pharmacotherapy and mechanical ventilation

... relevance in humans Conclusions and outlook Kneyber and colleagues present an interesting association between a major non-cross-linking AGE and sepsis combined with mechanical ventilation Whether this ... collagen and elastin content [8] and diabetic complications in animal models [9] These different approaches to treat AGE accumulation and the pathophysiological relevance of AGE formation in sepsis and ... effects in animal models, the availability of safe and cheap agents may offer an opportunity to target myocardial inflammation in sepsis and mechanical ventilation Competing interests The author declares...

Ngày tải lên: 13/08/2014, 16:21

... need better diagnostic tools, a better understanding of the pathophysiology of this disorder and, most importantly, we need to develop rational, specific and effective treatments Once these goals are ... substantially shorten the duration of MV in ICU patients and improve long-term outcomes in this growing population of patients Abbreviations MV = mechanical ventilation; TwPdi = twitch transdiaphragmatic ... 167:120-127 doi:10.1186/cc9189 Cite this article as: Callahan LA, Supinski GS: Diaphragm weakness and mechanical ventilation - what’s the critical issue? Critical Care 2010, 14:187 ...

Ngày tải lên: 13/08/2014, 21:21

... past 24 hours and still having ongoing losses • Surgical team wishes to take child to OR for exploratory laparatomy to control bleeding Current Support • Conventional Mechanical Ventilation – ... adults and 8-30% for children with ALI or ARDS Randolph 2009, 2003, Farias 2004, Dahlem 2003, Erickson 2007, Curley 2005, Willson 2005 Risk factors for death • Mortality for Pediatric ALI and ARDS ... permeability and edema in the injured lung  Capillary stress failure from over distention  Cyclic opening and closing of atelectatic alveoli  Alveolar overdistention plus cyclic opening and closing...

Ngày tải lên: 12/02/2014, 12:20

... continued mechanical ventilation, and extubation from low respiratory support Data collection and analysis Data were sought regarding effects on the incidence of mechanical ventilation (ventilation ... respiratory failure and initiation of mechanical ventilation PLAIN LANGUAGE SUMMARY Early surfactant administration with brief ventilation vs selective surfactant and continued mechanical ventilation ... surfactant, ventilation in babies with RDS., Outcome Need for mechanical ventilation Review: Early surfactant administration with brief ventilation vs selective surfactant and continued mechanical ventilation...

Ngày tải lên: 24/03/2014, 05:20

... failure, COPD and asthma [3] Task Initiating (and de-escalating) mechanical ventilation 2/ INITIATING (AND DE-ESCALATING) MECHANICAL VENTILATION In critical care, the indicaton for mechanical ventilation ... this module on Mechanical ventilation, you should: Understand the mechanical causes of respiratory failure Have the knowledge to institute mechanical ventilation safely Understand the principles ... Role of mechanical ventilation 2/ Initiating (and de-escalating) mechanical ventilation Invasive vs non-invasive techniques Strategies and timing ...

Ngày tải lên: 24/03/2014, 05:20

... (monitors and/ or ventilators) and test ECP robustness and reliability, and industry to finalize a product that will receive a European Community marking (CE mark) and a U.S marking (Food and Drug ... and in a timely manner Protocols and guidelines have been designed to make mechanical ventilation safer and protective for the lung However, variable effects and low compliance with use of written ... quality, safety, and reproducibility), ECP for mechanical ventilation will very soon be a “must.” Open-loop and decision support systems allow too much room for inter-physicians variability and may not...

Ngày tải lên: 18/06/2014, 18:20

... literature, drafted and completed the manuscript BP and MM assisted in drafting and reviewing the manuscript FA performed surgical interventions and reviewed the manuscript Both FA and BP participated ... when these changes were made Discussion A search of PubMed using the terms ventilation and artificial heart and autocycling and artificial heart on May 23, 2009, did not reveal any publications regarding ... could be potentially harmful to the patient Flow- and pressure-triggered mechanical ventilator modes are designed to allow and assist with spontaneous ventilation In a pressure-trigger mode, the patient's...

Ngày tải lên: 10/08/2014, 09:22

... in TNF-a and IL-6 serum levels (p = 0.012 and p = 0.010, respectively) (Figure 2B and 2C) Mechanical ventilation induced NF-B and up-regulated TLR4 but not TLR2 As shown in Figure 3, mechanically ... spontaneous breathing animals B and C) Effects of hours of spontaneous breathing in non-ventilated, anesthetized animals and of hours of mechanical ventilation with low VT (B) and high VT (C) on systemic ... ml/kg) tidal volume, and C) rats ventilated at high (20 ml/kg) tidal volume Black and white arrows in A and B point to cytoplasmatic and nuclear staining of epithelial type II cells and interstitial...

Ngày tải lên: 12/08/2014, 11:20

... inspiration and in proportion to flow Therefore, the aim of our study was to evaluate the NO and NO2 concentrations along the inspiratory limb of the respiratory tubing during mechanical ventilation and ... Technique of NO administration NO and NO2 measurement Pos Pos test lung Pos CLD 700 AL chemiluminometer Material and methods For the administration of NO during mechanical ventilation we used a prototype ... the humidifier was empty and not active and repeated for a water-filled heating column Study protocol Data analysis Using the pressure controlled mode of mechanical ventilation, NO was administered...

