pharmacokinetics of nanocarrier mediated drug and gene delivery

... nanotechnology offers the best promise for targeted delivery of drugs and genes to the tumor site and alleviation of the side effects of chemotherapeutic agents Multifunctional nanosystems offer tremendous ... Department of Pharmaceutical Sciences and Center for Nanomedicine and Cellular Delivery University of Maryland Baltimore, Maryland Maya Nair Departments of Molecular Biology and Immunology University of ... 19 Randall J Mrsny Chapter Pharmacokinetics of Nanocarrier- Mediated Drug and Gene Delivery 43 Yuriko Higuchi, Shigeru Kawakami, and Mitsuru Hashida...

Ngày tải lên: 04/06/2014, 14:30

... μCi) of 86Y-CHX-A"-panitumumab F(ab’)2 and imaged and days post-injection of the RIC (c) Specificity was demonstrated by co-injecting 100 μg of panitumumab with the RIC and blocking uptake of the ... vitro and in vivo studies KEB and KG carried out radiolabelings TN performed PET imaging and analysis MWB synthesized the chelate and participated in the design of the studies DEM conceived of and ... those of the F(ab’)2 fragment with a higher overall detection of tumor lesions The authors postulate that the success of these studies was the result of careful selection and matching of the...

Ngày tải lên: 21/06/2014, 02:20

... spectra of (a) pristine SPIONs and (b) PLMA2-SPIONs.      Figure 3-6  Schematic representation of the synthesis of PLMA-1-PEGSPIONs Site and extent of amide band formation between H2NPEG and PLMA-1 ... DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING NATIONAL UNIVERSITY OF SINGAPORE 2012               ACKNOWLEDGEMENTS My sincere and deep gratitude goes first and ... Release profiles of cisplatin from Pt-Fe-PNs in DI water, PBS, and artificial urine at 37 oC Inset shows the release profile in the first 10 h Figure 6-9 Size increase of a mixture of Pt-Fe-PNs and...

Ngày tải lên: 09/09/2015, 10:14

... physics and technology One of the major goals of molecular imaging has become the development of noninvasive strategies of ªmolecular profilingº in living subjects, i.e., the acquisition and analysis ... interdisciplinary nature and scientific diversity of this area of science was well reflected during the workshop, attracted great interest, and led to a better understanding of each other's expertise and knowledge ... degradation, and the absence of avidin immunogenicity and of the side effects of biotin administration In a recently published study by the groups at universities in Turku, Finland and Uppsala,...

Ngày tải lên: 29/06/2014, 11:20

... z-stacks of a series of confocal optical sectioning of CNE2 cells shown on the top and right side of the en face image show the staining on the cross section side profile of the cells The top and ... for the growth of gold shell [28]…… ……………… …126 Figure 5.1 Reaction schematic of the synthesis and pegylation of gold nanoshells with core of 81 nm radius and gold shell thickness of 23 nm used ... hydroxide nanoparticles at (a) pH of 4, (b) pH of 6, (c) pH of and (d) pH of 11 on the surface of amine functionalized silica cores to illustrate the influence of pH on the seeding efficiency using...

Ngày tải lên: 11/09/2015, 09:02

... longlasting and effective MMC delivery system In vitro cellular uptake of different kinds of NPs To visualize the effect of FA -mediated endocytosis of different kinds of modified NPs, the distribution of ... were compared Results and discussion The preparation and characteristics of differential kinds of NPs Figure shows the process of the preparation and modification of NPs, and the scanning electron ... prolong exposure of tumor cells to antitumor drug, EPR effect [20], and subsequently increase the therapeutic effect of antitumor drug PEG offers the advantage that it is nontoxic and non-immunogenic,...

Ngày tải lên: 20/06/2014, 22:20

... the type of malignancy and drugs used The use of low doses of rasburicase may permit to spare the total cost on the management of patients and to reduce the risk of the development of antibodies ... substances and drugs, with consequent risk of accumulation and toxicity Uric acid can determine the renal impairment in different ways: the local and direct obstruction and toxicity on tubules and the ... facilitates clearance of uric acid and neutralizes the tendency to lowering of pH in patients with vomiting and diarrhoea It increases solubility and renal excretion of uric acid and xanthine, maintaining...

Ngày tải lên: 31/10/2012, 14:59

... and cell–ECM interactions, and by maintaining the structural integrity and self-assembly of the ECM [10,11] Notably, one of the characteristics of malignant transformation is downregulation of ... remodeling of the ECM underlying tumor and endothelial cells, thereby facilitating cell invasion [23–25] Progress in the field and the generation of genetic tools (i.e heparanase transgenic and knockout ... head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion Squamous cell carcinoma of the head and...

Ngày tải lên: 15/03/2014, 23:20

... images of day planners, curled-up post-it papers stuck to the base of your monitor, to-do lists etched onto a coffee shop napkin, even cleaning up the office! (No, that random pile of books and ... photography and your setup I hope that you get a lot of mileage from these tips and that the book can serve as a frequent reference in your work Best of luck, and remember: There’s a part of this ... digital photographers and imaging professionals The introduction of Photoshop CS5 and ACR 6, as well as Lightroom 3, brought many new capabilities and improvements When I was offered the chance...

Ngày tải lên: 30/05/2014, 23:16

... image and its edges One of the major limitations of the MRI is the linear relation between the number of measured data and scan time As a result MRI machines tend to be slow, claustrophobic, and generally ... an overview of some of the recent works in computer vision and image understanding that make the use of compressive sampling and sparse representation In particular, we show have CS and sparse ... image understanding and computer vision problems such as background subtraction and target tracking one is often faced with the problem of data deluge [7] Large amounts of data can be of detriment...

