pet spect imaging in cns drug development
Tài liệu PROTEOMIC APPLICATIONS FOR THE EARLY DETECTION OF CANCER doc
Ngày tải lên :
15/02/2014, 05:20
... multiple combinations of discriminating proteomic patterns from a single mass spectral training set, each pattern combination readjusting as the models get better in the Incoming test data adaptive mode ... pathological diagnosis using retrospective or prospective study sets, its input can be added to an ever-expanding training set Training set model The AI tool learns, adapts and gains experience through ... Decreasing the amount of time allowed for incubation also allows the researcher to minimize non-specific binding, as the high-affinity interactions occur more quickly than low-affinity binding The...
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Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer pptx
Ngày tải lên :
05/03/2014, 12:20
... investigational device exemption insulin-like growth factor type Imaging Diagnostic System, Inc Institute of Medicine institutional review board LCIS LOH lobular carcinoma in situ loss of heterozygosity ... attention to breast cancer, in part as the result of findings derived from the rising federal research investment Advances in imaging (see Chapter 2) include reducing the dose of X rays needed, ... and Space Administration; HCFA, Health Care Financing Administration NCI-Industry Forum & Workshop on Biomedical Imaging in Oncology, NCI, industry, HCFA, FDA September 1999 New Initiatives and...
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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
Ngày tải lên :
16/03/2014, 04:20
... domain of p47phox binds intramolecularly to the SH3 domain in the same protein, and that this intramolecular interaction suppresses the lipid-binding activity of the PX domain in the resting ... putative protein of 910 amino acids that contains a PX domain (solid underlining) and four SH3 domains (dotted underlining) (Fig 2A) Moreover, the encoded protein also contained ten polyprolines (boxed), ... found in the FAD49 PX domain, as in many PX domains, suggesting that the PX domain could bind to an SH3 domain of FAD49 To test whether the PX domain could interact with an SH3 domain in FAD49,...
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Serum Biomarkers for Early Detection of Gynecologic Cancers ppt
Ngày tải lên :
22/03/2014, 11:20
... ovarian carcinoma in its early stage [84] Visintin et al proposed a set of serum biomarkers that consisted of leptin, prolactin, osteopontin, insulin-like growth factor II (IGFII), macrophage inhibitory ... thymidine kinase (TK) was demonstrated to be significantly higher in patients with cervical carcinoma than in normal women and patients with carcinoma in situ (p < 0.01 and p < 0.05, respectively) ... are under active investigation (Table 7) In a review by Li et al., HE4 displayed the highest sensitivity among single markers, including CA 125, in the detection of ovarian cancer in both the early...
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Báo cáo khoa học: Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2a receptor mediated activation of MEK⁄ ERK-CREB cascade doc
Ngày tải lên :
28/03/2014, 22:20
... protein kinase ⁄ extracellular signalregulated kinase kinase (MEK) ⁄ extracellular signalregulated kinase (ERK) cascade and the binding of cyclic AMP response element (CRE) binding protein (CREB) ... with an MEK inhibitor, PD98059; a PLC inhibitor, U73122; a PKC inhibitor, bisindolylmaleimide I; and a general COX inhibitor, indomethacin, or a selective COX-2 inhibitor, NS-398, in the presence ... which is a G-proteincoupled receptor; and this binding activates the downstream signaling pathways including the Gq heterotrimeric G protein, and then further increases the intracellular calcium...
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Báo cáo hóa học: "Early detection of urothelial premalignant lesions using hexaminolevulinate fluorescence cystoscopy in high risk patients" potx
Ngày tải lên :
18/06/2014, 16:20
... study and participated in its design and coordination All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: 20 ... urothelial carcinoma in situ with hexaminolevulinate fluorescence cystoscopy J Urol 2004, 171(1):135-8 Algaba F, Amin M, et al: Tumours of the urinary system: non invasive urothelial neoplasias In WHO ... using hexaminolevulinate imaging: a prospective, phase III multicenter J Urol 2005, 174(3):862-6 Page of 29 Kloek J, Akkermans W, Beijersbergen van Henegouwen GM: Derivatives of aminolevulinic...