Ngày tải lên: 12/08/2014, 18:20

... No and anti-inflammatory agents have become the standard of care for reactive airway disease and asthma However, some patients fail to respond to aggressive therapy and require mechanical ventilation ... independent lung mechanical ventilation and severe methacholine-induced bronchospasm, heliox improved pulmonary mechanics when compared to a nitrogen–oxygen gas mixture during mechanical ventilation ... determined randomly and data were compared by pulmonary function assessment number Results of PFTs obtained at and are reported as assessment number 1; the results of PFTs performed at and are reported...

Ngày tải lên: 12/08/2014, 18:20

... significant Results Demographic and MV parameters are described in Tables and The time lag between the initiation of MV and the study was ± and ± days for the furosemide and control groups, respectively ... P 0.03* 813 ±1036 0.64 Abbreviations: AC, assist/control ventilation; AMV, assisted mechanical ventilation; CMV, controlled mechanical ventilation; COPD, chronic obstructive pulmonary disease; ... SIMV, synchronized intermittent mandatory ventilation; VAPS, volume-assured pressure support, VE, minute volume *P < 0.05 duction and regulation of the volume and composition of the respiratory...

Ngày tải lên: 12/08/2014, 18:21

... evolution of the field of high-frequency ventilation and liquid ventilation As can be appreciated, this book presents a comprehensive approach to mechanical ventilation in a straightforward (but ... however, and the book provides easily understandable explanations of many difficult concepts in a way that I have not found in other textbooks In summary, this is a comprehensive and easily understandable ... comprehensive and easily understandable book on mechanical ventilation that will represent a valuable textbook for students and practitioners of respiratory therapy, and that will provide a valuable resource...

Ngày tải lên: 12/08/2014, 19:22

... damage of tissues and cells due to overdistention and shear stress (barotrauma or volutrauma) as well as mechanical damage due to the production, release and/ or activation of cytotoxic and inflammatory ... test Results Lung mechanics and blood gases Lung mechanics and blood gas alterations and the biochemical data are presented in Tables and 2, respectively Blood gases and the compliance of the respiratory ... of time tion and (j) prone position] prone and (d) prone and (b) prone posiposition and (h)in the lungs detected theposition diaphragm the kidneys Apoptoticliver [(c) supine(f) [(a) and using theintestine...

Ngày tải lên: 12/08/2014, 23:21

... requiring prolonged mechanical ventilation for up to 10 days The remifentanil-based sedation regimen reduced the duration of mechanical ventilation by 53.5 hours (P = 0.033) and reduced the time ... reduction in PEEP was paralleled by an increase in respiratory rate and in minute ventilation, and – paradoxically – tidal volume and inspiratory time were not significantly affected These data suggest ... design in patients without chronic respiratory failure, Nseir and colleagues [17] found that both duration of mechanical ventilation and ICU stay were prolonged in these patients, although there...

Ngày tải lên: 12/08/2014, 23:24

... between short-term ventilation and DRG 541/542; †P < 0.05 for comparison between short-term ventilation and ventilation ≥ 21 days ADL, activity of daily living; APACHE, Acute Physiology and Chronic ... analyses and interpreted data, and drafted the manuscript SC interpreted data and drafted the manuscript MO and JHL performed statistical analyses and drafted the manuscript JG interpreted the data and ... of mechanical ventilation; and patients with PMV have higher mortality rates, worse quality of life, and greater functional limitations at one year than patients requiring shorter periods of mechanical...

Ngày tải lên: 13/08/2014, 03:20

... prolonged mechanical ventilation Therefore, mechanical ventilation- induced air-space enlargement results in the majority of cases from the interaction between infection and mechanical ventilation and ... from mechanical ventilation and lung infection Key messages • Lung infection induces bronchiolar and alveolar distention • Mechanical ventilation rapidly induces secondary lung infection and air-space ... spontaneously breathing and mechanically ventilated piglets in order to assess how mechanical ventilation and lung infection influence air-space enlargement, respectively Materials and methods Animal...

Ngày tải lên: 13/08/2014, 03:20

... mortality and functional outcomes that are reliable and accurate at the level of the individual patient Such predictive models are eagerly awaited because they might provide patients and their ... our understanding of the molecular mechanisms that underlie chronic illness myopathy and of the impact of ageing on manifestations of chronic illnesses; facilitate better definition and application ... facilitate better definition and application of weaning protocols, and nutritional and physical therapy strategies; permit identification and correction of iatrogenic factors that contribute to prolongation...

Ngày tải lên: 13/08/2014, 03:20

... or prolonged mechanical ventilation • A simple model consisting of age and cardiopulmonary function on day of mechanical ventilation predicted death and/ or prolonged mechanical ventilation in ... few days of mechanical ventilation The distinction between patients who die and those who undergo prolonged mechanical ventilation could be related to the preferences of patients and physicians ... prolonged mechanical ventilation A model derived from age, oxygenation index, and cardiovascular failure three days after intubation predicts death or prolonged mechanical ventilation and may inform...

Ngày tải lên: 13/08/2014, 03:21

Ngày tải lên: 13/08/2014, 08:20

... PAMV, prolonged acute mechanical ventilation; SD, standard deviation among these patients, with the attendant attributable mortality, LOS, and cost increases of 21%, 6.3 days, and $48,972, respectively ... contributions to these outcomes of such high risk and costly events as nosocomial infections (HAP and BSI) and gastrointestinal bleeding, and cardiac, abdominal and orthopedic surgeries Page of (page number ... are expressed as percentages and mean ± standard deviation, and P < 0.05 was considered to represent statistical significance Frequencies (for categorical variables) and distributions (for continuous...

Ngày tải lên: 13/08/2014, 10:20