phần i thiết kế phần điện nhà máy thủy điện
Effects of exposure to environmental mycobacteria on immunity conferred by bacille calmette guerin (BCG) vaccine
Ngày tải lên :
05/10/2015, 13:53
... latent mycobacteria survive under conditions of nutrient deprivation and hypoxia within granulomas by reducing their metabolic activity and persisting in a nondividing or slowly dividing state (Raja ... Although insufficient in limiting Mtb infections by itself, IFN-γ plays an important role of activating macrophages by inducing phagosome maturation and upregulating their antimicrobial molecules, ... reduced the airway inflammation in mice with ovalbumin-induced eosinophilic airway inflammation In our lab, after M chelonae sensitisation followed by intranasal BCG administration, both lung...
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Báo cáo y học: "Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis" pptx
Ngày tải lên :
09/08/2014, 06:22
... cytokine profile, NKT cells in the synovial fluid exhibit a Th0-like cytokine profile that is comparable with that in healthy control individuals Cytokine profile of CD4+ and CD4- natural killer ... vivo stimulation of PBMCs with α-GalCer confirm a Th1-like bias of NKT cells in RA patients Strikingly, NKT cells in the synovial fluid not show this Th1-like bias, but have a Th0-like profile ... region PBMCs from healthy control individuals exhibited a polyclonal peak profile or a Gaussian-like distribution for Vα24, containing a peak at 350 base pairs, which corresponds to the invariant...
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Báo cáo y học: "Natural killer T cells and rheumatoid arthritis: friend or foe" ppt
Ngày tải lên :
09/08/2014, 06:22
... perpetuating role of V i NKT cells in this model Conversely, stimulation by repeated in vivo administration of α-GalCer resulted in a moderate increase in clinical paw swelling although no histological ... affecting joint inflammation in wild-type animals Although several studies have highlighted important immunoregulatory properties for TGF-β1 in experimental arthritis, the cellular communication ... RA, with a suppressive role in the induction phase and a provocative role in antibody-induced joint inflammation A particularly fascinating and novel aspect of the current report is the notion...
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Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt
Ngày tải lên :
09/08/2014, 13:21
... medical history, including specific questions on autoimmune diseases, medications, and comorbidities In addition, the physicians of patients and family members with lupus completed a questionnaire, ... relatives of lupus patients and found similar levels to those in control individuals Similarly, there were no significant differences in the proportion or killing activity of NK cells between first-degree ... is the recipient of The Arthritis Society/CIHR Investigator Award Dr Fortin is funded by an Investigator Award from The Arthritis Society/CIHR Institute of Musculoskeletal Health and Arthritis...
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Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
Ngày tải lên :
29/03/2014, 03:20
... Natural Killer Cell Subpopulations in Putative Resistant Individuals and Patients with Active Mycobacterium tuberculosis Infection Scand J Immunol., 68: 92-102 Batoni G, Esin S, Favilli FPM, Bottai ... prior to initiation of anti-tuberculosis therapy None of the patients included in the study had any evidence of suffering from diabetes, HIV infection or autoimmune diseases The study was limited ... cells in the optimal host response against MTB by increasing the infection inoculum (Vordermeier et al., 1996; Maglione et al., 2007) In addition the protection of mice against MTB infection by...
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Báo cáo sinh học: " Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Ngày tải lên :
19/06/2014, 08:20
... infection via the secretion of IFN-γ at early times p .i The following study was initiated to determine if NK cells provide innate resistance to HSV-1 infection via their capacity to rapidly deliver IFN-γ ... (IFN)-γ multiplies the potency with which the innate IFNs, IFN-α and/or IFN-β, suppress HSV-1 replication [28] This cooperative inhibition by IFN-α/β and IFN-γ effectively prevents virus-infected ... survived the infection (Fig 1D) Scid mice reconstituted with purified B cells eventually died, but the mean time of survival was increased to 22 ± days (Fig 1D) Reconstitution with purified T...
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báo cáo hóa học:" Re-evaluating the role of natural killer cells in innate resistance to herpes simplex virus type 1" pot
Ngày tải lên :
20/06/2014, 04:20
... infection via the secretion of IFN-γ at early times p .i The following study was initiated to determine if NK cells provide innate resistance to HSV-1 infection via their capacity to rapidly deliver IFN-γ ... (IFN)-γ multiplies the potency with which the innate IFNs, IFN-α and/or IFN-β, suppress HSV-1 replication [28] This cooperative inhibition by IFN-α/β and IFN-γ effectively prevents virus-infected ... survived the infection (Fig 1D) Scid mice reconstituted with purified B cells eventually died, but the mean time of survival was increased to 22 ± days (Fig 1D) Reconstitution with purified T...
