pharmacology drug mechanism and drug effects in nonocular diseases
Báo cáo khoa học: Allosteric water and phosphate effects in Hoplosternum littorale hemoglobins pdf
Ngày tải lên :
23/03/2014, 13:20
... transitions, and secondarily on phosphate binding Although having very different oxygen-binding properties, both Hbs respond to an increase in water activity with an increase on oxygen afnity, indicating ... obtained from samples containing more than 5% methemoglobin (nal concentration) were discarded The Hb solution osmolalities (Osm) were determined after binding experiments from freezing point ... activity in different experimental conditions: for the stripped Hb (in an ATP and chloride-free buffer solution), in the presence of 0.1 mM and mM of ATP, in a buffer containing 100 mM NaCl, and a...
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TAX AND LIQUIDITY EFFECTS IN PRICING GOVERNMENT BONDS doc
Ngày tải lên :
29/03/2014, 06:21
... gains and ordinary income Since the trade-off between these two rates is a major contributor to any tax effects, it is not surprising that we not find convincing evidence of their existence In ... important factor in pricing errors Using the spline approach described in Section IV, we compare the pricing errors obtained from fitting the CRSP and GovPX data over the period during which GovPX ... the data using the Nelson and Siegel methodology and find similar results in terms of magnitude and significance 15 See Green and Ødegaard ~1997!, Ronn and Shin ~1997!, or Fabozzi and Nirenberg...
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Báo cáo hóa học: " Investigation of Nucleation Mechanism and Tapering Observed in ZnO Nanowire Growth by Carbothermal Reduction Technique" ppt
Ngày tải lên :
21/06/2014, 08:20
... nm on average and the height H is about nm Incidentally, such faceting is observed only in tapered nanowires and not in straight ones as seen in Figure 5d, indicating such faceting might have ... Korea Science and Engineering Foundation from the Ministry of Education, Science, and Technology Author details Electrical and Computer Engineering Department, University of Illinois, Chicago, ... liquid–solid interface In our case, the angle a equals to zero at the beginning stages of nucleation As growth begins, the angle a has to increase, which is accompanied by an increase in the contact...
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Báo cáo khoa học: "Immunomodulatory and antitumor effects in vivo by the cytoplasmic fraction of Lactobacillus casei and Bifidobacterium longum" pot
Ngày tải lên :
07/08/2014, 17:22
... leukemia cells) were obtained from KCLB (Korean Cell Line Bank, Seoul, Korea) and maintained in RPMI medium containing 10% (v/v) fetal bovine serum (FBS, GibcoBRL, Grand Island, NY) in a humidified atmosphere ... suggesting that both L casei and B longum in intestinal microflora can activate immune system to prevent diseases including tumors References Fig Survival rate of F9-bearing mice after LABs administration ... Bifidobacterium longum, a lactic acidproducing intestinal baterium, inhibits colon cancer and modulates the intestinal biomarkers of colon carcinogenesis Carcinogenesis 1997, 18, 833-841 30 Skakelford...
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prediction of creep, shrinkage, and temperature effects in concrete structures
Ngày tải lên :
24/10/2014, 16:03
... differential shrinkage strain, also subscript denoting differential strain or differential stress shrinkage strain in in. /in or mm/mm at any time ultimate (in time) shrinkage strain in inc. /in or mm/mm ... humidity and temperature, assuming the strain at loading (nominal elastic strain) as the instantaneous strain at any time The above definition treats the initial instantaneous strain, the creep strain, ... creep strain to initial strain, (es& is the ultimate shrinkage strain, and t is the time after loading in Eq (2-6) and time from the end of the initial curing in Eq (2-7) When @ and QI are equal...
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Artificial gauge fields and topological effects in quantum gases
Ngày tải lên :
09/09/2015, 08:12
... here, P and r refer to the atomic COM momentum and coordinates; V (r) is an internal-state-independent external potential The operator Hint includes the atomic internal motion, but can in principle ... Dirac string becomes unobservable Indeed any interference loop encircling the Dirac string like in the Aharonov-Bohm effect would lead to a phaseshift being an integer multiple of 2π [31] and thus ... distance which is vanishing at the transition and then increases with larger interaction Chapter investigates the properties of spin-orbit coupled spin−1 condensate mentioned in Chapter We give a...
