peptide ogf and its receptor zet are present in human colon cancer
Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21" pdf
Ngày tải lên :
09/08/2014, 09:20
... that induces apoptosis in several murine and human cancer cell lines [4,5,8] This is our first attempt to understand the role of p53 and p21 in drug efficacy using colon cancer cells that are ... (HIF-1a) mRNA and protein in the human colon carcinoma cell line T-84, and in EMT6 mouse mammary carcinoma cells and Lewis Lung Carcinoma (LLC) cells [4,8] We also showed that DCQ inhibited cell ... study, DCQ was found to induce single strand breaks (SSB) in DNA of DLD-1 human colon cancer cells, and both SSB and double strand breaks (DSB) in EMT6 cells [5,11] DNA damage, in particular DSBs,...
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Báo cáo khoa học: " Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells" pdf
Ngày tải lên :
09/08/2014, 10:21
... examined in the FHs74Int normal human intestinal cell line to determine the sensitivity of normal cells to DCQ In addition, the DNA damaging potential of DCQ and its effects on the protein expression ... FHs74Int normal intestinal cell line After establishing effects of DCQ and IR in cancer cells, we compared DCQ efficacy in normal cells For this purpose, FHs74Int normal human intestinal cells were ... factor Human colon cancer cell lines (DLD1, HT-29, HCT-116, and SW-480) were grown in RPMI 1640 containing L-Glutamine and 25 mm HEPES All Cell cycle analysis using flow cytometry Following treatment,...
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báo cáo khoa học: "Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP" pptx
Ngày tải lên :
11/08/2014, 00:22
... proangiogenic and pro-inflammatory factors, VEGF, COX-2, IL-6 and IL-8, in cultured human colon cancer cells; (c) DCPIP and DCPIP NPs are similarly effective in inhibiting VEGF-induced angiogenesis in ovo; ... Angiogenesis in Gastric Cancer Cancer Microenviron 2009 in press 14 Waugh DJ, Wilson C: The interleukin-8 pathway in cancer Clin Cancer Res 2008, 14(21):6735-41 15 Nishimoto N: Interleukin-6 in rheumatoid ... CH and SA assisted in the design planning of all experiments PP participated in the design of XTT, CAM and Western experiments, assisted in data analysis and interpretation and in writing and...
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Báo cáo khoa học: The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids doc
Ngày tải lên :
06/03/2014, 11:20
... Wet et al domains (TMDs) and two intracellular nucleotide-binding domains (NBDs) It is thought that, as in other ATP-binding cassette (ABC) proteins [4], the NBDs of SUR associate in a head-to-tail ... of Kir6.2 ⁄ SUR2A and Kir6.2 ⁄ SUR2B channels [5], indicating that SUR2A and SUR2B not differentially in uence ATP binding to Kir6.2 In the presence of Mg2+, however, ATP inhibits Kir6.2 ⁄ SUR2B ... nucleotide-binding sites (site and site 2) that comprise the Walker A and Walker B motifs of one NBD and the linker domain of the other In the absence of Mg2+, there is little difference in ATP block...
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Báo cáo lâm nghiệp:"Stand history and its consequences for the present and future dynamic in two silver fir (Abies alba Mill.) stands in the high Pesio Valley (Piedmont, Italy)" potx
Ngày tải lên :
08/08/2014, 01:21
... that gave rise to the present stand in plot occurred in the five-year interval of 1935; indeed, intense logging was carried out in the Buscaié forest during that interval, and in the plot more than ... of shadeintolerant broadleaves prevented them from competing with the silver fir and from reaching the dominant, codominant and intermediate layers, thus making it possible to maintain stands which ... the origin of the present- day stand; indeed there are disturbances recorded in trees where a regeneration establishment did not subsequently take place Thinning and low-intensity cutting can...
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Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt
Ngày tải lên :
09/08/2014, 13:21
... 0.05, **P < 0.005, and ***P < 0.0005) were determined using the Wilcoxon test In panel a differences are as compared with control individuals, and in panel b comparisons are between indicated populations ... classification of SLE and had two living parents who agreed to participate in the study In total 144 patients, 288 parents, and 79 siblings were investigated Population control individuals for the ... models, with interleukin-4-secreting NKT cells inhibiting lupus and interferon-γ-secreting NKT cells exacerbating lupus [53,54,56,57] Similar findings have been observed in other autoimmune mouse models...
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Báo cáo y học: " Newly described human polyomaviruses Merkel Cell, KI and WU are present in urban sewage and may represent potential environmental contaminants" potx
Ngày tải lên :
12/08/2014, 04:20
... human polyomaviruses in environmental matrices Competing interests The authors declare that they have no competing interests Authors' contributions SBM coordinated the study, concentrated urine ... Barbanti-Brodano G, Sabbioni S, Martini F, Negrini M, Corallini A, Tognon M: BKvirus, JC virus and Simian Virus 40 infection in humans, and association with human tumors Adv Exp Med Biol 2006, ... virus DNA sequences are frequently present in human upper and lower gastrointestinal tract Gastroenterol 2000, 119:1228-1235 Bofill-Mas S, Albinana-Gimenez N, Clemente-Casares P, Hundesa A, Rodriguez-Manzano...
