 2008 The average water flow during the rainy season in the Kahayan River is 400 m3/s and that in the Rungan is 165 m3/s During the dry season, the respective flows are 55 ... than the Indonesian drinking water standard (1000 ng/l) (Public Health Minister of Indonesia, 2002) The highest of mercury concentrations at st 403 is related to the location of the sampling point,...

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Risk Assessment of Fenthion Oxide Derivatives in Aqueous Environment

Ngày tải lên : 05/09/2013, 10:15

... 343-352 Quintana J., Martí I and Ventura F (2001) Monitoring of pesticides in drinking and related waters in NE Spain with a multiresidue SPE-GC-MS method including an estimation of the uncertainty ... CONCLUSIONS In this study, the possible genesis of MPP oxide derivatives in the environment was investigated as well as their potential toxicity to humans in a cholinesterase assay The in vitro ... 219 - Moreover, the behavior of MPP oxon sulfone using CYP3A4 was examined because it is the product of the chlorination of MPP in the water purification process and it displays the strongest acute...

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Ecological Assessment of Water Quality by Three-species Acute Toxicity Test and GC/MS Analysis - A Case Study of Agricultural Drains

Ngày tải lên : 05/09/2013, 10:15

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