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Colossal electroresistance, magnetoimpedance, and magnetocaloric effects in selected manganites
Ngày tải lên :
11/09/2015, 09:57
... favor the DE-type ferromagnetic coupling, producing the spin canting [13] The spin canting angle continuously increases with increasing x, thereby transforming the canted antiferromagnetic phase ... local spins are relatively aligned and this results in an increase in the effective hopping interaction Thus the colossal magnetoresistance around TC in manganites can be intuitively explained on ... coupling energy) exceeds the inter-site hopping interaction t0ij of the eg electron between the neighboring sites, i and j In this strong coupling limit, when JH>>tij, the effective hopping interaction...
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Electrical conductivity switching behavior and memory effects in electroactive polymers and nanocomposites
Ngày tải lên :
11/09/2015, 09:59
... mentally and physically, to finish this work Nevertheless, my uncles, Professor Wang Erlin and Professor Gu Yaoxin, helped me to clarify my aspiration when I was hesitating and wandering in doubt ... (carbazole-nitro/cyano) and charge trapping center (azobenzene) at the same time, allowing effective stabilizing of the intra-molecular CT state, and leading to WORM memory effects with low switching voltages and ... memories in (a) linear scale (Ling et al., 2005) and (b) log scale (Ling et al., 2007) (c) Stability under continuous voltage stress and ON/OFF ratio (inset, Ling et al., 2007) (d) Effects of...
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Electrical switching and memory effects in electroactive polymers containing electron donor and acceptor moieties
Ngày tải lên :
11/09/2015, 09:59
... processing As alternatives to the more elaborated processes of vacuum deposition, solution processes, including spin-coating, spray-coating, dip-coating, roller-coating and ink-jet printing, promise ... reduction in component size and thus increase in speed, the structures of electronic devices are becoming more and more complicated and the fabrication processes are becoming more and more difficult and ... screening results, it can be concluded that both the π-conjugation and coordinating heteroatom that can bind to metal ions, regardless of the position of binding sites (side chain or main chain),...
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Báo cáo y học: " Role of ADAM and ADAMTS metalloproteinases in airway diseases" pot
Ngày tải lên :
12/08/2014, 14:20
... the prodomain maintaining the catalytic site inactive and the metalloproteinase domain containing the Zinc binding site ADAM activation mechanisms are mostly similar to MMP's activation and generally ... metalloproteinase domain with its catalytic consensus site is active in only about half of ADAM proteinases The following domains are characteristic of ADAMs and include a disintegrin domain mediating ... cell-matrix interactions via the interaction with integrins; a cystein-rich domain implicated in cell adhesion; an epidermal growth factor (EGF)-like domain and a cytoplasmic tail involved in various intracellular...
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Tài liệu Color Atlas of Pharmacology (Part 8): Adverse Drug Effects pptx
Ngày tải lên :
26/01/2014, 19:20
... to drugs Drug Therapeutic effect in mother ? Unwanted effect in child Extent of transfer of drug into milk Infant dose Distribution of drug in infant Rate of elimination of drug from infant Drug ... activity profile In assessing the risks attending drug use during pregnancy, the following points have to be considered: a) Time of drug use The possible sequelae of exposure to a drug depend on ... Adverse Drug Effects Decrease in pain perception (nociception) Respiratory depression Effect Decrease in Nociception Respiratory activity Safety margin Morphine Morphine overdose Dose A Adverse drug...
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FACING THE REALITY OF DRUG-RESISTANT TUBERCULOSIS: CHALLENGES AND POTENTIAL SOLUTIONS IN INDIA pot
Ngày tải lên :
05/03/2014, 11:20
... Beyond initial training, there is a need for retraining, on-the-job training, continuing education, and advanced training in management Training in problem solving, supervision, management, and ... (isoniazid and rifampicin), as well as any fluoroquinolone (levofloxacin, moxifloxacin, or ofloxacin) and at least one second-line injectable drug (kanamycin, amikacin, or capreomycin) Totally drug- resistant ... CONFRONTING CHALLENGES TO THE SUPPLY CHAIN FOR SECOND-LINE DRUGS Challenges in Drug Supply Chain Logistics, 77 India’s Second-Line Drug Supply Chain, 80 Improving the Availability and Reducing the...
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Báo cáo khoa học: Transmembrane helix 12 plays a pivotal role in coupling energy provision and drug binding in ABCB1 pot
Ngày tải lên :
06/03/2014, 22:21
... labelling intensity observed with the single-cysteine-containing isoforms Obtaining full labelling and its accurate quantitation are difficult to achieve in practice, resulting in occasional instances ... substrate-induced fit mechanism for drug binding J Biol Chem 278, 13603–13606 Loo TW, Bartlett MC & Clarke DM (2003) Simultaneous binding of two different drugs in the binding pocket of the human multidrug ... were examined by introducing cysteines at distinct positions in TM12 and assessing their accessibility to covalent modification with thiol-reactive probes In order to determine how changes in the...
