pharmacologic management of rheumatoid arthritis and osteoarthritis

... and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis Arthritis Research & Therapy 2010, 12:R86 Page 14 of 14 ... panel of ... in synovial fluids and whether plasma and synovial fluid miRNAs could be biomarkers of rheumatoid arthritis (RA) and osteoarthritis (OA). Methods: We measured concentrations of miR-16, miR-132, ... cutoff value of 67.8 pmol/l diagnosed RA at the sensitivity of 83.8% and the specificity of 80.7%. B. ROC plot of plasma miR-132 for the diagnosis of OA. AUC was 0.91. A cutoff value of 67.1 pmol/l...

Ngày tải lên: 12/08/2014, 12:20

... compared to osteoarthritis (OA) and normal donor (ND) STImmunostaining of pPaxillin is increased in rheumatoid arthritis synovial tissue (RA ST) compared to osteoarthritis (OA) and normal donor ... in comparison to osteoarthritis (OA) and normal donor (ND) STpPLCγ immunostaining is higher in rheumatoid arthritis synovial tissue (RA ST) in comparison to osteoarthritis (OA) and normal donor ... R, Hochberg M, et al.: Develop- ment of criteria for the classification and reporting of osteoar- thritis. Classification of osteoarthritis of the knee. Arthritis Rheum 1986, 29:1039-1049. 24....

Ngày tải lên: 09/08/2014, 10:21

... activities of synovial fibroblast samples of rheumatoid arthritis and osteoarthritis patients after TGF-β 1 treatmentEnzyme activities of synovial fibroblast samples of rheumatoid arthritis and osteoarthritis ... (histogram of the green fluorescence). [...]... C, Huet G, Flipo RM: Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis Scand J Rheumatol ... in synovial fibroblasts and synovial membrane samples of patients with rheumatoid arthritis and osteoarthritis by real-time PCR. β- D-Glucuronidase, β-D- glucosaminidase and β- D-galactosaminidase...

Ngày tải lên: 09/08/2014, 14:20

... for the treatment of rheumatoid arthritis NICE technology appraisal guidance 141 (2008) Available from www.nice.org.uk/TA141 • Osteoarthritis: the care and management of osteoarthritis in adults ... subgroups, on the grounds of clinical and cost effectiveness Other versions of this guideline 6.1 Full guideline The full guideline, ? ?Rheumatoid arthritis: the management of rheumatoid arthritis in adults’ ... about and agree all aspects of their care, and respect the decisions they make 1.2.1.2 Offer verbal and written information to people with RA to: • improve their understanding of the condition and...

Ngày tải lên: 08/03/2014, 14:20

... MALDI-TOF-MS analysis of tryptic glycopeptides of IgG1 and IgG2MALDI-TOF-MS analysis of tryptic glycopeptides of IgG1 and IgG2. A representative sample of an RA-patient before pregnancy (a) and ... galactosylation of IgG1 and IgG2 in cases and controls during pregnancy and postpartumMean galactosylation of IgG1 and IgG2 in cases and controls during pregnancy and postpartum. IgG1 (a) and IgG2 (b) ... tides of IgG1 and IgG2 was below 4% and 6%, respectively. The IgG4 glycopeptides were not analyzed due to their low abundance. Galactosylation profiles during pregnancy and postpartum of cases and...

Ngày tải lên: 12/08/2014, 11:22

... expression by mast cells and T cells in synovium of arthritis patients. Methods: Synovial samples of anti-citrullinated protein antibody-positive (ACPA) and - negative RA and osteoarthritis (OA) patients ... treatment of arthritis. Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial lining of the joint. In the majority of patients ... MØ: macrophage; OA: osteoarthritis; RA: rheumatoid arthritis Figure legends Figure 1 Expression of IL-17 by immunohistochemistry A Double-staining of IL-17 (black) and CD117+ mast cells...

