pegloticase for treatment of refractory gout pre clinical development

... of gout patient-specific urate-lowering prescriptions (absolute number of prescriptions/year) Allopurinol Probenecid 2.8 million 8,000 Demographics of allopurinol prescribing: percentage of gout ... sustainability of rasburicase treatment beyond to 12 months appear to be poor for treatment of refractory hyperuricemia in gout [52,53] A recent advance has been seen in clinical trials of recombinant ... definition of treatment- refractory gout and gout- specific quality of life and disability will need careful assessment and direct attention in clinical practice Such efforts would be timely, since treatment- refractory ...

Ngày tải lên: 09/08/2014, 14:21

... endoscopic laminoforaminoplasty for the treatment of foraminal spinal stenosis Methods This was a prospective study of 64 patients who underwent endoscopic laminoforaminoplasty for refractory foraminal ... laminoforaminotomy for unilateral radiculopathy: results of a new technique in 100 cases J Neurosurg 2001, 95:51-57 18 Khoo LT, Fessler RG: Microendoscopic decompressive laminotomy for the treatment ... complete foraminal decompression may be treated with a combined interlaminar and lateral approach [6] In a report of 65 surgical cases of lumbar foraminal stenosis, laminectomy and foraminotomy...

Ngày tải lên: 03/11/2012, 11:17

... counts of P aeruginosa before (pre) and after (post) treatment with inhalation alone (p i.) or combined treatment with inhalation and i v antibiotics (p i + i v.) Mean+SEM *: P < 0.05 vs pre RESULTS ... and in vivo (6-8) at present there is no information available on the clinical effect of fucose/galacatose when given to CF patients In the present study both inhalation of fucose/galactose solution ... number of patients and short period of time studied As the fucose/galactose inhalation is a novel treatment, an important question concerns the observation of adverse effects of this treatment...

Ngày tải lên: 03/11/2012, 11:48

... treatment of incomplete abortion? • Who can provide misoprostol for treatment of incomplete abortion? • Dose and timing • Route of administration • Safety of misoprostol for treatment of incomplete ... tongue for about 30 minutes Any remaining pill fragments can be swallowed with water E Safety of misoprostol for treatment of incomplete abortion Misoprostol has been studied for treatment of incomplete ... become comfortable with misoprostol for treatment of incomplete abortion, success rates will generally rise.25 C Schedule of clinic visits A woman who chooses misoprostol for treatment of her incomplete...

Ngày tải lên: 17/11/2012, 09:13

... metabolic diseases, and discuss whether these ANGPTLs could be targets for the prevention and treatment of these conditions Suppression of ANGPTL2 as an effective strategy against obesity-related insulin ... expression of other inflammatory cytokines In addition, because ANGPTL2 null mice survive and grow normally, it is predicted that the suppression of ANGPTL2 signaling has few side effects Therefore, ... induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia Similarly, hyperleptinemia is a consequence of the development of insulin resistance...

Ngày tải lên: 14/02/2014, 22:20

... increasing prevalence of MRSA as a cause of ABSSSI has made vancomycin become the empiric IV Healthy Aging & Clinical Care in the Elderly 2012:4 Daptomycin for treatment of cSSSI antibiotic of choice for ... sub-therapeutic troughs of vancomycin may select for hVISA sub-populations.20 However, the clinical implication of the presence of hVISA subpopulations is not clear In a retrospective analysis of patients ... comparative daptomycin trial for uSSSI No significant differences in outcomes were found between daptomycin and standard treatments.55 In summary of clinical trials for the treatment of cSSSI, daptomycin...

Ngày tải lên: 22/03/2014, 14:20

... the medical practices for the treatment of ethnic or aborigine people for their health care needs Present study focuses on the utilization of plants available with the people of Chhattisgarh, they ... Disease Method of Preparation Doses 10 11 12 13 14 Local Name Botanical Name Part Used Disease Method of Preparation Doses Local Name Botanical Name Part Used Disease Method of Preparation Doses ... Part Used Disease Method of Preparation Doses Local Name Botanical Name Part Used Disease Method of Preparation Doses Local Name Botanical Name Part Used Disease Method of Preparation Doses Local...