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Chapter 078. Prevention and Early Detection of Cancer (Part 1) pps
Ngày tải lên :
07/07/2014, 01:20
... effects of smokeless tobacco may increase risks for other cancers Esophageal cancer is linked to carcinogens in tobacco being dissolved in saliva, swallowed, and coming into contact with the esophagus ... includes counseling, behavioral strategies, and pharmacologic adjuncts, such as nicotine replacement (gum, patches, sprays, lozenges, and inhalers) and bupropion Cigar smoking has increased in ... assistance in quitting Current approaches to smoking cessation recognize that smoking is an addiction (Chap 390) The smoker who is quitting goes through a process with identifiable stages that include...
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Chapter 078. Prevention and Early Detection of Cancer (Part 2) ppt
Ngày tải lên :
07/07/2014, 01:20
... effects of increasing fiber and lowering dietary fat have not been proven in the context of a prospective clinical trial The putative protective mechanisms are complex and speculative Fiber binds ... routine diet for years No differences were noted in polyp formation The U.S National Institutes of Health Women's Health Initiative, launched in 1994, is a long-term clinical trial enrolling ... their risk of developing skin cancer have some impact Self examination for skin pigment characteristics associated with melanoma, such as freckling, may be useful in identifying people at high...
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Chapter 078. Prevention and Early Detection of Cancer (Part 3) doc
Ngày tải lên :
07/07/2014, 01:20
... of interest in chemoprevention often have antimutagenic, antioxidant, anti-inflammatory, antiproliferative, or pro-apoptotic activity (or a combination) Table 78-1 Suspected Carcinogens Carcinogensa ... (azathioprine, glucocorticoids) agents cyclosporine, Non-Hodgkin's lymphoma Nitrogen mustard gas Cancer of the lung, head and neck, nasal sinuses Nickel dust Cancer of the lung, nasal sinuses Phenacetin ... lung, skin (especially squamous cell carcinoma of scrotal skin) Schistosomiasis Bladder cancer (squamous cell) Sunlight (ultraviolet) Skin cancer (squamous cell and melanoma) Tobacco (including smokeless)...
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Chapter 078. Prevention and Early Detection of Cancer (Part 4) pdf
Ngày tải lên :
07/07/2014, 01:20
... associated with combined estrogen plus progestin therapy Colorectal cancers diagnosed in women taking estrogen and progestin were in more advanced stage than those in women taking placebo A case-control ... withdrawn, suggesting the need for chronic administration More tolerable doses of isoretinoin have not proven beneficial in the prevention of head and neck cancer Isoretinoin also failed to prevent ... evidence suggested interaction between the two drugs Patients receiving αtocopherol had a higher incidence of hemorrhagic stroke The β-Carotene and Retinol Efficacy Trial (CARET) involved 17,000...
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Chapter 078. Prevention and Early Detection of Cancer (Part 5) pdf
Ngày tải lên :
07/07/2014, 01:20
... these drugs is ongoing Vaccines and Cancer Prevention A number of infectious agents cause cancer Hepatitis B and C are linked to liver cancer, some human papilloma virus (HPV) strains are linked ... encouraging widespread administration of the hepatitis B vaccine, especially in Asia, where the disease is epidemic A four-valent HPV vaccine (Gardasil) is 100% effective at preventing infection ... trial had similar findings In both studies tamoxifen also reduced bone fractures; a small increase in risk of endometrial cancer, stroke, pulmonary emboli, and deep vein thrombosis was noted...
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Chapter 078. Prevention and Early Detection of Cancer (Part 6) ppsx
Ngày tải lên :
07/07/2014, 01:20
... use is widely encouraged in screening programs, as a matter of public policy Screening examinations, tests, or procedures are usually not diagnostic of cancer but instead indicate that a cancer ... should be investigated Currently, persons at high risk for a particular cancer can engage in intensive screening While this course is clinically prudent, it is not known if it saves lives in these ... for early intervention to prevent a cancer or limit its severity People at high risk may be ideal candidates for chemoprevention and screening; however, efficacy of these interventions in the high-risk...
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Chapter 078. Prevention and Early Detection of Cancer (Part 7) pps
Ngày tải lên :
07/07/2014, 01:20
... derived from the findings of internally controlled trials using intervention allocation methods other than randomization (e.g., allocation by birth date, date of clinic visit); the findings of cohort ... irrespective of the screening result This is termed the healthy volunteer effect Potential Drawbacks of Screening Risks associated with screening include harm caused by the screening intervention itself, ... considered in assessing the results of any screening effort The population most likely to seek screening may differ from the general population to which the screening test might be applied The individuals...
