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... reactions is still low, most studies lack sufficient statistical power to provide evidence of a strong correlation The increasing number of patients being treated with this type of medication will ... additional amino acid variations in HLA-DR that are located outside the shared epitope have also been strongly associated with susceptibility to RA [8, 9] The mechanism for MHC predisposition to RA remains ... autoimmune disease (Table 2.1) The known loci associated with RA, both MHC and non-MHC, are more strongly linked to seropositive RA, i.e., RA in which either rheumatoid factor (RF) or antibodies...

Ngày tải lên: 29/09/2016, 07:36

Ngày tải lên: 13/08/2014, 13:22

... among men, the OR for CT against CC is 0.34 (95% CI = 0.20 to 0.60; P = 0.0001) Here we also see a strong association in anti-CCP antibody negative men (OR = 0.4, 95% CI = 0.2 to 0.7; P = 0.0004) ... is lower than for the associated haplotype, indicating that the rs729749 SNP itself or a SNP in strong linkage disequilibrium is causing the haplotype association Homozygosity could explain the ... the risk for overlooking associations that are specific for a subgroup of RA patients There are strong medical and biological arguments in favour of subgrouping RA patients, and an analysis of...

Ngày tải lên: 09/08/2014, 10:21

Ngày tải lên: 13/12/2013, 04:15

... therapies 1.7.1.1 Inform people with RA who wish to experiment with their diet that there is no strong evidence that their arthritis will benefit However, they could be encouraged to follow the...

Ngày tải lên: 08/03/2014, 14:20

Ngày tải lên: 20/06/2014, 04:20

... copies/ml EBV DNA) were detected in his serum and X-linked lymphoproliferative disorder (XLP) was strongly suspected Sequencing the SH2D1A gene in this patient revealed a point mutation, c.261delT ... the examples drawn from our own experience, there are many others in the published literature We strongly encourage clinicians to refer their patients for genetic counseling before testing for these...

Ngày tải lên: 08/08/2014, 21:20

... deviation destructions and surgical histories were considered by the Delphi panel to be indicators strongly associated with severe RA, the prior surgical and radiologic subscales were given higher...

Ngày tải lên: 09/08/2014, 07:20

... composition of domains in relation to its main intention – the quantification of severity This depends strongly on the concept of severity that one adheres: Does severity only refer to irreversible aspects...

Ngày tải lên: 09/08/2014, 07:20

Ngày tải lên: 09/08/2014, 10:20

... peptide in the HLA-DR pocket; all peptides truncated beyond Phe265 (266–275 and 267–275) showed strongly reduced affinities (IC50 values > 100 μM) The 5G11 response was not affected by the amino-terminal ... (14G11) hybridomas Page of 11 (page number not for citation purposes) We and others have provided a strong case for a role of HC gp-39 as a target of the immune response in RA The finding that the ... [38,42] Furthermore, four different amino acid positions within the core region were found to strongly interact with the TCRs since substitution did not affect HLA-DR4 binding but abrogated recognition...

Ngày tải lên: 09/08/2014, 10:20

Ngày tải lên: 10/08/2014, 10:23

Ngày tải lên: 11/08/2014, 00:23

Ngày tải lên: 11/08/2014, 10:23

Ngày tải lên: 11/08/2014, 19:21

Ngày tải lên: 11/08/2014, 23:21

Ngày tải lên: 13/08/2014, 14:20

... York City and San Francisco (1) The U.S Air Mail Service was the first aviation service to place a strong emphasis on safety As regulations for aviation safety were developing, flight simulation was...

Ngày tải lên: 10/10/2014, 16:25

... mode of heat transfer during the initial stages of melting, natural convection of molten material strongly affects the melting behavior at later stages and can increase the melting rate by an order...

Ngày tải lên: 28/11/2015, 13:33

Ngày tải lên: 06/06/2016, 16:30