Ngày tải lên: 07/08/2014, 06:20
... terms of the donor’s gift. The duty resting on trustees to honour the terms of their trust and ensure that the objects of the charity prevail has always been seen as the primary means whereby the ... presumption that public benefit provision is wholly the responsibility of government has long gone. Government Policy The steady contraction of State responsibility for provision or delivery of public ... such missionary bodies should have the advancement of religion as their primary purpose. 95 Leaders of Voluntary Action By the end of the 19th century charities were the primary providers of health,...
Ngày tải lên: 29/03/2014, 05:20
Báo cáo " Study on the characteristics and catalytic properties of Pt/SBA-15 in the selective oxidation of D-Glucose " potx
... image of the products of D-glucose oxidation on PS-1 catalyst On the other hand, the reaction on Pt/SBA- 15 catalysts with pH control not only showed a high conversion, but also high D-gluconic ... 183-190 189 - From the results above, we found that both HNO 3 and Pt/SBA-15 present a good conversion in the oxidation reaction of glucose. The conversion of the reaction reached 87.67% when ... of plantinum nanoparticles in the selective oxidation of glucose. When the reaction was performed without pH control on PS-1 catalyst, the conversion decreased significantly. The pH at the...
Ngày tải lên: 05/03/2014, 11:21
Báo cáo khoa học: Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41 ppt
... coincide with the region that binds HR1 upon 6HB formation. The strong affinity of RC-101 for HR2 prevents the inter- action of HR1 and HR2, formation of the 6HB, and subsequent fusion of the host ... regions of gp41 [12]. During 100 days of serial passaging, HIV-1 strain BaL developed three cationic mutations in the presence of sublethal concentrations of RC-101 [14]. Of the three mutations, ... thus the dependence of viral replication on the presence of RC-101 is not surprising. The cationic mutations and loss of glycosylated residues suggest an attempt by the virus to repel the cationic...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Context-dependent effects of proline residues on the stability and folding pathway of ubiquitin docx
... substitutions imposed on the backbone conformation of WT* shows that the pattern of P37 P38 P19 W45 Fig. 1. Ribbon structure modelled on the X-ray structure of human ubiquitin [32]. The position and ... solution of native protein was unfolded by a 1 : 10 dilution to yield final concentrations of GdmCl near or above the midpoint of the equilibrium unfolding transition (concentrations of GdmCl in the range ... that the reduction in stability of these mutants is largely manifested in perturbations to the unfolding rates with the degree of compactness of the TSE (a D ) and linearity of the chevron plots...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Effects of salt on the kinetics and thermodynamic stability of endonuclease I from Vibrio salmonicida and Vibrio cholerae potx
... study, the effect of NaCl concentration on the kinetic constants and thermodynamic stability of VsEndA and VcEndA was investigated. In addition, the effects of reciprocal mutations of two non-con- served ... boundary conditions, and the resulting grid was adopted as the boundary condi- tion for one further focused calculation. The protein mole- cules occupied 90% of the box in the final calculations. The molecular ... activity conditions of the native enzymes [11]. The denaturation peaks were symmetrical, except for some exothermic distortion of the thermograms after the denaturation peak, especially in the VcEndA...
Ngày tải lên: 16/03/2014, 06:20
Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx
... iden- tified as the major and the minor forms of the holo- ACP structure, on the basis of their percentage contri- butions (65% and 35%, respectively) to the overall structure of the protein. The structures ... against the fraction number (AU, arbitrary unit). (d) The apparent molecular masses of apo-ACP and holo-ACP were estimated on the basis of the linear regression of the fraction number of the molecular ... elucidates the interactions respon- sible for the conformational stability of PfACP. The size exclusion chromatography profile of PfACP showed that the apparent molecular mass of PfACP monomer is...
Ngày tải lên: 16/03/2014, 10:20
Báo cáo khoa học: Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human a-tropomyosin docx
... assayed by varying the concen- tration of Tm in the presence of constant concentration of F-actin and myosin S1. In this condition, Tm inh ibits the ATPase activity as its concentration increases [33]. ... stability of the protein as a whole, rather than on the position of the mutation in the polypeptide chain, as demonstrated by the biophysical assays. Our studies h ave provided additional contributions ... f the mutant Tms. The mutations d id not affect the structure of the protein as there was no significant alteration in the f unction or in the amount of th e s econdary s tructure. However, the...