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Chapter 078. Prevention and Early Detection of Cancer (Part 8) potx
Ngày tải lên :
07/07/2014, 01:20
... recommendation Insufficient M: ≥50, Recommendation specific antigen evidence to every year against recommend Pap test F: 18–65, every 1–3 years F: uterine with Fair evidence to cervix, include in examination ... years (fair evidence) Complete skin examination Insufficient evidence for or exam Periodic Poor evidence to include or exclude against a Summary of the screening procedures recommended for the ... palpation exam reasons during >40, every year for other Not considered Breast self- examination Breast clinical examination ≥20, No Fair evidence to recommendation monthly Insufficient evidence as...
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Chapter 078. Prevention and Early Detection of Cancer (Part 9) potx
Ngày tải lên :
07/07/2014, 01:20
... these women turned 50 is not known In randomized screening studies of women aged 50–69, the mortality decline begins about years after initiation of screening Nearly half of women aged 40–49 ... cancer Unfortunately when to begin and the optimal frequency of screening have not been defined Mammography is less sensitive at detecting breast cancers in women carrying BRCA1 and -2 mutations, ... Debate continues on whether colonoscopy is too expensive and invasive for widespread use as a screening tool in standard-risk populations DRE and barium enema are both insensitive as screening tools...
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Chapter 078. Prevention and Early Detection of Cancer (Part 10) doc
Ngày tải lên :
07/07/2014, 01:20
... routine screening has not been shown Transvaginal ultrasound and endometrial sampling are indicated for workup of vaginal bleeding in postmenopausal women but are not considered as screening ... impotence and urinary incontinence Comparison of radical prostatectomy to "watchful waiting" in clinically diagnosed (not screen-detected) prostate cancers showed a small decrease in prostate cancer ... rate in the surgery arm One life was saved for every 18–20 men treated with radical prostatectomy Urinary incontinence and sexual impotence were more common in the surgery arm One current screening...
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Báo cáo y học: "Early Detection of cytokine protein expression in mouse lung homogenates using suspension bead array" ppt
Ngày tải lên :
11/08/2014, 08:21
... Journal of Inflammation 2006, 3:15 inflammatory cytokines, interleukin-6 (IL-6) and macrophage inflammatory protein-2 (MIP-2) protein levels in mouse lung tissue homogenates are increased following ... wells and incubated for hour After washing, 100 μl Streptavidinphycoerythrin was added to each well and incubated for 30 minutes After a final wash, the plate was analyzed using the Luminex 100 ... protein expression in lung tissue homogenates using suspension bead array These findings correlated with cytokine protein expression profiles detected using antibody array and were confirmed using...
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Báo cáo y học: " Early detection of Varicella-Zoster Virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report" potx
Ngày tải lên :
12/08/2014, 04:20
... under certain circumstances, as for example in cases of atypical or subclinical varicella or in the absence of detectable VZV DNA in plasma Consent Written informed consent was obtained from the ... heparinized blood Click here for file [ http://www.biomedcentral.com/content/supplementary/1743-422X-7-54S1.PDF ] Page of Competing interests The authors declare that they have no competing interests ... A: Viral strain identification in varicella vaccinees with disseminated rashes Pediatr Infect Dis J 2000, 19:1037-1039 Hambleton S, Gershon A: Preventing Varicella-Zoster Disease Clin Microbiol...
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Near infrared autofluorescence imaging and spectroscopy for early detection of precancer and cancer in the colon
Ngày tải lên :
10/09/2015, 08:29
... occult blood testing G-FOBT Guaiac-FOBT ICG Indocyanine green IRB Institutional Review Board LDA Linear discriminate analysis NADH Nicotinamide adenine dinucleotide NBI Narrow Band Imaging NHG National ... detail by spraying of stains, thus it has been widely applied in a variety of clinical settings and throughout all gastrointestinal tract segments (including the colon) by the endoscope in the past ... the initial tissue layer, which scatters back out of the tissue by one or two single scattering events, retains the linear polarization to the incident light The remaining incident light continues...
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