pharmacokinetic pharmacodynamic modelling simultaneous measurement of concentrations and effect

... analysis and drafted the manuscript DS and IK prepared Tar-GFP vector and discussed this study KY conceived of the study, and participated in its design and coordination All authors read and approved ... time course of the motility and the localization of the aspartate receptor protein (Tar) for several cell generations We also report cellular responses caused by the addition and removal of the aspartate ... inoculation To measure the localization-dynamics of expressed proteins and the motility of single cells simultaneously, we used the on-chip microcultivation system and assayed intracellular proteins tagged...

Ngày tải lên: 11/08/2014, 00:22

... availability of the possible simultaneous measure of kinematics data and fMRI, offering an innovative and extremely flexible experimental set-up for a better understanding of neural correlates of motor ... placement and the comparability of motion parameters represent the main Page 14 of 17 advantage of using motion capture system with respect to EMG, where the level of noise of the recorded signal and ... Implementation and evaluation of simultaneous video-electroencephalography and functional magnetic resonance imaging Magn Reson Imaging 2010 34 Mullinger K, Debener S, Coxon R, Bowtell R: Effects of simultaneous...

Ngày tải lên: 19/06/2014, 08:20

... allergic and control groups For the noninvasive measurement of pulmonary function separate groups of A fumigatus-sensitized and control mice were used (n = each group) Noninvasive measurement of pulmonary ... agreement between the invasive and noninvasive lung function methods was analyzed by the method of Bland and Altman [23] Graphically, the difference of each pair of measurement was plotted against ... the mean of the differences, the dashed lines show the upper and lower limits of agreement TG participated in the design and coordination of the study and drafted the manuscript MZ and RB carried...

Ngày tải lên: 12/08/2014, 18:20

... The sum of the pixel values of ΔZ V , ΔZ Q and ΔZ V \ΔZQ was calculated for dependent and non-dependent lung regions (each comprising half the image) in each position Profiles of ΔZV, ΔZQ, and ΔZV\ΔZQ ... Figure Sum of relative impedance change in dependent and non-dependent lung regions The sum of ΔZQ and ΔZV and ΔZV/ΔZQ in dependent and non-dependent regions for supine, prone, left and right ... http://ccforum.com/content/15/1/R37 bilateral and unilateral ventilation of the left and right lungs [2] They utilised a band pass filtering technique and linear regression fit to establish functional regions of interest (ROI),...

Ngày tải lên: 14/08/2014, 07:21

... HANOI UNIVERSITY OF SCIENCE TECHNISCHE UNIVERSITAT DRESDEN NGUYEN TIEN CU SIMULTANEOUS REMOVAL OF ARSENIC AND AMMONIA FROM GROUNDWATER BY PHYTOFILTRATION WITH CATTAILS (TYPHA ... BY PHYTOFILTRATION WITH CATTAILS (TYPHA SPP.) CULTIVATION MASTER THESIS FIELD: WASTE MANAGEMENT AND CONTAMINATED SITE TREATMENT SUPERVISOR: ASSC DR LE VAN CAT HANOI-2008 MỤC LỤC MỤC LỤC DANH MỤC...

Ngày tải lên: 09/01/2015, 08:53

... terms of low cost, small-scale treatment, simple operation and maintenance Moreover, requirements of simultaneous removal of both arsenic and ammonia should necessarily be taken into account Phytofiltration ... the affinity and solubility limitation of the resultant products [US EPA, 2002] The procedures are also time-consuming and expensive, and not cost-effective And another disadvantage of this method ... contaminants ) 1.4 Phytofiltration Systems 1.4.1 Characteristics of Phytofiltration Systems a/ Phytofiltration: Phytofiltration, the use of plant with extensive root systems and high accumulation...

Ngày tải lên: 09/01/2015, 08:53

... IR/07/045 Simultaneous Determination of PAHs and PCBs by GCMS Analysis The National Grid and other Ordnance Survey data are used with the permission of the Controller of Her Majesty’s Stationery Office ... Survey carries out the geological survey of Great Britain and Northern Ireland (the latter as an agency service for the government of Northern Ireland), and of the surrounding continental shelf, ... method for the simultaneous separation and identification of PAHs and PCBs by GCMS was successfully developed by this laboratory The programming of associated software to identify and differentiate...

Ngày tải lên: 09/09/2015, 09:39

... Distribution of Income and Wealth and Gender Equality and the Economy programs The central objective of the project is to develop a measure of time and income poverty for the Republic of Korea that ... reconsideration of the official measure of poverty Policies to combat poverty and promote equality require a deeper and more detailed understanding of the linkages between conditions of employment, ... insurance, and other organizations 22 INCOME AND TIME POVERTY 3.1 Hours of Employment, Time Deficits and Earnings The distinctive feature of our approach to the understanding of low-income persons and...

Ngày tải lên: 23/09/2015, 08:53

... (Omax-min and Pmax-min) and diurnal averages (Oavg and Pavg) with standard deviations (σo and σp) for SIM 1-8 81 Table 4-2: Difference measures of predicted and observed day- and nighttime ... error, r2 = coefficient of determination (dimensionless) and d = index of agreement (dimensionless) 90 Table 4-4: Summary of maximum, minimum and standard deviations of observed and predicted mean ... SIM 5-8 74 viii Table 4-1: Summary of maximum and minimum values for observed (Omax and Omin) and predicted (Pmax and Pmin) mean (average of all measurement/ receptor locations) 2-m air temperature...

Ngày tải lên: 30/09/2015, 10:11

... supervisors Associate Professor M.A Mannan and Professor A.Y.C Nee who shared their wealth of knowledge and research expertise and constantly helped me with their insightful advice and seemingly endless ... location and magnitude of the clamping force are controllable in real time, ensuring optimal workholding at all times A more practical and cost effective approach is to have off-line optimisation of ... analysis and synthesis of fixtures used in manufacturing This shows the importance of fixturing in manufacturing processes and the need for research and development in this field One of the first...