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Báo cáo y học: "Natural killer cells and autoimmunity" doc
Ngày tải lên :
09/08/2014, 01:23
... myocarditis by limiting viral replication and thus preventing prolonged immune activation and minimizing tissue damage with exposure of self antigens Infection with either CVB3 or murine cytomegalovirus ... in several murine models of autoimmunity Experimental autoimmune uveoretinitis (EAU) is induced by immunizing sensitive strains of mice with ocular autoantigens Depletion of NK cells before immunization ... systemic IgE production, consistent with a Th2 immune response [79] Depletion of NK cells before the initial immunization but not later during the challenge period resulted in a diminished infiltration...
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Báo cáo y học: "Interleukin-15 and interferon-γ participate in the cross-talk between natural killer and monocytic cells required for tumour necrosis factor production" docx
Ngày tải lên :
09/08/2014, 08:22
... the addition of antibodies against β2 integrins or of anti-IL-15 mAbs (Figure 4a and Table 2) Interestingly, this inhibition of CD69 expression was associated with a poorer capacity to induce ... eight independent experiments m-IL-15, membrane-bound IL-15; RFI, relative fluorescence intensity aStatistical significance: p < 0.01 by analysis of variance with Bonferroni multiple-comparison ... F, Baldani-Guerra B, Nisii C, Marchesini V, Carra G, Trinchieri G: Reciprocal activating interaction between natural killer cells and dendritic cells J Exp Med 2002, 195:327-333 Piccioli D, Sbrana...
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Báo cáo y học: " Natural killer cells control a T-helper 1 response in patients with Behçet''''s disease" doc
Ngày tải lên :
12/08/2014, 12:20
... confirm our findings Another limitation is the difficulty in classifying BD patients into those with active disease and those with inactive disease We used a strict definition to select patients ... manifestations or minor uveitis attack, which did not require intensive therapy, were therefore classified as having iBD This clinical heterogeneity in the iBD subset may result in variability in ... cells in iBD patients were intrinsically hyporesponsive to IL-12 due to their downregulated expression of IL-12Rβ2 and impaired IL-12 signaling, resulting in deficient IFNγ production even in the...
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Báo cáo y học: "MHC class I expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway" ppt
Ngày tải lên :
13/08/2014, 13:20
... hepatic NK cells were preincubated with DCI, a granzyme inhibitor in intact cells [30], hepatic NK cellmediated CC531s cytolysis was largely inhibited (Fig 3A) and apoptosis was completely inhibited ... proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins Biochemistry 1991, 30:2217-2227 Sarin A, Williams MS, Alexander-Miller MA, ... Triantis V, Eizirik DL, Kuppen PJ, Wisse E: Rat hepatic natural killer cells (pit cells) express mRNA and protein similar to in vitro interleukin-2 activated spleen natural killer cells Cell Immunol...
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Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts pot
Ngày tải lên :
06/03/2014, 04:20
... conclusions about risk differences by individual TLR2 genetic variant This is a major limitation of this study, and there is a need to replicate and validate these association results in another ... polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis Genes Immun 2007, 8(5):422-428 15 Muzio M, Bosisio D, Polentarutti N, D’amico G, Stoppacciaro A, Mancinelli ... ethnicity Age and male sex ratio were similar between the groups Traditional acquired risk factors, such as history of diabetes mellitus, malignancy, chronic bronchitis, and chronic renal insufficiency...
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Báo cáo Y học: Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity pptx
Ngày tải lên :
31/03/2014, 15:20
... viscotoxins are involved in immunologically mediated tumour cell destruction Future studies will aim to identify the viscotoxin receptors involved in this therapeutically interesting bioactivity ... determined For each time point, viscotoxin bioactivity was calculated as follows: (% of specific lysis with VT) ) (% of specific lysis without VTA2) For each time point, the viscotoxin bioactivity ... activation, which follows a complex array of activatory and inhibitory receptor–ligand interactions In hematopoietic cells, intracellular transduction of activation signals involves changes in...