Ngày tải lên: 28/03/2014, 14:20

... on, and FDA-approval of, VS is primarily for use in the treatment of knee osteoarthritis, it has also been used successfully in small trials for the treatment of arthritis of the temporomandibular, ... aspiration for blood, milliliter (ml) of iopamidol-300 (Isovue-300©) dye was injected, verifying intra-articular spread of the dye (Figure 2) This was followed with an injection of mL of 0.5% preservative-free ... Sodium Hyaluronate for the Treatment of Patients with Periarthritis of the Shoulder Clinical Therapeutics 1995, 17(5):946 Page of 18 Smith G, Myers S, Brandt K, Mickler E: Effect of Intra-articular...

Ngày tải lên: 20/06/2014, 04:20

... on, and FDA-approval of, VS is primarily for use in the treatment of knee osteoarthritis, it has also been used successfully in small trials for the treatment of arthritis of the temporomandibular, ... aspiration for blood, milliliter (ml) of iopamidol-300 (Isovue-300©) dye was injected, verifying intra-articular spread of the dye (Figure 2) This was followed with an injection of mL of 0.5% preservative-free ... Sodium Hyaluronate for the Treatment of Patients with Periarthritis of the Shoulder Clinical Therapeutics 1995, 17(5):946 Page of 18 Smith G, Myers S, Brandt K, Mickler E: Effect of Intra-articular...

Ngày tải lên: 20/06/2014, 07:20

... lacinilc fo noitaulave yb demrofrep saw sisongaid MCT skeew 21 gnirud demrofrep saw tnemtaert erutcnupucaortcele elohw ehT snoitacilppa tsal eht rof syad 41 yreve neht ,skeew rof keew a ecno erutcnupucaortcele ... alumrof tsrif eht elbane oT niap etaivella dna noitalucric pleh ,ygrene revil dna yendik ecnahne ,ssenpmad dna dniw lepxe ot nesohc saw alumrof tsrif ehT ]51,31[ ,alumrof cinot a yb dewollof , ... dna :tnemtaert rof nesohc erew )1 elbaT( salumrof labreh esenihC lanoitidart gniwollof ehT seigrene yendiK dna neelpS , ecnahne dna ssenpmad esrepsid ot desu saw 6PS dna worram rof tniop laitneulfni...

Ngày tải lên: 07/08/2014, 20:23

... reported topiramate lack of efficacy in a case report of recurrent major depression Topiramate was used as adjunctive treatment for weeks at a dose of 300 mg/day Anxiety and depressive features supervened ... greater in the treatment arm The rate of decrease in Hamilton Depression Rating Scale scores did not differ between treatment groups The mean weight loss for Page of 14 (page number not for citation ... in the treatment of bipolar depression as alternative or adjuvant to mood stabilisers The role of topiramate in the treatment of rapid cycling bipolar disorders [75], and as adjunctive treatment...

Ngày tải lên: 08/08/2014, 21:20

... [20] The present review addresses the possible role of IFN-β in immune-mediated diseases such as MS and RA This antiangiogenic capacity of IFN-β may also be of relevance for the treatment of RA ... procedure has the advantage of a constant level of expression of IFN-β by syngeneic fibroblasts Mice were injected with IFN-βexpressing fibroblasts before the onset of arthritis, and paw swelling, ... because of lack of the major histocompatibility complex class I allele A-26 Three out of four monkeys had active polyarthritis at the time of treatment initiation The fourth monkey was in a preclinical...

Ngày tải lên: 09/08/2014, 01:21

... mucinous tumour of the pancreas: the treatment of choice HPB (Oxford) 2001, 3(4):257-262 Swope TJ, Wade TP, Neuberger TJ, Virgo KS, Johnson FE: A reappraisal of total pancreatectomy for pancreatic ... attempted because of locally unresectable disease [29] In an analysis by Shimada et al of 88 patients with extended DP, which Page of 10 (page number not for citation purposes) World Journal of Surgical ... contraindication for tumor removal Since Appleby et al first proposed en-bloc resection of the celiac trunk with distal pancreatectomy and total gastrectomy for the treatment of locally advanced...