Ngày tải lên: 05/06/2014, 12:05

... imaging and confirmed by dissection and counting Results: NOTA-monomer, NOTA-dimers and were prepared with purity of 99%.The inhibition constants of the three BBN peptides were comparable and in ... uptake and efflux, the in vivo stability and the biodistribution of radiolabeled NOTA-BBN monomer and NOTA-BBN homodimers and which differed by the spacer length between the two peptide ligands ... µCi; 100 µL) of 64 Cu/NOTA-monomer and 64Cu/NOTA-dimer via the caudal vein and sacrificed with CO2 at different periods of time after injection Organs of interest were then collected and weighed...

Ngày tải lên: 21/06/2014, 17:20

... slides and stained with haematoxylin and eosin (H&E) and safranin O (0.5% in 0.1-M sodium acetate, pH 4.6, for 30 s) for general histology, measurement of cartilage thickness, and assessment of metachromasia ... Germany) with a gradient strength of 25 mT/m and VB33A software: T1 sagittal and coronal spin echo sequence This provides information on the general anatomy of the joint, for example, identifying ... not applicable; N/A not available with standard and polarised light and images captured and digitised using a closed-circuit television and Image Grabber software (Neotech Ltd, Hampshire, UK) R62...

Ngày tải lên: 09/08/2014, 01:21

... goal of increasing the volume of the FLR [2] First reported by Makuuchi et al [3], the aim of PVE is to bring about atrophy of the segments to be resected and induce a compensatory hypertrophy of ... graph Figureanalysis of left and right hepatic lobe volumes during the course of the treatment Graph Graph analysis of left and right hepatic lobe volumes during the course of the treatment Note ... tumors, and its indications have been subsequently extended to patients with metastatic liver tumors [3-9] Induction of hypertrophy of the nondiseased portion of the liver reduces the risk of hepatic...

Ngày tải lên: 09/08/2014, 04:21

... synovial tissues of RA and osteoarthritis (OA), correlation of ADAM15 expression with synovial pathology, localization of ADAM15 in RA synovium, and the mechanism of regulation of ADAM15 expression ... expression was examined in a larger number of RA and OA samples, ADAM15 was detected in 100% of the RA samples (16 of 16 cases) and in 60% of the OA samples (12 of 20 cases) (data not shown) By real-time ... major immunoreactive bands of 100, 76, 66, 47, 41, 38, 34 and 29 kDa were observed (Fig 6, lane 2) Because the molecular weight of the 100-kDa band Effect of cytokines and growth factors on ADAM15...

Ngày tải lên: 09/08/2014, 07:20

... and 63% of treatments along the L-R, S-I and A-P axes respectively, of which 14%, 31% and 29% were larger than mm In 88% of all treatments, the patient’s position had to be adjusted because of ... S-I2 and A-P2 , and L-R1 , S-I1 and A-P1, represent during-treatment and pre-treatment (uncorrected) isocenter positions along the L-R, S-I and A-P axes respectively, and cL-R , cS-I and cA-P represent ... diameter and mm in length) under trans-rectal ultrasound guidance The gold seeds were placed in the prostate base, mid-gland and apex Antibiotic prophylaxis was used, and typically consisted of ciprofloxacin...

Ngày tải lên: 09/08/2014, 09:20

... Boxplot depicting changes of mean ADC of nontreated and treated tumors at early and follow-up MRI compared to baseline MRI Boxplot illustrates changes of mean ADC of non-treated and treated colorectal ... participated in the design of the study and the treatment planning procedures OD conceived of the study and participated in its design and coordination All authors have read and approved the final ... (C) indicates the area of irradiation induced reversible hepatocyte dysfunction Figure Boxplot depicting changes of mean volume of nontreated and treated tumors at early and follow-up MRI compared...

Ngày tải lên: 09/08/2014, 09:20

... with an average of 26 mm Of the 55 lesions, tumor location was the right upper, middle and lower lobes in 17, and 13 cases, respectively, and the left upper and lower lobes in 13 and 10 cases, ... study and drafted the manuscript YS indicated the design of the study and gave final approval of the version to be published NT participated in analysis and interpretation of data CIH, KO and SA ... acquisition and analysis of data HO participated in the design of the study and helped to perform the statistical analysis CS participated in analysis and interpretation of data and helped to...

Ngày tải lên: 09/08/2014, 09:22

... clinical examination, by both the head and neck surgeon and the radiation oncologist, endoscopy and CT scan of the head and neck region A chest X-ray or chest CT and blood test were performed to rule ... parotid and submandibular glands, as well as the spinal cord, were outlined on the planning CTscan The goal of treatment planning was maximal exclusion of the contralateral parotid gland, while ... the dose homogeneity of the deep part of the target, always sparing the parotid gland The use of wedges in some fields was common http://www.ro-journal.com/content/4/1/33 dry mouth?) and 42 (Have...

Ngày tải lên: 09/08/2014, 10:20

... phase and by the rate of shedding of cells from the solid phase into the fluid phase We assume that adhesion and shedding are described by the product of cell number and the rate constants kadh and ... effect of initial number of tumor cells in the brain parenchyma, Nb,t, and radiosensitivity, D0, on treatment outcome is shown Failure is more likely the higher the value of Nb,t and D0 Page of (page ... helped conceive of the model, analyzed the scenarios, and drafted the manuscript EH and LM provided insights into the model structure and edited the manuscript JK conceived of the model and helped...

Ngày tải lên: 09/08/2014, 10:21