Ngày tải lên: 12/08/2014, 18:20

... from rheumatoid arthritis and osteoarthritis patients and organ donors. Representative western blots of syn- ovial fluid samples from asymptomatic donors (D) and osteoarthritis (OA) and rheumatoid ... levels of tumor necrosis fac- tor α and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. ... background of the osteoarthritis patients and of the rheumatoid arthritis patients was not available to us. Table 1 (Continued) Demographical representation of human subjects enrolled in the study Arthritis...

Ngày tải lên: 09/08/2014, 08:22

... Rothschild B, Segal M, Sokoloff L, Wolfe F: Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986, 29:1039-1049. ... levels of tumor necrosis factor α and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. ... tissue of patients with rheumatoid arthritis: inflammation and other proinflammatory cytokines. Mod Rheumatol 2003, 13:121-128. 8. Huebner JL, Kraus VB: Assessment of the utility of biomarkers of osteoarthritis...

Ngày tải lên: 12/08/2014, 15:22

... Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res 2, 361–367. 4 Paleolog EM & Miotla JM (1998) Angiogenesis in arthritis: role in disease pathogenesis and ... chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte–macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and ... or absence of 10 lgÆmL )1 of a-amanitin for 20 h (A), 25 lgÆmL )1 of cycloheximide (CHX) for 20 h (B) and 20 l M MG-132 for 6 h (C). The expression of MLN51 was assessed by RT-PCR and western...

Ngày tải lên: 23/03/2014, 07:20

... Switzerland). Water and food were provided ad libitum and all experiments were approved by the Institutional Animal Care and Use Committee of Switzerland. Induction and treatment of arthritis ... potential and mechanism of action of IFN-β protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice. At the first clinical sign of disease, ... AE, Tak PP: Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. J Pathol 1997, 181:444-450....

Ngày tải lên: 09/08/2014, 01:23

... characteristics of anti-CCP-positive RA patients and Figure 3 Erosion and joint space narrowing scores of MCP and PIP joints at inclusion and follow-upErosion and joint space narrowing scores of MCP and ... 1 Swelling of the MCP and PIP joints at inclusion and follow-pSwelling of the MCP and PIP joints at inclusion and follow-up. Joint swelling (mean and 95% confidence interval [CI]) of the metacarpophalangeal ... metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of the hands at inclusion and at 2 and 4 years follow-up in rheumatoid arthritis patients with (CCP+) and without (CCP-) anti-cyclic-citrullinated...

Ngày tải lên: 09/08/2014, 06:23

... concentrations in sera Sera of healthy controls and of sera patients with rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis were tested in a standard ELISA test A D450 of 0.06 corresponds ... (CD19+) is shown The percentages of CXCR5+ and CXCR3hi B cells are given for healthy controls (con) and patients with osteoarthritis (OA), rheumatoid arthritis (RA) and systemic lupus erythematosus ... fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis Arthritis Rheum 2001, 44:1022-1032 10 Patel DD, Zachariah JP, Whichard LP: CXCR3 and CCR5 ligands in rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 06:23

... the pathogenesis of rheumatoid arthritis? Aleksi Sedo 1 , Jonathan S Duke-Cohan 2 , Eva Balaziova 1 and Liliana R Sedova 3 1 Laboratory of Cancer Cell Biology of the 1 st Faculty of Medicine, Charles ... membrane and fluid in RA, psoriatic arthritis and OA, with quantitative differences observed dependent both upon disease type and severity [87-89]. Levels of TNF-α, IL-1 and IL-6 in RA SF and synovial ... preference and downstream signaling. In this article, we examine the role of DPPIV homologs, including CD26, the canonical DPPIV, and their substrates in the pathogenesis of rheumatoid arthritis. ...