Ngày tải lên: 09/08/2014, 07:22

... Diagram of Treatment Time for CAT (Conformal Arc Therapy) in black and for RA (Rapid Arc) in white The treatment time does not include the setup of patient and setup between every single arc for ... carefully for choice of technique and could afford an important benefit for RA In this context, number of MU was clearly lower for RA in of 10 patients This item could be an advantage for patients ... with longer estimated lifetime were analysed for irradiation, risk of development of a secondary tumour should be more weighted for final choice of treatment technique Especially, patient with...

Ngày tải lên: 09/08/2014, 09:20

... nodes and areas of risk for harboring microscopic disease (Figure 1) There is one ongoing prospective fase II trial using preoperative SIB-IMRT strategy and capecitabine for treatment of locally advanced ... this article as: Ferrigno et al.: Comparison of conformal and intensity modulated radiation therapy techniques for treatment of pelvic tumors Analysis of acute toxicity Radiation Oncology 2010 5:117 ... symptoms to patients under RT treatment is a considerable advantage for IMRT Because use of CT is now well established for treatment of some pelvic tumors sites, such as the rectum, cervix, anal canal...

Ngày tải lên: 09/08/2014, 09:20

... been published Therefore, in the present double-blind and placebo-controlled clinical study, we sought to evaluate the efficacy and safety of 5-Loxin® in treatment of OA of the knee We assessed ... the colour development was read with the help of micro-plate Statistical analysis We performed detailed statistical analyses using SAS software to evaluate the efficacy of two doses of 5-Loxin® ... joint stiffness For power calculations, the estimates for variability and assumed mean changes for each treatment group were based on results from previous placebo-controlled studies of celecoxib,...

Ngày tải lên: 09/08/2014, 10:23

... 87:6058-62 Lard-Whiteford SL, Matecka D, O'Rear JJ, Yuen IS, Litterst C, Reichelderfer P: Recommendations for the nonclinical development of topical microbicides for prevention of HIV transmission: ... mechanism of action [10] Notably, these terpenoid derivates are non-toxic up to 500 mg/ kg body weight in mice[6] The purpose of the present study was to evaluate the first steps of preclinical development ... standard deviation of primary cells, expressed in percentage Means are representative of independent experiments and assays were performed in duplicates Results High concentrations of C14 are not...

Ngày tải lên: 10/08/2014, 05:21

... hypercholersterinemia and performance of PTCA of the left coronary artery in 2002 In the Department of Thoracic-, Cardiac- and Vascular Surgery of the University of Goettingen, Germany, we performed CABG with ... design of the study and performed the statistical analysis SAM participated in the design of the study and performed the statistical analysis AW participated in the design of the study and performed ... was obtained from the patient for publication of this case report and accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal Acknowledgements...

Ngày tải lên: 10/08/2014, 10:20

... a corticosteroid for treatment of soft tissue disorders, guidelines in the rheumatology literature recommend use of an agent with high tissue solubility [42], and avoidance of fluorinated compounds ... control for intervention effects not due to the pharmacological action of corticosteroids Prescription of a standardised stretching program has been introduced in order to compensate for the presence ... regarding the use of corticosteroid injection for treatment of this condition Competing interests HBM and KBL are Editor-in-Chief and Deputy Editor-in-Chief, respectively, of the Journal of Foot and...

Ngày tải lên: 10/08/2014, 21:24

... contraindications for the presacral approach include insufficient presacral fat pad, previously explored presacral space, large vessels crossing the presacral space, and anatomic abnormalities that preclude ... Likert scale, of mechanical type (exacerbated by Page of standing or walking for extended periods of time and improved by lying down), and refractory to extensive conservative treatment During ... female who presented with a 10-year history of axial low back pain and a one-year history of radiculopathy The pain was described as out of 10 on average and 10 out of 10 at its worst, of mechanical...

Ngày tải lên: 10/08/2014, 23:20