pharmacological activities of antisense drugs inflammatory diseases

... secondary effect of adenosine The recent success of anti-TNF therapy highlights the role of cytokines as important mediators of inflammatory activity Not surprisingly, methotrexate, still one of the most ... the anti -inflammatory effects of methotrexate in vivo [36] An interesting study by Silke et al showed that ingestion of caffeine, a nonselective antagonist of adenosine receptors, in coffee correlates ... on P1 receptors, exerts a number of actions on a variety of cell types relevant to the anti -inflammatory effect of methotrexate Cellular effects the modification of the adhesive capacity and ability...

Ngày tải lên: 09/08/2014, 03:24

... activity of snake venom 50 1.7.2 Anti-neoplastic activity of snake venom 51 1.7.3 Anti -inflammatory activity of snake venom 51 1.7.4 Other therapeutic activities of snake venom 52 1.8 The study of ... BIOCHEMICAL ACTIVITIES OF NAJA SPUTATRIX VENOM CHARMIAN CHER DYI NI B.Sc (Hons) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF BIOCHEMISTRY NATIONAL UNIVERSITY OF SINGAPORE ... defensive behaviour of spitting fine jets of venom from the orifice of the fangs whilst spreading of the hood and the vertical stance of the body’s anterior end are characteristic features of the snake...

Ngày tải lên: 16/09/2015, 08:31

... Chronic Diseases and Cancer’, which deals with immunobiology and clinical perspectives of mechanisms of immune inflammatory responses in the genesis and progression of a number of inflammatory diseases ... in inflammatory diseases Lack of appetite and weight loss in inflammatory diseases are common components of a set of nonspecific symptoms called sickness behavior that occurs under conditions of ... multidisciplinary fields of inflammatory diseases This book is dedicated to the loving memory of my parents, Kazem and Badri-Zaman Khatami The invaluable support and encouragement of the following professionals...

Ngày tải lên: 27/06/2014, 13:20

... amount of IL-2 is produced to overcome the inhibitory effects of TGF-β, the costimulatory effects of this cytokine induce the precursors of CD4+ CD25+ T cells to become contact-dependent ‘professional’ ... is the generation of ‘professional’ regulatory T cells remains to be determined Our finding that both IL-2 and TGF-β are critical in the generation of regulatory T cells is of particular importance ... with SLE since production of IL-2 and the active form of TGF-β is decreased [53] Figure The role of transforming growth factor-β (TGF-β) in the differentiation pathway of CD4+ regulatory T cells...

Ngày tải lên: 09/08/2014, 03:24

... investigation of the pleiotropic effects of these drugs Many data now suggest a key role for inflammation in the pathogenesis of atherosclerosis [12] This provides a context in which various anti -inflammatory ... moderate degree of hyperlipidaemia but no prior personal history of cardiovascular disease The value of statin therapy in patients with known coronary artery disease and normal lipid profiles is perhaps ... http://arthritis-research.com/content/7/2/55 Effects of statins beyond lipid lowering in cardiovascular disease? The increasing body of evidence for the efficacy of statins in protecting against vascular events irrespective of cholesterol...

Ngày tải lên: 09/08/2014, 06:22

... IL-32, we supposed CD4+ T cells to be one of the important sources of IL-32 in the pathogenesis of inflammatory arthritis To examine the proinflammatory effects of IL-32 produced by CD4+ T cells, we ... effect The proinflammatory effects of IL-32 were therefore generally dependent on the TNFα-inducing effect in these mouse models of inflammatory diseases Discussion TNFα is a potent proinflammatory ... proinflammatory cytokine related to the pathogenesis of inflammatory diseases such as RA and IBDs [5,6,11] The precise mechanism of TNFα induction in the inflammatory diseases, however, is still unclear We...

Ngày tải lên: 09/08/2014, 08:23

... anti -inflammatory properties of nonsteroidal anti -inflammatory drugs (NSAIDs) are based on the inhibition of the cyclooxygenase (COX) enzyme isoforms [6] Traditional NSAIDs inhibit both isoforms of ... launching of rofecoxib into the market based their rationale mainly on the presence of cardiovascular events [54-57] In the case of celecoxib, very low frequencies for the development of this type of ... development of gastrointestinal, renal and/or cardiovascular complications NSAIDs, nonsteroidal anti -inflammatory drugs; GI, gastrointestinal In this study, the QUORUM (quality of reporting of metaanalyses)...

Ngày tải lên: 13/08/2014, 11:22

... NSAIDs Aspirin Site of infection: lung (n = 71)a NSAIDs Aspirin Site of infection: urinary tract (n = 30)a Site of infection: skin and soft tissue (n = 16)a NSAIDs Aspirin Site of infection: other ... and non steroidal anti -inflammatory drugs: a case series and review of the literature N Z Med J 2001, 114:3-6 Holder EP, Moore PT, Browne BA: Nonsteroidal anti -inflammatory drugs and necrotising ... between the use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus Medicine 2003, 82:225-235 Stevens DL: Could nonsteroidal anti -inflammatory drugs (NSAIDs)...

Ngày tải lên: 13/08/2014, 16:20

... efficacy of current drugs used in the treatment of such diseases, drugs like aspirin and warfarin are associated with numerous adverse effects, which will be elaborated later 1.1.1 Antiplatelet drugs ... addition to that, a revival of interest in the traditional screening of drugs from plants has been observed following success stories of discovery of blockbuster drugs from natural sources Examples ... GPIIb/IIIa antagonists Table 1.2 List of reports of active compounds from medicinal plants with antiplatelet or anticoagulant activities 14 Table 1.3 List of biological activities studied scientifically...