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Báo cáo y học: "Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis" pps
Ngày tải lên :
12/08/2014, 14:21
... proliferating FLSs produce proteinases that degrade cartilage and underlying cortical bone [4] We noticed that proinflammatory cytokines upregulate NGF/TrkA in FLSs, NGF/TrkA is upregulated in FLSs of in ammatory ... stimulated cells were cultured in DMEM with cytokines tumor necrosis factor-alpha (TNF-α) (1 ng/mL) and interleukin-1-beta (IL-1β) (1 ng/mL) Data are expressed as mean ± standard deviation Nerve growth ... FACS, fluorescence-activated cell sorting; OA, osteoarthritis; PsA, psoriatic arthritis; RA, rheumatoid arthritis in uence angiogenesis and cell trafficking [3] In patients with RA or PsA, pannus...
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Báo cáo y học: "Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA" pdf
Ngày tải lên :
13/08/2014, 13:20
... as a continuous sinusoidal staining and in the stroma of portal tracts (Fig 7A) In the cirrhotic liver, the sinusoidal staining was enhanced, whereas a very faint staining was observed in fibrous ... questioned in humans [2] LIF exerts its biological activities through its binding to a hetero-oligomeric receptor complex between the low-affinity LIF receptor subunit gp190 and the signal-transducing ... expression in various cell lines and in human liver RT-PCR analysis of LIF-M expression in various cell lines and in human liver (A): LIF-M expression was analyzed with the hLIF-M2 and hLIF-3N...
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Functional characterization of HGF and its receptor c met in zebrafish development
Ngày tải lên :
12/09/2015, 08:18
... β1-integrin and erbB2 p125FAK (focal adhesion kinase) is a 125 kDa protein, consisting of a N-terminus integrin-binding site, a central kinase domain, and a C-terminus focal adhesion targeting and ... domain-containing proteins such as Crk/CRKL and Src, five leucineand aspartate-rich (LD) domains, and four tandem-repeat double-zinc finger LIM domains that are employed to recruit signaling ... paxillinbinding domains (Schaller and Sasaki, 1997) p125FAK family members include proteins such as PYK2 and FAK-B p125FAK can interact with integrins, paxillin, PI3-K, SH3 domain-containing adapter...
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Cloning of medaka glial cell derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Ngày tải lên :
03/10/2015, 20:57
... serine-threonine kinase Instead, it signals through a receptor complex formed by the receptor tyrosine kinase RET and a novel class of protein, known as GDNF Family Receptor- α (GFRα), which are linked and ... functional domain of GFRα1, namely the N-terminal secretory signal peptide, GPI signal peptide and Cterminal hydrophobic region are underlined However, the corresponding domains in medaka are currently ... of Gdnf compared to its alleged receptor in the brain This suggests the presence of another binding ligand to Gfrα1 in the medaka brain and also probably, a different role for Gdnf in the medaka...
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Prevalence and Its Predictors of Extrapulmonary Involvement in Patients with Pulmonary Tuberculosis pdf
Ngày tải lên :
15/03/2014, 03:20
... Table Sites and methods of diagnois of extrapulmonary involvement in 40 patients Involved organ* Miliary involvement Lymph node Intestine Larynx Soft tissue Bone and joint Peritoneum Meninges 40 ... status in patients with TB (23, 24) In addition, hypoalbuminemia/protein malnutrition itself could impair host immunity against M tuberculosis through decreased production of cytokines including interferon-γ(25) ... production and impaired antimycobacterial immunity in protein-malnourished guinea pigs Infect Immun 1998; 66: 3562-8 26 Mainali ES, McMurray DN Protein deficiency induces alterations in the distribution...
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Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc
Ngày tải lên :
16/03/2014, 18:20
... Overlays are shown in A and B with yellow color indicating colocalization, red color indicating mycRab4Q67L, and green color indicating EGFPfused proteins The black -and white insets in panels A¢ and ... Interestingly, both the deletion found in the Rabaptin-5d polypeptide chain and the Rab4 binding site of Rabaptin-5 are located in the N-terminal portion of protein However, some discrepancy exists in ... CC2–1, CC2–2) are shown in black Positions of the Rab4 binding domain (R4BD) are marked as white and black hatched boxes as determined in [14] and [26], respectively The Rab5 binding domain (R5BD)...