Ngày tải lên: 03/10/2015, 21:56

... X X X The RAND Evaluation RAND’s evaluation of the asthma demonstration consisted of two components: a process evaluation and an analysis of the effects of the guideline on a series of outcome ... and providing feedback needed for effective performance improvement (Palmer and Hargraves, 1996; Sasala and Jasovsky, 1998; Cox, Wilcock, and Young, 1999; Lescoe-Long and Long, 1999; Savitz and ... al., 2005) For each demonstration, RAND performed a process evaluation of the implementation process and an assessment of the effects of the Implementation of the Asthma Practice Guideline in...

Ngày tải lên: 17/02/2014, 22:20

... for the two soft and one hard wheat noodle samples but there appeared to be a varietal effect on this relationship, as the linear effect of protein Fig Effect of protein on soft- and hard-grained ... lightness (L*) and an increase in redness (a*) and yellowness (b*) values of raw WSN sheets from soft and hard wheat flour samples Measurements of L*, a*, and b* usually give low standard deviations ... translucency %/mm, and all measurements were adjusted to a standard cooked noodle thickness of mm Experiment The effect of water addition and vacuum on color, gloss, and translucency for soft wheat WSN was...

Ngày tải lên: 16/12/2012, 15:25

... economic capital purposes (v) Profit and loss attribution Analysis of profit and loss on a regular basis (eg annually) and comparison between causes of actual profit and loss and the risk drivers in ... simplicity in terms of data and computational requirements, and ease of communication about the method and interpretation of the outcome Abstracting from the possibility of mis -measurement and negative ... efficiency of trading execution and settlement In practice, however, risks are often measured by reference to different lines of business and/ or 24 Range of practices and issues in economic capital modelling...

Ngày tải lên: 20/02/2014, 19:20

... objects and maintain retroactive control of a process In this sense, Fundamentals of Instrumentation and Measurement instruments and systems of measurement constitute the “tools” of measurement and ... (conventional) true value of the measurand” A systematic error is “the component of the error of measurement which, in the course of a number of measurements of the same measurand, remains constant ... this the accuracy of measurement, or “the closeness of agreement between the result of a measurement and the (conventional) true value of the measurand” and the experimental standard deviation,...

Ngày tải lên: 05/03/2014, 10:10

... analysis of the consequent hits was also performed to investigate the simultaneous improvement of the activity and stability of Symbiobacterium toebii TPL, as a better structural understanding of how ... standard Homology modeling and structural analysis To examine the structural and functional effects of the detected mutations, three-dimensional models were generated of both the wild-type and ... recruitment of the original characteristics of the parental mutants The wild-type protein and two mutants, AS4 and AS7, were purified to homogeneity with purification yields of over 40%, and investigated...

Ngày tải lên: 07/03/2014, 00:20

... study of polymers III Technique of mechanical tests of vulcanizates of rubber and plastics Rubber Chem Tech., 13, 904–917 Haward, R.N (1942) Extension and rupture of cellulose acetate and celluloid ... in the range of temperatures and strain rates of interest A linear dependence of yield stress as a function of log strain rate can be observed over a large interval of strain rates and temperatures, ... sub-Tg secondary transitions) The strength and magnitude of these transitions depends on the degree of crystallinity and the size of the lamellae, and therefore is influenced by the thermal history...

Ngày tải lên: 09/03/2014, 00:20

... period of exploration of specific plants For example a mining can be explored yearly or seasonally Through this, investors and managers can understand the scale of the mining and the potential profits ... empirical study of advantages and disadvantages of ABC in order to judge the effectiveness that this method can bring to the organizations as well as the impacts of its on the decisions of the managers ... about the impacts and effectiveness of ABC as a cost effective measurement to some companies in Coal Industry CHAPTER II: Literature review 2.1 ABC costing method: history and calculation method...

Ngày tải lên: 13/03/2014, 14:19

... the effects of size and shape of Si-nc on the incorporation of group-III (B and Al), group-IV (C and Ge) and group-V (N and P) impurities Single-doping has been investigated both in spherical and ... electronic properties of B- and P-codoped Si-nc are qualitatively and quantitatively different from those of either B- or P- single-doped Si-nc The presence of both a n and a p impurity leads ... the FE and the electronic properties of the Si-nc are influenced by the insertion of more and more impurities We call this insertion of several impurities multidoping Fig shows how the FE of a large...

Ngày tải lên: 16/03/2014, 15:15

... olomoucine and p21 in assays of transient transfections This increase takes place at concentrations of the inhibitors where the expression of Rb and Sp1 starts to increase At higher concentrations of ... Rb and Sp1 protein caused by CDK inhibitors in CHO cells The increase in total levels of Rb and Sp1 proteins caused by UCN-01 may be a result of the enhanced transcription and stability of Rb and ... Biochem 270) 4813 Fig Effects of UCN-01 on the levels of Rb and Sp1 protein (A), (B) Dose–response of the effect of UCN-01 on the levels of retinoblastoma gene product (Rb) and Sp1 proteins, respsectively...

Ngày tải lên: 16/03/2014, 23:20

... of elements) Cardinality of a relationship times a factor based on the selectivity of the predicate Number of referenced objects Number of windows of input Size of a window of input (number of ... Cardinality of the left input Cardinality of the right input Length of the predicate Type of the object Number of objects Extent of the database (e.g AtomicParts) Number of pages Size of a bucket ... single-valued partOf relationship select struct(A:a.id, B:a.partOf.id) from a in AtomicParts where a.id

Ngày tải lên: 17/03/2014, 00:20