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An Unbreakable Cycle - Drug Dependency Treatment, Mandatory Confinement, And HIV/AIDS In China''''s Guangxi Province potx
Ngày tải lên :
14/03/2014, 23:20
... Unbreakable Cycle Drug Dependency, Mandatory Confinement, and HIV/AIDS in China’s Guangxi Province In China, illicit drug use is an administrative offense and Chinese law dictates that drug users “must ... my son again I wish I could go back and never try drugs.121 The cycle of going into detox, being released, not being able to find work, returning to drug use and then being arrested again, appears ... for HIV infection while detained in detox or RTL centers Every formerly detained drug user interviewed reported being forced to undergo HIV testing while in confinement and none reported being told...
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Promoting Student Health and Wellbeing: A guide to drug education in schools ppt
Ngày tải lên :
22/03/2014, 15:20
... Thinking and critical thinking • • • • • Decision-making Understanding consequences and predictive thinking Shaping actions around situations involving drugs to improve wellbeing and wellbeing ... analysis Knowing about legal and illegal drugs Using language symbols and texts • Understanding and interpreting label information • Critically evaluate scientific information • Understanding the ... in the school setting (encouraging formal and informal opportunities for increasing connectedness) Encouraging and valuing family/whānau involvement in drug education planning and policy/procedure...
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Báo cáo khoa học: Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium ppt
Ngày tải lên :
23/03/2014, 05:22
... Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro Methods Find Exp Clin Pharmacol 22, 609–613 28 Papandreou ... et al and suppressing arrhythmia However, recent findings have demonstrated that vagal nerve endings are rarely detected in the left ventricle in humans, guinea pigs and rats, although the innervation ... a mixture of type II and type IV collagenases and type XIV protease (SigmaAldrich), and inoculated onto dishes precoated with a mixture of gelatin, fibronectin, and laminin [33] HEK293 cells were...
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báo cáo hóa học:" Quality of life and the impact of drug toxicities in a South African community-based antiretroviral programme" docx
Ngày tải lên :
20/06/2014, 08:20
... and safety of three non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens (nevirapine, efavirenz, and nevirapine plus efavirenz in combination with stavudine and lamivudine) ... estimated 549 700 HIV-positive individuals were receiving HAART in South Africa [3] With increasing numbers of HIV-positive individuals being enrolled onto HAART and increasing survival among these ... using standardised factor analysis-based weights Missing questionnaire items were estimated using a standard scoring algorithm that estimates missing values [24] Scores for screening and baseline...
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Báo cáo y học: " Effectiveness of antiretroviral therapy and development of drug resistance in HIV-1 infected patients in Mombasa, Kenya" doc
Ngày tải lên :
10/08/2014, 05:21
... molecular work and sequence analysis and prepared the manuscript SL and CV assisted in designing the study and drafting the manuscript KD and JR performed viral loads and genotyping KM supervised ... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... genotyping of HIV RNA was performed by nested RT-PCR and an in- house sequencing assay as described elsewhere [4] The interpretations of genotyping data and subtyping were performed using Smartgene™...
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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx
Ngày tải lên :
11/08/2014, 00:22
... airway diseases, including COPD and CF Distinct etiologies and inflammatory responses drive mucous hypersecretion in these diseases In CF and COPD, the inflammatory response is neutrophilic and ... sustained release and delivery of FDA approved proteasome inhibitor drug, PS341 in murine lungs by its ability to control Pseudomonas aeruginosa LPS induced CF lung disease in murine model In this ... with PLGA nanoparticles using ring-opening polymerization method, results in increased residence in blood (intravenous) or airway (intranasal) and enhanced accumulation in target tissues or cells...
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báo cáo khoa học: "Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohor" pot
Ngày tải lên :
11/08/2014, 12:21
... Variant calling and association testing CRISP detected 1221 SNVs and 118 indels (1339 variants in total) Validation with original GWAS SNP data and HapMap data CRISP called all 15 of the SNPs individually ... Surrounding SNPs closest to this SNP also show clear recessive effects These results in combination are explained by the haplotype effect displayed in Table Haplotypes and linkage disequilibrium In ... Queensland 4102, Australia 14The University of Queensland, School of Medicine, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia 15Gastrointestinal and Liver...
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