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natural killer cell protocols
Ngày tải lên :
11/04/2014, 09:58
... important IL-2-deficient mice have no NK activity, but this activity is inducible in these mice (17), indicating that IL-2 is dispensable These findings together make it likely that IL-15 is important ... Wells containing colonies are identified using an inverting microscope ideally fitted with an objective that allows the entire well to be seen in the field of vision The cloning efficiencies are ... amplification using Ly49A-specific primers (1st PCR) An aliquot of the first reaction is reamplified using an internal pair of Ly49A-specific primers (2nd PCR) The B6 or BALB/ c origin, respectively,...
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báo cáo hóa học:" Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy – a case report" doc
Ngày tải lên :
18/06/2014, 15:20
... with our previous findings from the phase I clinical trial In this study an intrinsic NK cell activity was initiated only in patients who received more than repeated reinfusion cycles of TKD/IL-2-activated, ... interestingly, after the fourth re-infusion cycle, patient-derived PBMNC exhibited an intrinsically enhanced NK cell activity This finding is in line with the kinetics of the NK cell activation ... period and the clinical follow-up for year The kinetics of the initiation and maintenance of an in vivo cytolytic response against Hsp70-positive tumors within the first therapy cycles is in line...
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báo cáo hóa học:" Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy" potx
Ngày tải lên :
18/06/2014, 15:20
... cells initially-obtained their name due to their natural cytotoxicity against tumor cells requiring no prior sensitization, unlike T cells [4] It is well established that the cytotoxicity of ... haploidentical individuals presenting a functional mismatch in the NK cell repertoire towards recipients MHC -I ligands In this context, NK cell alloreactivity has been shown to increase prognosis ... leading to this selective expansion process, we intuitively hypothesised a direct stimulation of NK cells by dendrimers which would induce their selective proliferation Then, using freshly isolated...
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Báo cáo hóa học: "Thymoglobulin, interferon-g and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures" potx
Ngày tải lên :
18/06/2014, 16:20
... staining positively for a given antigen is indicated 2A-2B (cumulative data) and in Figure (a representative experiment out of 10 with similar results) At this time-point in culture, the increase ... Negrin RS: Expansion of Philadelphia chromosome-negative CD3+CD56+ cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease ... Functional assays are individually shown in Figure 8A and indicated that in vitro K562 cell lysis by CIK cells was highly efficient in out of cases here examined (patients #2 and #3), especially...
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Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot
Ngày tải lên :
09/08/2014, 06:22
... cytolytic activity However, logistic regression analysis showed no statistically significant differences in NK function between patients with or without immunosuppressive treatment (independent variables: ... K, Davis J, Filipovich AH: Characterization of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis J Med ... hemorrhagic, hepatic, and neurologic manifestations in juvenile rheumatoid arthritis: possible relationship to drugs or infection J Pediatr 1985, 106:561-566 Ravelli A, De Benedetti F, Viola S, Martini...
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Báo cáo y học: "The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors" pot
Ngày tải lên :
09/08/2014, 10:22
... cytotoxic By placing a KIR-negative population in culture, this equilibrium may be significantly modified, resulting in the reactivation or resetting of KIR genes that in turn are susceptible to ... Linehan WM, Caligiuri MA, Childs RW: Enhanced cytotoxicity of allogeneic NK cells with killer immunoglobulin-like receptor ligand incompatibility against Available online http://arthritis-research.com/content/9/6/R125 ... mediate cytotoxicity after proliferation ex vivo in the presence of cytokines Activation of NK cells in vivo is mediated by a variety of signals, leading to cytokine secretion and cytotoxic activity...
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Báo cáo y học: "Leukocyte numbers and function in subjects eating n-3 enriched foods: selective depression of natural killer cell levels" potx
Ngày tải lên :
09/08/2014, 10:23
... and enumeration of the number of surviving bacteria Neutrophil iodination reaction The quantitative neutrophil iodination reaction, which examines the ability to produce oxygen radicals and the ... rheumatoid arthritis (RA), Crohn's disease, ulcerative colitis, systemic lupus erythematosus, psoriasis, atherosclerosis and asthma [9] Despite the finding of such beneficial effects there is still insufficient ... adhesion and bactericidal activity were unaffected by n-3 LCPUFA supplementation Our finding of bell-shaped relationships for the iodination activity may also be of importance in protection against...
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