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Báo cáo khoa học: The starch-binding capacity of the noncatalytic SBD2 region and the interaction between the N- and C-terminal domains are involved in the modulation of the activity of starch synthase III fromArabidopsis thaliana pdf
Ngày tải lên :
22/03/2014, 21:20
... tryptophan in binding site II and an aromatic residue (mainly tryptophan or tyrosine) in binding site I [22] We have shown that the tryptophan residue involved in binding site II is conserved in the ... W366 and Y394 involved in starch binding are located in the D2 domain, between the D(316–344) and D(495–535) interacting loops (see Fig 3D) Indeed, it has also been suggested that the tandem ... the N-terminal region responsible for SSIII regulation We found evidence indicating that two regions, D(316–344) in the D2 domain and D(495–535) in the D3 domain, are involved in the interaction...
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Báo cáo Y học: Supermolecular organization of photosystem II and its associated light-harvesting antenna in Arabidopsis thaliana docx
Ngày tải lên :
24/03/2014, 04:21
... (‘c’), the S-type and M-type LHCII trimers (‘s and ‘m’) indicated in yellow, the CP29, CP26 and CP24 areas in green and the strongest difference area from image (C) indicated in red; (F) image ... two-dimensional crystals The study of negatively stained intact inside-out paired membranes can give interesting insight into the packing and ordering of PSII supercomplexes, because the row-like ... previously been found in spinach [11,12,25] They consist of C2S2M2, C2S2M, C2SM and C2S2 configurations and are depicted in Fig 1A–D, respectively An interesting result in the present data set was...
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Báo cáo hóa học: " Maximum Likelihood Turbo Iterative Channel Estimation for Space-Time Coded Systems and Its Application to Radio Transmission in Subway Tunnels" potx
Ngày tải lên :
23/06/2014, 01:20
... results obtained with the proposed estimator using a training sequence of M = bits and those obtained with classical LS using a training sequence of M = 26 bits (the length standardized in GSM) The ... technique enables us to diminish the training sequence length up to only bits, instead of the 26 bits considered in the GSM standard, thus achieving a 14% increase in the system throughput where ... by the GSM standard, Gaussian minimum shift keying (GMSK), induces controlled ISI and thus Turbo ST Equalization can be employed for the purpose of joint demodulating and decoding In addition,...
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Báo cáo lâm nghiệp: "Evaluation of changes in the landscape management and its influence on animal migration in the vicinity of the D1 motorway in Central Bohemia" ppsx
Ngày tải lên :
07/08/2014, 10:21
... forest land in the USA, change in use is planned in the next 50 years due to infrastructure and urbanization (Alig, Plantinga 2004) Also wetlands and natural areas are likely to be transformed into ... combination help to explain the existence of diverse landscapes? Fenina, 178: 55–80 Wrbka T (1998): Landscape structure as indicators for sustainable land use? A case study in alpine and lowland ... and forest land and increase its separation effect Lipský (2000) stated that overall changes in the landscape, and especially in the manner of land use, are most preferably monitored using a time...
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Báo cáo khoa học: "Flowering and cone production variability and its effect on parental balance in a Scots pine clonal seed orchard" docx
Ngày tải lên :
08/08/2014, 18:21
... flowering was observed the fifth day from the beginning of pollen shedding for three clones in 1990 and for one clone in 1991 The ranks of clones according to their flowering beginning in 1990 and ... done following partitioning variance and covariance components cones RESULTS = Phenology The phenograms of male and female flowering in 1990 and1 991 are presented in figure In 1990 flowering started ... T (1988) Variation in flowering of North Finnish clones in a Norway spruce J Linn Soc seed orchard in Central Finland In: Proc IUFRO Meeting on Norway Spruce; ProveBreeding and Genetic Conservation...
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Báo cáo khoa học: "The incidence of recurrent flushing and its effect on branch production in Quercus petraea (Matt) Liebl growing in southern England" ppt
Ngày tải lên :
08/08/2014, 23:22
... overwintered bud, may be determined during the previous growing season; the lengths of FIRST and SECOND flushes reflecting, in part, different patterns of growth, physiology and apical dominance in ... overwintered buds and resting summer buds (Champagnat, 1989) In order to obtain a greater understanding of shoot growth, further studies should include the timing of reactivation, growth and development ... Recurrent flushing on trees in the same stand was also assessed for 1988 and 1989/ 1990 using 10 and 21 trees respectively; shoots formed in 1990 were observed in February 1991 In the analysis...
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Báo cáo y học: "Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis" ppt
Ngày tải lên :
09/08/2014, 06:22
... for min, and kept frozen at -20°C until analysis We prepared cell lysates by incubating the cell pellet for hour in mM EDTA buffer containing M urea and proteinase inhibitors (Complete MiniTab; ... leflunomide, and one patient used azathioprine The inhibitors of TNF-α were used in 47 patients (42 patients in combination with MTX, three patients in combination with azathioprine, one patient in combination ... to the cell cycle being upregulated in the G2/M phase Inside the dividing cell, survivin is found incorporated in centrosomes and mitotic spindles, and relocates to midbodies in the late telophase...
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