Ngày tải lên: 10/09/2015, 08:25

Ngày tải lên: 14/09/2015, 08:45

... vitro antimicrobial activities of the three kinds of Rice-fluid against various species of microorganisms including H pylori strains by the timekill-curve assay [14, 16] Every kind of Rice-fluid derived ... kind of Rice-fluid was proved to be devoid of bactericidal activity against strains of E coli, S aureus, S epidermidis, E faecalis and P aeruginosa, and strains of K pneumoniae and strains of K ... consisting of three kinds of Rice-fluid derived from the two kinds of raw rice; i e., polished (pH6.32) and unpolished (pH5.98), and the usually cocked rice (pH5.91), and remaining one compound of the...

Ngày tải lên: 31/10/2012, 17:03

... Increasing enterprise profit is higher will lead salary as well as life of each worker is better Solutions to improve selling activities of Ha Trung JSC As is given the selling process of Ha trung has ... 1,147 MT of both raw materials and finished products The plastic import value was $1,426mil, equal to four times of export value of $350 in 2005 In 2004, Vietnam exported only 10 percent of total ... information which helps Management Board control annual plan of company and development strategies, II Business activities of Hatrung JSC 1.Business activities a/ Materials: Company searches material resources...

Ngày tải lên: 16/04/2013, 08:07

... number of companies with capital of less than VND billion has accounted for 44.1%, of the total number of companies, employing less than ten workers accounting for 46.6% of the total number of workers ... 0918.775.368 growth of the nation’s standard of living, the level and growth of aggregate productivity and the ability of the nation’s firms to increase their penetration of world markets through ... rules of competition, the threat of substitutes, the bargaining power of buyers, the bargaining power of suppliers, and the rivalry among the exiting competitors The collective strength of these...

Ngày tải lên: 22/04/2013, 15:35

... effectiveness of those activities - Recommending some solutions to enhance import activities Scope of this report: The scope of this report is about the real situation of import activities of Vietnam ... through the activities of the company in recent years that I researched during my internship period, I would like to make a report on: “Evaluation of the real situation of import activities of Vietnam ... controlling all business activities of the company such as ensuring profitability, growth and development of the entire company, achieving the objectives of the company on sales growth, profit, personnel...

Ngày tải lên: 24/07/2013, 09:11

... periods may result to the development of oseltamivir-resistant influenza viruses Furthermore, Japan is at the top of the list of countries for per capita consumption of Oseltamivir (Soderstrom et al., ... drastic increase in antiviral drugs consumption It is therefore worthy to monitor the drugs in surface waters in the winter season to get more insight of whether the drugs really exist in alarming ... ST-2 from the 34th week of 2009 to the 7th week of 2010 period were obtained from Osaka Prefectural Institute of Public Health (2010) An index value gives the total number of influenza cases (average)...

Ngày tải lên: 05/09/2013, 10:15

... Ordinal scale of tone intensity 0–5 Bohannon & Smith, 1986 Oswestry scale of grading Ordinal scale of stage and distribution of tone and quality of isolated movements Goff, 1976 Degree of adductor ... and safety of baclofen therapy without evidence of drug tolerance, even after many years There have been few studies investigating the effect of baclofen in treatment of spasticity of cerebral ... comparison of single doses of DS103–282, baclofen, and placebo for suppression of spasticity J Neurol Neurosurg Psychiatry, 43: 1132–6 Hattab, J R (1980) Review of European clinical trials with baclofen...

Ngày tải lên: 01/11/2013, 10:20

... degree of the participation before the experiment of Class A O2: the degree of the participation at the end of the experiment of Class A O3: the degree of the participation before the experiment of ... goes for demanding challenges, high proficiency, top grades • Goal orientation: The learner is very aware of the goals of learning, or of specific learning activities, and directs his or her efforts ... students of the two former groups are often obstacles towards creating an encouraging learning environment Second, students’ knowledge including both knowledge of English proficiency and knowledge of...

Ngày tải lên: 29/01/2014, 14:35

... 00133 Rome, Italy Professor Paolo Milani University of Milan Department of Physics Via Celoria, 26 20133, Milan, Italy Volume 1: Medicinal Chemistry and Pharmacological Potential of Fullerenes and ... considered both one of the most promising applications and one of the most studied since the publication of the fundamental works of Dugan and coworkers, who analyzed fullerene capability of scavenging ... been obtained by covalent linkage of the drug to the C60 by means of an ester, the hydrolysis of which presents a favorable kinetic profile, with consequent release of paclitaxel (Zakharian et al.,...

Ngày tải lên: 17/02/2014, 05:20

... chemical instability of DNA To protect the vital genetic information from the deleterious effects of DNA injury a network of genome care-taking mechanisms has evolved of which a set of DNA repair systems ... heparin HBEGF and hyposecretion of adiponectin, which results in the development of a variety of metabolic and circulatory diseases In this review, the importance of adipocytokines, especially ... characterization of yeast mutants blocked at various stages of transport pathways are an invaluable method for unravelling the molecular details of vacuolar and lysosomal traffic The activities of lysosomes...

Ngày tải lên: 19/02/2014, 07:20

... value (e) of 1.49 · 105 M)1Æcm)1 at 407 nm for MP8 In the case of BSA, mol of MP8 were bound per mol of protein, whereas in the case of KLH, 22 mol of MP8 were bound per 100 000 g of protein ... function of time, between 350 and 550 nm Kinetic data were then obtained by measuring the absorbance at the maximum of absorption of the MP8–Fe(II)–RNO complex, as a function of time S-oxidation of ... consistent with the insertion of the MP8–Fe(II)–RNO complex into a hydrophobic pocket with no change of the Fe(II) spin state and no replacement of any of the two axial ligands of the iron, His18 or...

Ngày tải lên: 19/02/2014, 12:20