Ngày tải lên: 16/03/2014, 18:20
influence of binders on the sensing and electrical characteristics of wo3-based gas sensors
... semiconductor, electron transfer occurs between the semiconductor and the adsorbates. If the electron affinity of the adsorbates is larger than the work function of the n-type semiconductor, the ... characteristics of WO film mostly through the chemi- 3 cal nature of GB rather than the modification of physical properties of polycrystals. 5. Conclusion The origin of binder effects on the sensing ... than the exponential one since the desorption effect adds on the exponential temperature de- Ž. pendence given by Eq. 5 . But the decrease of film resistance is faster than the exponential one only...
Ngày tải lên: 20/03/2014, 13:04
Báo cáo "Effects of Zn content on the magnetic and magnetocaloric properties of Ni-Zn ferrites " pdf
... lattice constant and volume of unit cell increase with Zn content in the samples due to larger ionic radius of Zn 2+ ion (0.82 Å) substituted for Ni 2+ ion (0.78 Å). The X-ray density, the real ... Exchange interactions between magnetic ions through oxygen ion are superexchange interaction with antiferromagnetic nature. These interactions depend on bond distance and bond length. Normally ... each other below the freezing temperature T f indicating the onset of blocking of clusters. The sample settles into the frozen state below temperature T f . This behavior is attributed to the...
Ngày tải lên: 22/03/2014, 11:20
Báo cáo khoa học: The ‘pair of sugar tongs’ site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity potx
... with the reduced DMA of the AMY1 Y380A ‘sugar tongs’ mutant, these effects may stem from allosteric regula- tion. The mutational analysis of the ‘sugar tongs’ in barley AMY1 explored the role of ... This is the first demonstration of a function for a C domain from the large GH clan-H. The work contributes to the unraveling of the molecular basis of multivalent enzyme–polysaccharide interactions. ... connects b5 and a5 of the catalytic (b ⁄ a) 8 -barrel at the end of the aglycon-binding area of the active site cleft. Earlier, significant deviation was found in this region between the backbone...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
... host response depending on the genetic constitution of the plant and the pathogen. In an incompatible inter- action, the pathogen remains localized at the primary infection sites that often are ... zone 1 (lanes 1,3,5,7) included necrotic tissue from the lesions, whereas leaf material of zone 2 was collected in a region 7–14 mm away from the center of the lesions. Due to the expansion of ... collected from a narrow zone including the lesion and from a more distant zone around single lesions of each plant. Whereas samples from the distant zone of control plants never contained necrotic leaf...
Ngày tải lên: 23/03/2014, 15:21
THE EXPOSURE OF YOUTH TO UNWANTED SEXUAL MATERIAL ON THE INTERNET: A National Survey of Risk, Impact, and Prevention pdf
... supportive of different contentions about harm, depending on the emphasis one chooses to give them. On one hand, it is clear from their reactions that the majority of youth regard their personal unwanted ... to confirm a causal relationship.) On the other hand, one of the cautionary findings is that despite its ability to decrease exposure, the software seems far from foolproof. At least 18% of the ... av - erage of 24% of the health information and 91% of the pornography. Although such studies show possible weaknesses in the software ap - proach, they do not address the question of how the programs...
Ngày tải lên: 29/03/2014, 19:20
Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers ppt
... obtained for the bilayer in the presence of 1 m M Zn ions, as a function of time, after the addition of A b (5 lM bulk concentration in the sample cell). Initial binding occurred mainly in the SM-rich ... facilitate peptide penetration of the hydrocarbon core of the membrane and subse- quent aggregation [22,37]. In order to test the effect of zinc addition in the present experiments on peptide binding ... without loss of bilayer integrity. A structural interpretation of peptide interaction with the bilayer is presented based on the results of simulation analysis of the PWR spectra. Abbreviations Ab,...
Ngày tải lên: 30/03/2014, 11:20
Báo cáo khoa học: Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4 doc
... of the peptide seems to contribute to the effective anchoring of the tryptophan residue. Concluding remarks The C-terminal 14 residue truncation of GGN4 abolished the biological activity of the ... tryptophanyl substitution at position 16 on the biological activity was confirmed for the native GGN4. Consistent with the results of the C-terminally truncated GGN4, the D16W substitution in the native GGN4 ... amphiphilic in nature. The tryptophan side chain conformation was more clearly defined in both of the environments than those of the other residues (Fig. 2D). However, the orientation of the tryptophan...
Ngày tải lên: 31/03/2014, 09:20
Manual on the management, maintenance and use of blood cold chain equipment potx
Ngày tải lên: 31/03/2014, 12:20
EFFECT OF STORAGE TEMPERATURES ON THE PHYSIOLOGICAL AND BIOCHEMICAL PROPERTIES OF HYLOCEREUS POLYRHIZUS
Ngày tải lên: 05/05/2014, 08:39