Ngày tải lên: 09/08/2014, 07:20

... interpretation and discussion of the data. JJ, YEC and YJ performed most of the studies and were responsible for the execution of most of the experiments. SAY and WUK provided the patients' FLS and ... expression is upregulated in rheumatoid arthritis FLSs com-pared with osteoarthritis FLSsMLN51 expression is upregulated in rheumatoid arthritis FLSs com- pared with osteoarthritis FLSs. (a) Total ... B: Pathology of rheumatoid arthritis and associated disorders In Arthritis and Allied Conditions: A Textbook of Rheumatology Edited by: Koopman W Baltimore: Williams and Wilkins;...

Ngày tải lên: 09/08/2014, 08:23

... junction in rheumatoid arthritis Ann Rheum Dis 1981, 40:396-399 Wipke BT, Allen PM: Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis J ... polyvinylidene difluoride; RA = rheumatoid arthritis; RANK = receptor activator of nuclear factor-kappa-B; RANK-L = ligand of receptor activator of nuclear factor-kappa-B; RF = rheumatoid factor; RT-PCR ... C, Buckley CD, Salmon M: Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin Arthritis Res Ther 2005, 7:R784-795...

Ngày tải lên: 09/08/2014, 10:20

... probability of patients with more than 10 years of DD and those with less than 10 years of DD as a function of the SvdH score. Available online http:/ /arthritis- research.com/content/9/2/R37 Page 5 of ... TC coordi- nated and designed part of the laboratorial work. JAPdS, JB, and MVQ participated in the design of the study and in the draft of the manuscript. All authors read and approved the final ... development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:44-48. 13. Antunes M, Andreozzi V, Amaral Turkman MA: A Note on the Use of...

Ngày tải lên: 09/08/2014, 10:20

... in synovial tissue from patients with early and longstanding rheumatoid arthritis compared with patients with reactive arthritis and osteoarthritis Arthritis Rheum 1999, 42:948-953 Yamanishi Y, ... benefits of HDACi in animal models of arthritis, or the potential advantages of enhancing HDAC activity, will require a thorough analysis of the effects of HAT and HDAC modulation on Page of 13 ... tissue derived from rheumatoid arthritis and osteoarthritis patients Arthritis Rheum 2007, 56:10871093 Choo QY, Ho PC, Lin HS: Histone deacetylase inhibitors: new hope for rheumatoid arthritis? Curr...

Ngày tải lên: 09/08/2014, 11:20

... our past findings of associations between reproductive factors and the risk of developing RA in the NHS [56] Data on pack-years of smoking (product of years of smoking and packs of cigarettes per ... online http:/ /arthritis- research.com/content/11/3/R97 Research article Vol 11 No Open Access A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis Elizabeth ... 6Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA 7Division of Aging, Department of Medicine,...

Ngày tải lên: 09/08/2014, 14:22

... grants-in-aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Science, Sports and Culture, Japan, and the Japanese Ministry of Education, Global Center of Excellence (GCOE) ... GR: Cells of the synovium in rheumatoid arthritis Macrophages Arthritis Res Ther 2007, 9:224 Lutzky V, Hannawi S, Thomas R: Cells of the synovium in rheumatoid arthritis Dendritic cells Arthritis ... cellular proliferation and expression of cytokines and activation markers by peripheral blood T cells [36,37], and that CCL2, CCL5 and CXCL12 upregulated the expression of cytokines and chemokines by...

Ngày tải lên: 09/08/2014, 14:22

... (SLE) and rheumatoid arthritis (RA) Methods We measured plasma levels of total, platelet and leukocyte MPs by prothrombinase capture assay and flow cytometry in 43 patients with pSS, 20 with SLE and ... total), leukocyte and platelet circulating MPs in pSS and other AIDs (SLE and RA) as a biomarker of cell activation Materials and methods Materials and controls The characteristics of all subjects ... expressed as number and percentage and median and range Results for MP levels are expressed as mean ± standard error of the mean Comparisons of mean MP levels, sPLA2 activity, sCD40L and sCD62P concentrations...

Ngày tải lên: 09/08/2014, 14:22